DGIdb - LISINOPRIL Drug Record

LISINOPRIL chembl:CHEMBL1237 Approved

Alternate Names:

LISINOPRIL DIHYDRATE
LISINOPRIL HYDRATE
LISINOPRIL
MK-521
(S)-1-(N(2)-(1-CARBOXY-3-PHENYLPROPYL)-L-LYSYL)-L-PROLINE
[N2-[(S)-1-CARBOXY-3-PHENYLPROPYL]-L-LYSYL-L-PROLINE
ZESTRIL®
LISINOPRILUM
PRINIVIL®
LISINOPRIL ANHYDROUS
chemidplus:76547-98-3
pubchem.compound:5362119
chembl:CHEMBL1237
drugbank:00722
rxcui:1546022

Drug Info:

FDA Approval	approved
Drug Indications	antihypertensive agent
Drug Class	Small Molecule
Drug Class	antihypertensive agents
Year of Approval	1987

(2 More Sources)

Publications:

Mukae S et al., 2002, Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough., J Hum Hypertens
Woie et al., 1987, Increase in vasoactive intestinal polypeptides (VIP) by the angiotensin converting enzyme (ACE) inhibitor lisinopril in congestive heart failure. Relation to haemodynamic and hormonal changes., Gen. Pharmacol.
Piepho, 2000, Overview of the angiotensin-converting-enzyme inhibitors., Am J Health Syst Pharm
Song et al., 2002, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update., Clin Pharmacokinet
Téllez-Sanz et al., 1998, Calorimetric analysis of lisinopril binding to angiotensin I-converting enzyme., FEBS Lett.
Andújar-Sánchez et al., 2007, Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method., FEBS Lett.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
O'Toole L et al., 1998, Effect of the insertion/deletion polymorphism of the angiotensin-converting enzyme gene on response to angiotensin-converting enzyme inhibitors in patients with heart failure., J Cardiovasc Pharmacol
Irvin MR et al., 2010, Pharmacogenetic association of hypertension candidate genes with fasting glucose in the GenHAT Study., J Hypertens
Kohno M et al., 1999, Association between angiotensin-converting enzyme gene polymorphisms and regression of left ventricular hypertrophy in patients treated with angiotensin-converting enzyme inhibitors., Am J Med
Penno G et al., 1998, Effect of angiotensin-converting enzyme (ACE) gene polymorphism on progression of renal disease and the influence of ACE inhibition in IDDM patients: findings from the EUCLID Randomized Controlled Trial. EURODIAB Controlled Trial of Lisinopril in IDDM., Diabetes
Zee RY et al., 1998, Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis., Hypertension
Ohmichi N et al., 1997, Relationship between the response to the angiotensin converting enzyme inhibitor imidapril and the angiotensin converting enzyme genotype., Am J Hypertens
Sasaki M et al., 1996, Relationship between the angiotensin converting enzyme gene polymorphism and the effects of enalapril on left ventricular hypertrophy and impaired diastolic filling in essential hypertension: M-mode and pulsed Doppler echocardiographic studies., J Hypertens
Rudnicki M et al., 2009, Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease., Pharmacogenomics
Arnett DK et al., 2005, Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study., Circulation
Yu Y et al., 2005, Associations of baseline blood pressure levels and efficacy of Benazepril treatment with interaction of alpha-adducin and ACE gene polymorphisms in hypertensives., Clin Exp Hypertens
Takahashi T et al., 2001, The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage., Respir Med
Ha SK et al., 2000, ACE DD genotype is more susceptible than ACE II and ID genotypes to the antiproteinuric effect of ACE inhibitors in patients with proteinuric non-insulin-dependent diabetes mellitus., Nephrol Dial Transplant
Stavroulakis GA et al., 2000, Predicting response to chronic antihypertensive treatment with fosinopril: the role of angiotensin-converting enzyme gene polymorphism., Cardiovasc Drugs Ther
Parish et al., Adverse effects of angiotensin converting enzyme (ACE) inhibitors. An update., Drug Saf
Hacihanefioglu et al., 2002, Effect of hypertension therapy with the angiotensin-converting enzyme inhibitor lisinopril on hyperandrogenism in women with polycystic ovary syndrome., Fertil. Steril.

LISINOPRIL ACE2

Interaction Score: 11.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MC-4232

Novel drug target Established target

PMIDs:
11030016 11929321 1536695 11752352

Sources:
TdgClinicalTrial
LISINOPRIL ACE

Interaction Score: 3.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name lisinopril ,Zestril, Prinivil

Novel drug target Established target

Trial Name MC-4232

PMIDs:
11030016 11929321 9506845 17618628 11752352 9869506 20577119 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources:
TdgClinicalTrial TEND PharmGKB TTD
LISINOPRIL SHBG

Interaction Score: 3.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11872207

Sources:
NCI
LISINOPRIL VIP

Interaction Score: 2.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2822521

Sources:
NCI
LISINOPRIL BDKRB2

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12522467

Sources:
PharmGKB
LISINOPRIL MMP3

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LISINOPRIL AGT

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: LISINOPRIL
- Version: 01-August-2011
Alternate Names:

LISINOPRIL Primary Drug Name

Drug Info:

Year of Approval 1987

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: LISINOPRIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small Molecule

Drug Indications antihypertensive agent

FDA Approval approved

Publications:

NCI: LISINOPRIL

Version: 14-September-2017

Alternate Names:

C29159 NCI drug code

Drug Info:

Publications:

Hacihanefioglu et al., 2002, Effect of hypertension therapy with the angiotensin-converting enzyme inhibitor lisinopril on hyperandrogenism in women with polycystic ovary syndrome., Fertil. Steril.

Woie et al., 1987, Increase in vasoactive intestinal polypeptides (VIP) by the angiotensin converting enzyme (ACE) inhibitor lisinopril in congestive heart failure. Relation to haemodynamic and hormonal changes., Gen. Pharmacol.

PharmGKB: lisinopril

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Mukae S et al., 2002, Association of polymorphisms of the renin-angiotensin system and bradykinin B2 receptor with ACE-inhibitor-related cough., J Hum Hypertens

Rudnicki M et al., 2009, Significance of genetic polymorphisms of the renin-angiotensin-aldosterone system in cardiovascular and renal disease., Pharmacogenomics

Zee RY et al., 1998, Three candidate genes and angiotensin-converting enzyme inhibitor-related cough: a pharmacogenetic analysis., Hypertension

TTD: Lisinopril
- Version: 2020.06.01
Alternate Names:

D07HGR TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1237
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	lisinopril ,Zestril, Prinivil
Novel drug target	Established target
Trial Name	MC-4232

LISINOPRIL Drug Record

LISINOPRIL chembl:CHEMBL1237 Approved

Alternate Names:

Drug Info:

Publications:

LISINOPRIL ACE2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name MC-4232 Novel drug target Established target

PMIDs: 11030016 11929321 1536695 11752352

Sources: TdgClinicalTrial

LISINOPRIL ACE

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name lisinopril ,Zestril, Prinivil Novel drug target Established target Trial Name MC-4232

PMIDs: 11030016 11929321 9506845 17618628 11752352 9869506 20577119 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources: TdgClinicalTrial TEND PharmGKB TTD

LISINOPRIL SHBG

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11872207

Sources: NCI

LISINOPRIL VIP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2822521

Sources: NCI

LISINOPRIL BDKRB2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12522467

Sources: PharmGKB

LISINOPRIL MMP3

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

LISINOPRIL AGT

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TEND: LISINOPRIL

Alternate Names: LISINOPRIL Primary Drug Name

Drug Info: Year of Approval 1987 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: LISINOPRIL

Alternate Names:

Drug Info: Drug Class Small Molecule Drug Indications antihypertensive agent FDA Approval approved

Publications:

NCI: LISINOPRIL

Alternate Names: C29159 NCI drug code

Drug Info:

PharmGKB: lisinopril

Alternate Names:

Drug Info:

TTD: Lisinopril

Alternate Names: D07HGR TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1237

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name MC-4232

Novel drug target Established target

PMIDs:
11030016 11929321 1536695 11752352

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name lisinopril ,Zestril, Prinivil

Novel drug target Established target

Trial Name MC-4232

PMIDs:
11030016 11929321 9506845 17618628 11752352 9869506 20577119 10335726 9726242 9535416 9270093 8986921 19290794 15967849 15773232 11217909 11007831 10999650

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
11872207

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2822521

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12522467

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

LISINOPRIL Primary Drug Name

Drug Info:

Year of Approval 1987

Drug Class antihypertensive agents

Drug Info:

Drug Class Small Molecule

Drug Indications antihypertensive agent

FDA Approval approved

Alternate Names:

C29159 NCI drug code

Alternate Names:

D07HGR TTD Drug ID