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LINSITINIB Drug Record

  • Summary
  • Interactions
  • Claims
  • LINSITINIB chembl:CHEMBL1091644 Antineoplastic

    Alternate Names:

    ASP-7487
    OSI-906AA
    LINSITINIB
    OSI-906

    Drug Info:

    Pharmaceutical Developer OSI Pharmaceuticals
    Source Reported Drug Name(s) OSI-906
    Drug Class IGF1R Inhibitor
    FDA Approval not approved
    Drug Class small molecule
    Drug Indications antineoplastic agent
    Drug Class Kinase Inhibitors
    Drug Type small molecule
    Drug Groups investigational
    (8 More Sources)

    Publications:

    de Lint et al., 2016, Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R., Mol. Cancer Ther.
    Ma et al., 2016, InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma., Clin. Cancer Res.
    Vidal et al., 2015, A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer., Cancer Cell
    Hayes et al., 2016, Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression., Cancer Cell
  • LINSITINIB   INSRR

    Interaction Score: 2.37

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • LINSITINIB   IGF1R

    Interaction Score: 1.52

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name OSI-906
    Novel drug target Established target
    Notes

    PMIDs:
    None found


    Sources:
    ClearityFoundationClinicalTrial CancerCommons TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • LINSITINIB   IGF2

    Interaction Score: 1.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25670080


    Sources:
    CIViC

  • LINSITINIB   INSR

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    TALC GuideToPharmacology ChemblInteractions

  • LINSITINIB   PTEN

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Gefitinib + Linsitinib
    Indication/Tumor Type glioblastoma multiforme
    Response Type sensitive

    PMIDs:
    26561558


    Sources:
    JAX-CKB

  • LINSITINIB   KRAS

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Linsitinib + SCH772984
    Indication/Tumor Type pancreatic ductal adenocarcinoma
    Response Type sensitive

    PMIDs:
    26725216


    Sources:
    JAX-CKB

  • LINSITINIB   PIK3CA

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy GDC-0941 + Linsitinib
    Indication/Tumor Type triple-receptor negative breast cancer
    Response Type sensitive

    PMIDs:
    27196766


    Sources:
    JAX-CKB

  • LINSITINIB   EGFR

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Gefitinib + Linsitinib
    Indication/Tumor Type glioblastoma multiforme
    Response Type sensitive

    PMIDs:
    26561558


    Sources:
    JAX-CKB

  • MyCancerGenome: LINSITINIB

    • Version: 20-Jun-2017

    Alternate Names:
    OSI-906 Development Name
    LINSITINIB Generic Name

    Drug Info:
    Drug Class Kinase Inhibitors

    Publications:

  • CancerCommons: LINSITINIB

    • Version: 25-July-2013

    Alternate Names:
    3-(8-amino-1-(2-phenylquinolin-7-yl)imidazo(1,5-a)pyrazin-3-yl)-1-methylcyclobutanol PubChem Drug Name
    11640390 PubChem Drug ID
    OSI-906 Drug Trade Name

    Drug Info:
    Drug Class IGF1R Inhibitor
    Source Reported Drug Name(s) OSI-906
    Pharmaceutical Developer OSI Pharmaceuticals

    Publications:

  • DrugBank: DB06075

    • Version: 5.1.7

    Alternate Names:
    LINSITINIB DrugBank Drug Name
    867160-71-2 CAS Number
    CHEMBL1091644 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups investigational

    Publications:

  • TdgClinicalTrial: OSI-906

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class small molecule
    FDA Approval not approved

    Publications:

  • JAX-CKB: Linsitinib

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    de Lint et al., 2016, Sensitizing Triple-Negative Breast Cancer to PI3K Inhibition by Cotargeting IGF1R., Mol. Cancer Ther.
    Hayes et al., 2016, Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression., Cancer Cell
    Ma et al., 2016, InsR/IGF1R Pathway Mediates Resistance to EGFR Inhibitors in Glioblastoma., Clin. Cancer Res.

  • CIViC: LINSITINIB

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Vidal et al., 2015, A targetable GATA2-IGF2 axis confers aggressiveness in lethal prostate cancer., Cancer Cell

  • TTD: OSI-906

    • Version: 2020.06.01

    Alternate Names:
    D01GFX TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 178103995

    • Version: 29-September-2020

    Alternate Names:
    LINSITINIB GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TALC: LINSITINIB

    • Version: 12-May-2016

    Alternate Names:
    LINSITINIB Primary Drug Name
    LINSITINIB Drug Generic Name
    OSI-906 Drug Synonym

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1091644

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1091644

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ClearityFoundationClinicalTrial: LINSITINIB

    • Version: 15-June-2013

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13