DGIdb - LEVOTHYROXINE Drug Record

LEVOTHYROXINE chembl:CHEMBL1624 Approved

Alternate Names:

LEVOTHYROXINE
NSC-36397
4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODO-L-PHENYLALANINE
3,3',5,5'-TETRAIODO-L-THYRONINE
T4
O-(4-HYDROXY-3,5-DIIODOPHENYL)-3,5-DIIODO-L-TYROSINE
LEVOTHYROXINE SODIUM
L-T4
LEVOTHYROXIN
L-THYROXINE
O-(4-HYDROXY-3,5-DIIDOPHENYL)-3,5-DIIODO-L-TYROSINE
LT4
3,5,3',5'-TETRAIODO-L-THYRONINE
chemidplus:51-48-9
rxcui:10582
drugbank:00451
pubchem.compound:5819
chembl:CHEMBL1624

Drug Info:

Year of Approval	approved before 1982
Drug Class	hormone replacement agents
Drug Categories	systemic hormonal preparations, excl. sex hormones and insulins
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	hormone replacement
Drug Categories	agents used to treat hypothyroidism
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (moderate)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	narrow therapeutic index drugs
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	oatp1b3 inhibitors
Drug Categories	p-glycoprotein inducers
Drug Categories	thyroxine-binding globulin substrates
Drug Categories	ugt1a1 substrates
Drug Categories	ugt1a1 substrates with narrow therapeutic index

(3 More Sources)

Publications:

Grasberger et al., 2005, Resistance to thyroid hormone in a patient with thyroid dysgenesis., Thyroid
Marazuela et al., 2008, Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment., Thyroid
Sivakumar et al., 2010, Resistance to thyroid hormone in a patient with coexisting Graves' disease., Thyroid
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Cheng SY et al., 2010, Molecular aspects of thyroid hormone actions., Endocr Rev
Bernal, 2007, Thyroid hormone receptors in brain development and function., Nat Clin Pract Endocrinol Metab
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Nakajima et al., 2010, Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor., Thyroid
Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.
Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.
Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)
Hammes SR et al., 2015, Overlapping nongenomic and genomic actions of thyroid hormone and steroids., Best Pract Res Clin Endocrinol Metab
Davis PJ et al., 2008, Mechanisms of nongenomic actions of thyroid hormone., Front Neuroendocrinol

LEVOTHYROXINE THRB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

Publications:

Grasberger et al., 2005, Resistance to thyroid hormone in a patient with thyroid dysgenesis., Thyroid

Marazuela et al., 2008, Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment., Thyroid

Sivakumar et al., 2010, Resistance to thyroid hormone in a patient with coexisting Graves' disease., Thyroid

LEVOTHYROXINE THRA

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

Publications:

Bernal, 2007, Thyroid hormone receptors in brain development and function., Nat Clin Pract Endocrinol Metab

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov

Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

LEVOTHYROXINE SERPINE1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

LEVOTHYROXINE THBD

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.

LEVOTHYROXINE TSHB

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)
LEVOTHYROXINE F9

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

LEVOTHYROXINE ITGB3

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hammes SR et al., 2015, Overlapping nongenomic and genomic actions of thyroid hormone and steroids., Best Pract Res Clin Endocrinol Metab

Davis PJ et al., 2008, Mechanisms of nongenomic actions of thyroid hormone., Front Neuroendocrinol

LEVOTHYROXINE ITGAV

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Hammes SR et al., 2015, Overlapping nongenomic and genomic actions of thyroid hormone and steroids., Best Pract Res Clin Endocrinol Metab

Davis PJ et al., 2008, Mechanisms of nongenomic actions of thyroid hormone., Front Neuroendocrinol

LEVOTHYROXINE NFE2L2

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
LEVOTHYROXINE AHR

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
LEVOTHYROXINE PPARG

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

DrugBank: DB00451

Version: 5.1.7

Alternate Names:

LEVOTHYROXINE DrugBank Drug Name

51-48-9 CAS Number

Eltroxin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents used to treat hypothyroidism

Publications:

Sivakumar et al., 2010, Resistance to thyroid hormone in a patient with coexisting Graves' disease., Thyroid

Grasberger et al., 2005, Resistance to thyroid hormone in a patient with thyroid dysgenesis., Thyroid

Marazuela et al., 2008, Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment., Thyroid

TEND: LEVOTHYROXINE
- Version: 01-August-2011
Alternate Names:

LEVOTHYROXINE Primary Drug Name

Drug Info:

Drug Class hormone replacement agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: LEVOTHYROXINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications hormone replacement

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: LEVOTHYROXINE

Version: 14-September-2017

Alternate Names:

C888 NCI drug code

Drug Info:

Publications:

Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.

Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)

DTC: LEVOTHYROXINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1624 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Levothyroxine
- Version: 2020.06.01
Alternate Names:

D06RGG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1624
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	levothyroxine sodium,Unithroid
Novel drug target	Established target
Trial Name	levothyroxine,Levoxyl

LEVOTHYROXINE	DrugBank Drug Name
51-48-9	CAS Number
Eltroxin	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	agents used to treat hypothyroidism

LEVOTHYROXINE Drug Record

LEVOTHYROXINE chembl:CHEMBL1624 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name levothyroxine sodium,Unithroid Novel drug target Established target Trial Name levothyroxine,Levoxyl

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name levothyroxine sodium,Unithroid Novel drug target Established target Trial Name levothyroxine,Levoxyl

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hammes SR et al., 2015, Overlapping nongenomic and genomic actions of thyroid hormone and steroids., Best Pract Res Clin Endocrinol Metab Davis PJ et al., 2008, Mechanisms of nongenomic actions of thyroid hormone., Front Neuroendocrinol

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Hammes SR et al., 2015, Overlapping nongenomic and genomic actions of thyroid hormone and steroids., Best Pract Res Clin Endocrinol Metab Davis PJ et al., 2008, Mechanisms of nongenomic actions of thyroid hormone., Front Neuroendocrinol

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

DrugBank: DB00451

Alternate Names: LEVOTHYROXINE DrugBank Drug Name 51-48-9 CAS Number Eltroxin Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories agents used to treat hypothyroidism

TEND: LEVOTHYROXINE

Alternate Names: LEVOTHYROXINE Primary Drug Name

Drug Info: Drug Class hormone replacement agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: LEVOTHYROXINE

Alternate Names:

Drug Info: Drug Indications hormone replacement Drug Class Small Molecule FDA Approval approved

Publications:

NCI: LEVOTHYROXINE

Alternate Names: C888 NCI drug code

Drug Info:

DTC: LEVOTHYROXINE

Alternate Names: CHEMBL1624 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Levothyroxine

Alternate Names: D06RGG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1624

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

Interaction Types & Directionality:

n/a

Publications:

Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

Interaction Types & Directionality:

n/a

Publications:

Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.

Interaction Types & Directionality:

n/a

Publications:

Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)

Interaction Types & Directionality:

n/a

Publications:

Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

Interaction Types & Directionality:

n/a

Publications:

Hammes SR et al., 2015, Overlapping nongenomic and genomic actions of thyroid hormone and steroids., Best Pract Res Clin Endocrinol Metab

Davis PJ et al., 2008, Mechanisms of nongenomic actions of thyroid hormone., Front Neuroendocrinol

Interaction Types & Directionality:

n/a

Publications:

Hammes SR et al., 2015, Overlapping nongenomic and genomic actions of thyroid hormone and steroids., Best Pract Res Clin Endocrinol Metab

Davis PJ et al., 2008, Mechanisms of nongenomic actions of thyroid hormone., Front Neuroendocrinol

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

LEVOTHYROXINE DrugBank Drug Name

51-48-9 CAS Number

Eltroxin Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents used to treat hypothyroidism

Alternate Names:

LEVOTHYROXINE Primary Drug Name

Drug Info:

Drug Class hormone replacement agents

Year of Approval approved before 1982

Drug Info:

Drug Indications hormone replacement

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C888 NCI drug code

Alternate Names:

CHEMBL1624 ChEMBL Drug ID

Alternate Names:

D06RGG TTD Drug ID