DGIdb - LEVOTHYROXINE Drug Record

LEVOTHYROXINE chembl:CHEMBL1624 Approved

Alternate Names:

LEVOTHYROXINE
NSC-36397
4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODO-L-PHENYLALANINE
3,3',5,5'-TETRAIODO-L-THYRONINE
T4
O-(4-HYDROXY-3,5-DIIODOPHENYL)-3,5-DIIODO-L-TYROSINE
LEVOTHYROXINE SODIUM
L-T4
LEVOTHYROXIN
L-THYROXINE
O-(4-HYDROXY-3,5-DIIDOPHENYL)-3,5-DIIODO-L-TYROSINE
LT4
3,5,3',5'-TETRAIODO-L-THYRONINE
chemidplus:51-48-9
rxcui:10582
drugbank:00451
pubchem.compound:5819
chembl:CHEMBL1624

Drug Info:

Year of Approval	approved before 1982
Drug Class	hormone replacement agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	hormone replacement

(2 More Sources)

Publications:

Grasberger et al., 2005, Resistance to thyroid hormone in a patient with thyroid dysgenesis., Thyroid
Marazuela et al., 2008, Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment., Thyroid
Sivakumar et al., 2010, Resistance to thyroid hormone in a patient with coexisting Graves' disease., Thyroid
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Cheng SY et al., 2010, Molecular aspects of thyroid hormone actions., Endocr Rev
Bernal, 2007, Thyroid hormone receptors in brain development and function., Nat Clin Pract Endocrinol Metab
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Nakajima et al., 2010, Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor., Thyroid
Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.
Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.
Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)

LEVOTHYROXINE THRA

Interaction Score: 6.87

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

PMIDs:
17315033 17016423 17139284 11752352 20615127 20051527

Sources:
TdgClinicalTrial TEND TTD
LEVOTHYROXINE THBD

Interaction Score: 2.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14763909

Sources:
NCI
LEVOTHYROXINE F9

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16075920

Sources:
NCI
LEVOTHYROXINE TSHB

Interaction Score: 1.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12390336

Sources:
NCI
LEVOTHYROXINE SERPINE1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16075920

Sources:
NCI
LEVOTHYROXINE THRB

Interaction Score: 0.56

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

PMIDs:
16053391 18816177 20151830 17016423 20051527

Sources:
DTC TdgClinicalTrial TEND
LEVOTHYROXINE AHR

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEVOTHYROXINE PPARG

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
LEVOTHYROXINE NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: LEVOTHYROXINE
- Version: 01-August-2011
Alternate Names:

LEVOTHYROXINE Primary Drug Name

Drug Info:

Drug Class hormone replacement agents

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: LEVOTHYROXINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications hormone replacement

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: LEVOTHYROXINE

Version: 14-September-2017

Alternate Names:

C888 NCI drug code

Drug Info:

Publications:

Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.

Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.

Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)

DTC: LEVOTHYROXINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1624 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Levothyroxine
- Version: 2020.06.01
Alternate Names:

D06RGG TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1624
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	levothyroxine sodium,Unithroid
Novel drug target	Established target
Trial Name	levothyroxine,Levoxyl

LEVOTHYROXINE Drug Record

LEVOTHYROXINE chembl:CHEMBL1624 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name levothyroxine sodium,Unithroid Novel drug target Established target Trial Name levothyroxine,Levoxyl

PMIDs: 17315033 17016423 17139284 11752352 20615127 20051527

Sources: TdgClinicalTrial TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14763909

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16075920

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12390336

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16075920

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name levothyroxine sodium,Unithroid Novel drug target Established target Trial Name levothyroxine,Levoxyl

PMIDs: 16053391 18816177 20151830 17016423 20051527

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: LEVOTHYROXINE

Alternate Names: LEVOTHYROXINE Primary Drug Name

Drug Info: Drug Class hormone replacement agents Year of Approval approved before 1982

Publications:

TdgClinicalTrial: LEVOTHYROXINE

Alternate Names:

Drug Info: Drug Indications hormone replacement Drug Class Small Molecule FDA Approval approved

Publications:

NCI: LEVOTHYROXINE

Alternate Names: C888 NCI drug code

Drug Info:

DTC: LEVOTHYROXINE

Alternate Names: CHEMBL1624 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Levothyroxine

Alternate Names: D06RGG TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1624

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

PMIDs:
17315033 17016423 17139284 11752352 20615127 20051527

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
14763909

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16075920

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12390336

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16075920

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name levothyroxine sodium,Unithroid

Novel drug target Established target

Trial Name levothyroxine,Levoxyl

PMIDs:
16053391 18816177 20151830 17016423 20051527

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

LEVOTHYROXINE Primary Drug Name

Drug Info:

Drug Class hormone replacement agents

Year of Approval approved before 1982

Drug Info:

Drug Indications hormone replacement

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C888 NCI drug code

Alternate Names:

CHEMBL1624 ChEMBL Drug ID

Alternate Names:

D06RGG TTD Drug ID