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LEVOTHYROXINE Drug Record

  • Summary
  • Interactions
  • Claims
  • LEVOTHYROXINE chembl:CHEMBL1624 Approved

    Alternate Names:

    LEVOTHYROXINE
    NSC-36397
    4-(4-HYDROXY-3,5-DIIODOPHENOXY)-3,5-DIIODO-L-PHENYLALANINE
    3,3',5,5'-TETRAIODO-L-THYRONINE
    T4
    O-(4-HYDROXY-3,5-DIIODOPHENYL)-3,5-DIIODO-L-TYROSINE
    LEVOTHYROXINE SODIUM
    L-T4
    LEVOTHYROXIN
    L-THYROXINE
    O-(4-HYDROXY-3,5-DIIDOPHENYL)-3,5-DIIODO-L-TYROSINE
    LT4
    3,5,3',5'-TETRAIODO-L-THYRONINE
    chemidplus:51-48-9
    rxcui:10582
    drugbank:00451
    pubchem.compound:5819
    chembl:CHEMBL1624

    Drug Info:

    Year of Approval approved before 1982
    Drug Class hormone replacement agents
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications hormone replacement
    (2 More Sources)

    Publications:

    Grasberger et al., 2005, Resistance to thyroid hormone in a patient with thyroid dysgenesis., Thyroid
    Marazuela et al., 2008, Thyroid hormone resistance and pituitary enlargement after thyroid ablation in a woman on levothyroxine treatment., Thyroid
    Sivakumar et al., 2010, Resistance to thyroid hormone in a patient with coexisting Graves' disease., Thyroid
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Cheng SY et al., 2010, Molecular aspects of thyroid hormone actions., Endocr Rev
    Bernal, 2007, Thyroid hormone receptors in brain development and function., Nat Clin Pract Endocrinol Metab
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Nakajima et al., 2010, Resistance to thyroid hormone due to a novel thyroid hormone receptor mutant in a patient with hypothyroidism secondary to lingual thyroid and functional characterization of the mutant receptor., Thyroid
    Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.
    Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.
    Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)
  • LEVOTHYROXINE   THRA

    Interaction Score: 6.87

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name levothyroxine sodium,Unithroid
    Novel drug target Established target
    Trial Name levothyroxine,Levoxyl

    PMIDs:
    17315033 17016423 17139284 11752352 20615127 20051527


    Sources:
    TdgClinicalTrial TEND TTD

  • LEVOTHYROXINE   THBD

    Interaction Score: 2.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14763909


    Sources:
    NCI

  • LEVOTHYROXINE   F9

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16075920


    Sources:
    NCI

  • LEVOTHYROXINE   TSHB

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12390336


    Sources:
    NCI

  • LEVOTHYROXINE   SERPINE1

    Interaction Score: 0.69

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16075920


    Sources:
    NCI

  • LEVOTHYROXINE   THRB

    Interaction Score: 0.56

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name levothyroxine sodium,Unithroid
    Novel drug target Established target
    Trial Name levothyroxine,Levoxyl

    PMIDs:
    16053391 18816177 20151830 17016423 20051527


    Sources:
    DTC TdgClinicalTrial TEND

  • LEVOTHYROXINE   AHR

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LEVOTHYROXINE   PPARG

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • LEVOTHYROXINE   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: LEVOTHYROXINE

    • Version: 01-August-2011

    Alternate Names:
    LEVOTHYROXINE Primary Drug Name

    Drug Info:
    Drug Class hormone replacement agents
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: LEVOTHYROXINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications hormone replacement
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: LEVOTHYROXINE

    • Version: 14-September-2017

    Alternate Names:
    C888 NCI drug code

    Drug Info:

    Publications:
    Chadarevian et al., 2005, Effect of levothyroxine replacement therapy on coagulation and fibrinolysis in severe hypothyroidism., J. Endocrinol. Invest.
    Nagasaki et al., 2004, Change in von Willebrand factor and carotid intima-media thickness in hypothyroid patients with normal thyroid function after levothyroxine replacement therapy., Eur. J. Endocrinol.
    Koc et al., 2002, Effect of low- and high-dose levothyroxine on thyroid nodule volume: a crossover placebo-controlled trial., Clin. Endocrinol. (Oxf)

  • DTC: LEVOTHYROXINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1624 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Levothyroxine

    • Version: 2020.06.01

    Alternate Names:
    D06RGG TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1624

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21