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LENVATINIB Drug Record

  • Summary
  • Interactions
  • Claims
  • LENVATINIB chembl:CHEMBL1289601 ApprovedAntineoplastic

    Alternate Names:

    E-7080
    ER-203492-00
    LENVIMA
    LENVATINIB
    KISPLYX
    E7080
    LENVIMA®
    E 7080
    UNII-EE083865G2
    4-(3-CHLORO-4-(N'-CYCLOPROPYLUREIDO)PHENOXY)-7-METHOXYQUINOLINE-6-CARBOXAMIDE
    LENVATINIB MESYLATE
    4-{3-CHLORO-4-[(CYCLOPROPYLCARBAMOYL)AMINO]PHENOXY}-7-METHOXYQUINOLINE-6-CARBOXAMIDE
    chemidplus:417716-92-8
    chembl:CHEMBL1289601
    rxcui:1603296
    drugbank:09078
    pubchem.compound:9823820

    Drug Info:

    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    FDA Approval Renal cell carcinoma, Thyroid cancer
    Drug Class Kinase Inhibitors
    Drug Groups investigational
    Drug Categories bsep/abcb11 inhibitors
    Drug Categories cytochrome p-450 cyp1a2 inhibitors
    Drug Categories cytochrome p-450 cyp1a2 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2b6 inhibitors
    Drug Categories cytochrome p-450 cyp2b6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c19 inhibitors
    Drug Categories cytochrome p-450 cyp2c19 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c8 inhibitors
    Drug Categories cytochrome p-450 cyp2c8 inhibitors (moderate)
    Drug Categories cytochrome p-450 cyp2c9 inhibitors
    Drug Categories cytochrome p-450 cyp2c9 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2d6 inhibitors
    Drug Categories cytochrome p-450 cyp2d6 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a inducers
    Drug Categories cytochrome p-450 cyp3a inhibitors
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers (weak)
    Drug Categories cytochrome p-450 cyp3a4 inhibitors
    Drug Categories cytochrome p-450 cyp3a4 inhibitors (weak)
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories kinase inhibitor
    Drug Categories oat1/slc22a6 inhibitors
    Drug Categories oat3/slc22a8 inhibitors
    Drug Categories oatp1b1/slco1b1 inhibitors
    Drug Categories oct2 inhibitors
    Drug Categories p-glycoprotein substrates
    Drug Categories qtc prolonging agents
    Drug Categories receptor tyrosine kinase inhibitors
    Drug Categories tyrosine kinase inhibitors
    (6 More Sources)

    Publications:

    Matsui et al., 2008, E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition., Int. J. Cancer
    Tohyama et al., 2014, Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models., J Thyroid Res
    Huang et al., 2016, Preclinical Modeling of KIF5B-RET Fusion Lung Adenocarcinoma., Mol. Cancer Ther.
    Hong et al., 2015, Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma., Clin. Cancer Res.
  • LENVATINIB   RET

    Interaction Score: 0.4

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical
    Response Type sensitive

    PMIDs:
    25295214 27496134 17943726


    Sources:
    JAX-CKB CIViC DrugBank TALC

  • LENVATINIB   FLT4

    Interaction Score: 0.27

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False

    PMIDs:
    17943726


    Sources:
    TdgClinicalTrial DrugBank TALC MyCancerGenome GuideToPharmacology

  • LENVATINIB   FGFR4

    Interaction Score: 0.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17943726


    Sources:
    DrugBank

  • LENVATINIB   FGFR2

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    17943726


    Sources:
    DrugBank TALC

  • LENVATINIB   FGFR1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical
    Response Type sensitive

    PMIDs:
    25295214 17943726


    Sources:
    JAX-CKB TdgClinicalTrial DrugBank

  • LENVATINIB   KDR

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name E7080
    Novel drug target Established target
    Specific Action of the Ligand Inhibition

    PMIDs:
    17943726


    Sources:
    TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology

  • LENVATINIB   FLT1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name E7080
    Novel drug target Established target
    Notes

    PMIDs:
    17943726


    Sources:
    TdgClinicalTrial DrugBank TALC

  • LENVATINIB   PDGFRA

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name E7080
    Novel drug target Established target

    PMIDs:
    17943726


    Sources:
    TdgClinicalTrial DrugBank

  • LENVATINIB   NRAS

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type melanoma
    Response Type sensitive
    Approval Status Phase I

    PMIDs:
    26169970


    Sources:
    JAX-CKB

  • LENVATINIB   KIT

    Interaction Score: 0.16

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name E7080
    Novel drug target Established target

    PMIDs:
    17943726


    Sources:
    TdgClinicalTrial DrugBank

  • LENVATINIB   FGFR3

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    17943726


    Sources:
    DrugBank

  • LENVATINIB   BRAF

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Phase I
    Response Type sensitive

    PMIDs:
    26169970


    Sources:
    JAX-CKB

  • LENVATINIB   PDGFRB

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name E7080
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • LENVATINIB   YES1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB09078

    • Version: 5.1.7

    Alternate Names:
    LENVATINIB DrugBank Drug Name
    417716-92-8 CAS Number
    Lenvima Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Matsui et al., 2008, E7080, a novel inhibitor that targets multiple kinases, has potent antitumor activities against stem cell factor producing human small cell lung cancer H146, based on angiogenesis inhibition., Int. J. Cancer

  • MyCancerGenome: LENVATINIB

    • Version: 20-Jun-2017

    Alternate Names:
    LENVATINIB Generic Name

    Drug Info:
    Drug Class Kinase Inhibitors
    FDA Approval Renal cell carcinoma, Thyroid cancer

    Publications:

  • TdgClinicalTrial: LENVATINIB

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • JAX-CKB: Lenvatinib

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Hong et al., 2015, Phase I Dose-Escalation Study of the Multikinase Inhibitor Lenvatinib in Patients with Advanced Solid Tumors and in an Expanded Cohort of Patients with Melanoma., Clin. Cancer Res.
    Tohyama et al., 2014, Antitumor activity of lenvatinib (e7080): an angiogenesis inhibitor that targets multiple receptor tyrosine kinases in preclinical human thyroid cancer models., J Thyroid Res

  • CIViC: LENVATINIB

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Huang et al., 2016, Preclinical Modeling of KIF5B-RET Fusion Lung Adenocarcinoma., Mol. Cancer Ther.

  • DTC: LENVATINIB

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1289601 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TALC: LENVATINIB

    • Version: 12-May-2016

    Alternate Names:
    LENVATINIB Primary Drug Name
    LENVATINIB Drug Generic Name
    E7081 Drug Synonym

    Drug Info:

    Publications:

  • GuideToPharmacology: 178103998

    • Version: 29-September-2020

    Alternate Names:
    LENVATINIB GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • TTD: Lenvatinib

    • Version: 2020.06.01

    Alternate Names:
    D0R0FO TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1289601

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21