DGIdb - LAMOTRIGINE Drug Record

LAMOTRIGINE chembl:CHEMBL741 Approved

Alternate Names:

LAMICTAL CD
LAMOTRIGINE
BW-430C
LAMICTAL ODT
LAMICTAL
LAMICTAL XR
LAMOTRIGINUM
QÍN
LAMICTAL®
LAMOTRIGINA
3,5-DIAMINO-6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZINE
GIZORD
QIN
drugbank:00555
pubchem.compound:3878
chembl:CHEMBL741
rxcui:28439
chemidplus:84057-84-1

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	anticonvulsant
Drug Categories	agents causing hyperkalemia
Drug Categories	agents producing tachycardia
Drug Categories	anti-epileptic agent
Drug Categories	antiarrhythmic agents
Drug Categories	anticholinergic agents
Drug Categories	bradycardia-causing agents
Drug Categories	calcium-regulating hormones and agents
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	decreased central nervous system disorganized electrical activity
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	drugs that are mainly renally excreted
Drug Categories	miscellaneous anticonvulsants
Drug Categories	mood stabilizer
Drug Categories	muscarinic antagonists
Drug Categories	oct1 substrates
Drug Categories	oct2 inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	photosensitizing agents
Drug Categories	potential qtc-prolonging agents
Drug Categories	psychotropic drugs
Drug Categories	qtc prolonging agents
Drug Categories	tranquilizing agents
Drug Categories	triazines
Drug Categories	ugt1a1 inducers
Drug Categories	ugt1a1 substrates
Drug Categories	ugt1a3 substrates
Drug Categories	ugt1a4 substrates

(4 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Zhou Y et al., 2015, Polymorphisms of ABCG2, ABCB1 and HNF4α are associated with Lamotrigine trough concentrations in epilepsy patients., Drug Metab Pharmacokinet
Inoue K et al., 2016, Factors that influence the pharmacokinetics of lamotrigine in Japanese patients with epilepsy., Eur J Clin Pharmacol
Milosheska D et al., 2016, Pharmacokinetics of lamotrigine and its metabolite N-2-glucuronide: Influence of polymorphism of UDP-glucuronosyltransferases and drug transporters., Br J Clin Pharmacol
Singkham N et al., 2013, Influence of the UGT2B7 -161C>T polymorphism on the population pharmacokinetics of lamotrigine in Thai patients., Eur J Clin Pharmacol
Kwan P et al., 2008, Multidrug resistance in epilepsy and polymorphisms in the voltage-gated sodium channel genes SCN1A, SCN2A, and SCN3A: correlation among phenotype, genotype, and mRNA expression., Pharmacogenet Genomics
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Lipkind et al., 2005, Molecular modeling of local anesthetic drug binding by voltage-gated sodium channels., Mol. Pharmacol.
Ma CL et al., 2014, Association of SCN1A, SCN2A and ABCC2 gene polymorphisms with the response to antiepileptic drugs in Chinese Han patients with epilepsy., Pharmacogenomics
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Shen CH et al., 2016, Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy., Epilepsy Res
Aberg et al., 1997, Lamotrigine therapy in infantile neuronal ceroid lipofuscinosis (INCL)., Neuropediatrics
Kazeem GR et al., 2009, High-resolution HLA genotyping and severe cutaneous adverse reactions in lamotrigine-treated patients., Pharmacogenet Genomics
Klarica Domjanović I et al., 2018, Interaction between ABCG2 421C>A polymorphism and valproate in their effects on steady-state disposition of lamotrigine in adults with epilepsy., Br J Clin Pharmacol
Chang Y et al., 2014, Correlation of the UGT1A4 gene polymorphism with serum concentration and therapeutic efficacy of lamotrigine in Han Chinese of Northern China., Eur J Clin Pharmacol
Zhou J et al., 2011, Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes., Pharmacogenomics
Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics
Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet
Bertok S et al., 2017, The association of SCN1A p.Thr1067Ala polymorphism with epilepsy risk and the response to antiepileptic drugs in Slovenian children and adolescents with epilepsy., Seizure
Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem
Meldrum BS, 1996, Update on the mechanism of action of antiepileptic drugs., Epilepsia
Abelaira HM et al., 2012, Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats., Pharmacol Biochem Behav
Braga MF et al., 2002, Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders., Neuropharmacology
Wang JF et al., 2002, Lamotrigine increases gene expression of GABA-A receptor beta3 subunit in primary cultured rat hippocampus cells., Neuropsychopharmacology
Lapidus KA et al., 2013, Novel glutamatergic drugs for the treatment of mood disorders., Neuropsychiatr Dis Treat
Leng Y et al., 2013, Neuroprotective effects of the mood stabilizer lamotrigine against glutamate excitotoxicity: roles of chromatin remodelling and Bcl-2 induction., Int J Neuropsychopharmacol
Chartoff EH et al., 2014, It's MORe exciting than mu: crosstalk between mu opioid receptors and glutamatergic transmission in the mesolimbic dopamine system., Front Pharmacol
Vinod KY et al., 2002, Lamotrigine induced selective changes in 5-HT(1A) receptor mediated response in rat brain., Neurochem Int
Bourin M et al., 2005, Evidence for the activity of lamotrigine at 5-HT(1A) receptors in the mouse forced swimming test., J Psychiatry Neurosci
Kotwal A et al., 2015, Serotonin Syndrome in the Setting of Lamotrigine, Aripiprazole, and Cocaine Use., Case Rep Med
Dibué-Adjei M et al., 2017, Cav2.3 (R-Type) Calcium Channels are Critical for Mediating Anticonvulsive and Neuroprotective Properties of Lamotrigine In Vivo., Cell Physiol Biochem
Kaur S et al., 1996, Motor effects of lamotrigine in naive and dopamine-depleted mice., Eur J Pharmacol
Vallés AS et al., 2007, Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor., Neuroreport
Zheng C et al., 2010, The anticonvulsive drug lamotrigine blocks neuronal {alpha}4{beta}2 nicotinic acetylcholine receptors., J Pharmacol Exp Ther

LAMOTRIGINE PPT1

Interaction Score: 0.69

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9151331

Sources:
NCI
LAMOTRIGINE UGT1A4

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29791014 26790665 23263737 24820767 22047493

Sources:
PharmGKB
LAMOTRIGINE AQP4

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18572411

Sources:
DTC
LAMOTRIGINE UGT2B7

Interaction Score: 0.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26213157 26790665 27096250 23263737

Sources:
PharmGKB
LAMOTRIGINE CACNA1E

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
29176325

Sources:
DrugBank
LAMOTRIGINE CHRNA1

Interaction Score: 0.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17259859 20688974 22306746

Sources:
DrugBank
LAMOTRIGINE HNF4A

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27610747 26213157

Sources:
PharmGKB
LAMOTRIGINE HLA-C

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19668019

Sources:
PharmGKB
LAMOTRIGINE HLA-DQB1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19668019

Sources:
PharmGKB
LAMOTRIGINE SLC22A1

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27610747

Sources:
PharmGKB
LAMOTRIGINE SCN2A

Interaction Score: 0.18

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Lamictal

Novel drug target Established target

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
18784617 17139284 16174788 25155934 17016423

Sources:
PharmGKB TdgClinicalTrial ChemblInteractions
LAMOTRIGINE SCN1A

Interaction Score: 0.15

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23859570 21747585 28753467 16174788 25155934

Sources:
PharmGKB DrugBank ChemblInteractions
LAMOTRIGINE GRIA1

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
23976856 22564541

Sources:
DrugBank
LAMOTRIGINE HLA-DRB1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19668019

Sources:
PharmGKB
LAMOTRIGINE ABCG2

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27610747 29791014 26213157

Sources:
PharmGKB
LAMOTRIGINE GABRA1

Interaction Score: 0.05

Interaction Types & Directionality:

antagonist (inhibitory)

inducer (activating)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8941036 22306746 11955522 11927166

Sources:
DrugBank
LAMOTRIGINE ADORA1

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746

Sources:
DrugBank
LAMOTRIGINE ADORA2A

Interaction Score: 0.05

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746

Sources:
DrugBank
LAMOTRIGINE SCN11A

Interaction Score: 0.05

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions
LAMOTRIGINE HTR3A

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
26339247

Sources:
DrugBank
LAMOTRIGINE OPRK1

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746 24904419

Sources:
DrugBank
LAMOTRIGINE HRH1

Interaction Score: 0.03

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
11792461 22306746 16049571

Sources:
DrugBank
LAMOTRIGINE SCN7A

Interaction Score: 0.03

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE SCN8A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE SCN3A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE ADRB1

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746

Sources:
DrugBank
LAMOTRIGINE SCN4A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE ADRA2A

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746

Sources:
DrugBank
LAMOTRIGINE SCN9A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE DRD2

Interaction Score: 0.02

Interaction Types & Directionality:

agonist (activating)

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8813577 22306746

Sources:
DrugBank
LAMOTRIGINE SCN10A

Interaction Score: 0.02

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE ADRA1A

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746

Sources:
DrugBank
LAMOTRIGINE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746

Sources:
DrugBank
LAMOTRIGINE SCN5A

Interaction Score: 0.01

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
LAMOTRIGINE HTR2A

Interaction Score: 0.01

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22306746

Sources:
DrugBank
LAMOTRIGINE CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
LAMOTRIGINE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
LAMOTRIGINE ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
LAMOTRIGINE CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
LAMOTRIGINE CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
LAMOTRIGINE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DrugBank: DB00555

Version: 5.1.7

Alternate Names:

LAMOTRIGINE DrugBank Drug Name

84057-84-1 CAS Number

Apo-lamotrigine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Meldrum BS, 1996, Update on the mechanism of action of antiepileptic drugs., Epilepsia

Abelaira HM et al., 2012, Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats., Pharmacol Biochem Behav

Braga MF et al., 2002, Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders., Neuropharmacology

TdgClinicalTrial: LAMOTRIGINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anticonvulsant

Drug Class Small Molecule

FDA Approval approved

Publications:
NCI: LAMOTRIGINE
- Version: 14-September-2017
Alternate Names:

C38703 NCI drug code

Drug Info:

Publications:

Aberg et al., 1997, Lamotrigine therapy in infantile neuronal ceroid lipofuscinosis (INCL)., Neuropediatrics

DTC: LAMOTRIGINE

Version: 02-September-2020

Alternate Names:

CHEMBL741 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Yang B et al., 2008, Lack of aquaporin-4 water transport inhibition by antiepileptics and arylsulfonamides., Bioorg Med Chem

PharmGKB: lamotrigine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Shen CH et al., 2016, Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy., Epilepsy Res

Haerian BS et al., 2013, SCN1A, SCN2A and SCN3A gene polymorphisms and responsiveness to antiepileptic drugs: a multicenter cohort study and meta-analysis., Pharmacogenomics

Kumari R et al., 2011, Pharmacogenomic association study on the role of drug metabolizing, drug transporters and drug target gene polymorphisms in drug-resistant epilepsy in a north Indian population., Indian J Hum Genet

TTD: Lamotrigine
- Version: 2020.06.01
Alternate Names:

D03FLC TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL741
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL741
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	Lamictal
Novel drug target	Established target
Mechanism of Interaction	Sodium channel alpha subunit blocker

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

LAMOTRIGINE	DrugBank Drug Name
84057-84-1	CAS Number
Apo-lamotrigine	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
inducer (activating)
inhibitor (inhibitory)

LAMOTRIGINE Drug Record

LAMOTRIGINE chembl:CHEMBL741 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9151331

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29791014 26790665 23263737 24820767 22047493

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18572411

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26213157 26790665 27096250 23263737

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 29176325

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17259859 20688974 22306746

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27610747 26213157

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19668019

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19668019

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27610747

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name Lamictal Novel drug target Established target Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 18784617 17139284 16174788 25155934 17016423

Sources: PharmGKB TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: 23859570 21747585 28753467 16174788 25155934

Sources: PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 23976856 22564541

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19668019

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27610747 29791014 26213157

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory) inducer (activating) inhibitor (inhibitory)

Interaction Info:

PMIDs: 8941036 22306746 11955522 11927166

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 22306746

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 22306746

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
9151331

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29791014 26790665 23263737 24820767 22047493

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
18572411

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
26213157 26790665 27096250 23263737

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
29176325

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17259859 20688974 22306746

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
27610747 26213157

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19668019

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19668019

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27610747

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name Lamictal

Novel drug target Established target

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
18784617 17139284 16174788 25155934 17016423

Sources:
PharmGKB TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
23859570 21747585 28753467 16174788 25155934

Sources:
PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
23976856 22564541

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
19668019

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
27610747 29791014 26213157

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

inducer (activating)

inhibitor (inhibitory)

PMIDs:
8941036 22306746 11955522 11927166

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22306746

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22306746

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
TTD ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
26339247

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22306746 24904419

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
11792461 22306746 16049571

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found