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KETOCONAZOLE Drug Record

  • Summary
  • Interactions
  • Claims
  • KETOCONAZOLE chembl:CHEMBL157101 Approved

    Alternate Names:

    J02AB02
    DANDRAZOL
    KETOSIDIN
    KETOCONAZOLE
    KETOZOLE
    NIZORAL A-D
    DAKTARIN INTENSIV
    NIZORELLE
    XOLEGEL
    DAKTARIN GOLD
    DANDRID
    EXTINA
    NIZORAL
    KETOPINE
    PANFUNGOL
    LEVOKETOCONAZOLE
    NSC-317629
    R-41400
    SID456469
    1-[4-[4-[[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY]PHENYL]-1-PIPERAZINYL]ETHANONE
    KETOCONAZOL
    KETOCONAZOLUM
    NSC 317629
    chemidplus:79156-75-5
    chembl:CHEMBL157101
    rxcui:6135
    chemidplus:65277-42-1
    pubchem.compound:3823
    drugbank:01026

    Drug Info:

    (1 More Sources)

    Publications:

    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Parker RS et al., 2004, Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism., Ann N Y Acad Sci
    Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci
    Reinhardt et al., 1989, Ketoconazole inhibits self-induced metabolism of 1,25-dihydroxyvitamin D3 and amplifies 1,25-dihydroxyvitamin D3 receptor up-regulation in rat osteosarcoma cells., Arch. Biochem. Biophys.
    Kamiński K et al., 2015, Design, synthesis, and anticonvulsant activity of new hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)propanamides and 2-(2,5-dioxopyrrolidin-1-yl)butanamides., J Med Chem
    Łażewska D et al., 2014, Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands., Eur J Med Chem
    Kamińska K et al., 2015, (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands., Eur J Med Chem
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Tripathi et al., 2005, Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria., Parasitology
  • KETOCONAZOLE   CYP3A43

    Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15991489


    Sources:
    NCI

  • KETOCONAZOLE   CYP4F2

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15753130


    Sources:
    PharmGKB

  • KETOCONAZOLE   SNCA

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   ABCG2

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17518356


    Sources:
    NCI

  • KETOCONAZOLE   NR1H4

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   MPHOSPH8

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   CYP3A4

    Interaction Score: 0.03

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    26052884 22931300 24996140 26360048 9187528


    Sources:
    DTC PharmGKB

  • KETOCONAZOLE   HSP90AA1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   VDR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2546501


    Sources:
    DTC NCI

  • KETOCONAZOLE   CBX1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • KETOCONAZOLE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • KETOCONAZOLE   ABCB1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • KETOCONAZOLE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • KETOCONAZOLE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • KETOCONAZOLE   BAZ2B

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   KDM4A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • KETOCONAZOLE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: KETOCONAZOLE

    • Version: 14-September-2017

    Alternate Names:
    C605 NCI drug code

    Drug Info:

    Publications:
    Reinhardt et al., 1989, Ketoconazole inhibits self-induced metabolism of 1,25-dihydroxyvitamin D3 and amplifies 1,25-dihydroxyvitamin D3 receptor up-regulation in rat osteosarcoma cells., Arch. Biochem. Biophys.
    Tripathi et al., 2005, Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria., Parasitology
    Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci

  • DTC: KETOCONAZOLE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL295698 ChEMBL Drug ID

    Drug Info:

    Publications:
    Kamińska K et al., 2015, (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands., Eur J Med Chem
    Łażewska D et al., 2014, Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands., Eur J Med Chem
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • PharmGKB: ketoconazole

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Parker RS et al., 2004, Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism., Ann N Y Acad Sci
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Ketoconazole

    • Version: 2020.06.01

    Alternate Names:
    D0B4IF TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL157101

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21