DGIdb - KETOCONAZOLE Drug Record

KETOCONAZOLE chembl:CHEMBL157101 Approved

Alternate Names:

J02AB02
DANDRAZOL
KETOSIDIN
KETOCONAZOLE
KETOZOLE
NIZORAL A-D
DAKTARIN INTENSIV
NIZORELLE
XOLEGEL
DAKTARIN GOLD
DANDRID
EXTINA
NIZORAL
KETOPINE
PANFUNGOL
LEVOKETOCONAZOLE
NSC-317629
R-41400
SID456469
1-[4-[4-[[2-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YLMETHYL)-1,3-DIOXOLAN-4-YL]METHOXY]PHENYL]-1-PIPERAZINYL]ETHANONE
KETOCONAZOL
KETOCONAZOLUM
NSC 317629
chemidplus:79156-75-5
chembl:CHEMBL157101
rxcui:6135
chemidplus:65277-42-1
pubchem.compound:3823
drugbank:01026

Drug Info:

(2 More Sources)

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Parker RS et al., 2004, Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism., Ann N Y Acad Sci
Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci
Reinhardt et al., 1989, Ketoconazole inhibits self-induced metabolism of 1,25-dihydroxyvitamin D3 and amplifies 1,25-dihydroxyvitamin D3 receptor up-regulation in rat osteosarcoma cells., Arch. Biochem. Biophys.
Kamiński K et al., 2015, Design, synthesis, and anticonvulsant activity of new hybrid compounds derived from 2-(2,5-dioxopyrrolidin-1-yl)propanamides and 2-(2,5-dioxopyrrolidin-1-yl)butanamides., J Med Chem
Łażewska D et al., 2014, Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands., Eur J Med Chem
Kamińska K et al., 2015, (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands., Eur J Med Chem
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Tripathi et al., 2005, Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria., Parasitology

KETOCONAZOLE CYP3A43

Interaction Score: 0.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15991489

Sources:
NCI
KETOCONAZOLE CYP4F2

Interaction Score: 0.8

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15753130

Sources:
PharmGKB
KETOCONAZOLE KCNA10

Interaction Score: 0.46

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology
KETOCONAZOLE SNCA

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE ABCG2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17518356

Sources:
NCI
KETOCONAZOLE NR1H4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE CYP3A4

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Direct Interaction? False

PMIDs:
26052884 22931300 24996140 26360048 9187528

Sources:
DTC GuideToPharmacology PharmGKB
KETOCONAZOLE MPHOSPH8

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE HSP90AA1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE VDR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2546501

Sources:
DTC NCI
KETOCONAZOLE CBX1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
KETOCONAZOLE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
KETOCONAZOLE ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
KETOCONAZOLE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
KETOCONAZOLE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
KETOCONAZOLE BAZ2B

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE KDM4A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
KETOCONAZOLE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

NCI: KETOCONAZOLE

Version: 14-September-2017

Alternate Names:

C605 NCI drug code

Drug Info:

Publications:

Reinhardt et al., 1989, Ketoconazole inhibits self-induced metabolism of 1,25-dihydroxyvitamin D3 and amplifies 1,25-dihydroxyvitamin D3 receptor up-regulation in rat osteosarcoma cells., Arch. Biochem. Biophys.

Tripathi et al., 2005, Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria., Parasitology

Gupta et al., 2007, Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP)., J Pharm Sci

DTC: KETOCONAZOLE

Version: 02-September-2020

Alternate Names:

CHEMBL295698 ChEMBL Drug ID

Drug Info:

Publications:

Kamińska K et al., 2015, (2-Arylethenyl)-1,3,5-triazin-2-amines as a novel histamine H4 receptor ligands., Eur J Med Chem

Łażewska D et al., 2014, Aryl-1,3,5-triazine derivatives as histamine H4 receptor ligands., Eur J Med Chem

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

PharmGKB: ketoconazole

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Parker RS et al., 2004, Discovery, characterization, and significance of the cytochrome P450 omega-hydroxylase pathway of vitamin E catabolism., Ann N Y Acad Sci

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Ketoconazole
- Version: 2020.06.01
Alternate Names:

D0B4IF TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650454
- Version: 29-September-2020
Alternate Names:

KETOCONAZOLE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL157101
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Endogenous Drug?	False
Specific Action of the Ligand	Inhibition
Direct Interaction?	False

KETOCONAZOLE Drug Record

KETOCONAZOLE chembl:CHEMBL157101 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15991489

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15753130

Sources: PharmGKB

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand None

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17518356

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inhibition Direct Interaction? False

PMIDs: 26052884 22931300 24996140 26360048 9187528

Sources: DTC GuideToPharmacology PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2546501

Sources: DTC NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22931300

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
15991489

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15753130

Sources:
PharmGKB

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17518356

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

Direct Interaction? False

PMIDs:
26052884 22931300 24996140 26360048 9187528

Sources:
DTC GuideToPharmacology PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
2546501

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

C605 NCI drug code

Alternate Names:

CHEMBL295698 ChEMBL Drug ID

Alternate Names:

D0B4IF TTD Drug ID

Alternate Names:

KETOCONAZOLE GuideToPharmacology Ligand Name