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ISOTRETINOIN Drug Record

  • Summary
  • Interactions
  • Claims
  • ISOTRETINOIN chembl:CHEMBL547 Approved

    Alternate Names:

    ISOTRETINOIN
    PAT-001
    CLARAVIS
    SOTRET
    AMNESTEEM
    ISOTREX
    RO-43780
    MYORISAN
    ACCUTANE
    RETINOIC ACID 13-CIS-FORM
    ABSORICA
    ROACCUTANE
    ZENATANE
    RO-4-3780
    13 CIS-RETINOIC ACID
    (13-CIS)-RETINOIC ACID
    RETINOIC ACID
    13-RA
    13-CIS-VITAMIN A ACID
    NEOVITAMIN A ACID
    CIS-RETINOIC ACID
    (2Z,4E,6E,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)NONA-2,4,6,8-TETRAENOIC ACID
    CIS-RA
    13-CIS-RETINOIC ACID
    (7E,9E,11E,13Z)-RETINOIC ACID
    chembl:CHEMBL547
    rxcui:6064
    pubchem.compound:5282379
    drugbank:00982
    chemidplus:4759-48-2

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications for treatment of acne
    Drug Class keratolytic agents
    Year of Approval 1982
    (4 More Sources)

    Publications:

    Layton A, 2009, The use of isotretinoin in acne., Dermatoendocrinol
    Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
    Taylor et al., Altered gene expression in murine branchial arches following in utero exposure to retinoic acid., J. Craniofac. Genet. Dev. Biol.
    Dahl et al., 2000, Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study., Clin. Cancer Res.
    Zouboulis, 2006, Isotretinoin revisited: pluripotent effects on human sebaceous gland cells., J. Invest. Dermatol.
    Vu-Dac et al., 1998, Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids., J. Clin. Invest.
    Grüning et al., 2003, Retinoic acid for redifferentiation of thyroid cancer--does it hold its promise?, Eur. J. Endocrinol.
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Oikarinen et al., 1992, Comparison of muscle-derived serum carbonic anhydrase III and myoglobin in dermatological patients: effects of isotretinoin treatment., Acta Derm. Venereol.
    Tetè et al., 1999, The role of apoptosis and bcl-2 protein in topical treatment of oral leukoplakia with isotretinoin., Minerva Stomatol
    Piattelli et al., 1999, bcl-2 expression and apoptotic bodies in 13-cis-retinoic acid (isotretinoin)-topically treated oral leukoplakia: a pilot study., Oral Oncol.
    Bershad et al., 1985, Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne., N. Engl. J. Med.
  • ISOTRETINOIN   CA3

    Interaction Score: 3.75

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1361281


    Sources:
    NCI

  • ISOTRETINOIN   RARA

    Interaction Score: 1.5

    Interaction Types & Directionality:
    agonist (activating)
    other/unknown

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes
    Trial Name CIP-isotretinoin

    PMIDs:
    9204085 7601910 10955779 16983322 9691099


    Sources:
    TdgClinicalTrial ChemblInteractions TEND

  • ISOTRETINOIN   RARG

    Interaction Score: 0.7

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes

    PMIDs:
    20436884


    Sources:
    ChemblInteractions

  • ISOTRETINOIN   LPL

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2931603


    Sources:
    NCI

  • ISOTRETINOIN   TG

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12656659


    Sources:
    NCI

  • ISOTRETINOIN   RARB

    Interaction Score: 0.4

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Retinoic acid receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • ISOTRETINOIN   BCL2

    Interaction Score: 0.39

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10638174 10621853


    Sources:
    NCI

  • ISOTRETINOIN   CYP3A5

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18695978


    Sources:
    PharmGKB

  • ISOTRETINOIN   THRB

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ISOTRETINOIN   VDR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ISOTRETINOIN   AR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: ISOTRETINOIN

    • Version: 01-August-2011

    Alternate Names:
    ISOTRETINOIN Primary Drug Name

    Drug Info:
    Year of Approval 1982
    Drug Class keratolytic agents

    Publications:

  • TdgClinicalTrial: ISOTRETINOIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications for treatment of acne
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: ISOTRETINOIN

    • Version: 14-September-2017

    Alternate Names:
    C603 NCI drug code

    Drug Info:

    Publications:
    Piattelli et al., 1999, bcl-2 expression and apoptotic bodies in 13-cis-retinoic acid (isotretinoin)-topically treated oral leukoplakia: a pilot study., Oral Oncol.
    Tetè et al., 1999, The role of apoptosis and bcl-2 protein in topical treatment of oral leukoplakia with isotretinoin., Minerva Stomatol
    Bershad et al., 1985, Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne., N. Engl. J. Med.

  • PharmGKB: isotretinoin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

  • DTC: ISOTRETINOIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL547 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Isotretinoin

    • Version: 2020.06.01

    Alternate Names:
    D00DKK TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL547

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL547

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21