DGIdb - ISOTRETINOIN Drug Record

ISOTRETINOIN chembl:CHEMBL547 Approved

Alternate Names:

ISOTRETINOIN
PAT-001
CLARAVIS
SOTRET
AMNESTEEM
ISOTREX
RO-43780
MYORISAN
ACCUTANE
RETINOIC ACID 13-CIS-FORM
ABSORICA
ROACCUTANE
ZENATANE
RO-4-3780
13 CIS-RETINOIC ACID
(13-CIS)-RETINOIC ACID
RETINOIC ACID
13-RA
13-CIS-VITAMIN A ACID
NEOVITAMIN A ACID
CIS-RETINOIC ACID
(2Z,4E,6E,8E)-3,7-DIMETHYL-9-(2,6,6-TRIMETHYLCYCLOHEX-1-EN-1-YL)NONA-2,4,6,8-TETRAENOIC ACID
CIS-RA
13-CIS-RETINOIC ACID
(7E,9E,11E,13Z)-RETINOIC ACID
chembl:CHEMBL547
rxcui:6064
pubchem.compound:5282379
drugbank:00982
chemidplus:4759-48-2

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	for treatment of acne
Drug Class	keratolytic agents
Year of Approval	1982
Drug Categories	retinoids for treatment of acne
Drug Categories	retinoids
Drug Categories	polyenes
Drug Categories	carotenoids
Drug Categories	anti-acne preparations for systemic use
Drug Categories	agents causing muscle toxicity
Drug Categories	anti-acne preparations for topical use
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	drugs that are mainly renally excreted
Drug Categories	drugs that are mainly renally excreted with narrow therapeutic index
Drug Categories	misc. skin and mucous membrane agents
Drug Categories	narrow therapeutic index drugs
Drug Categories	photosensitizing agents
Drug Categories	retinoids for topical use in acne

(5 More Sources)

Publications:

Layton A, 2009, The use of isotretinoin in acne., Dermatoendocrinol
Shroot et al., 1997, Pharmacology and chemistry of adapalene., J. Am. Acad. Dermatol.
Taylor et al., Altered gene expression in murine branchial arches following in utero exposure to retinoic acid., J. Craniofac. Genet. Dev. Biol.
Dahl et al., 2000, Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study., Clin. Cancer Res.
Zouboulis, 2006, Isotretinoin revisited: pluripotent effects on human sebaceous gland cells., J. Invest. Dermatol.
Vu-Dac et al., 1998, Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids., J. Clin. Invest.
Grüning et al., 2003, Retinoic acid for redifferentiation of thyroid cancer--does it hold its promise?, Eur. J. Endocrinol.
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Oikarinen et al., 1992, Comparison of muscle-derived serum carbonic anhydrase III and myoglobin in dermatological patients: effects of isotretinoin treatment., Acta Derm. Venereol.
Tetè et al., 1999, The role of apoptosis and bcl-2 protein in topical treatment of oral leukoplakia with isotretinoin., Minerva Stomatol
Piattelli et al., 1999, bcl-2 expression and apoptotic bodies in 13-cis-retinoic acid (isotretinoin)-topically treated oral leukoplakia: a pilot study., Oral Oncol.
Bershad et al., 1985, Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne., N. Engl. J. Med.

ISOTRETINOIN RARA

Interaction Score: 1.5

Interaction Types & Directionality:

agonist (activating)

other/unknown

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name CIP-isotretinoin

PMIDs:
9204085 7601910 10955779 16983322 9691099

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND
ISOTRETINOIN CA3

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1361281

Sources:
NCI
ISOTRETINOIN RARG

Interaction Score: 0.7

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
20436884

Sources:
DrugBank ChemblInteractions
ISOTRETINOIN TG

Interaction Score: 0.57

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12656659

Sources:
NCI
ISOTRETINOIN LPL

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2931603

Sources:
NCI
ISOTRETINOIN RARB

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ISOTRETINOIN BCL2

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10638174 10621853

Sources:
NCI
ISOTRETINOIN CYP3A5

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18695978

Sources:
PharmGKB
ISOTRETINOIN THRB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOTRETINOIN VDR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ISOTRETINOIN AR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00982

Version: 5.1.7

Alternate Names:

ISOTRETINOIN DrugBank Drug Name

4759-48-2 CAS Number

Absorica Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents causing muscle toxicity

Publications:

Vu-Dac et al., 1998, Retinoids increase human apo C-III expression at the transcriptional level via the retinoid X receptor. Contribution to the hypertriglyceridemic action of retinoids., J. Clin. Invest.

Zouboulis, 2006, Isotretinoin revisited: pluripotent effects on human sebaceous gland cells., J. Invest. Dermatol.

Dahl et al., 2000, Inhaled isotretinoin (13-cis retinoic acid) is an effective lung cancer chemopreventive agent in A/J mice at low doses: a pilot study., Clin. Cancer Res.

TEND: ISOTRETINOIN
- Version: 01-August-2011
Alternate Names:

ISOTRETINOIN Primary Drug Name

Drug Info:

Year of Approval 1982

Drug Class keratolytic agents

Publications:
TdgClinicalTrial: ISOTRETINOIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications for treatment of acne

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: ISOTRETINOIN

Version: 14-September-2017

Alternate Names:

C603 NCI drug code

Drug Info:

Publications:

Piattelli et al., 1999, bcl-2 expression and apoptotic bodies in 13-cis-retinoic acid (isotretinoin)-topically treated oral leukoplakia: a pilot study., Oral Oncol.

Tetè et al., 1999, The role of apoptosis and bcl-2 protein in topical treatment of oral leukoplakia with isotretinoin., Minerva Stomatol

Bershad et al., 1985, Changes in plasma lipids and lipoproteins during isotretinoin therapy for acne., N. Engl. J. Med.

PharmGKB: isotretinoin
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
DTC: ISOTRETINOIN
- Version: 02-September-2020
Alternate Names:

CHEMBL547 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Isotretinoin
- Version: 2020.06.01
Alternate Names:

D00DKK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL547
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL547
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Retinoic acid receptor agonist
Direct Interaction	yes
Trial Name	CIP-isotretinoin

ISOTRETINOIN	DrugBank Drug Name
4759-48-2	CAS Number
Absorica	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	agents causing muscle toxicity

agonist (activating)
other/unknown

ISOTRETINOIN Drug Record

ISOTRETINOIN chembl:CHEMBL547 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating) other/unknown

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes Trial Name CIP-isotretinoin

PMIDs: 9204085 7601910 10955779 16983322 9691099

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1361281

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes

PMIDs: 20436884

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12656659

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2931603

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Retinoic acid receptor agonist Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10638174 10621853

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18695978

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00982

Alternate Names: ISOTRETINOIN DrugBank Drug Name 4759-48-2 CAS Number Absorica Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories agents causing muscle toxicity

TEND: ISOTRETINOIN

Alternate Names: ISOTRETINOIN Primary Drug Name

Drug Info: Year of Approval 1982 Drug Class keratolytic agents

Publications:

TdgClinicalTrial: ISOTRETINOIN

Alternate Names:

Drug Info: Drug Indications for treatment of acne Drug Class Small Molecule FDA Approval approved

Publications:

NCI: ISOTRETINOIN

Alternate Names: C603 NCI drug code

Drug Info:

PharmGKB: isotretinoin

Alternate Names:

Drug Info:

Publications: Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

DTC: ISOTRETINOIN

Alternate Names: CHEMBL547 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Isotretinoin

Alternate Names: D00DKK TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL547

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL547

Interaction Types & Directionality:

agonist (activating)

other/unknown

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

Trial Name CIP-isotretinoin

PMIDs:
9204085 7601910 10955779 16983322 9691099

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
1361281

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
20436884

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
12656659

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2931603

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Retinoic acid receptor agonist

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
10638174 10621853

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ISOTRETINOIN DrugBank Drug Name

4759-48-2 CAS Number

Absorica Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories agents causing muscle toxicity

Alternate Names:

ISOTRETINOIN Primary Drug Name

Drug Info:

Year of Approval 1982

Drug Class keratolytic agents

Drug Info:

Drug Indications for treatment of acne

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C603 NCI drug code

Publications:

Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem

Alternate Names:

CHEMBL547 ChEMBL Drug ID

Alternate Names:

D00DKK TTD Drug ID