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INOSITOL Drug Record

  • Summary
  • Interactions
  • Claims
  • INOSITOL chembl:CHEMBL1222251

    Alternate Names:

    NSC-25142
    MESO-INOSITOL
    NSC-55551
    NSC-404118
    CYCLOHEXANEHEXOL
    INOSITOL
    NSC-8101

    Drug Info:

    (0 More Sources)

    Publications:

    Pula et al., 2004, Agonist-independent internalization of metabotropic glutamate receptor 1a is arrestin- and clathrin-dependent and is suppressed by receptor inverse agonists., J. Neurochem.
    Hauschildt et al., 1988, Role of inositol starvation on ecto-5'-nucleotidase activity during mitogen-induced lymphocyte activation., Immunol. Lett.
    Langlois et al., 1994, Regulation by growth factors of angiotensin II type-1 receptor and the alpha subunit of Gq and G11 in bovine adrenal cells., Endocrinology
    Müller et al., 1994, Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport., J. Cell Biol.
    He et al., 2000, Intracellular Ca(2+) and Ca(2+)/calmodulin-dependent kinase II mediate acute potentiation of neurotransmitter release by neurotrophin-3., J. Cell Biol.
    Alberola-Ila et al., 1992, Intracellular events involved in CD5-induced human T cell activation and proliferation., J. Immunol.
    Kojima et al., 1997, Characterization of the pleckstrin homology domain of Btk as an inositol polyphosphate and phosphoinositide binding domain., Biochem. Biophys. Res. Commun.
    Takeuchi et al., 1998, PTB domain of insulin receptor substrate-1 binds inositol compounds., Biochem. J.
    Chowdhury et al., 2004, Regulation of connective tissue growth factor (CTGF/CCN2) gene transcription and mRNA stability in smooth muscle cells. Involvement of RhoA GTPase and p38 MAP kinase and sensitivity to actin dynamics., Eur. J. Biochem.
    Milligan et al., 1989, Identification of the pertussis and cholera toxin substrates in normal and N-ras transformed NIH3T3 fibroblasts and an assessment of their involvement in bombesin-stimulation of inositol phospholipid metabolism., Oncogene
    Weng et al., 1996, Novel CCK-B receptor agonists: diketopiperazine analogues derived for CCK4 bioactive conformation., Regul. Pept.
    Olszewska-Pazdrak et al., 2004, Epidermal growth factor potentiates cholecystokinin/gastrin receptor-mediated Ca2+ release by activation of mitogen-activated protein kinases., J. Biol. Chem.
    Liepkalns et al., 1991, Cell signalling associated with fibrinolytic ligand binding to human colorectal carcinoma cells., J. Cancer Res. Clin. Oncol.
    Iijima et al., 2005, Hzf protein regulates dendritic localization and BDNF-induced translation of type 1 inositol 1,4,5-trisphosphate receptor mRNA., Proc. Natl. Acad. Sci. U.S.A.
    Weglarz et al., 2006, Quantitative analysis of the level of p53 and p21(WAF1) mRNA in human colon cancer HT-29 cells treated with inositol hexaphosphate., Acta Biochim. Pol.
  • INOSITOL   TEC

    Interaction Score: 4.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9240435


    Sources:
    NCI

  • INOSITOL   CD5

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1371522


    Sources:
    NCI

  • INOSITOL   GRM1

    Interaction Score: 2.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15140199


    Sources:
    NCI

  • INOSITOL   IRS1

    Interaction Score: 1.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9693122


    Sources:
    NCI

  • INOSITOL   CCKBR

    Interaction Score: 0.88

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8876029 14602717


    Sources:
    NCI

  • INOSITOL   NT5E

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2847980


    Sources:
    NCI

  • INOSITOL   NTF3

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10811820


    Sources:
    NCI

  • INOSITOL   LPL

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8063863


    Sources:
    NCI

  • INOSITOL   CCN2

    Interaction Score: 0.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15560785


    Sources:
    NCI

  • INOSITOL   PLG

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1648562


    Sources:
    NCI

  • INOSITOL   TGFB1

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8013389


    Sources:
    NCI

  • INOSITOL   NRAS

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2498808


    Sources:
    NCI

  • INOSITOL   BDNF

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16286649


    Sources:
    NCI

  • INOSITOL   TP53

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16733561


    Sources:
    NCI

  • NCI: INOSITOL

    • Version: 14-September-2017

    Alternate Names:
    C28163 NCI drug code

    Drug Info:

    Publications:
    Hauschildt et al., 1988, Role of inositol starvation on ecto-5'-nucleotidase activity during mitogen-induced lymphocyte activation., Immunol. Lett.
    Müller et al., 1994, Stimulation of a glycosyl-phosphatidylinositol-specific phospholipase by insulin and the sulfonylurea, glimepiride, in rat adipocytes depends on increased glucose transport., J. Cell Biol.
    Alberola-Ila et al., 1992, Intracellular events involved in CD5-induced human T cell activation and proliferation., J. Immunol.

  • ChemblDrugs: chembl:CHEMBL1222251

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21