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INDOMETHACIN Drug Record

  • Summary
  • Interactions
  • Claims
  • INDOMETHACIN chembl:CHEMBL6 ApprovedImmunotherapy

    Alternate Names:

    INDOMAX-25
    INDOCID-R
    ARTRACIN SR
    INDOLAR
    INDOMETHACIN
    INDOTARD MR 75
    INDOMOD
    MOBILAN
    INDOMETACIN FARNESIL
    ARTRACIN
    RHEUMACIN LA
    INDOLAR SR
    NSC-77541
    BERLIND 75 RET
    MAXIMET SR
    IMBRILON
    FLEXIN-50 CONTINUS
    INDODERM
    INDOMAX-75 SR
    INDOFLEX
    LEDMECIN
    INDOCIN
    FLEXIN-75 CONTINUS
    INDOPTOL
    INDOCID RET
    INDO-PAED
    RIMACID
    TIVORBEX
    INDO-LEMMON
    INDOMETACIN
    FLEXIN-25 CONTINUS
    PARDELPRIN MR
    SLO-INDO
    INDOCIN SR
    INDOCID®
    INDOMETACINE
    INDOMETACINA
    ACONIP
    1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
    INDOMETACINUM
    {1-[(4-CHLOROPHENYL)CARBONYL]-5-METHOXY-2-METHYL-1H-INDOL-3-YL}ACETIC ACID
    INDOCIN®
    rxcui:5781
    chembl:CHEMBL6
    pubchem.compound:3715
    drugbank:00328
    chemidplus:53-86-1

    Drug Info:

    Year of Approval approved before 1982
    Drug Class anti-inflammatory agents, non-steroidal
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications NSAID
    (4 More Sources)

    Publications:

    Higuchi et al., 2004, Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach., Drugs Exp Clin Res
    Moth et al., 2005, Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1., J. Med. Chem.
    Bobadilla L et al., 2005, Effect of pregnancy on the roles of nitric oxide and prostaglandins in 5-hydroxytryptamine-induced contractions in rat isolated thoracic and abdominal aorta., Clin. Exp. Pharmacol. Physiol.
    Kundu et al., 2005, Cyclooxygenase inhibitors modulate NK activities that control metastatic disease., Cancer Immunol. Immunother.
    Fornai et al., 2005, Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice., Gut
    Christ AN et al., 2010, Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases., J Med Chem
    Hanna MM, 2012, New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies., Eur J Med Chem
    Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem
    Blanco et al., 1999, Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes., J. Rheumatol.
    Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem
    Lovering et al., 2004, Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin., Cancer Res.
    Mohagheghpour et al., 1997, Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes., Cell. Immunol.
    Tsukamoto et al., 1989, Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat., Gut
    Fujita et al., 2007, Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil., Intern. Med.
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Xu et al., 2003, Effect of indomethacin on the c-fos expression in AVP and TH neurons in rat brain induced by lipopolysaccharide., Brain Res.
    Ashjian et al., 2003, In vitro differentiation of human processed lipoaspirate cells into early neural progenitors., Plast. Reconstr. Surg.
    Kocaoğlu et al., 1997, Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity., Arch. Immunol. Ther. Exp. (Warsz.)
    Zarza J, 2003, Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9., Thromb Haemost
    Stadnyk et al., 2002, Neutrophil migration into indomethacin induced rat small intestinal injury is CD11a/CD18 and CD11b/CD18 co-dependent., Gut
    Duncan et al., 2005, Connective tissue growth factor expression in the human corpus luteum: paracrine regulation by human chorionic gonadotropin., J. Clin. Endocrinol. Metab.
    Liakos et al., 1997, ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells., Am. J. Physiol.
    Duric et al., 2006, Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat., J. Pharmacol. Exp. Ther.
    Szabó et al., 2005, Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice., J. Pharmacol. Exp. Ther.
    Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.
    Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
    Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
    Armstrong et al., 2005, Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors., Ann Vasc Surg
    Jerde et al., 2005, Celecoxib inhibits ureteral contractility and prostanoid release., Urology
    Zhang et al., 2004, [Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression]., Zhonghua Xue Ye Xue Za Zhi
    Yokota et al., 2005, Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats., J. Pharmacol. Exp. Ther.
    Pilane et al., 2005, Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids., J. Cell. Physiol.
    Andreis et al., 2000, Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: receptor subtype involved and signaling mechanism., Endocrinology
    Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.
    Zhu et al., 1999, Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc., Biochem. Pharmacol.
    Tsutsumi et al., 2004, Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis., Cell Death Differ.
    Koeberle A et al., 2008, Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase., J Med Chem
    Aussel et al., 1987, Effect of alpha-fetoprotein and indomethacin on arachidonic acid metabolism in P388D1 macrophages: role of leukotrienes., Prostaglandins Leukot Med
    Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut
    Sakoguchi-Okada et al., 2007, Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells., Biochem. Pharmacol.
    Zhou et al., 2008, Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses., J. Immunol.
    Sekhar et al., 2002, Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase., Free Radic. Biol. Med.
    Lee WY et al., 2010, Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells., J Nat Prod
    Jaramillo et al., 1992, Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation., Curr. Eye Res.
  • INDOMETHACIN   FST

    Interaction Score: 1.77

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15941869


    Sources:
    NCI

  • INDOMETHACIN   SAG

    Interaction Score: 0.71

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1324133


    Sources:
    NCI

  • INDOMETHACIN   PTGES

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    19053751


    Sources:
    DTC

  • INDOMETHACIN   AKR1C3

    Interaction Score: 0.53

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    23432095 14996743


    Sources:
    DTC

  • INDOMETHACIN   ADM

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10830296


    Sources:
    NCI

  • INDOMETHACIN   CD86

    Interaction Score: 0.5

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9070321


    Sources:
    NCI

  • INDOMETHACIN   ENO2

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12711954


    Sources:
    NCI

  • INDOMETHACIN   KCNE1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name Indaflex
    Novel drug target Established target

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • INDOMETHACIN   PTGS1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Cyclooxygenase inhibitor
    Direct Interaction yes

    PMIDs:
    15700751 15887968 15743404 15891886 15831902 20684598 22818041 23651359 10381057


    Sources:
    DTC ChemblInteractions TEND

  • INDOMETHACIN   PTGS2

    Interaction Score: 0.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Cyclooxygenase inhibitor

    PMIDs:
    20684598 22818041 24697244 19602986 15770365 15667901 15730717 15831440 15668944 10381057


    Sources:
    DTC ChemblInteractions TEND PharmGKB TTD

  • INDOMETHACIN   STAT6

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18832692


    Sources:
    NCI

  • INDOMETHACIN   AFP

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2443931


    Sources:
    NCI

  • INDOMETHACIN   TH

    Interaction Score: 0.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12646303


    Sources:
    NCI

  • INDOMETHACIN   GGT1

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9090444


    Sources:
    NCI

  • INDOMETHACIN   FCGR3B

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17329922


    Sources:
    NCI

  • INDOMETHACIN   ITGB2

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11950807


    Sources:
    NCI

  • INDOMETHACIN   FGF2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9071932


    Sources:
    NCI

  • INDOMETHACIN   FCGR3A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17329922


    Sources:
    NCI

  • INDOMETHACIN   KCNQ1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name Indaflex

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial

  • INDOMETHACIN   DDIT3

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15131590


    Sources:
    NCI

  • INDOMETHACIN   BIRC5

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17270149


    Sources:
    NCI

  • INDOMETHACIN   TRPV1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15831443


    Sources:
    NCI

  • INDOMETHACIN   TYMS

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2707640


    Sources:
    NCI

  • INDOMETHACIN   MYC

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10403534


    Sources:
    NCI

  • INDOMETHACIN   SLC2A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8557642


    Sources:
    NCI

  • INDOMETHACIN   AGTR1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9357777


    Sources:
    NCI

  • INDOMETHACIN   ABCC1

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    20455578


    Sources:
    DTC

  • INDOMETHACIN   ACE

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3937925


    Sources:
    NCI

  • INDOMETHACIN   BDNF

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16956981


    Sources:
    NCI

  • INDOMETHACIN   CYP2C9

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12876643 22931300


    Sources:
    DTC PharmGKB

  • INDOMETHACIN   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC PharmGKB

  • INDOMETHACIN   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • INDOMETHACIN   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • INDOMETHACIN   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11909699


    Sources:
    NCI

  • INDOMETHACIN   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • TEND: INDOMETHACIN

    • Version: 01-August-2011

    Alternate Names:
    INDOMETHACIN Primary Drug Name

    Drug Info:
    Drug Class anti-inflammatory agents, non-steroidal
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: INDOMETHACIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications NSAID
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: INDOMETHACIN

    • Version: 14-September-2017

    Alternate Names:
    C576 NCI drug code

    Drug Info:

    Publications:
    Ashjian et al., 2003, In vitro differentiation of human processed lipoaspirate cells into early neural progenitors., Plast. Reconstr. Surg.
    Kocaoğlu et al., 1997, Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity., Arch. Immunol. Ther. Exp. (Warsz.)
    Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.

  • DTC: INDOMETHACIN

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL6 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem
    Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem

  • PharmGKB: indomethacin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Zarza J, 2003, Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9., Thromb Haemost
    Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

  • TTD: Indomethacin

    • Version: 2020.06.01

    Alternate Names:
    D0R1RS TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL6

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL6

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21