DGIdb - INDOMETHACIN Drug Record

INDOMETHACIN chembl:CHEMBL6 ApprovedImmunotherapy

Alternate Names:

INDOMAX-25
INDOCID-R
ARTRACIN SR
INDOLAR
INDOMETHACIN
INDOTARD MR 75
INDOMOD
MOBILAN
INDOMETACIN FARNESIL
ARTRACIN
RHEUMACIN LA
INDOLAR SR
NSC-77541
BERLIND 75 RET
MAXIMET SR
IMBRILON
FLEXIN-50 CONTINUS
INDODERM
INDOMAX-75 SR
INDOFLEX
LEDMECIN
INDOCIN
FLEXIN-75 CONTINUS
INDOPTOL
INDOCID RET
INDO-PAED
RIMACID
TIVORBEX
INDO-LEMMON
INDOMETACIN
FLEXIN-25 CONTINUS
PARDELPRIN MR
SLO-INDO
INDOCIN SR
INDOCID®
INDOMETACINE
INDOMETACINA
ACONIP
1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
INDOMETACINUM
{1-[(4-CHLOROPHENYL)CARBONYL]-5-METHOXY-2-METHYL-1H-INDOL-3-YL}ACETIC ACID
INDOCIN®
rxcui:5781
chembl:CHEMBL6
pubchem.compound:3715
drugbank:00328
chemidplus:53-86-1

Drug Info:

Year of Approval	approved before 1982
Drug Class	anti-inflammatory agents, non-steroidal
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	NSAID

(4 More Sources)

Publications:

Higuchi et al., 2004, Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach., Drugs Exp Clin Res
Moth et al., 2005, Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1., J. Med. Chem.
Bobadilla L et al., 2005, Effect of pregnancy on the roles of nitric oxide and prostaglandins in 5-hydroxytryptamine-induced contractions in rat isolated thoracic and abdominal aorta., Clin. Exp. Pharmacol. Physiol.
Kundu et al., 2005, Cyclooxygenase inhibitors modulate NK activities that control metastatic disease., Cancer Immunol. Immunother.
Fornai et al., 2005, Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice., Gut
Christ AN et al., 2010, Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases., J Med Chem
Hanna MM, 2012, New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies., Eur J Med Chem
Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem
Blanco et al., 1999, Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes., J. Rheumatol.
Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem
Lovering et al., 2004, Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin., Cancer Res.
Mohagheghpour et al., 1997, Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes., Cell. Immunol.
Tsukamoto et al., 1989, Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat., Gut
Fujita et al., 2007, Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil., Intern. Med.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Xu et al., 2003, Effect of indomethacin on the c-fos expression in AVP and TH neurons in rat brain induced by lipopolysaccharide., Brain Res.
Ashjian et al., 2003, In vitro differentiation of human processed lipoaspirate cells into early neural progenitors., Plast. Reconstr. Surg.
Kocaoğlu et al., 1997, Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity., Arch. Immunol. Ther. Exp. (Warsz.)
Zarza J, 2003, Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9., Thromb Haemost
Stadnyk et al., 2002, Neutrophil migration into indomethacin induced rat small intestinal injury is CD11a/CD18 and CD11b/CD18 co-dependent., Gut
Duncan et al., 2005, Connective tissue growth factor expression in the human corpus luteum: paracrine regulation by human chorionic gonadotropin., J. Clin. Endocrinol. Metab.
Liakos et al., 1997, ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells., Am. J. Physiol.
Duric et al., 2006, Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat., J. Pharmacol. Exp. Ther.
Szabó et al., 2005, Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice., J. Pharmacol. Exp. Ther.
Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.
Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
Armstrong et al., 2005, Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors., Ann Vasc Surg
Jerde et al., 2005, Celecoxib inhibits ureteral contractility and prostanoid release., Urology
Zhang et al., 2004, [Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression]., Zhonghua Xue Ye Xue Za Zhi
Yokota et al., 2005, Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats., J. Pharmacol. Exp. Ther.
Pilane et al., 2005, Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids., J. Cell. Physiol.
Andreis et al., 2000, Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: receptor subtype involved and signaling mechanism., Endocrinology
Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.
Zhu et al., 1999, Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc., Biochem. Pharmacol.
Tsutsumi et al., 2004, Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis., Cell Death Differ.
Koeberle A et al., 2008, Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase., J Med Chem
Aussel et al., 1987, Effect of alpha-fetoprotein and indomethacin on arachidonic acid metabolism in P388D1 macrophages: role of leukotrienes., Prostaglandins Leukot Med
Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut
Sakoguchi-Okada et al., 2007, Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells., Biochem. Pharmacol.
Zhou et al., 2008, Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses., J. Immunol.
Sekhar et al., 2002, Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase., Free Radic. Biol. Med.
Lee WY et al., 2010, Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells., J Nat Prod
Jaramillo et al., 1992, Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation., Curr. Eye Res.

INDOMETHACIN FST

Interaction Score: 1.77

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15941869

Sources:
NCI
INDOMETHACIN SAG

Interaction Score: 0.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1324133

Sources:
NCI
INDOMETHACIN PTGES

Interaction Score: 0.59

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053751

Sources:
DTC
INDOMETHACIN AKR1C3

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
23432095 14996743

Sources:
DTC
INDOMETHACIN ADM

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10830296

Sources:
NCI
INDOMETHACIN CD86

Interaction Score: 0.5

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9070321

Sources:
NCI
INDOMETHACIN ENO2

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12711954

Sources:
NCI
INDOMETHACIN KCNE1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Indaflex

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
INDOMETHACIN PTGS1

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
15700751 15887968 15743404 15891886 15831902 20684598 22818041 23651359 10381057

Sources:
DTC ChemblInteractions TEND
INDOMETHACIN PTGS2

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
20684598 22818041 24697244 19602986 15770365 15667901 15730717 15831440 15668944 10381057

Sources:
DTC ChemblInteractions TEND PharmGKB TTD
INDOMETHACIN STAT6

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18832692

Sources:
NCI
INDOMETHACIN AFP

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2443931

Sources:
NCI
INDOMETHACIN TH

Interaction Score: 0.25

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12646303

Sources:
NCI
INDOMETHACIN GGT1

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9090444

Sources:
NCI
INDOMETHACIN FCGR3B

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17329922

Sources:
NCI
INDOMETHACIN ITGB2

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11950807

Sources:
NCI
INDOMETHACIN FGF2

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9071932

Sources:
NCI
INDOMETHACIN FCGR3A

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17329922

Sources:
NCI
INDOMETHACIN KCNQ1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Indaflex

PMIDs:
None found

Sources:
TdgClinicalTrial
INDOMETHACIN DDIT3

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15131590

Sources:
NCI
INDOMETHACIN BIRC5

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17270149

Sources:
NCI
INDOMETHACIN TRPV1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15831443

Sources:
NCI
INDOMETHACIN TYMS

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2707640

Sources:
NCI
INDOMETHACIN MYC

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10403534

Sources:
NCI
INDOMETHACIN SLC2A4

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8557642

Sources:
NCI
INDOMETHACIN AGTR1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9357777

Sources:
NCI
INDOMETHACIN ABCC1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20455578

Sources:
DTC
INDOMETHACIN ACE

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3937925

Sources:
NCI
INDOMETHACIN BDNF

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16956981

Sources:
NCI
INDOMETHACIN CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12876643 22931300

Sources:
DTC PharmGKB
INDOMETHACIN CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC PharmGKB
INDOMETHACIN CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
INDOMETHACIN CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
INDOMETHACIN NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11909699

Sources:
NCI
INDOMETHACIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

TEND: INDOMETHACIN
- Version: 01-August-2011
Alternate Names:

INDOMETHACIN Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agents, non-steroidal

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: INDOMETHACIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications NSAID

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: INDOMETHACIN

Version: 14-September-2017

Alternate Names:

C576 NCI drug code

Drug Info:

Publications:

Ashjian et al., 2003, In vitro differentiation of human processed lipoaspirate cells into early neural progenitors., Plast. Reconstr. Surg.

Kocaoğlu et al., 1997, Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity., Arch. Immunol. Ther. Exp. (Warsz.)

Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.

DTC: INDOMETHACIN

Version: 02-September-2020

Alternate Names:

CHEMBL6 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem

Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem

PharmGKB: indomethacin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zarza J, 2003, Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9., Thromb Haemost

Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

TTD: Indomethacin
- Version: 2020.06.01
Alternate Names:

D0R1RS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL6
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL6
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Cyclooxygenase inhibitor
Direct Interaction	yes

Trial Name	Indaflex
Novel drug target	Established target

INDOMETHACIN Drug Record

INDOMETHACIN chembl:CHEMBL6 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15941869

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1324133

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053751

Sources: DTC

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 23432095 14996743

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10830296

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9070321

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12711954

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Indaflex Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes

PMIDs: 15700751 15887968 15743404 15891886 15831902 20684598 22818041 23651359 10381057

Sources: DTC ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs: 20684598 22818041 24697244 19602986 15770365 15667901 15730717 15831440 15668944 10381057

Sources: DTC ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18832692

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2443931

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12646303

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9090444

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17329922

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11950807

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9071932

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17329922

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name Indaflex

PMIDs: None found

Interaction Types & Directionality:

n/a

PMIDs:
15941869

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1324133

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
19053751

Sources:
DTC

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
23432095 14996743

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10830296

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9070321

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12711954

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Indaflex

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
15700751 15887968 15743404 15891886 15831902 20684598 22818041 23651359 10381057

Sources:
DTC ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
20684598 22818041 24697244 19602986 15770365 15667901 15730717 15831440 15668944 10381057

Sources:
DTC ChemblInteractions TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
18832692

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2443931

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12646303

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9090444

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17329922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
11950807

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9071932

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17329922

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Indaflex

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
15131590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17270149

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15831443

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2707640

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10403534

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8557642

Sources:
NCI

Interaction Types & Directionality:

n/a