DGIdb - INDOMETHACIN Drug Record

INDOMETHACIN chembl:CHEMBL6 ApprovedImmunotherapy

Alternate Names:

INDOMAX-25
INDOCID-R
ARTRACIN SR
INDOLAR
INDOMETHACIN
INDOTARD MR 75
INDOMOD
MOBILAN
INDOMETACIN FARNESIL
ARTRACIN
RHEUMACIN LA
INDOLAR SR
NSC-77541
BERLIND 75 RET
MAXIMET SR
IMBRILON
FLEXIN-50 CONTINUS
INDODERM
INDOMAX-75 SR
INDOFLEX
LEDMECIN
INDOCIN
FLEXIN-75 CONTINUS
INDOPTOL
INDOCID RET
INDO-PAED
RIMACID
TIVORBEX
INDO-LEMMON
INDOMETACIN
FLEXIN-25 CONTINUS
PARDELPRIN MR
SLO-INDO
INDOCIN SR
INDOCID®
INDOMETACINE
INDOMETACINA
ACONIP
1-(P-CHLOROBENZOYL)-5-METHOXY-2-METHYLINDOLE-3-ACETIC ACID
INDOMETACINUM
{1-[(4-CHLOROPHENYL)CARBONYL]-5-METHOXY-2-METHYL-1H-INDOL-3-YL}ACETIC ACID
INDOCIN®
rxcui:5781
chembl:CHEMBL6
pubchem.compound:3715
drugbank:00328
chemidplus:53-86-1

Drug Info:

Year of Approval	approved before 1982
Drug Class	anti-inflammatory agents, non-steroidal
Drug Categories	anti-inflammatory agents
Drug Categories	analgesics
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	NSAID
Drug Categories	acetic acid derivatives and related substances
Drug Categories	agents causing hyperkalemia
Drug Categories	agents that produce hypertension
Drug Categories	anti-inflammatory agents, non-steroidal (non-selective)
Drug Categories	antigout preparations
Drug Categories	antiinflammatory and antirheumatic products
Drug Categories	antiinflammatory and antirheumatic products, non-steroids
Drug Categories	antiinflammatory preparations, non-steroids for topical use
Drug Categories	bsep/abcb11 substrates
Drug Categories	cytochrome p-450 cyp2c19 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	hypoglycemia-associated agents
Drug Categories	immunosuppressive agents
Drug Categories	musculo-skeletal system
Drug Categories	myelosuppressive agents
Drug Categories	nephrotoxic agents
Drug Categories	non cox-2 selective nsaids
Drug Categories	oat1/slc22a6 inhibitors
Drug Categories	oat1/slc22a6 substrates
Drug Categories	oat3/slc22a8 inhibitors
Drug Categories	oat3/slc22a8 substrates
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	ophthalmologicals
Drug Categories	other nonsteroidal anti-inflammatory agents
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	sensory organs
Drug Categories	topical products for joint and muscular pain
Drug Categories	ugt1a1 substrates
Drug Categories	ugt1a9 substrates
Drug Categories	ugt2b7 inhibitors
Drug Categories	ugt2b7 substrates

(6 More Sources)

Publications:

Kundu et al., 2005, Cyclooxygenase inhibitors modulate NK activities that control metastatic disease., Cancer Immunol. Immunother.
Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem
Higuchi et al., 2004, Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach., Drugs Exp Clin Res
Bobadilla L et al., 2005, Effect of pregnancy on the roles of nitric oxide and prostaglandins in 5-hydroxytryptamine-induced contractions in rat isolated thoracic and abdominal aorta., Clin. Exp. Pharmacol. Physiol.
Christ AN et al., 2010, Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D(2) synthases., J Med Chem
Moth et al., 2005, Stereoselective binding of indomethacin ethanolamide derivatives to cyclooxygenase-1., J. Med. Chem.
Hanna MM, 2012, New pyrimido[5,4-e]pyrrolo[1,2-c]pyrimidines: synthesis, 2D-QSAR, anti-inflammatory, analgesic and ulcerogenicity studies., Eur J Med Chem
Blanco et al., 1999, Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes., J. Rheumatol.
Fornai et al., 2005, Role of cyclooxygenases 1 and 2 in the modulation of neuromuscular functions in the distal colon of humans and mice., Gut
Lovering et al., 2004, Crystal structures of prostaglandin D(2) 11-ketoreductase (AKR1C3) in complex with the nonsteroidal anti-inflammatory drugs flufenamic acid and indomethacin., Cancer Res.
Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem
Hata et al., 2005, Identification of determinants of ligand binding affinity and selectivity in the prostaglandin D2 receptor CRTH2., J. Biol. Chem.
Hata et al., 2005, Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2., Mol. Pharmacol.
Mathiesen et al., 2005, Identification of indole derivatives exclusively interfering with a G protein-independent signaling pathway of the prostaglandin D2 receptor CRTH2., Mol. Pharmacol.
Mohagheghpour et al., 1997, Mycobacterium avium reduces expression of costimulatory/adhesion molecules by human monocytes., Cell. Immunol.
Tsukamoto et al., 1989, Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat., Gut
Fujita et al., 2007, Successful treatment of primary Sjögren's syndrome with chronic natural killer lymphocytosis by high-dose prednisolone and indomethacin farnesil., Intern. Med.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Xu et al., 2003, Effect of indomethacin on the c-fos expression in AVP and TH neurons in rat brain induced by lipopolysaccharide., Brain Res.
Lehmann et al., 1997, Peroxisome proliferator-activated receptors alpha and gamma are activated by indomethacin and other non-steroidal anti-inflammatory drugs., J. Biol. Chem.
Cho et al., 2003, A simple ELISA for screening ligands of peroxisome proliferator-activated receptor-gamma., J. Biochem. Mol. Biol.
Ashjian et al., 2003, In vitro differentiation of human processed lipoaspirate cells into early neural progenitors., Plast. Reconstr. Surg.
Kocaoğlu et al., 1997, Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity., Arch. Immunol. Ther. Exp. (Warsz.)
Zarza J, 2003, Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9., Thromb Haemost
Stadnyk et al., 2002, Neutrophil migration into indomethacin induced rat small intestinal injury is CD11a/CD18 and CD11b/CD18 co-dependent., Gut
Duncan et al., 2005, Connective tissue growth factor expression in the human corpus luteum: paracrine regulation by human chorionic gonadotropin., J. Clin. Endocrinol. Metab.
Liakos et al., 1997, ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cells., Am. J. Physiol.
Duric et al., 2006, Effects of analgesic or antidepressant drugs on pain- or stress-evoked hippocampal and spinal neurokinin-1 receptor and brain-derived neurotrophic factor gene expression in the rat., J. Pharmacol. Exp. Ther.
Szabó et al., 2005, Role of transient receptor potential vanilloid 1 receptors in adjuvant-induced chronic arthritis: in vivo study using gene-deficient mice., J. Pharmacol. Exp. Ther.
Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.
Pilane et al., 2005, Nitric oxide stimulated vascular smooth muscle cells undergo apoptosis induced in part by arachidonic acid derived eicosanoids., J. Cell. Physiol.
Pergola C et al., 2014, Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase., J Med Chem
Zhang et al., 2004, [Proliferation inhibition effect of indomethacin on CML cells associated with down-regulation of phosphorylated STAT1/STAT5 and inhibition of COX-2 expression]., Zhonghua Xue Ye Xue Za Zhi
Yokota et al., 2005, Rofecoxib produces intestinal but not gastric damage in the presence of a low dose of indomethacin in rats., J. Pharmacol. Exp. Ther.
Armstrong et al., 2005, Suppression of experimental aortic aneurysms: comparison of inducible nitric oxide synthase and cyclooxygenase inhibitors., Ann Vasc Surg
Jerde et al., 2005, Celecoxib inhibits ureteral contractility and prostanoid release., Urology
Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med
Andreis et al., 2000, Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: receptor subtype involved and signaling mechanism., Endocrinology
Long et al., 1996, Regulation of GLUT4 gene expression by arachidonic acid. Evidence for multiple pathways, one of which requires oxidation to prostaglandin E2., J. Biol. Chem.
Zhu et al., 1999, Differential apoptosis by indomethacin in gastric epithelial cells through the constitutive expression of wild-type p53 and/or up-regulation of c-myc., Biochem. Pharmacol.
Tsutsumi et al., 2004, Endoplasmic reticulum stress response is involved in nonsteroidal anti-inflammatory drug-induced apoptosis., Cell Death Differ.
Koeberle A et al., 2008, Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase., J Med Chem
Aussel et al., 1987, Effect of alpha-fetoprotein and indomethacin on arachidonic acid metabolism in P388D1 macrophages: role of leukotrienes., Prostaglandins Leukot Med
Hull et al., 1997, Healing with basic fibroblast growth factor is associated with reduced indomethacin induced relapse in a human model of gastric ulceration., Gut
Sakoguchi-Okada et al., 2007, Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells., Biochem. Pharmacol.
Wu et al., 2008, Structural basis for catalytic and inhibitory mechanisms of human prostaglandin reductase PTGR2., Structure
Zhou et al., 2008, Cyclooxygenase inhibition during allergic sensitization increases STAT6-independent primary and memory Th2 responses., J. Immunol.
Sekhar et al., 2002, Redox-sensitive interaction between KIAA0132 and Nrf2 mediates indomethacin-induced expression of gamma-glutamylcysteine synthetase., Free Radic. Biol. Med.
Sato et al., 2007, Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin., J. Am. Chem. Soc.
Lee WY et al., 2010, Cytotoxic effects of tanshinones from Salvia miltiorrhiza on doxorubicin-resistant human liver cancer cells., J Nat Prod
Jaramillo et al., 1992, Modulation of immune responses by cyclo-oxygenase inhibitors during intraocular inflammation., Curr. Eye Res.

INDOMETHACIN PTGR2

Interaction Score: 2.71

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19000823

Sources:
DrugBank
INDOMETHACIN FST

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15941869

Sources:
NCI
INDOMETHACIN SAG

Interaction Score: 0.54

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1324133

Sources:
NCI
INDOMETHACIN GLO1

Interaction Score: 0.45

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
17243824

Sources:
DrugBank
INDOMETHACIN PTGES

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19053751

Sources:
DTC
INDOMETHACIN ADM

Interaction Score: 0.39

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10830296

Sources:
NCI
INDOMETHACIN SLC46A1

Interaction Score: 0.34

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology
INDOMETHACIN CD86

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9070321

Sources:
NCI
INDOMETHACIN AKR1C3

Interaction Score: 0.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
14996743 23432095

Sources:
DTC DrugBank
INDOMETHACIN ENO2

Interaction Score: 0.3

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12711954

Sources:
NCI
INDOMETHACIN PTGDR2

Interaction Score: 0.28

Interaction Types & Directionality:

agonist (activating)

other/unknown

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
16030019 15563582 15870392

Sources:
DrugBank GuideToPharmacology
INDOMETHACIN STAT6

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18832692

Sources:
NCI
INDOMETHACIN AFP

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2443931

Sources:
NCI
INDOMETHACIN KCNE1

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Indaflex

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
INDOMETHACIN PTGS2

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
15668944 24697244 15730717 20684598 15831440 22818041 15770365 10381057 15667901 19602986

Sources:
TEND DTC PharmGKB TTD DrugBank GuideToPharmacology ChemblInteractions
INDOMETHACIN TH

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12646303

Sources:
NCI
INDOMETHACIN PTGS1

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
15891886 23651359 15700751 15743404 20684598 15887968 22818041 10381057 15831902

Sources:
TEND DTC DrugBank GuideToPharmacology ChemblInteractions
INDOMETHACIN ITGB2

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11950807

Sources:
NCI
INDOMETHACIN GGT1

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9090444

Sources:
NCI
INDOMETHACIN FGF2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9071932

Sources:
NCI
INDOMETHACIN DDIT3

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15131590

Sources:
NCI
INDOMETHACIN FCGR3B

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17329922

Sources:
NCI
INDOMETHACIN FCGR3A

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17329922

Sources:
NCI
INDOMETHACIN KCNQ1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Indaflex

PMIDs:
None found

Sources:
TdgClinicalTrial
INDOMETHACIN PLA2G2A

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
INDOMETHACIN BIRC5

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17270149

Sources:
NCI
INDOMETHACIN MYC

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10403534

Sources:
NCI
INDOMETHACIN SLC2A4

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8557642

Sources:
NCI
INDOMETHACIN TYMS

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2707640

Sources:
NCI
INDOMETHACIN AGTR1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9357777

Sources:
NCI
INDOMETHACIN TRPV1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15831443

Sources:
NCI
INDOMETHACIN ABCC1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20455578

Sources:
DTC
INDOMETHACIN BDNF

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16956981

Sources:
NCI
INDOMETHACIN ACE

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3937925

Sources:
NCI
INDOMETHACIN PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

activator (activating)

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Partial agonist

PMIDs:
9013583 12689521

Sources:
DrugBank GuideToPharmacology
INDOMETHACIN PPARA

Interaction Score: 0.03

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
9013583

Sources:
DrugBank
INDOMETHACIN CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300 12876643

Sources:
DTC PharmGKB
INDOMETHACIN CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC PharmGKB
INDOMETHACIN CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
INDOMETHACIN CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
INDOMETHACIN NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11909699

Sources:
NCI
INDOMETHACIN CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC

DrugBank: DB00328

Version: 5.1.7

Alternate Names:

INDOMETHACIN DrugBank Drug Name

53-86-1 CAS Number

Aconip Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Kundu et al., 2005, Cyclooxygenase inhibitors modulate NK activities that control metastatic disease., Cancer Immunol. Immunother.

Higuchi et al., 2004, Indomethacin, but not Helicobacter pylori, inhibits adaptive relaxation in isolated guinea-pig stomach., Drugs Exp Clin Res

Bobadilla L et al., 2005, Effect of pregnancy on the roles of nitric oxide and prostaglandins in 5-hydroxytryptamine-induced contractions in rat isolated thoracic and abdominal aorta., Clin. Exp. Pharmacol. Physiol.

TEND: INDOMETHACIN
- Version: 01-August-2011
Alternate Names:

INDOMETHACIN Primary Drug Name

Drug Info:

Drug Class anti-inflammatory agents, non-steroidal

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: INDOMETHACIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications NSAID

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: INDOMETHACIN

Version: 14-September-2017

Alternate Names:

C576 NCI drug code

Drug Info:

Publications:

Ashjian et al., 2003, In vitro differentiation of human processed lipoaspirate cells into early neural progenitors., Plast. Reconstr. Surg.

Kocaoğlu et al., 1997, Urinary gamma-glutamyl transferase activity in rats with nonsteroidal anti-inflammatory drug-induced nephrotoxicity., Arch. Immunol. Ther. Exp. (Warsz.)

Ogawa et al., 1985, No role for prostaglandins and bradykinin in the autoregulation of renal blood flow., Jpn. J. Pharmacol.

DTC: INDOMETHACIN

Version: 02-September-2020

Alternate Names:

CHEMBL6 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

Liedtke AJ et al., 2013, Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer., J Med Chem

Vitale P et al., 2013, Synthesis, pharmacological characterization, and docking analysis of a novel family of diarylisoxazoles as highly selective cyclooxygenase-1 (COX-1) inhibitors., J Med Chem

PharmGKB: indomethacin

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Zarza J, 2003, Major bleeding during combined treatment with indomethacin and low doses of acenocoumarol in a homozygous patient for 2C9*3 variant of cytochrome p-450 CYP2C9., Thromb Haemost

Grosser T, 2009, Variability in the response to cyclooxygenase inhibitors: toward the individualization of nonsteroidal anti-inflammatory drug therapy., J Investig Med

TTD: Indomethacin
- Version: 2020.06.01
Alternate Names:

D0R1RS TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650390
- Version: 29-September-2020
Alternate Names:

INDOMETHACIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL6
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL6
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Direct Interaction	yes
Mechanism of Interaction	Cyclooxygenase inhibitor
Specific Action of the Ligand	Inhibition

INDOMETHACIN	DrugBank Drug Name
53-86-1	CAS Number
Aconip	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

agonist (activating)
other/unknown

Trial Name	Indaflex
Novel drug target	Established target

INDOMETHACIN Drug Record

INDOMETHACIN chembl:CHEMBL6 ApprovedImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19000823

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15941869

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1324133

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 17243824

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19053751

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10830296

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9070321

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 14996743 23432095

Sources: DTC DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12711954

Sources: NCI

Interaction Types & Directionality: agonist (activating) other/unknown

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Full agonist

PMIDs: 16030019 15563582 15870392

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18832692

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2443931

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Trial Name Indaflex Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Cyclooxygenase inhibitor Specific Action of the Ligand Inhibition

PMIDs: 15668944 24697244 15730717 20684598 15831440 22818041 15770365 10381057 15667901 19602986

Sources: TEND DTC PharmGKB TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12646303

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 15891886 23651359 15700751 15743404 20684598 15887968 22818041 10381057 15831902

Sources: TEND DTC DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11950807

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9090444

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19000823

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15941869

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1324133

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
17243824

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
19053751

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
10830296

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
9070321

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
14996743 23432095

Sources:
DTC DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12711954

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

other/unknown

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
16030019 15563582 15870392

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18832692

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2443931

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name Indaflex

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Cyclooxygenase inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
15668944 24697244 15730717 20684598 15831440 22818041 15770365 10381057 15667901 19602986

Sources:
TEND DTC PharmGKB TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
12646303

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
15891886 23651359 15700751 15743404 20684598 15887968 22818041 10381057 15831902

Sources:
TEND DTC DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
11950807

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9090444

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9071932

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15131590

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17329922

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17329922

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name Indaflex

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found