DGIdb - INDIRUBIN Drug Record

INDIRUBIN chembl:CHEMBL1276127 Antineoplastic

Alternate Names:

C.I. 75790
NSC-105327
INDIRUBIN

Drug Info:

Drug Type	small molecule
Drug Groups	investigational
Drug Categories	antibiotics, antineoplastic
Drug Categories	antineoplastic agents
Drug Categories	coloring agents
Drug Categories	compounds used in a research, industrial, or household setting
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	leukemia, myelogenous, chronic, bcr-abl positive
Drug Categories	protein kinase inhibitors

(0 More Sources)

Publications:

Adachi J et al., 2004, Comparison of gene expression patterns between 2,3,7,8-tetrachlorodibenzo-p-dioxin and a natural arylhydrocarbon receptor ligand, indirubin., Toxicol Sci
Perkins A et al., 2014, A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain., Biology (Basel)

INDIRUBIN CYP1A1

Interaction Score: 2.27

Interaction Types & Directionality:

substrate

Interaction Info:

PMIDs:
15056799

Sources:
DrugBank
INDIRUBIN AHR

Interaction Score: 1.14

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
15056799 25329374

Sources:
DrugBank

DrugBank: DB12379

Version: 5.1.7

Alternate Names:

INDIRUBIN DrugBank Drug Name

479-41-4 CAS Number

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories antibiotics, antineoplastic

Publications:

Adachi J et al., 2004, Comparison of gene expression patterns between 2,3,7,8-tetrachlorodibenzo-p-dioxin and a natural arylhydrocarbon receptor ligand, indirubin., Toxicol Sci

Perkins A et al., 2014, A Structural Switch between Agonist and Antagonist Bound Conformations for a Ligand-Optimized Model of the Human Aryl Hydrocarbon Receptor Ligand Binding Domain., Biology (Basel)

ChemblDrugs: chembl:CHEMBL1276127
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications: