DGIdb - ILOPROST Drug Record

ILOPROST chembl:CHEMBL494 ApprovedAntineoplastic

Alternate Names:

CILOPROST
ZK-36374
ILOPROST
VENTAVIS
ZK-00036374
drugbank:01088
chembl:CHEMBL494
pubchem.compound:5311181
rxcui:40138
chemidplus:78919-13-8

Drug Info:

Year of Approval	2004
Drug Class	antihypertensive agents
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Categories	agents causing muscle toxicity
Drug Categories	anticoagulants
Drug Categories	antiplatelet agents
Drug Categories	vasodilating agents

(4 More Sources)

Publications:

Schermuly et al., 2003, Zardaverine and aerosolised iloprost in a model of acute respiratory failure., Eur. Respir. J.
Wilkens et al., 2001, Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension., Circulation
Ghofrani et al., 2002, Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension., Crit. Care Med.
Grant et al., 1988, cAMP-mediated phosphorylation of the low-Km cAMP phosphodiesterase markedly stimulates its catalytic activity., Proc. Natl. Acad. Sci. U.S.A.
Sharif et al., 2002, Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques., J. Pharm. Pharmacol.
Walch et al., 2001, Prostanoid EP(1)- and TP-receptors involved in the contraction of human pulmonary veins., Br. J. Pharmacol.
Idzko et al., 2007, Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function., J. Clin. Invest.
Crutchley et al., 1992, Prostacyclin analogues inhibit tissue factor expression in the human monocytic cell line THP-1 via a cyclic AMP-dependent mechanism., Arterioscler. Thromb.
Mubarak, 2010, A review of prostaglandin analogs in the management of patients with pulmonary arterial hypertension., Respir Med
Tsai et al., 1988, Interaction between platelet receptor and iloprost isomers., Biochim. Biophys. Acta
Schermuly et al., 2007, Iloprost-induced desensitization of the prostacyclin receptor in isolated rabbit lungs., Respir. Res.
Krug et al., 2009, Inhaled iloprost for the control of pulmonary hypertension., Vasc Health Risk Manag
Anderson et al., Pharmacotherapeutic management of pulmonary arterial hypertension., Cardiol Rev
Olschewski et al., 2004, Prostacyclin and its analogues in the treatment of pulmonary hypertension., Pharmacol. Ther.
Takamatsu et al., 2002, Specific ligand for a central type prostacyclin receptor attenuates neuronal damage in a rat model of focal cerebral ischemia., Brain Res.
Nicolini et al., 1990, Prostacyclin analogue iloprost decreases thrombolytic potential of tissue-type plasminogen activator in canine coronary thrombosis., Circulation
Kerins et al., 1992, Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue., Circulation
Nizankowski et al., [Effect of thromboxane A2 synthetase inhibitor and prostacyclin analogue on arterial blood pressure, fibrinolysis and platelet function in patients with hypertension]., Pol Tyg Lek
Nichols et al., 1991, Combined thrombolytic effects of tissue-plasminogen activator and a fibrinogen-degradation product peptide 6A or iloprost., J. Cardiovasc. Pharmacol.
Herczenik et al., 2007, Activation of human platelets by misfolded proteins., Arterioscler. Thromb. Vasc. Biol.
Wright et al., 1998, Characterization of the recombinant human prostanoid DP receptor and identification of L-644,698, a novel selective DP agonist., Br. J. Pharmacol.

ILOPROST PTGIR

Interaction Score: 2.95

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid IP receptor agonist

Direct Interaction yes

Trial Name iloprost,Ventavis

PMIDs:
17273558 1375507 19683911 2456096 17257398 19475782 20395700 15163595 11792366

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
ILOPROST PLAT

Interaction Score: 2.07

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
1689620 1370924 1726988 1717784 17510465

Sources:
DrugBank
ILOPROST PTGER1

Interaction Score: 1.08

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name iloprost,Ventavis

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
11999132 11739243

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology
ILOPROST PDE4C

Interaction Score: 1.0

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank
ILOPROST PDE4A

Interaction Score: 0.5

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank
ILOPROST PTGER2

Interaction Score: 0.45

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology
ILOPROST PDE4D

Interaction Score: 0.43

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank
ILOPROST PDE4B

Interaction Score: 0.42

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank
ILOPROST PTGDR2

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
9579725

Sources:
DrugBank
ILOPROST PTGDR

Interaction Score: 0.27

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ILOPROST PTGFR

Interaction Score: 0.22

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology
ILOPROST PTGER3

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of Interaction EP<sub>3</sub>-III isoform

Endogenous Drug? False

Details of Interaction EP<sub>3</sub>-I isoform

PMIDs:
None found

Sources:
GuideToPharmacology
ILOPROST PTGER4

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ILOPROST TBXA2R

Interaction Score: 0.16

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
ILOPROST PPARA

Interaction Score: 0.04

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

DrugBank: DB01088

Version: 5.1.7

Alternate Names:

ILOPROST DrugBank Drug Name

78919-13-8 CAS Number

Ventavis Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Schermuly et al., 2003, Zardaverine and aerosolised iloprost in a model of acute respiratory failure., Eur. Respir. J.

Wilkens et al., 2001, Effect of inhaled iloprost plus oral sildenafil in patients with primary pulmonary hypertension., Circulation

Ghofrani et al., 2002, Amplification of the pulmonary vasodilatory response to inhaled iloprost by subthreshold phosphodiesterase types 3 and 4 inhibition in severe pulmonary hypertension., Crit. Care Med.

TEND: ILOPROST
- Version: 01-August-2011
Alternate Names:

ILOPROST Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 2004

Publications:
TdgClinicalTrial: ILOPROST
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:
TALC: ILOPROST
- Version: 12-May-2016
Alternate Names:

ILOPROST Primary Drug Name

ILOPROST Drug Generic Name

VENTAVIS Drug Trade Name

Drug Info:

Publications:
GuideToPharmacology: 135650378
- Version: 29-September-2020
Alternate Names:

ILOPROST GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Iloprost
- Version: 2020.06.01
Alternate Names:

D05ZTH TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL494
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL494
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Prostanoid IP receptor agonist
Direct Interaction	yes
Trial Name	iloprost,Ventavis

Trial Name	iloprost,Ventavis
Novel drug target	Established target
Specific Action of the Ligand	Full agonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False

Details of Interaction	EP<sub>3</sub>-III isoform
Endogenous Drug?	False
Details of Interaction	EP<sub>3</sub>-I isoform

ILOPROST	DrugBank Drug Name
78919-13-8	CAS Number
Ventavis	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

ILOPROST	Primary Drug Name
ILOPROST	Drug Generic Name
VENTAVIS	Drug Trade Name

ILOPROST Drug Record

ILOPROST chembl:CHEMBL494 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Prostanoid IP receptor agonist Direct Interaction yes Trial Name iloprost,Ventavis

PMIDs: 17273558 1375507 19683911 2456096 17257398 19475782 20395700 15163595 11792366

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: 1689620 1370924 1726988 1717784 17510465

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name iloprost,Ventavis Novel drug target Established target Specific Action of the Ligand Full agonist

PMIDs: 11999132 11739243

Sources: TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: inducer (activating)

Interaction Info:

PMIDs: 12952271 11551870 12441759 2461561

Sources: DrugBank

Interaction Types & Directionality: inducer (activating)

Interaction Info:

PMIDs: 12952271 11551870 12441759 2461561

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: TTD GuideToPharmacology

Interaction Types & Directionality: inducer (activating)

Interaction Info:

PMIDs: 12952271 11551870 12441759 2461561

Sources: DrugBank

Interaction Types & Directionality: inducer (activating)

Interaction Info:

PMIDs: 12952271 11551870 12441759 2461561

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 9579725

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Full agonist

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Details of Interaction EP<sub>3</sub>-III isoform Endogenous Drug? False Details of Interaction EP<sub>3</sub>-I isoform

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: activator (activating)

Interaction Info: Notes

PMIDs: None found

Sources: TALC

DrugBank: DB01088

Alternate Names: ILOPROST DrugBank Drug Name 78919-13-8 CAS Number Ventavis Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: ILOPROST

Alternate Names: ILOPROST Primary Drug Name

Drug Info: Drug Class antihypertensive agents Year of Approval 2004

Publications:

TdgClinicalTrial: ILOPROST

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

TALC: ILOPROST

Alternate Names: ILOPROST Primary Drug Name ILOPROST Drug Generic Name VENTAVIS Drug Trade Name

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Prostanoid IP receptor agonist

Direct Interaction yes

Trial Name iloprost,Ventavis

PMIDs:
17273558 1375507 19683911 2456096 17257398 19475782 20395700 15163595 11792366

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

other/unknown

PMIDs:
1689620 1370924 1726988 1717784 17510465

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name iloprost,Ventavis

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
11999132 11739243

Sources:
TEND TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

inducer (activating)

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank

Interaction Types & Directionality:

inducer (activating)

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
TTD GuideToPharmacology

Interaction Types & Directionality:

inducer (activating)

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank

Interaction Types & Directionality:

inducer (activating)

PMIDs:
12952271 11551870 12441759 2461561

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
9579725

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Details of Interaction EP<sub>3</sub>-III isoform

Endogenous Drug? False

Details of Interaction EP<sub>3</sub>-I isoform

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Notes

PMIDs:
None found

Sources:
TALC

Alternate Names:

ILOPROST DrugBank Drug Name

78919-13-8 CAS Number

Ventavis Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

ILOPROST Primary Drug Name

Drug Info:

Drug Class antihypertensive agents

Year of Approval 2004

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

ILOPROST Primary Drug Name

ILOPROST Drug Generic Name

VENTAVIS Drug Trade Name

Alternate Names:

ILOPROST GuideToPharmacology Ligand Name

Alternate Names:

D05ZTH TTD Drug ID