• IDELALISIB chembl:CHEMBL2216870 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    CAL-101
    GS-1101
    IDELALISIB
    GS-11CAL-101
    ZYDELIG
    5-FLUORO-3-PHENYL-2-((S)-1-(9H-PURIN-6-YLAMINO)-PROPYL)-3H-QUINAZOLIN-4-ONE
    5-FLUORO-3-PHENYL-2-[(1S)-1-(3H-PURIN-6-YLAMINO)PROPYL]QUINAZOLIN-4(3H)-ONE
    CAL-101/CAL101
    ZYDELIG®
    chembl:CHEMBL2216870
    chemidplus:870281-82-6
    rxcui:1544460
    drugbank:09054
    pubchem.compound:11625818

    Drug Info:

    FDA Approval Chronic lymphocytic leukemia, Follicular B-cell non-Hodgkin lymphoma, Small lymphocytic lymphoma
    Drug Class Small molecule inhibitor
    Drug Class Kinase Inhibitors
    Drug Categories class ia phosphatidylinositol 3-kinase, antagonists & inhibitors
    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    Drug Categories cytochrome p-450 cyp2b6 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp2c19 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c8 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp2c8 inhibitors (weak)
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a4 inducers
    Drug Categories cytochrome p-450 cyp3a4 inducers (strength unknown)
    Drug Categories cytochrome p-450 cyp3a4 inhibitors
    Drug Categories cytochrome p-450 cyp3a4 substrates
    Drug Categories cytochrome p-450 cyp3a4 substrates (strength unknown)
    Drug Categories cytochrome p-450 cyp3a4 substrates with a narrow therapeutic index
    Drug Categories cytochrome p-450 cyp3a5 inhibitors
    Drug Categories cytochrome p-450 cyp3a5 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 cyp3a7 inhibitors
    Drug Categories cytochrome p-450 cyp3a7 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a7 substrates
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories cytochrome p-450 substrates
    Drug Categories hepatotoxic agents
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories kinase inhibitor
    Drug Categories oatp1b1/slco1b1 inhibitors
    Drug Categories oatp1b3 inhibitors
    Drug Categories p-glycoprotein inhibitors
    Drug Categories p-glycoprotein substrates
    Drug Categories ugt1a4 inhibitors
    Drug Categories ugt1a4 substrates
    (6 More Sources)
  • Interaction Score: 0.87

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name CAL-101
    Novel drug target Novel Target
    Mechanism of Interaction PI3-kinase p110-delta subunit inhibitor

  • Interaction Score: 0.31

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    combination therapy Idelalisib + MK2206
    Indication/Tumor Type diffuse large B-cell lymphoma
    Response Type predicted – sensitive

    PMIDs:
    28178345


    Sources:
    JAX-CKB

  • Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type melanoma
    Response Type no benefit
    Approval Status Preclinical

    PMIDs:
    26137449


    Sources:
    JAX-CKB

  • Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


  • Interaction Score: 0.09

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found