DGIdb - HYDROXYCHLOROQUINE Drug Record

HYDROXYCHLOROQUINE chembl:CHEMBL1535 ApprovedAntineoplasticImmunotherapy

Alternate Names:

HYDROXYCHLOROQUINE
7-CHLORO-4-[4-(N-ETHYL-N-BETA-HYDROXYETHYLAMINO)-1-METHYLBUTYLAMINO]QUINOLINE
7-CHLORO-4-[5-(N-ETHYL-N-2-HYDROXYETHYLAMINO)-2-PENTYL]AMINOQUINOLINE
OXICHLOROCHINE
OXICHLOROQUINE
(±)-HYDROXYCHLOROQUINE
7-CHLORO-4-(4-(N-ETHYL-N-BETA-HYDROXYETHYLAMINO)-1-METHYLBUTYLAMINO)QUINOLINE
2-(N-(4-(7-CHLOR-4-CHINOLYLAMINO)-4-METHYLBUTYL)ETHYLAMINO)ETHANOL
POLIRREUMIN
PLAQUENIL®
HIDROXICLOROQUINA
2-((4-((7-CHLORO-4-QUINOLYL)AMINO)PENTYL)ETHYLAMINO)ETHANOL
(+-)-HYDROXYCHLOROQUINE
DOLQUINE®
NSC4375
7-CHLORO-4-(4-(ETHYL(2-HYDROXYETHYL)AMINO)-1-METHYLBUTYLAMINO)QUINOLINE
HYDROXYCHLOROQUINUM
drugbank:01611
pubchem.compound:3652
chembl:CHEMBL1535
chemidplus:118-42-3
rxcui:5521

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antirheumatic agent
Drug Categories	cytochrome p-450 cyp2c8 substrates
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2d6 substrates
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	immunosuppressive agents
Drug Categories	p-glycoprotein inhibitors
Drug Categories	photosensitizing agents
Drug Categories	potential qtc-prolonging agents
Drug Categories	qtc prolonging agents

(5 More Sources)

Publications:

van den Borne et al., 1997, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells., J. Rheumatol.
James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
Trevani et al., 2003, Bacterial DNA activates human neutrophils by a CpG-independent pathway., Eur. J. Immunol.
Sun et al., 2007, TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders., Inflamm Allergy Drug Targets
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ben-Chetrit et al., 2005, The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2., Rheumatol. Int.
Sperber et al., 1993, Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells., J. Rheumatol.
Nitsch et al., 2000, The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease., Ann. Neurol.
Somer et al., 2000, Influence of hydroxychloroquine on the bioavailability of oral metoprolol., Br J Clin Pharmacol
Brentano et al., 2005, RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3., Arthritis Rheum.
Vincent MJ et al., 2005, Chloroquine is a potent inhibitor of SARS coronavirus infection and spread., Virol J

HYDROXYCHLOROQUINE TLR7

Interaction Score: 2.55

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of hTLR7 R848-induced luciferase reporter gene activation.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
14579285 18220957 11752352

Sources:
TdgClinicalTrial TTD DrugBank GuideToPharmacology
HYDROXYCHLOROQUINE TLR3

Interaction Score: 2.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16142732

Sources:
NCI
HYDROXYCHLOROQUINE IL1A

Interaction Score: 1.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8336306

Sources:
NCI
HYDROXYCHLOROQUINE TLR9

Interaction Score: 1.39

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
14579285 18220957

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology
HYDROXYCHLOROQUINE ACE2

Interaction Score: 1.35

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
16115318

Sources:
DrugBank
HYDROXYCHLOROQUINE TYMSOS

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18322994

Sources:
PharmGKB
HYDROXYCHLOROQUINE APP

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11117548

Sources:
NCI
HYDROXYCHLOROQUINE TYMS

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18322994

Sources:
PharmGKB
HYDROXYCHLOROQUINE G6PD

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA PharmGKB
HYDROXYCHLOROQUINE TNF

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9002011

Sources:
NCI
HYDROXYCHLOROQUINE PTGS2

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14963695

Sources:
NCI
HYDROXYCHLOROQUINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10848718

Sources:
NCI

DrugBank: DB01611

Version: 5.1.7

Alternate Names:

118-42-3 CAS Number

Apo-hydroxyquine Drug Brand

Dolquine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories aminoquinolines

Publications:

Koranda, 1981, Antimalarials., J. Am. Acad. Dermatol.

Trevani et al., 2003, Bacterial DNA activates human neutrophils by a CpG-independent pathway., Eur. J. Immunol.

Sun et al., 2007, TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders., Inflamm Allergy Drug Targets

TdgClinicalTrial: HYDROXYCHLOROQUINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antirheumatic agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: HYDROXYCHLOROQUINE

Version: 14-September-2017

Alternate Names:

C557 NCI drug code

Drug Info:

Publications:

van den Borne et al., 1997, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells., J. Rheumatol.

Nitsch et al., 2000, The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease., Ann. Neurol.

Somer et al., 2000, Influence of hydroxychloroquine on the bioavailability of oral metoprolol., Br J Clin Pharmacol

PharmGKB: hydroxychloroquine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
TTD: Hydroxychloroquine
- Version: 2020.06.01
Alternate Names:

D0OJ4L TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1535
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: HYDROXYCHLOROQUINE
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:
FDA: Hydroxychloroquine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 178103773
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:

Details of the Assay for Interaction	Inhibition of hTLR7 R848-induced luciferase reporter gene activation.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Details of the Assay for Interaction	Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

118-42-3	CAS Number
Apo-hydroxyquine	Drug Brand
Dolquine	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	aminoquinolines

HYDROXYCHLOROQUINE Drug Record

HYDROXYCHLOROQUINE chembl:CHEMBL1535 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of hTLR7 R848-induced luciferase reporter gene activation. Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 14579285 18220957 11752352

Sources: TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16142732

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8336306

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation. Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 14579285 18220957

Sources: TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 16115318

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18322994

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11117548

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18322994

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9002011

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14963695

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10848718

Sources: NCI

DrugBank: DB01611

Alternate Names: 118-42-3 CAS Number Apo-hydroxyquine Drug Brand Dolquine Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories aminoquinolines

TdgClinicalTrial: HYDROXYCHLOROQUINE

Alternate Names:

Drug Info: Drug Indications antirheumatic agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: HYDROXYCHLOROQUINE

Alternate Names: C557 NCI drug code

Drug Info:

PharmGKB: hydroxychloroquine

Alternate Names:

Drug Info:

Publications: James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol

TTD: Hydroxychloroquine

Alternate Names: D0OJ4L TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1535

Alternate Names:

Drug Info:

Publications:

MyCancerGenomeClinicalTrial: HYDROXYCHLOROQUINE

Alternate Names:

Drug Info:

Publications:

FDA: Hydroxychloroquine

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of hTLR7 R848-induced luciferase reporter gene activation.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
14579285 18220957 11752352

Sources:
TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
16142732

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8336306

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
14579285 18220957

Sources:
TdgClinicalTrial DrugBank GuideToPharmacology

Interaction Types & Directionality:

modulator

PMIDs:
16115318

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
18322994

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11117548

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18322994

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9002011

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14963695

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10848718

Sources:
NCI

Alternate Names:

118-42-3 CAS Number

Apo-hydroxyquine Drug Brand

Dolquine Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories aminoquinolines

Drug Info:

Drug Indications antirheumatic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C557 NCI drug code

Publications:

James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol

Alternate Names:

D0OJ4L TTD Drug ID