DGIdb - HYDROXYCHLOROQUINE Drug Record

HYDROXYCHLOROQUINE chembl:CHEMBL1535 ApprovedAntineoplasticImmunotherapy

Alternate Names:

HYDROXYCHLOROQUINE
7-CHLORO-4-[4-(N-ETHYL-N-BETA-HYDROXYETHYLAMINO)-1-METHYLBUTYLAMINO]QUINOLINE
7-CHLORO-4-[5-(N-ETHYL-N-2-HYDROXYETHYLAMINO)-2-PENTYL]AMINOQUINOLINE
OXICHLOROCHINE
OXICHLOROQUINE
(±)-HYDROXYCHLOROQUINE
7-CHLORO-4-(4-(N-ETHYL-N-BETA-HYDROXYETHYLAMINO)-1-METHYLBUTYLAMINO)QUINOLINE
2-(N-(4-(7-CHLOR-4-CHINOLYLAMINO)-4-METHYLBUTYL)ETHYLAMINO)ETHANOL
POLIRREUMIN
PLAQUENIL®
HIDROXICLOROQUINA
2-((4-((7-CHLORO-4-QUINOLYL)AMINO)PENTYL)ETHYLAMINO)ETHANOL
(+-)-HYDROXYCHLOROQUINE
DOLQUINE®
NSC4375
7-CHLORO-4-(4-(ETHYL(2-HYDROXYETHYL)AMINO)-1-METHYLBUTYLAMINO)QUINOLINE
HYDROXYCHLOROQUINUM
drugbank:01611
pubchem.compound:3652
chembl:CHEMBL1535
chemidplus:118-42-3
rxcui:5521

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antirheumatic agent

(4 More Sources)

Publications:

van den Borne et al., 1997, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells., J. Rheumatol.
James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
Sun et al., 2007, TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders., Inflamm Allergy Drug Targets
Trevani et al., 2003, Bacterial DNA activates human neutrophils by a CpG-independent pathway., Eur. J. Immunol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Ben-Chetrit et al., 2005, The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2., Rheumatol. Int.
Sperber et al., 1993, Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells., J. Rheumatol.
Nitsch et al., 2000, The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease., Ann. Neurol.
Somer et al., 2000, Influence of hydroxychloroquine on the bioavailability of oral metoprolol., Br J Clin Pharmacol
Brentano et al., 2005, RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3., Arthritis Rheum.

HYDROXYCHLOROQUINE TLR3

Interaction Score: 2.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16142732

Sources:
NCI
HYDROXYCHLOROQUINE TLR7

Interaction Score: 2.9

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of hTLR7 R848-induced luciferase reporter gene activation.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18220957 14579285 11752352

Sources:
TdgClinicalTrial GuideToPharmacology TTD
HYDROXYCHLOROQUINE IL1A

Interaction Score: 1.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8336306

Sources:
NCI
HYDROXYCHLOROQUINE TLR9

Interaction Score: 1.45

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18220957 14579285

Sources:
TdgClinicalTrial GuideToPharmacology
HYDROXYCHLOROQUINE TYMSOS

Interaction Score: 0.89

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18322994

Sources:
PharmGKB
HYDROXYCHLOROQUINE APP

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11117548

Sources:
NCI
HYDROXYCHLOROQUINE TYMS

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18322994

Sources:
PharmGKB
HYDROXYCHLOROQUINE TNF

Interaction Score: 0.17

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9002011

Sources:
NCI
HYDROXYCHLOROQUINE G6PD

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA
HYDROXYCHLOROQUINE PTGS2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14963695

Sources:
NCI
HYDROXYCHLOROQUINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10848718

Sources:
NCI

TdgClinicalTrial: HYDROXYCHLOROQUINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antirheumatic agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: HYDROXYCHLOROQUINE

Version: 14-September-2017

Alternate Names:

C557 NCI drug code

Drug Info:

Publications:

van den Borne et al., 1997, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells., J. Rheumatol.

Nitsch et al., 2000, The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease., Ann. Neurol.

Somer et al., 2000, Influence of hydroxychloroquine on the bioavailability of oral metoprolol., Br J Clin Pharmacol

PharmGKB: hydroxychloroquine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
TTD: Hydroxychloroquine
- Version: 2020.06.01
Alternate Names:

D0OJ4L TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1535
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
MyCancerGenomeClinicalTrial: HYDROXYCHLOROQUINE
- Version: 30-February-2014
Alternate Names:

Drug Info:

Publications:
FDA: Hydroxychloroquine
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 178103773
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:

Details of the Assay for Interaction	Inhibition of hTLR7 R848-induced luciferase reporter gene activation.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

Details of the Assay for Interaction	Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.
Specific Action of the Ligand	Antagonist
Endogenous Drug?	False

HYDROXYCHLOROQUINE Drug Record

HYDROXYCHLOROQUINE chembl:CHEMBL1535 ApprovedAntineoplasticImmunotherapy

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16142732

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of hTLR7 R848-induced luciferase reporter gene activation. Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 18220957 14579285 11752352

Sources: TdgClinicalTrial GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8336306

Sources: NCI

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Details of the Assay for Interaction Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation. Specific Action of the Ligand Antagonist Endogenous Drug? False

PMIDs: 18220957 14579285

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18322994

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11117548

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18322994

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9002011

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14963695

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10848718

Sources: NCI

TdgClinicalTrial: HYDROXYCHLOROQUINE

Alternate Names:

Drug Info: Drug Indications antirheumatic agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: HYDROXYCHLOROQUINE

Alternate Names: C557 NCI drug code

Drug Info:

PharmGKB: hydroxychloroquine

Alternate Names:

Drug Info:

Publications: James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol

TTD: Hydroxychloroquine

Alternate Names: D0OJ4L TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1535

Alternate Names:

Drug Info:

Publications:

MyCancerGenomeClinicalTrial: HYDROXYCHLOROQUINE

Alternate Names:

Drug Info:

Publications:

FDA: Hydroxychloroquine

Alternate Names:

Drug Info:

Publications:

GuideToPharmacology: 178103773

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
16142732

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of hTLR7 R848-induced luciferase reporter gene activation.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18220957 14579285 11752352

Sources:
TdgClinicalTrial GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
8336306

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Details of the Assay for Interaction Inhibition of hTLR9 CpG2006-induced luciferase reporter gene activation.

Specific Action of the Ligand Antagonist

Endogenous Drug? False

PMIDs:
18220957 14579285

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
18322994

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11117548

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
18322994

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9002011

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
14963695

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10848718

Sources:
NCI

Drug Info:

Drug Indications antirheumatic agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C557 NCI drug code

Publications:

James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol

Alternate Names:

D0OJ4L TTD Drug ID