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HYDROXYCHLOROQUINE Drug Record

  • Summary
  • Interactions
  • Claims
  • HYDROXYCHLOROQUINE chembl:CHEMBL1535 ApprovedAntineoplasticImmunotherapy

    Alternate Names:

    HYDROXYCHLOROQUINE
    7-CHLORO-4-[4-(N-ETHYL-N-BETA-HYDROXYETHYLAMINO)-1-METHYLBUTYLAMINO]QUINOLINE
    7-CHLORO-4-[5-(N-ETHYL-N-2-HYDROXYETHYLAMINO)-2-PENTYL]AMINOQUINOLINE
    OXICHLOROCHINE
    OXICHLOROQUINE
    (±)-HYDROXYCHLOROQUINE
    7-CHLORO-4-(4-(N-ETHYL-N-BETA-HYDROXYETHYLAMINO)-1-METHYLBUTYLAMINO)QUINOLINE
    2-(N-(4-(7-CHLOR-4-CHINOLYLAMINO)-4-METHYLBUTYL)ETHYLAMINO)ETHANOL
    POLIRREUMIN
    PLAQUENIL®
    HIDROXICLOROQUINA
    2-((4-((7-CHLORO-4-QUINOLYL)AMINO)PENTYL)ETHYLAMINO)ETHANOL
    (+-)-HYDROXYCHLOROQUINE
    DOLQUINE®
    NSC4375
    7-CHLORO-4-(4-(ETHYL(2-HYDROXYETHYL)AMINO)-1-METHYLBUTYLAMINO)QUINOLINE
    HYDROXYCHLOROQUINUM
    drugbank:01611
    pubchem.compound:3652
    chembl:CHEMBL1535
    chemidplus:118-42-3
    rxcui:5521

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antirheumatic agent
    (3 More Sources)

    Publications:

    van den Borne et al., 1997, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells., J. Rheumatol.
    James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol
    Sun et al., 2007, TLR7/9 antagonists as therapeutics for immune-mediated inflammatory disorders., Inflamm Allergy Drug Targets
    Trevani et al., 2003, Bacterial DNA activates human neutrophils by a CpG-independent pathway., Eur. J. Immunol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Ben-Chetrit et al., 2005, The effects of colchicine and hydroxychloroquine on the cyclo-oxygenases COX-1 and COX-2., Rheumatol. Int.
    Sperber et al., 1993, Selective regulation of cytokine secretion by hydroxychloroquine: inhibition of interleukin 1 alpha (IL-1-alpha) and IL-6 in human monocytes and T cells., J. Rheumatol.
    Nitsch et al., 2000, The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease., Ann. Neurol.
    Somer et al., 2000, Influence of hydroxychloroquine on the bioavailability of oral metoprolol., Br J Clin Pharmacol
    Brentano et al., 2005, RNA released from necrotic synovial fluid cells activates rheumatoid arthritis synovial fibroblasts via Toll-like receptor 3., Arthritis Rheum.
  • HYDROXYCHLOROQUINE   TLR3

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16142732


    Sources:
    NCI

  • HYDROXYCHLOROQUINE   TLR7

    Interaction Score: 2.34

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name AHCQ, aersolized hydroxychloroquine
    Novel drug target Established target

    PMIDs:
    18220957 14579285 11752352


    Sources:
    TdgClinicalTrial TTD

  • HYDROXYCHLOROQUINE   IL1A

    Interaction Score: 1.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8336306


    Sources:
    NCI

  • HYDROXYCHLOROQUINE   TLR9

    Interaction Score: 1.05

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name AHCQ, aersolized hydroxychloroquine
    Novel drug target Established target

    PMIDs:
    18220957 14579285


    Sources:
    TdgClinicalTrial

  • HYDROXYCHLOROQUINE   TYMSOS

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18322994


    Sources:
    PharmGKB

  • HYDROXYCHLOROQUINE   APP

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11117548


    Sources:
    NCI

  • HYDROXYCHLOROQUINE   TYMS

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18322994


    Sources:
    PharmGKB

  • HYDROXYCHLOROQUINE   TNF

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9002011


    Sources:
    NCI

  • HYDROXYCHLOROQUINE   G6PD

    Interaction Score: 0.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB FDA

  • HYDROXYCHLOROQUINE   PTGS2

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14963695


    Sources:
    NCI

  • HYDROXYCHLOROQUINE   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10848718


    Sources:
    NCI

  • TdgClinicalTrial: HYDROXYCHLOROQUINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antirheumatic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: HYDROXYCHLOROQUINE

    • Version: 14-September-2017

    Alternate Names:
    C557 NCI drug code

    Drug Info:

    Publications:
    van den Borne et al., 1997, Chloroquine and hydroxychloroquine equally affect tumor necrosis factor-alpha, interleukin 6, and interferon-gamma production by peripheral blood mononuclear cells., J. Rheumatol.
    Nitsch et al., 2000, The selective muscarinic M1 agonist AF102B decreases levels of total Abeta in cerebrospinal fluid of patients with Alzheimer's disease., Ann. Neurol.
    Somer et al., 2000, Influence of hydroxychloroquine on the bioavailability of oral metoprolol., Br J Clin Pharmacol

  • PharmGKB: hydroxychloroquine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    James HM et al., 2008, Common polymorphisms in the folate pathway predict efficacy of combination regimens containing methotrexate and sulfasalazine in early rheumatoid arthritis., J Rheumatol

  • TTD: Hydroxychloroquine

    • Version: 2020.06.01

    Alternate Names:
    D0OJ4L TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1535

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • MyCancerGenomeClinicalTrial: HYDROXYCHLOROQUINE

    • Version: 30-February-2014

    Alternate Names:

    Drug Info:

    Publications:

  • FDA: Hydroxychloroquine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21