• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

HYDROQUINONE Drug Record

  • Summary
  • Interactions
  • Claims
  • HYDROQUINONE chembl:CHEMBL537 Approved

    Alternate Names:

    NCI-C55834
    ELDOQUIN FORTE
    HYDROQUINONE
    ELDOPAQUE FORTE
    CHEBI:17594
    BLACK AND WHITE BLEACHING CREAM
    CHEMBL537
    NSC-9247
    SOLAQUIN FORTE
    1,4-DIIDROBENZENE
    ALPHA-HYDROQUINONE
    1,4-BENZENEDIOL
    DIHYDROQUINONE
    HYDROQUINONE GR
    HYDROQUINOUE
    1,4-DIHYDROXY-BENZEEN
    HYDROCHINON
    HYDROQUINOL
    QUINOL
    MELANEX
    P-DIHYDROXYBENZENE
    HYDROQUINOLE
    HYDROCHINONE
    1,4-DIHYDROXY-BENZOL
    4-HYDROXYPHENOL
    BENZOQUINOL
    P-HYDROXYBENZENE
    DIHYDROXYBENZENE
    PHIAQUIN
    1,4-DIHYDROXYBENZENE
    P-HYDROXYPHENOL
    B-QUINOL
    HYDROQUINONE FOR SYNTHESIS
    P-DIOXOBENZENE
    P-DIOXYBENZENE
    P-BENZENEDIOL
    BENZENE-1,4-DIOL
    BETA-QUINOL
    IDROCHINONE
    P-HYDROQUINONE
    BENZOHYDROQUINONE
    A-HYDROQUINONE
    1,4-DIHYDROXYBENZEN
    ELDOQUIN
    rxcui:5509
    chemidplus:123-31-9
    pubchem.compound:785
    chembl:CHEMBL537
    drugbank:09526

    Drug Info:

    (0 More Sources)

    Publications:

    Kuo et al., 1999, Suppression of apoptosis by Bcl-2 to enhance benzene metabolites-induced oxidative DNA damage and mutagenesis: A possible mechanism of carcinogenesis., Mol. Pharmacol.
    Iasinskaia, [Effect of reducing agents-antioxidants on rat uterine aromatase activity in vitro]., Ukr Biokhim Zh (1999)
    Patil et al., 2016, Interaction of small molecules with human tyrosinase: A surface plasmon resonance and molecular docking study., Int. J. Biol. Macromol.
    Miyazawa et al., 2007, Phenotypic alterations and cytokine production in THP-1 cells in response to allergens., Toxicol In Vitro
    Silva et al., 2004, GSTM1, GSTT1, and GSTP1 genotypes and the genotoxicity of hydroquinone in human lymphocytes., Environ. Mol. Mutagen.
    Colinas et al., 1995, The effects of interleukin-1 beta and tumor necrosis factor-alpha on in vitro colony formation by human hematopoietic progenitor cells exposed to doxorubicin or hydroquinone., Exp. Hematol.
    Lindsey et al., 2005, Effects of benzene metabolites on DNA cleavage mediated by human topoisomerase II alpha: 1,4-hydroquinone is a topoisomerase II poison., Chem. Res. Toxicol.
    Moran et al., 1999, A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity., Proc. Natl. Acad. Sci. U.S.A.
  • HYDROQUINONE   TYR

    Interaction Score: 0.91

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    27519292


    Sources:
    TTD

  • HYDROQUINONE   CD40

    Interaction Score: 0.66

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17118622


    Sources:
    NCI

  • HYDROQUINONE   NQO1

    Interaction Score: 0.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10393963


    Sources:
    NCI

  • HYDROQUINONE   CYP19A1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10979580


    Sources:
    NCI

  • HYDROQUINONE   IL1B

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    7589278


    Sources:
    NCI

  • HYDROQUINONE   CXCL8

    Interaction Score: 0.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17118622


    Sources:
    DTC NCI

  • HYDROQUINONE   BCL2

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10220568


    Sources:
    NCI

  • HYDROQUINONE   GSTP1

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15141365


    Sources:
    NCI

  • HYDROQUINONE   TOP2A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15833037


    Sources:
    NCI

  • HYDROQUINONE   THPO

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDROQUINONE   RORC

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDROQUINONE   NFKB1

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDROQUINONE   HIF1A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDROQUINONE   HPGD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDROQUINONE   HSD17B10

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDROQUINONE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • HYDROQUINONE   EHMT2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • NCI: HYDROQUINONE

    • Version: 14-September-2017

    Alternate Names:
    C29823 NCI drug code

    Drug Info:

    Publications:
    Kuo et al., 1999, Suppression of apoptosis by Bcl-2 to enhance benzene metabolites-induced oxidative DNA damage and mutagenesis: A possible mechanism of carcinogenesis., Mol. Pharmacol.
    Miyazawa et al., 2007, Phenotypic alterations and cytokine production in THP-1 cells in response to allergens., Toxicol In Vitro
    Iasinskaia, [Effect of reducing agents-antioxidants on rat uterine aromatase activity in vitro]., Ukr Biokhim Zh (1999)

  • DTC: HYDROQUINONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL537 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Hydroquinone

    • Version: 2020.06.01

    Alternate Names:
    D03UOT TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL537

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21