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GLYCINE Drug Record

  • Summary
  • Interactions
  • Claims
  • GLYCINE chembl:CHEMBL773 Approved

    Alternate Names:

    AMINOACETIC ACID
    GLYCINE
    NSC-25936
    GLYCOLIXIR
    FEMA NO. 3287
    GLYCOCOLL
    GLY
    HGLY
    H2N-CH2-COOH
    AMINOETHANOIC ACID
    جلايسين
    AMINOESSIGSAEURE
    LEIMZUCKER
    GLYKOKOLL
    AMINOESSIGSÄURE
    G
    GLYZIN
    GLYCIN
    rxcui:4919
    chemidplus:56-40-6
    chembl:CHEMBL773
    pubchem.compound:750
    drugbank:00145

    Drug Info:

    Drug Categories irrigating solutions
    Drug Categories glycine agents
    (1 More Sources)

    Publications:

    Velichkova et al., 2005, Methyl transfer in glycine N-methyltransferase. A theoretical study., J Phys Chem B
    Luka et al., 2007, 5-methyltetrahydrofolate is bound in intersubunit areas of rat liver folate-binding protein glycine N-methyltransferase., J. Biol. Chem.
    Soriano et al., 2006, Catalysis in glycine N-methyltransferase: testing the electrostatic stabilization and compression hypothesis., Biochemistry
    Widdowson et al., 1996, Failure of glycine site NMDA receptor antagonists to protect against L-2-chloropropionic acid-induced neurotoxicity highlights the uniqueness of cerebellar NMDA receptors., Brain Res.
    Al-Ghoul et al., 1997, Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in vasopressin and oxytocin neuroendocrine cells., Brain Res. Mol. Brain Res.
    Malayev et al., 2002, Inhibition of the NMDA response by pregnenolone sulphate reveals subtype selective modulation of NMDA receptors by sulphated steroids., Br. J. Pharmacol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Styles et al., 2007, Quantification and regulation of the subcellular distribution of bile acid coenzyme A:amino acid N-acyltransferase activity in rat liver., J. Lipid Res.
    Nakamura et al., 2007, Central efferent pathways mediating skin cooling-evoked sympathetic thermogenesis in brown adipose tissue., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Pellicoro et al., 2007, Human and rat bile acid-CoA:amino acid N-acyltransferase are liver-specific peroxisomal enzymes: implications for intracellular bile salt transport., Hepatology
    Visser et al., 2007, Demonstration of bile acid transport across the mammalian peroxisomal membrane., Biochem. Biophys. Res. Commun.
    Heinze et al., 2007, Diversity of glycine receptors in the mouse retina: localization of the alpha4 subunit., J. Comp. Neurol.
    Majumdar et al., Glycine receptors of A-type ganglion cells of the mouse retina., Vis. Neurosci.
    Lu et al., 2007, Analgesic and anti-inflammatory activities of aqueous extract from Glycine tomentella root in mice., J Ethnopharmacol
    Ricoult et al., 2006, Characterization of alanine aminotransferase (AlaAT) multigene family and hypoxic response in young seedlings of the model legume Medicago truncatula., J. Exp. Bot.
    Han et al., 2006, Crystal structures of Aedes aegypti alanine glyoxylate aminotransferase., J. Biol. Chem.
    Wang et al., 2007, Spatiotemporal expression of the creatine metabolism related genes agat, gamt and ct1 during zebrafish embryogenesis., Int. J. Dev. Biol.
    Dutta et al., 2007, Non-enzymatic interactions of glyoxylate with lysine, arginine, and glucosamine: a study of advanced non-enzymatic glycation like compounds., Bioorg. Chem.
    Zhou et al., 2007, Frequent genetic alterations and reduced expression of the Axin1 gene in oral squamous cell carcinoma: involvement in tumor progression and metastasis., Oncol. Rep.
    Narasipura et al., 2006, An efficient method for homologous gene reconstitution in Cryptococcus gattii using URA5 auxotrophic marker., Mycopathologia
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
    Waluk DP et al., 2010, Identification of glycine N-acyltransferase-like 2 (GLYATL2) as a transferase that produces N-acyl glycines in humans., FASEB J
    He et al., 2007, [Purification and production of the extracellular 5-aminolevulinate from recombiniant Escherichia coli expressing yeast ALAS]., Sheng Wu Gong Cheng Xue Bao
    Turbeville et al., 2007, Histidine 282 in 5-aminolevulinate synthase affects substrate binding and catalysis., Biochemistry
    Parmar N et al., 2010, N-arachidonoyl glycine, an endogenous lipid that acts as a vasorelaxant via nitric oxide and large conductance calcium-activated potassium channels., Br J Pharmacol
    Eulenburg et al., 2006, Mutations within the human GLYT2 (SLC6A5) gene associated with hyperekplexia., Biochem. Biophys. Res. Commun.
    Tsang et al., 2008, Alterations in NMDA receptor subunit densities and ligand binding to glycine recognition sites are associated with chronic anxiety in Alzheimer's disease., Neurobiol. Aging
    Okamoto et al., 2005, Recognition sites of glycine tRNA for glycyl-tRNA synthetase from hyperthermophilic archaeon, Aeropyrum pernix K1., Nucleic Acids Symp Ser (Oxf)
    Scherer, 2006, Inherited neuropathies: new genes don't fit old models., Neuron
    Cader et al., 2007, Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophy., FEBS Lett.
    Antonellis et al., 2006, Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons., J. Neurosci.
    Liu et al., 2007, NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo., J. Neurosci.
    Gabra et al., 2007, Decrease in N-methyl-D-aspartic acid receptor-NR2B subunit levels by intrathecal short-hairpin RNA blocks group I metabotropic glutamate receptor-mediated hyperalgesia., J. Pharmacol. Exp. Ther.
    Milutinovic et al., 2007, Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and N-methyl-d-aspartate receptors by coreleased neurotransmitters., Anesth. Analg.
    Brosnan et al., 2007, Ammonia has anesthetic properties., Anesth. Analg.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Domingues et al., 2007, Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunits., Neurochem. Int.
    Hungerer et al., 1995, Regulation of the hemA gene during 5-aminolevulinic acid formation in Pseudomonas aeruginosa., J. Bacteriol.
    Shoolingin-Jordan et al., 2003, 5-Aminolevulinic acid synthase: mechanism, mutations and medicine., Biochim. Biophys. Acta
    Munakata et al., 1993, Purification and structure of rat erythroid-specific delta-aminolevulinate synthase., J. Biochem.
    Matsuo M et al., 2012, Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma., Biochem Biophys Res Commun
    Qi et al., 2006, Calcium entry mediated by GLR3.3, an Arabidopsis glutamate receptor with a broad agonist profile., Plant Physiol.
    Young-Pearse et al., 2006, Characterization of mice with targeted deletion of glycine receptor alpha 2., Mol. Cell. Biol.
    Goyer A et al., 2004, Characterization and metabolic function of a peroxisomal sarcosine and pipecolate oxidase from Arabidopsis., J Biol Chem
    Bashir et al., 2006, Mechanism and substrate stereochemistry of 2-amino-3-oxobutyrate CoA ligase: implications for 5-aminolevulinate synthase and related enzymes., Chem. Commun. (Camb.)
    Rajinikanth et al., 2007, The glycine decarboxylase complex multienzyme family in Populus., J. Exp. Bot.
    Mukherjee et al., 2006, Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis., Eukaryotic Cell
    Gagnon et al., 2006, Stage specific gene expression and cellular localization of two isoforms of the serine hydroxymethyltransferase in the protozoan parasite Leishmania., Mol. Biochem. Parasitol.
    Chang et al., 2007, Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases., Drug Metab. Dispos.
    Vatsyayan et al., 2007, Molecular cloning and biochemical characterization of Leishmania donovani serine hydroxymethyltransferase., Protein Expr. Purif.
    Baker et al., 2004, Glycolate and glyoxylate metabolism in HepG2 cells., Am. J. Physiol., Cell Physiol.
    Takada et al., 1984, The effect of vitamin B6 deficiency on alanine: glyoxylate aminotransferase isoenzymes in rat liver., Arch. Biochem. Biophys.
    Janáky et al., 2007, Modulation of [3H]dopamine release by glutathione in mouse striatal slices., Neurochem. Res.
    Ducruix et al., 2006, New insights into the regulation of phytochelatin biosynthesis in A. thaliana cells from metabolite profiling analyses., Biochimie
    Ristoff et al., 2007, Inborn errors in the metabolism of glutathione., Orphanet J Rare Dis
    Herrera et al., 2007, Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues., J. Biol. Chem.
    Pai et al., 2006, Dual binding sites for translocation catalysis by Escherichia coli glutathionylspermidine synthetase., EMBO J.
    Smothers et al., 2007, Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits., J. Pharmacol. Exp. Ther.
    Nijhout et al., 2006, In silico experimentation with a model of hepatic mitochondrial folate metabolism., Theor Biol Med Model
  • GLYCINE   GARS

    Interaction Score: 10.33

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17433503 17150752 16982409 17544401 17035524


    Sources:
    DrugBank

  • GLYCINE   BAAT

    Interaction Score: 8.61

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17379925 16931649 17256745 17416343


    Sources:
    DrugBank

  • GLYCINE   PIPOX

    Interaction Score: 6.89

    Interaction Types & Directionality:
    product of

    Interaction Info:

    PMIDs:
    14766747 17139284 17016423


    Sources:
    DrugBank

  • GLYCINE   GLYATL1

    Interaction Score: 6.89

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    22475485 17139284 17016423


    Sources:
    DrugBank

  • GLYCINE   GLYATL2

    Interaction Score: 6.89

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    20305126 17139284 17016423


    Sources:
    DrugBank

  • GLYCINE   ALAS2

    Interaction Score: 5.16

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    7883699 12686158 8407861 17139284 17016423


    Sources:
    DrugBank

  • GLYCINE   GLYAT

    Interaction Score: 5.16

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17143481 17146584


    Sources:
    DrugBank

  • GLYCINE   AGXT2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    product of

    Interaction Info:

    PMIDs:
    15240345 17139284 6703688 17016423 16970975


    Sources:
    DrugBank

  • GLYCINE   SHMT2

    Interaction Score: 2.58

    Interaction Types & Directionality:
    product of

    Interaction Info:

    PMIDs:
    17355947 16980404 16876889 17664250 17142057


    Sources:
    DrugBank

  • GLYCINE   ALAS1

    Interaction Score: 2.58

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17578005 17469798


    Sources:
    DrugBank

  • GLYCINE   GSS

    Interaction Score: 1.72

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17401648 16996193 17397529 17452339 17124497


    Sources:
    DrugBank

  • GLYCINE   GCAT

    Interaction Score: 1.72

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17146529


    Sources:
    DrugBank

  • GLYCINE   GPR18

    Interaction Score: 1.38

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    20136843 17139284 17016423


    Sources:
    DrugBank

  • GLYCINE   AGXT

    Interaction Score: 1.38

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17616291 16899523 16990263


    Sources:
    DrugBank

  • GLYCINE   GNMT

    Interaction Score: 1.38

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    16851960 17158459 17154529


    Sources:
    DrugBank

  • GLYCINE   SHMT1

    Interaction Score: 1.03

    Interaction Types & Directionality:
    product of

    Interaction Info:

    PMIDs:
    17355947 17150100 16876889 17664250 17142057


    Sources:
    DrugBank

  • GLYCINE   GATM

    Interaction Score: 0.86

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17486546 16970975


    Sources:
    DrugBank

  • GLYCINE   GLRA2

    Interaction Score: 0.49

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    17012403 16847326 17550639


    Sources:
    DrugBank

  • GLYCINE   GLRA3

    Interaction Score: 0.4

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    17154252 17550639


    Sources:
    DrugBank

  • GLYCINE   GRIN2A

    Interaction Score: 0.39

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? True
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    17360906 17405869 17646495 17513636 11752352 17403555


    Sources:
    TTD DrugBank GuideToPharmacology

  • GLYCINE   GRIN2C

    Interaction Score: 0.33

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? True
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    8955518 9073168 11861317 17139284 17016423


    Sources:
    DrugBank GuideToPharmacology

  • GLYCINE   GPRC6A

    Interaction Score: 0.22

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GLYCINE   GLRB

    Interaction Score: 0.22

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    16884688


    Sources:
    DrugBank

  • GLYCINE   GLRA1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    ligand

    Interaction Info:

    PMIDs:
    17154252 16884688


    Sources:
    DrugBank

  • GLYCINE   GRIN3B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    substrate

    Interaction Info:

    PMIDs:
    17502428


    Sources:
    DrugBank

  • GLYCINE   GRIN2D

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? True
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GLYCINE   GRIN2B

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Agonist
    Details of Interaction GluN2D > GluN2C > GluN2B > GluN2A

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GLYCINE   GRIN1

    Interaction Score: 0.03

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Binding Site for Interaction glycine site
    Specific Action of the Ligand Agonist
    Endogenous Drug? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GLYCINE   CYP2C9

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • GLYCINE   CYP2C19

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • GLYCINE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • GLYCINE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • GLYCINE   CYP3A4

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22931300


    Sources:
    DTC

  • DrugBank: DB00145

    • Version: 5.1.7

    Alternate Names:
    GLYCINE DrugBank Drug Name
    56-40-6 CAS Number
    2.5% Travasol Amino Acid Injection With Electrolytes In 10% Dextrose Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups nutraceutical

    Publications:
    Hungerer et al., 1995, Regulation of the hemA gene during 5-aminolevulinic acid formation in Pseudomonas aeruginosa., J. Bacteriol.
    Shoolingin-Jordan et al., 2003, 5-Aminolevulinic acid synthase: mechanism, mutations and medicine., Biochim. Biophys. Acta
    Munakata et al., 1993, Purification and structure of rat erythroid-specific delta-aminolevulinate synthase., J. Biochem.

  • DTC: GLYCINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL773 ChEMBL Drug ID

    Drug Info:

    Publications:
    Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

  • TTD: Glycine

    • Version: 2020.06.01

    Alternate Names:
    D0M8AB TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135651492

    • Version: 29-September-2020

    Alternate Names:
    GLYCINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL773

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21