DGIdb - GLYBURIDE Drug Record

GLYBURIDE chembl:CHEMBL472 Approved

Alternate Names:

DIABETAMIDE 5
MALIX
GLYNASE
CALABREN
GLIBENCLAMIDE
HB 419
U-26452
U-26,45
GLYNASE PRESTAB
MICRONASE
DIABETA
LIBANIL
DAONIL
DIABETAMIDE 2.5
GLYBURIDE
LEDERGLIB
HB-419
EUGLUCON
SEMI-DAONIL
GLYBURIDE (MICRONIZED)
GLIKEN
DIABETA®
GLIBENCLAMIDUM
1-(P-(2-(5-CHLORO-2-METHOXYBENZAMIDO)ETHYL)BENZENESULFONYL)-3-CYCLOHEXYLUREA
5-CHLORO-N-(2-(4-((((CYCLOHEXYLAMINO)CARBONYL)AMINO)SULFONYL)PHENYL)ETHYL)-2-METHOXYBENZAMIDE
1-((P-(2-(5-CHLORO-O-ANISAMIDO)ETHYL)PHENYL)SULFONYL)-3-CYCLOHEXYLUREA
GLIBENCLAMIDA
GLYNASE®
chembl:CHEMBL472
chemidplus:10238-21-8
drugbank:01016
pubchem.compound:3488
rxcui:4815

Drug Info:

Drug Class	hypoglycemic agents
Year of Approval	1984
Drug Categories	hypoglycemia-associated agents
FDA Approval	1984
Drug Class	small molecule
Drug Indications	Hypoglycemic Agents
FDA Approval	approved
Drug Indications	antidiabetic
Drug Categories	bsep/abcb11 substrates
Drug Categories	cytochrome p-450 cyp2c9 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (weak)
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 cyp3a7 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	oat1/slc22a6 inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	photosensitizing agents

(8 More Sources)

Publications:

Cook, 1987, The hypoglycemic sulfonylureas glyburide and tolbutamide inhibit fatty acid oxidation by inhibiting carnitine palmitoyltransferase., J. Biol. Chem.
Patel, 1986, Effect of sulfonylureas on hepatic fatty acid oxidation., Am. J. Physiol.
Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol
Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab
Gloyn AL et al., 2001, Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)., Diabet Med
Jabůrek et al., 1998, State-dependent inhibition of the mitochondrial KATP channel by glyburide and 5-hydroxydecanoate., J. Biol. Chem.
Javorsky M et al., 2012, KCNJ11 gene E23K variant and therapeutic response to sulfonylureas., Eur J Intern Med
Li Q et al., 2014, KCNJ11 E23K variant is associated with the therapeutic effect of sulphonylureas in Chinese type 2 diabetic patients., Clin Exp Pharmacol Physiol
Babenko et al., 2002, SUR-dependent modulation of KATP channels by an N-terminal KIR6.2 peptide. Defining intersubunit gating interactions., J. Biol. Chem.
Serrano-Martín et al., 2006, Glibenclamide, a blocker of K+(ATP) channels, shows antileishmanial activity in experimental murine cutaneous leishmaniasis., Antimicrob. Agents Chemother.
Nielsen et al., 2002, 6-Chloro-3-alkylamino-4H-thieno[3,2-e]-1,2,4-thiadiazine 1,1-dioxide derivatives potently and selectively activate ATP sensitive potassium channels of pancreatic beta-cells., J. Med. Chem.
Dabrowski et al., 2002, The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener., Diabetes
Ueda et al., 1999, Cooperative binding of ATP and MgADP in the sulfonylurea receptor is modulated by glibenclamide., Proc. Natl. Acad. Sci. U.S.A.
Hambrock et al., 2002, Four novel splice variants of sulfonylurea receptor 1., Am. J. Physiol., Cell Physiol.
Hambrock et al., 2002, Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides., Br. J. Pharmacol.
Rainbow et al., 2004, Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels., Biochem. J.
Wang et al., 2007, Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes., Sheng Li Xue Bao
Zhao et al., 2006, Pretreatment with fosinopril or valsartan reduces myocardial no-reflow after acute myocardial infarction and reperfusion., Coron. Artery Dis.
Felsch et al., 2004, Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075., Br. J. Pharmacol.
Zhang YF et al., 2005, [Impact of cytochrome P450 CYP2C9 variant allele CYP2C9 * 3 on the pharmacokinetics of glibenclamide and lornoxicam in Chinese subjects]., Yao Xue Xue Bao
Kemp et al., 2004, Viability assessment in sandwich-cultured rat hepatocytes after xenobiotic exposure., Toxicol In Vitro
Horikawa et al., 2003, Potential cholestatic activity of various therapeutic agents assessed by bile canalicular membrane vesicles isolated from rats and humans., Drug Metab. Pharmacokinet.
Byrne et al., 2002, The human bile salt export pump: characterization of substrate specificity and identification of inhibitors., Gastroenterology
Abu-Hamdah et al., 2004, Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex., Cell Biol. Int.
Sireci et al., 1999, Effects of glyburide-cyclosporin A interaction on interleukin-2 production in rats., Immunopharmacol Immunotoxicol
Carette C et al., 2011, Diabetes mellitus and glucose-6-phosphate dehydrogenase deficiency: from one crisis to another., Diabetes Metab
Youngster I et al., 2010, Medications and glucose-6-phosphate dehydrogenase deficiency: an evidence-based review., Drug Saf
Vinzio S et al., 2004, Glibenclamide-induced acute haemolytic anaemia revealing a G6PD-deficiency., Diabetes Res Clin Pract
Meloni G et al., 1996, Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM., Br J Haematol
Kharbanda C et al., 2015, Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect., Bioorg Med Chem Lett
Spraggs C et al., 2007, Genetic variants in the epithelial sodium channel associate with oedema in type 2 diabetic patients receiving the peroxisome proliferator-activated receptor gamma agonist farglitazar., Pharmacogenet Genomics
Mühl et al., 2003, Inhibition of lipopolysaccharide/ATP-induced release of interleukin-18 by KN-62 and glyburide., Eur. J. Pharmacol.
Nieland et al., 2004, Cross-inhibition of SR-BI- and ABCA1-mediated cholesterol transport by the small molecules BLT-4 and glyburide., J. Lipid Res.
Lamkanfi et al., 2009, Glyburide inhibits the Cryopyrin/Nalp3 inflammasome., J. Cell Biol.
Reddy et al., 2002, ATP-binding cassette transporter 1 participates in LDL oxidation by artery wall cells., Arterioscler. Thromb. Vasc. Biol.
Alder-Baerens et al., 2005, Headgroup-specific exposure of phospholipids in ABCA1-expressing cells., J. Biol. Chem.
Agassandian et al., 2004, Oxysterols trigger ABCA1-mediated basolateral surfactant efflux., Am. J. Respir. Cell Mol. Biol.
Ren Q et al., 2016, Genetic and Clinical Predictive Factors of Sulfonylurea Failure in Patients with Type 2 Diabetes., Diabetes Technol Ther
Kern et al., 1993, Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose transporter (GLUT4) protein., Int. J. Biochem.
Zhou et al., 2002, Probing an open CFTR pore with organic anion blockers., J. Gen. Physiol.
Reddy et al., 2002, Effect of anion transport blockers on CFTR in the human sweat duct., J. Membr. Biol.
Jiang et al., 2003, Pleural surface fluorescence measurement of Na+ and Cl- transport across the air space-capillary barrier., J. Appl. Physiol.
Larsen et al., 2003, Beta-adrenergic receptors couple to CFTR chloride channels of intercalated mitochondria-rich cells in the heterocellular toad skin epithelium., Biochim. Biophys. Acta
Lee et al., 2005, Inhibition of Na+-K+ pump and L-type Ca2+ channel by glibenclamide in Guinea pig ventricular myocytes., J. Pharmacol. Exp. Ther.
King ZA et al., 2018, Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date., Drug Des Devel Ther

GLYBURIDE CPT1A

Interaction Score: 2.47

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
3104327 3090894

Sources:
DrugBank
GLYBURIDE ABCA1

Interaction Score: 2.16

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
14660039 15102890 19805629 12426219 15905177 15039140

Sources:
DrugBank
GLYBURIDE ABCC8

Interaction Score: 1.43

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name glyburide + metformin,Glucovance

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

PMIDs:
12213829 17015627 12213059 12031979 9990013 12107069 12145099

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions
GLYBURIDE ABCC9

Interaction Score: 1.35

Interaction Types & Directionality:

modulator

Interaction Info:

PMIDs:
14672537 17294036 16845255 12145099 15023854

Sources:
DrugBank
GLYBURIDE AQP1

Interaction Score: 0.99

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14759764

Sources:
NCI
GLYBURIDE ABCB11

Interaction Score: 0.99

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
15465654 15618715 12404239

Sources:
DrugBank
GLYBURIDE KCNJ11

Interaction Score: 0.93

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
24442125 16595597 11318841 9593694 22385882 25115353

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions
GLYBURIDE TRPM4

Interaction Score: 0.82

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
30147301

Sources:
DrugBank
GLYBURIDE SCNN1B

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18004211

Sources:
PharmGKB
GLYBURIDE CFTR

Interaction Score: 0.58

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
12407077 12202948 12391048 14729151 15365090

Sources:
DrugBank GuideToPharmacology
GLYBURIDE ABCC5

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
27403931

Sources:
PharmGKB
GLYBURIDE KCNJ1

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial
GLYBURIDE KCNJ8

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
GLYBURIDE G6PD

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21147013 20701405 15126005 8562390

Sources:
FDA PharmGKB
GLYBURIDE IL2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10466081

Sources:
NCI
GLYBURIDE SLC2A4

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8224371

Sources:
NCI
GLYBURIDE SLCO2B1

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology
GLYBURIDE PPARG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26384286

Sources:
DTC
GLYBURIDE CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
24442125 16342679

Sources:
DTC PharmGKB
GLYBURIDE NR1I2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
GLYBURIDE CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GLYBURIDE CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
GLYBURIDE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB01016

Version: 5.1.7

Alternate Names:

GLYBURIDE DrugBank Drug Name

10238-21-8 CAS Number

Apo Glyburide Tab 2.5mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories alimentary tract and metabolism

Publications:

King ZA et al., 2018, Profile of intravenous glyburide for the prevention of cerebral edema following large hemispheric infarction: evidence to date., Drug Des Devel Ther

Zhou et al., 2002, Probing an open CFTR pore with organic anion blockers., J. Gen. Physiol.

Reddy et al., 2002, Effect of anion transport blockers on CFTR in the human sweat duct., J. Membr. Biol.

TEND: GLIBENCLAMIDE
- Version: 01-August-2011
Alternate Names:

GLIBENCLAMIDE Primary Drug Name

Drug Info:

Year of Approval 1984

Drug Class hypoglycemic agents

Publications:
TdgClinicalTrial: GLIBENCLAMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval 1984

Publications:
TdgClinicalTrial: GLYBURIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidiabetic

Drug Class Small molecule

FDA Approval approved

Publications:

NCI: GLYBURIDE

Version: 14-September-2017

Alternate Names:

C29076 NCI drug code

Drug Info:

Publications:

Abu-Hamdah et al., 2004, Regulation of the water channel aquaporin-1: isolation and reconstitution of the regulatory complex., Cell Biol. Int.

Sireci et al., 1999, Effects of glyburide-cyclosporin A interaction on interleukin-2 production in rats., Immunopharmacol Immunotoxicol

Kern et al., 1993, Increased muscle glucose uptake in response to chronic glyburide treatment is not related to changes in glucose transporter (GLUT4) protein., Int. J. Biochem.

DTC: GLYBURIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL472 ChEMBL Drug ID

Drug Info:

Publications:

Kharbanda C et al., 2015, Antidiabetic effect of novel benzenesulfonylureas as PPAR-γ agonists and their anticancer effect., Bioorg Med Chem Lett

PharmGKB: glibenclamide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Klen J et al., 2014, CYP2C9, KCNJ11 and ABCC8 polymorphisms and the response to sulphonylurea treatment in type 2 diabetes patients., Eur J Clin Pharmacol

Sesti G et al., 2006, The E23K variant of KCNJ11 encoding the pancreatic beta-cell adenosine 5'-triphosphate-sensitive potassium channel subunit Kir6.2 is associated with an increased risk of secondary failure to sulfonylurea in patients with type 2 diabetes., J Clin Endocrinol Metab

Gloyn AL et al., 2001, Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)., Diabet Med

TTD: Glibenclamide
- Version: 2020.06.01
Alternate Names:

D05LYX TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650306
- Version: 29-September-2020
Alternate Names:

GLIBENCLAMIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL472
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL472
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
FDA: Glyburide
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	glyburide + metformin,Glucovance
Mechanism of Interaction	Sulfonylurea receptor 1, Kir6.2 blocker

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	None

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False

GLYBURIDE	DrugBank Drug Name
10238-21-8	CAS Number
Apo Glyburide Tab 2.5mg	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	alimentary tract and metabolism

blocker (inhibitory)
inhibitor (inhibitory)

antagonist (inhibitory)
blocker (inhibitory)

GLYBURIDE Drug Record

GLYBURIDE chembl:CHEMBL472 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 3104327 3090894

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 14660039 15102890 19805629 12426219 15905177 15039140

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Novel drug target Established target Trial Name glyburide + metformin,Glucovance Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

PMIDs: 12213829 17015627 12213059 12031979 9990013 12107069 12145099

Sources: TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality: modulator

Interaction Info:

PMIDs: 14672537 17294036 16845255 12145099 15023854

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14759764

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 15465654 15618715 12404239

Sources: DrugBank

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand None

PMIDs: 24442125 16595597 11318841 9593694 22385882 25115353

Sources: TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 30147301

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 18004211

Sources: PharmGKB

Interaction Types & Directionality: antagonist (inhibitory) blocker (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False

PMIDs: 12407077 12202948 12391048 14729151 15365090

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 27403931

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: None found

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand None Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21147013 20701405 15126005 8562390

Sources: FDA PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10466081

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8224371

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26384286

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 24442125 16342679

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
3104327 3090894

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
14660039 15102890 19805629 12426219 15905177 15039140

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name glyburide + metformin,Glucovance

Mechanism of Interaction Sulfonylurea receptor 1, Kir6.2 blocker

PMIDs:
12213829 17015627 12213059 12031979 9990013 12107069 12145099

Sources:
TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality:

modulator

PMIDs:
14672537 17294036 16845255 12145099 15023854

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
14759764

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
15465654 15618715 12404239

Sources:
DrugBank

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand None

PMIDs:
24442125 16595597 11318841 9593694 22385882 25115353

Sources:
TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
30147301

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
18004211

Sources:
PharmGKB

Interaction Types & Directionality:

antagonist (inhibitory)

blocker (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

PMIDs:
12407077 12202948 12391048 14729151 15365090

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
27403931

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
None found

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand None

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
21147013 20701405 15126005 8562390

Sources:
FDA PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
10466081

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8224371

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
26384286

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
24442125 16342679

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

GLYBURIDE DrugBank Drug Name

10238-21-8 CAS Number

Apo Glyburide Tab 2.5mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories alimentary tract and metabolism

Alternate Names:

GLIBENCLAMIDE Primary Drug Name

Drug Info:

Year of Approval 1984

Drug Class hypoglycemic agents

Drug Info:

Drug Indications Hypoglycemic Agents

Drug Class small molecule

FDA Approval 1984