DGIdb - GLUTATHIONE Drug Record

GLUTATHIONE chembl:CHEMBL1543

Alternate Names:

GLUTATHIONE
AGIFUTOL S
GLUTATIONE
TATHIONE
L-G-GLUTAMYL-L-CYSTEINYL-GLYCINE
L-GAMMA-GLUTAMYL-L-CYSTEINYL-GLYCINE
BAKEZYME RX
GLUTATIOL
GSH
GLUTATHION
GAMMA-GLUTAMYLCYSTEINYLGLYCINE
GLUTINAL
L-GLUTAMYL-L-CYSTEINYLGLYCINE
COPREN
RED. GLUTATHIONE
GAMMA-L-GLUTAMYL-L-CYSTEINYLGLYCINE
GLUTATHIONE RED
TATHION
ISETHION
GLUTATHIONE REDUCED
DELTATHIONE
(2S)-2-AMINO-4-{[(1R)-1-[(CARBOXYMETHYL)CARBAMOYL]-2-SULFANYLETHYL]CARBAMOYL}BUTANOIC ACID
GLUTIDE
N-(N-GAMMA-L-GLUTAMYL-L-CYSTEINYL)GLYCINE
LEDAC
GLUTATHIONE-SH
REDUCED GLUTATHIONE
NEUTHION
TRIPTIDE
L-GLUTATHIONE REDUCE
5-L-GLUTAMYL-L-CYSTEINYLGLYCINE
L-GLUTATHIONE
GAMMA-L-GLUTAMYL-L-CYSTEINYL-GLYCINE
chemidplus:70-18-8
pubchem.compound:124886
rxcui:4890
chembl:CHEMBL1543
drugbank:00143

Drug Info:

Drug Groups	investigational
Drug Categories	glutathione, antagonists & inhibitors

(0 More Sources)

Publications:

Gallagher et al., 2007, Transfection of HepG2 cells with hGSTA4 provides protection against 4-hydroxynonenal-mediated oxidative injury., Toxicol In Vitro
Yalçinkaya et al., 2007, Methionine-supplemented diet augments hepatotoxicity and prooxidant status in chronically ethanol-treated rats., Exp. Toxicol. Pathol.
Kurtovic et al., 2007, Colorimetric endpoint assay for enzyme-catalyzed iodide ion release for high-throughput screening in microtiter plates., Arch. Biochem. Biophys.
Roh et al., 2007, Toxic effects of di(2-ethylhexyl)phthalate on mortality, growth, reproduction and stress-related gene expression in the soil nematode Caenorhabditis elegans., Toxicology
Vararattanavech et al., 2007, A functionally conserved basic residue in glutathione transferases interacts with the glycine moiety of glutathione and is pivotal for enzyme catalysis., Biochem. J.
Jacobson et al., 2007, Elevated plasma glutathione peroxidase concentration in acute severe asthma: comparison with plasma glutathione peroxidase activity, selenium and malondialdehyde., Scand. J. Clin. Lab. Invest.
Carmeli et al., Biochemical assessments of total antioxidant status in active and nonactive female adults with intellectual disability., Res Sports Med
Ago et al., 2007, Crystal structure of a human membrane protein involved in cysteinyl leukotriene biosynthesis., Nature
Inoue et al., 2004, First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase., J. Biochem.
Aritake et al., 2006, Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase., J. Biol. Chem.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Urade et al., 1993, Dominant expression of mRNA for prostaglandin D synthase in leptomeninges, choroid plexus, and oligodendrocytes of the adult rat brain., Proc. Natl. Acad. Sci. U.S.A.
Ramachandran et al., Methylation-mediated silencing of genes is not altered by selenium treatment of prostate cancer cells., Anticancer Res.
Kadokawa et al., 2007, Intracellular balance of oxidative stress and cytoprotective molecules in damaged interlobular bile ducts in autoimmune hepatitis and primary biliary cirrhosis: In situ detection of 8-hydroxydeoxyguanosine and glutathione-S-transferase-pi., Hepatol. Res.
Lim et al., 2004, Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of alpha, mu, and pi class glutathione transferases., Am. J. Pathol.
Fernández-Cañón et al., 2002, Maleylacetoacetate isomerase (MAAI/GSTZ)-deficient mice reveal a glutathione-dependent nonenzymatic bypass in tyrosine catabolism., Mol. Cell. Biol.
Hagedorn et al., 1985, Glutathione-independent maleylacetoacetate isomerase in gram-positive bacteria., J. Bacteriol.
Destro-Bisol et al., 1989, Anthropological survey on red cell glutathione peroxidase (GPX1) polymorphism in central western Africa: a tentative hypothesis on the interaction between GPX12 and Hb beta S allelic products., Am. J. Phys. Anthropol.
Du et al., 2007, N-Acetyltransferase Mpr1 confers ethanol tolerance on Saccharomyces cerevisiae by reducing reactive oxygen species., Appl. Microbiol. Biotechnol.
Walshe et al., 2007, Inactivation of glutathione peroxidase activity contributes to UV-induced squamous cell carcinoma formation., Cancer Res.
Liddell et al., 2006, Glutathione peroxidase 1 and glutathione are required to protect mouse astrocytes from iron-mediated hydrogen peroxide toxicity., J. Neurosci. Res.
Sheridan et al., 2007, Decreased selenoprotein expression alters the immune response during influenza virus infection in mice., J. Nutr.
Chattopadhyay et al., 2007, Differential expression profiles of antioxidant enzymes and glutathione redox status in hyperthyroid rats: a temporal analysis., Comp. Biochem. Physiol. C Toxicol. Pharmacol.
Ursini et al., 2005, Native specific activity of glutathione peroxidase (GPx-1), phospholipid hydroperoxide glutathione peroxidase (PHGPx) and glutathione reductase (GR) does not differ between normo- and hypomotile human sperm samples., Int. J. Androl.
Sordillo et al., 2007, Shifts in thioredoxin reductase activity and oxidant status in mononuclear cells obtained from transition dairy cattle., J. Dairy Sci.
McHugh et al., 1996, Binding of the aflatoxin-glutathione conjugate to mouse glutathione S-transferase A3-3 is saturated at only one ligand per dimer., J. Biol. Chem.
McDonagh et al., 1999, Determinants of specificity for aflatoxin B1-8,9-epoxide in alpha-class glutathione S-transferases., Biochem. J.
Board, 1998, Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4., Biochem. J.
Martinez Molina et al., 2007, Structural basis for synthesis of inflammatory mediators by human leukotriene C4 synthase., Nature
Schnakenberg et al., 2000, Susceptibility genes: GSTM1 and GSTM3 as genetic risk factors in bladder cancer., Cytogenet. Cell Genet.
Rao et al., 2001, Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane., FEBS Lett.
Sheng et al., 2007, Crystallization and preliminary X-ray crystallographic analysis of Escherichia coliglutaredoxin 2 in complex with glutathione and of a cysteine-less variant without glutathione., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
Sagemark et al., 2007, Redox properties and evolution of human glutaredoxins., Proteins
Hashemy et al., 2007, Oxidation and S-nitrosylation of cysteines in human cytosolic and mitochondrial glutaredoxins: effects on structure and activity., J. Biol. Chem.
Ouerhani et al., The role of glutathione transferases M1 and T1 in individual susceptibility to bladder cancer in a Tunisian population., Ann. Hum. Biol.
Moore et al., 2007, Glutathione S-transferase polymorphisms, cruciferous vegetable intake and cancer risk in the Central and Eastern European Kidney Cancer Study., Carcinogenesis
Schwartzbaum et al., 2007, An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors., Cancer Epidemiol. Biomarkers Prev.
Jönsson et al., 2007, Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries., Int Arch Occup Environ Health
Gawecki et al., 2007, The role of genetic factor in etiopathogenesis of squamous cell carcinoma of the head and neck in young adults., Eur Arch Otorhinolaryngol
Guruvayoorappan et al., 2006, Antioxidant potential of Biophytum sensitivum extract in vitro and in vivo., J Basic Clin Physiol Pharmacol
Skamarauskas et al., 2007, The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation., Toxicology
Gupta et al., 2007, Role of oxidative stress in celecoxib-induced renal damage in wistar rats., Dig. Dis. Sci.
Ozkilic et al., 2006, The role of N-acetylcysteine treatment on anti-oxidative status in patients with type II diabetes mellitus., J Basic Clin Physiol Pharmacol
Sharma et al., 2007, Role of combined administration of Tiron and glutathione against aluminum-induced oxidative stress in rat brain., J Trace Elem Med Biol
Siritantikorn et al., 2007, Protection of cells from oxidative stress by microsomal glutathione transferase 1., Biochem. Biophys. Res. Commun.
Busenlehner et al., 2007, Location of substrate binding sites within the integral membrane protein microsomal glutathione transferase-1., Biochemistry
Deponte et al., 2007, Allosteric coupling of two different functional active sites in monomeric Plasmodium falciparum glyoxalase I., J. Biol. Chem.
Barati et al., 2007, Proteomic analysis defines altered cellular redox pathways and advanced glycation end-product metabolism in glomeruli of db/db diabetic mice., Am. J. Physiol. Renal Physiol.
Ridderström et al., 2000, The active-site residue tyr-175 in human glyoxalase II contributes to binding of glutathione derivatives., Biochim. Biophys. Acta
Chyan et al., S-fluorenylmethoxycarbonyl glutathione and diesters: inhibition of mammalian glyoxalase II., Enzyme Protein
Al-Timari et al., 1986, Inhibition by glutathione derivatives of bovine liver glyoxalase II (hydroxyacylglutathione hydrolase) as a probe of the N- and S-sites for substrate binding., Biochim. Biophys. Acta
Giovannini et al., 2008, Apoptosis induced by oxidized lipids is associated with up-regulation of p66Shc in intestinal Caco-2 cells: protective effects of phenolic compounds., J. Nutr. Biochem.
Cantlay et al., 1994, Heterogeneous expression and polymorphic genotype of glutathione S-transferases in human lung., Thorax
Efferth et al., Glutathione-related enzymes contribute to resistance of tumor cells and low toxicity in normal organs to artesunate., In Vivo
Beuckmann et al., 2000, Identification of mu-class glutathione transferases M2-2 and M3-3 as cytosolic prostaglandin E synthases in the human brain., Neurochem. Res.
Moreno et al., 2003, Testis-specific expression of the nuclear form of phospholipid hydroperoxide glutathione peroxidase (PHGPx)., Biol. Chem.
Baek et al., 2007, Tissue expression and cellular localization of phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA in male mice., J. Mol. Histol.
Nam et al., 2003, Effects of 17beta-estradiol and tamoxifen on the selenoprotein phospholipid hydroperoxide glutathione peroxidase (PHGPx) mRNA expression in male reproductive organs of rats., J. Reprod. Dev.
Moore et al., 2007, Polymorphisms in one-carbon metabolism and trans-sulfuration pathway genes and susceptibility to bladder cancer., Int. J. Cancer
Sakoda et al., 2008, Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women., Breast Cancer Res. Treat.
Contreras-Vergara et al., 2007, A Mu-class glutathione S-transferase from gills of the marine shrimp Litopenaeus vannamei: purification and characterization., J. Biochem. Mol. Toxicol.
Tulayakul et al., 2007, The effect of feeding piglets with the diet containing green tea extracts or coumarin on in vitro metabolism of aflatoxin B1 by their tissues., Toxicon
Harju et al., 2007, Glutathione S-transferase omega in the lung and sputum supernatants of COPD patients., Respir. Res.
Kim et al., Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation., Clin Transplant
Söderdahl et al., 2007, Glutathione transferases in hepatocyte-like cells derived from human embryonic stem cells., Toxicol In Vitro
Martin et al., 2007, Localization of members of the gamma-glutamyl transpeptidase family identifies sites of glutathione and glutathione S-conjugate hydrolysis., Plant Physiol.
Adamis et al., 2007, Vacuolar compartmentation of the cadmium-glutathione complex protects Saccharomyces cerevisiae from mutagenesis., Toxicol. Lett.
Anilakumar et al., 2007, Reduction of hexachlorocyclohexane-induced oxidative stress and cytotoxicity in rat liver by Emblica officinalis gaertn., Indian J. Exp. Biol.
Ohkama-Ohtsu et al., 2007, Glutathione conjugates in the vacuole are degraded by gamma-glutamyl transpeptidase GGT3 in Arabidopsis., Plant J.
Zhu et al., 2007, Altered glutathione homeostasis in animals prenatally exposed to lipopolysaccharide., Neurochem. Int.
Janáky et al., 2007, Modulation of [3H]dopamine release by glutathione in mouse striatal slices., Neurochem. Res.
Mohanpuria et al., 2007, Cadmium induced oxidative stress influence on glutathione metabolic genes of Camellia sinensis (L.) O. Kuntze., Environ. Toxicol.
Forcella et al., 2007, Antioxidant defenses preserve membrane transport activity in Chironomus riparius larvae exposed to anoxia., Arch. Insect Biochem. Physiol.
Herrera et al., 2007, Reaction mechanism of glutathione synthetase from Arabidopsis thaliana: site-directed mutagenesis of active site residues., J. Biol. Chem.
Bridges et al., 2007, Transport of thiol-conjugates of inorganic mercury in human retinal pigment epithelial cells., Toxicol. Appl. Pharmacol.
Whitbread et al., 2003, Characterization of the human Omega class glutathione transferase genes and associated polymorphisms., Pharmacogenetics
Whitbread et al., 2005, Characterization of the omega class of glutathione transferases., Meth. Enzymol.
Board et al., 2007, Glutathione transferase omega 1 catalyzes the reduction of S-(phenacyl)glutathiones to acetophenones., Chem. Res. Toxicol.
Robinson et al., 2004, Modelling and bioinformatics studies of the human Kappa-class glutathione transferase predict a novel third glutathione transferase family with similarity to prokaryotic 2-hydroxychromene-2-carboxylate isomerases., Biochem. J.
Koh et al., 2007, Crystal structures of a poplar thioredoxin peroxidase that exhibits the structure of glutathione peroxidases: insights into redox-driven conformational changes., J. Mol. Biol.
Neben et al., 1980, Studies on an enzyme, S-formylglutathione hydrolase, of the dissimilatory pathway of methanol in Candida boidinii., Biochim. Biophys. Acta
Sabatier et al., 1989, The decrease of catalase or esterase D activity in patients with microdeletions of 11p or 13q does not increase their radiosensitivity., Ann. Genet.
Yurimoto et al., 2003, Physiological role of S-formylglutathione hydrolase in C(1) metabolism of the methylotrophic yeast Candida boidinii., Microbiology (Reading, Engl.)
Wang et al., 2007, Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner., Arterioscler. Thromb. Vasc. Biol.
Håkansson et al., 2007, Structure of glutaredoxin Grx1p C30S mutant from yeast., Acta Crystallogr. D Biol. Crystallogr.
Lu et al., 2007, Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide., Proc. Natl. Acad. Sci. U.S.A.
Rouhier et al., 2007, Functional, structural, and spectroscopic characterization of a glutathione-ligated [2Fe-2S] cluster in poplar glutaredoxin C1., Proc. Natl. Acad. Sci. U.S.A.
Diwakar et al., 2007, Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: implications in excitotoxicity., Neurochem. Int.
Kazi et al., 2002, Expression of rat liver glutathione-S-transferase GSTA5 in cell lines provides increased resistance to alkylating agents and toxic aldehydes., Chem. Biol. Interact.
McLeod et al., 1997, Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin., Cancer Res.
Brocardo et al., 2007, Zinc attenuates malathion-induced depressant-like behavior and confers neuroprotection in the rat brain., Toxicol. Sci.
Maity et al., 2008, Antioxidant responses of the earthworm Lampito mauritii exposed to Pb and Zn contaminated soil., Environ. Pollut.
Markaryan et al., 2006, Peroxide-eliminating oxidoreductases as biosensors of antioxidant components of medicinal plants., Bull. Exp. Biol. Med.
Messarah et al., 2007, The impact of thyroid activity variations on some oxidizing-stress parameters in rats., C. R. Biol.
Brigelius-Flohé, Glutathione peroxidases and redox-regulated transcription factors., Biol. Chem.
Myllylä et al., 1986, Activities of some antioxidative and hexose monophosphate shunt enzymes of skeletal muscle in neuromuscular diseases., Acta Neurol. Scand.
Davydov DR et al., 2008, Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4., Arch Biochem Biophys
Pei P et al., 2006, Reduced nonprotein thiols inhibit activation and function of MMP-9: implications for chemoprevention., Free Radic Biol Med
Ramana KV et al., 2001, Characterization of the glutathione binding site of aldose reductase., Chem Biol Interact

GLUTATHIONE GSTA3

Interaction Score: 10.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8910329 10592235 17139284 10085232 9480897 17016423

Sources:
DrugBank
GLUTATHIONE GPX6

Interaction Score: 8.74

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
17081103 17588737 17139284 17016423 3532684

Sources:
DrugBank
GLUTATHIONE GSTA5

Interaction Score: 8.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12076520 17139284 10085232 17016423 9331086

Sources:
DrugBank
GLUTATHIONE GLRX

Interaction Score: 8.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17431186 17327665 17640917 17460036 17512091

Sources:
DrugBank
GLUTATHIONE ESD

Interaction Score: 8.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7397203 17139284 2554783 12904537 17016423

Sources:
DrugBank
GLUTATHIONE GSTO2

Interaction Score: 8.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12618591 16399380 17226937 17139284 17016423

Sources:
DrugBank
GLUTATHIONE GPX4

Interaction Score: 8.74

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
12751792 17503194 17139284 17016423 14967915

Sources:
DrugBank
GLUTATHIONE HAGH

Interaction Score: 8.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11018726 8589803 17139284 17016423 3955057

Sources:
DrugBank
GLUTATHIONE GSTK1

Interaction Score: 7.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14709161 10592235 17139284 17016423

Sources:
DrugBank
GLUTATHIONE GSTM5

Interaction Score: 7.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11173863 17139284 11684093 17016423

Sources:
DrugBank
GLUTATHIONE GLRX2

Interaction Score: 5.83

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17401194 17546662 17355958

Sources:
DrugBank
GLUTATHIONE GPX1

Interaction Score: 5.34

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
2742004 17387467 17510403 16721761 17513408 17561443 15679624 17139284 17016423 17297093

Sources:
DrugBank
GLUTATHIONE GSTM4

Interaction Score: 5.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7974294 15796179 10905636 10592235 17139284 17016423

Sources:
DrugBank
GLUTATHIONE GSTO1

Interaction Score: 4.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17537474 17617905

Sources:
DrugBank
GLUTATHIONE GSTA2

Interaction Score: 4.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17338281 17321661 17401685 17338280 17317527

Sources:
DrugBank
GLUTATHIONE GPX3

Interaction Score: 4.37

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
17558897 17578749

Sources:
DrugBank
GLUTATHIONE GPX2

Interaction Score: 2.91

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
17510403

Sources:
DrugBank
GLUTATHIONE MGST2

Interaction Score: 2.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17632548

Sources:
DrugBank
GLUTATHIONE GPX7

Interaction Score: 2.91

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
17588737

Sources:
DrugBank
GLUTATHIONE MGST3

Interaction Score: 2.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17632548

Sources:
DrugBank
GLUTATHIONE GSTA4

Interaction Score: 2.91

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17553661

Sources:
DrugBank
GLUTATHIONE GSTM3

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17617661 17372252

Sources:
DrugBank
GLUTATHIONE MGST1

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17306223 17297922

Sources:
DrugBank
GLUTATHIONE GSTZ1

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15277241 12052898 4019417 17139284 17016423

Sources:
DrugBank
GLUTATHIONE GSTM2

Interaction Score: 2.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17498936 17553661 17490601 17604895 17523921

Sources:
DrugBank
GLUTATHIONE GSS

Interaction Score: 1.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17401648 17607728 17630655 17452339 17467761

Sources:
DrugBank
GLUTATHIONE LTC4S

Interaction Score: 1.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17632546 17632548

Sources:
DrugBank
GLUTATHIONE HPGDS

Interaction Score: 0.93

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15113825 16547010 10592235 17139284 17016423 8415655

Sources:
DrugBank
GLUTATHIONE GSTT1

Interaction Score: 0.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17381051 17617661 17372252 17333241 17653748

Sources:
DrugBank
GLUTATHIONE GPX5

Interaction Score: 0.73

Interaction Types & Directionality:

cofactor (activating)

Interaction Info:

PMIDs:
17531267

Sources:
DrugBank
GLUTATHIONE GLO1

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17664277 17609286

Sources:
DrugBank
GLUTATHIONE GSTA1

Interaction Score: 0.52

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17425746 17333241 10592235 17346923

Sources:
DrugBank
GLUTATHIONE GGT1

Interaction Score: 0.46

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17545509 17644279 17569287 17316176 17291629

Sources:
DrugBank
GLUTATHIONE GSR

Interaction Score: 0.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17327255 17338281 17512104 17369902 17303537

Sources:
DrugBank
GLUTATHIONE GSTM1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17381051 17311259 17372252 17624589 17427177

Sources:
DrugBank
GLUTATHIONE MMP9

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17015178

Sources:
DrugBank
GLUTATHIONE AKR1B1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11306073

Sources:
DrugBank
GLUTATHIONE GSTP1

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17465221 17517071

Sources:
DrugBank
GLUTATHIONE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
18206979

Sources:
DrugBank

DrugBank: DB00143

Version: 5.1.7

Alternate Names:

GLUTATHIONE DrugBank Drug Name

70-18-8 CAS Number

Isethion Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Kim et al., Glutathione S-transferase A1 polymorphisms and acute graft-vs.-host disease in HLA-matched sibling allogeneic hematopoietic stem cell transplantation., Clin Transplant

Jönsson et al., 2007, Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries., Int Arch Occup Environ Health

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

TTD: Glutathione
- Version: 2020.06.01
Alternate Names:

D02HFD TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1543
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

GLUTATHIONE	DrugBank Drug Name
70-18-8	CAS Number
Isethion	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

GLUTATHIONE Drug Record

GLUTATHIONE chembl:CHEMBL1543

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8910329 10592235 17139284 10085232 9480897 17016423

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 17081103 17588737 17139284 17016423 3532684

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12076520 17139284 10085232 17016423 9331086

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17431186 17327665 17640917 17460036 17512091

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7397203 17139284 2554783 12904537 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12618591 16399380 17226937 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 12751792 17503194 17139284 17016423 14967915

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11018726 8589803 17139284 17016423 3955057

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14709161 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11173863 17139284 11684093 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17401194 17546662 17355958

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 2742004 17387467 17510403 16721761 17513408 17561443 15679624 17139284 17016423 17297093

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7974294 15796179 10905636 10592235 17139284 17016423

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17537474 17617905

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17338281 17321661 17401685 17338280 17317527

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 17558897 17578749

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 17510403

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17632548

Sources: DrugBank

Interaction Types & Directionality: cofactor (activating)

Interaction Info:

PMIDs: 17588737

Interaction Types & Directionality:

n/a

PMIDs:
8910329 10592235 17139284 10085232 9480897 17016423

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
17081103 17588737 17139284 17016423 3532684

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12076520 17139284 10085232 17016423 9331086

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17431186 17327665 17640917 17460036 17512091

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
7397203 17139284 2554783 12904537 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
12618591 16399380 17226937 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
12751792 17503194 17139284 17016423 14967915

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11018726 8589803 17139284 17016423 3955057

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
14709161 10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11173863 17139284 11684093 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17401194 17546662 17355958

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
2742004 17387467 17510403 16721761 17513408 17561443 15679624 17139284 17016423 17297093

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
7974294 15796179 10905636 10592235 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17537474 17617905

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17338281 17321661 17401685 17338280 17317527

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
17558897 17578749

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
17510403

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17632548

Sources:
DrugBank

Interaction Types & Directionality:

cofactor (activating)

PMIDs:
17588737

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17632548

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17553661

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17617661 17372252

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17306223 17297922

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
15277241 12052898 4019417 17139284 17016423

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17498936 17553661 17490601 17604895 17523921

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17401648 17607728 17630655 17452339 17467761

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
17632546 17632548