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GLUTAMINE Drug Record

  • Summary
  • Interactions
  • Claims
  • GLUTAMINE chembl:CHEMBL930 Approved

    Alternate Names:

    L-GLUTAMINE
    LEVOGLUTAMIDE
    FEMA NO. 3684
    ENDARI
    GLUTAMINE
    NSC-27421
    NUTRESTORE
    (2S)-2,5-DIAMINO-5-OXOPENTANOIC ACID
    L-GLUTAMIC ACID GAMMA-AMIDE
    L-(+)-GLUTAMINE
    GLN
    (2S)-2-AMINO-4-CARBAMOYLBUTANOIC ACID
    L-GLUTAMIC ACID Γ-AMIDE
    GLUTAMIC ACID 5-AMIDE
    L-GLUTAMIN
    L-GLUTAMINSAEURE-5-AMID
    GLUTAMIC ACID AMIDE
    (S)-2,5-DIAMINO-5-OXOPENTANOIC ACID
    L-2-AMINOGLUTARAMIC ACID
    L-GLUTAMINSÄURE-5-AMID
    Q
    chemidplus:56-85-9
    rxcui:4885
    drugbank:00130
    chembl:CHEMBL930
    pubchem.compound:5961

    Drug Info:

    Drug Categories amino acids and derivatives
    Drug Categories glutamine
    (2 More Sources)

    Publications:

    Zhou et al., 2006, [The effect of glutamine on the growth, metabolism and endostatin production of microencapsulated rCHO cells]., Sheng Wu Gong Cheng Xue Bao
    Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer
    Taylor et al., 2006, Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate., J. Org. Chem.
    Martin E et al., 2014, CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation., Nature
    MacLeod et al., 2006, The role of lysine residues 297 and 306 in nucleoside triphosphate regulation of E. coli CTP synthase: inactivation by 2',3'-dialdehyde ATP and mutational analyses., Biochim. Biophys. Acta
    Fijolek et al., 2007, Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness., J. Biol. Chem.
    Wasa et al., 2002, Characterization of L-glutamine transport by a human neuroblastoma cell line., Am. J. Physiol., Cell Physiol.
    Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.
    Noguchi et al., 1997, Increased glutamine consumption in small intestine epithelial cells during sepsis in rats., Am. J. Surg.
    Smith et al., 1984, Regulation of glutamine synthetase and glutaminase activities in cultured skeletal muscle cells., J. Cell. Physiol.
    Squires et al., 1997, Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat., Diabetes
    Curthoys, 2001, Role of mitochondrial glutaminase in rat renal glutamine metabolism., J. Nutr.
    Kovacević, 1975, Possible mechanisms of the efflux of glutamate from kidney mitochondria generated by the activity of mitochondrial glutaminase., Biochim. Biophys. Acta
    Castell et al., 2004, Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity., J. Biol. Chem.
    Huang et al., 1999, Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine., Biochem. J.
    Jiang et al., 2007, Escherichia coli glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49): kinetic characterization of regulation by PII, PII-UMP, glutamine, and alpha-ketoglutarate., Biochemistry
    Jiang et al., 2007, Structure-function analysis of glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49) of Escherichia coli., Biochemistry
    Raushel FM et al., 1999, The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia., Biochemistry
    Rose et al., 2005, Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide., Metab Brain Dis
    Mong et al., 2006, Estradiol modulation of astrocytic form and function: implications for hormonal control of synaptic communication., Neuroscience
    Tan et al., 2006, Herbicidal inhibitors of amino acid biosynthesis and herbicide-tolerant crops., Amino Acids
    Chatauret et al., 2006, Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure., J. Hepatol.
    Miguel-Hidalgo, Withdrawal from free-choice ethanol consumption results in increased packing density of glutamine synthetase-immunoreactive astrocytes in the prelimbic cortex of alcohol-preferring rats., Alcohol Alcohol.
  • GLUTAMINE   CTPS1

    Interaction Score: 28.4

    Interaction Types & Directionality:
    antagonist (inhibitory)
    substrate

    Interaction Info:

    PMIDs:
    17137369 24870241 16427816 17331943


    Sources:
    DrugBank

  • GLUTAMINE   GLUL

    Interaction Score: 17.04

    Interaction Types & Directionality:
    product of

    Interaction Info:

    PMIDs:
    16382338 16326016 16547651 16530878 16484281


    Sources:
    DrugBank

  • GLUTAMINE   PPAT

    Interaction Score: 3.79

    Interaction Types & Directionality:
    product of
    substrate

    Interaction Info:

    PMIDs:
    17355125 17355124 10387030


    Sources:
    DrugBank

  • GLUTAMINE   SLC1A5

    Interaction Score: 3.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11997238


    Sources:
    NCI

  • GLUTAMINE   COL18A1

    Interaction Score: 1.42

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16572858


    Sources:
    NCI

  • GLUTAMINE   IGF2

    Interaction Score: 0.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14746834


    Sources:
    NCI

  • GLUTAMINE   GPRC6A

    Interaction Score: 0.71

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? True

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • GLUTAMINE   GLS

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9124626 6146632 9392478 11533299 1174515 14722097


    Sources:
    NCI

  • GLUTAMINE   DDIT3

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10377266


    Sources:
    NCI

  • GLUTAMINE   MYC

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16898871


    Sources:
    NCI

  • DrugBank: DB00130

    • Version: 5.1.7

    Alternate Names:
    L-GLUTAMINE DrugBank Drug Name
    56-85-9 CAS Number
    Earthlink Science Glutamine Chews Chocolate Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Taylor et al., 2006, Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate., J. Org. Chem.
    Martin E et al., 2014, CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation., Nature
    MacLeod et al., 2006, The role of lysine residues 297 and 306 in nucleoside triphosphate regulation of E. coli CTP synthase: inactivation by 2',3'-dialdehyde ATP and mutational analyses., Biochim. Biophys. Acta

  • NCI: GLUTAMINE

    • Version: 14-September-2017

    Alternate Names:
    C522 NCI drug code

    Drug Info:

    Publications:
    Noguchi et al., 1997, Increased glutamine consumption in small intestine epithelial cells during sepsis in rats., Am. J. Surg.
    Smith et al., 1984, Regulation of glutamine synthetase and glutaminase activities in cultured skeletal muscle cells., J. Cell. Physiol.
    Squires et al., 1997, Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat., Diabetes

  • NCI: L-GLUTAMINE

    • Version: 14-September-2017

    Alternate Names:
    C522 NCI drug code

    Drug Info:

    Publications:
    Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.

  • NCI: GLN

    • Version: 14-September-2017

    Alternate Names:
    C522 NCI drug code

    Drug Info:

    Publications:
    Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer

  • GuideToPharmacology: 135651502

    • Version: 29-September-2020

    Alternate Names:
    L-GLUTAMINE GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL930

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21