DGIdb - GLUTAMINE Drug Record

GLUTAMINE chembl:CHEMBL930 Approved

Alternate Names:

L-GLUTAMINE
LEVOGLUTAMIDE
FEMA NO. 3684
ENDARI
GLUTAMINE
NSC-27421
NUTRESTORE
(2S)-2,5-DIAMINO-5-OXOPENTANOIC ACID
L-GLUTAMIC ACID GAMMA-AMIDE
L-(+)-GLUTAMINE
GLN
(2S)-2-AMINO-4-CARBAMOYLBUTANOIC ACID
L-GLUTAMIC ACID Γ-AMIDE
GLUTAMIC ACID 5-AMIDE
L-GLUTAMIN
L-GLUTAMINSAEURE-5-AMID
GLUTAMIC ACID AMIDE
(S)-2,5-DIAMINO-5-OXOPENTANOIC ACID
L-2-AMINOGLUTARAMIC ACID
L-GLUTAMINSÄURE-5-AMID
Q
chemidplus:56-85-9
rxcui:4885
drugbank:00130
chembl:CHEMBL930
pubchem.compound:5961

Drug Info:

Drug Categories	amino acids and derivatives
Drug Categories	glutamine

(2 More Sources)

Publications:

Zhou et al., 2006, [The effect of glutamine on the growth, metabolism and endostatin production of microencapsulated rCHO cells]., Sheng Wu Gong Cheng Xue Bao
Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer
Taylor et al., 2006, Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate., J. Org. Chem.
Martin E et al., 2014, CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation., Nature
MacLeod et al., 2006, The role of lysine residues 297 and 306 in nucleoside triphosphate regulation of E. coli CTP synthase: inactivation by 2',3'-dialdehyde ATP and mutational analyses., Biochim. Biophys. Acta
Fijolek et al., 2007, Expression, purification, characterization, and in vivo targeting of trypanosome CTP synthetase for treatment of African sleeping sickness., J. Biol. Chem.
Wasa et al., 2002, Characterization of L-glutamine transport by a human neuroblastoma cell line., Am. J. Physiol., Cell Physiol.
Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.
Noguchi et al., 1997, Increased glutamine consumption in small intestine epithelial cells during sepsis in rats., Am. J. Surg.
Smith et al., 1984, Regulation of glutamine synthetase and glutaminase activities in cultured skeletal muscle cells., J. Cell. Physiol.
Squires et al., 1997, Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat., Diabetes
Curthoys, 2001, Role of mitochondrial glutaminase in rat renal glutamine metabolism., J. Nutr.
Kovacević, 1975, Possible mechanisms of the efflux of glutamate from kidney mitochondria generated by the activity of mitochondrial glutaminase., Biochim. Biophys. Acta
Castell et al., 2004, Granule localization of glutaminase in human neutrophils and the consequence of glutamine utilization for neutrophil activity., J. Biol. Chem.
Huang et al., 1999, Induction of gadd153 mRNA by nutrient deprivation is overcome by glutamine., Biochem. J.
Jiang et al., 2007, Escherichia coli glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49): kinetic characterization of regulation by PII, PII-UMP, glutamine, and alpha-ketoglutarate., Biochemistry
Jiang et al., 2007, Structure-function analysis of glutamine synthetase adenylyltransferase (ATase, EC 2.7.7.49) of Escherichia coli., Biochemistry
Raushel FM et al., 1999, The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia., Biochemistry
Rose et al., 2005, Limited capacity for ammonia removal by brain in chronic liver failure: potential role of nitric oxide., Metab Brain Dis
Mong et al., 2006, Estradiol modulation of astrocytic form and function: implications for hormonal control of synaptic communication., Neuroscience
Tan et al., 2006, Herbicidal inhibitors of amino acid biosynthesis and herbicide-tolerant crops., Amino Acids
Chatauret et al., 2006, Direct molecular and spectroscopic evidence for increased ammonia removal capacity of skeletal muscle in acute liver failure., J. Hepatol.
Miguel-Hidalgo, Withdrawal from free-choice ethanol consumption results in increased packing density of glutamine synthetase-immunoreactive astrocytes in the prelimbic cortex of alcohol-preferring rats., Alcohol Alcohol.

GLUTAMINE CTPS1

Interaction Score: 28.4

Interaction Types & Directionality:

antagonist (inhibitory)

substrate

Interaction Info:

PMIDs:
17137369 24870241 16427816 17331943

Sources:
DrugBank
GLUTAMINE GLUL

Interaction Score: 17.04

Interaction Types & Directionality:

product of

Interaction Info:

PMIDs:
16382338 16326016 16547651 16530878 16484281

Sources:
DrugBank
GLUTAMINE PPAT

Interaction Score: 3.79

Interaction Types & Directionality:

product of

substrate

Interaction Info:

PMIDs:
17355125 17355124 10387030

Sources:
DrugBank
GLUTAMINE SLC1A5

Interaction Score: 3.79

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11997238

Sources:
NCI
GLUTAMINE COL18A1

Interaction Score: 1.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16572858

Sources:
NCI
GLUTAMINE IGF2

Interaction Score: 0.81

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14746834

Sources:
NCI
GLUTAMINE GPRC6A

Interaction Score: 0.71

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology
GLUTAMINE GLS

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9124626 6146632 9392478 11533299 1174515 14722097

Sources:
NCI
GLUTAMINE DDIT3

Interaction Score: 0.44

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10377266

Sources:
NCI
GLUTAMINE MYC

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16898871

Sources:
NCI

DrugBank: DB00130

Version: 5.1.7

Alternate Names:

L-GLUTAMINE DrugBank Drug Name

56-85-9 CAS Number

Earthlink Science Glutamine Chews Chocolate Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Taylor et al., 2006, Synthesis of methylene- and difluoromethylenephosphonate analogues of uridine-4-phosphate and 3-deazauridine-4-phosphate., J. Org. Chem.

Martin E et al., 2014, CTP synthase 1 deficiency in humans reveals its central role in lymphocyte proliferation., Nature

MacLeod et al., 2006, The role of lysine residues 297 and 306 in nucleoside triphosphate regulation of E. coli CTP synthase: inactivation by 2',3'-dialdehyde ATP and mutational analyses., Biochim. Biophys. Acta

NCI: GLUTAMINE

Version: 14-September-2017

Alternate Names:

C522 NCI drug code

Drug Info:

Publications:

Noguchi et al., 1997, Increased glutamine consumption in small intestine epithelial cells during sepsis in rats., Am. J. Surg.

Smith et al., 1984, Regulation of glutamine synthetase and glutaminase activities in cultured skeletal muscle cells., J. Cell. Physiol.

Squires et al., 1997, Regulation of hepatic glutaminase in the streptozotocin-induced diabetic rat., Diabetes

NCI: L-GLUTAMINE
- Version: 14-September-2017
Alternate Names:

C522 NCI drug code

Drug Info:

Publications:

Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.
NCI: GLN
- Version: 14-September-2017
Alternate Names:

C522 NCI drug code

Drug Info:

Publications:

Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer
GuideToPharmacology: 135651502
- Version: 29-September-2020
Alternate Names:

L-GLUTAMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL930
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Full agonist
Endogenous Drug?	True

L-GLUTAMINE	DrugBank Drug Name
56-85-9	CAS Number
Earthlink Science Glutamine Chews Chocolate	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

antagonist (inhibitory)
substrate

product of
substrate

GLUTAMINE Drug Record

GLUTAMINE chembl:CHEMBL930 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory) substrate

Interaction Info:

PMIDs: 17137369 24870241 16427816 17331943

Sources: DrugBank

Interaction Types & Directionality: product of

Interaction Info:

PMIDs: 16382338 16326016 16547651 16530878 16484281

Sources: DrugBank

Interaction Types & Directionality: product of substrate

Interaction Info:

PMIDs: 17355125 17355124 10387030

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11997238

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16572858

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14746834

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9124626 6146632 9392478 11533299 1174515 14722097

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10377266

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16898871

Sources: NCI

DrugBank: DB00130

Alternate Names: L-GLUTAMINE DrugBank Drug Name 56-85-9 CAS Number Earthlink Science Glutamine Chews Chocolate Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

NCI: GLUTAMINE

Alternate Names: C522 NCI drug code

Drug Info:

NCI: L-GLUTAMINE

Alternate Names: C522 NCI drug code

Drug Info:

Publications: Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.

NCI: GLN

Alternate Names: C522 NCI drug code

Drug Info:

Publications: Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer

GuideToPharmacology: 135651502

Alternate Names: L-GLUTAMINE GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL930

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

substrate

PMIDs:
17137369 24870241 16427816 17331943

Sources:
DrugBank

Interaction Types & Directionality:

product of

PMIDs:
16382338 16326016 16547651 16530878 16484281

Sources:
DrugBank

Interaction Types & Directionality:

product of

substrate

PMIDs:
17355125 17355124 10387030

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
11997238

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16572858

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14746834

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
9124626 6146632 9392478 11533299 1174515 14722097

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10377266

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16898871

Sources:
NCI

Alternate Names:

L-GLUTAMINE DrugBank Drug Name

56-85-9 CAS Number

Earthlink Science Glutamine Chews Chocolate Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

C522 NCI drug code

Alternate Names:

C522 NCI drug code

Publications:

Meng et al., 2004, Insulin-like growth factor-2 activation of intestinal glutamine transport is mediated by mitogen-activated protein kinases., J. Gastrointest. Surg.

Alternate Names:

C522 NCI drug code

Publications:

Todorova et al., 2006, Modulation of p53 and c-myc in DMBA-induced mammary tumors by oral glutamine., Nutr Cancer

Alternate Names:

L-GLUTAMINE GuideToPharmacology Ligand Name