DGIdb - GLUCAGON Drug Record

GLUCAGON chembl:CHEMBL266481 Approved

Alternate Names:

GLUCAGON
GLUCAGEN HYPOKIT
GLUCAGON RECOMBINANT
GLUCAGON EMERGENCY KIT
GCG(53-81)
GLUCAGONUM
GLUCAGONE
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
drugbank:00040
pubchem.compound:16186314
chemidplus:9007-92-5
chembl:CHEMBL266481

Drug Info:

Drug Type	biotech
Drug Groups	approved
Drug Categories	amino acids, peptides, and proteins
Drug Categories	antihypoglycemic agent
Drug Categories	decreased gi motility
Drug Categories	decreased gi smooth muscle tone
Drug Categories	decreased glycolysis
Drug Categories	gastrointestinal agents
Drug Categories	gastrointestinal hormones
Drug Categories	gastrointestinal motility inhibitor
Drug Categories	glucagon, antagonists & inhibitors
Drug Categories	glycogenolytic agents
Drug Categories	glycogenolytic hormones
Drug Categories	hormones
Drug Categories	hormones, hormone substitutes, and hormone antagonists
Drug Categories	increased gluconeogenesis
Drug Categories	increased glycogenolysis
Drug Categories	pancreatic hormones
Drug Categories	peptide hormones
Drug Categories	peptides
Drug Categories	proglucagon
Drug Categories	protein precursors
Drug Categories	proteins
Drug Categories	systemic hormonal preparations, excl. sex hormones and insulins

(2 More Sources)

Publications:

Baggio et al., 2007, Biology of incretins: GLP-1 and GIP., Gastroenterology
Körner et al., 2007, GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting., J. Nucl. Med.
Fischer et al., 2007, Development of bullwhip neurons in the embryonic chicken retina., J. Comp. Neurol.
Brubaker et al., 2002, Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors., Recept. Channels
Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod
Liu Q et al., 2012, Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor., J Med Chem
Lok et al., 1994, The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization., Gene
Katayama et al., 2007, Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach., Biochem. Biophys. Res. Commun.
Li et al., 2007, Design, synthesis and crystallization of a novel glucagon analog as a therapeutic agent., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
Winzell et al., 2007, Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet., Diabetologia
Li et al., 2007, Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise., Clin. Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Menzel et al., 1994, Localization of the glucagon receptor gene to human chromosome band 17q25., Genomics
Yamanaka et al., 2007, Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice., Diabetes Obes Metab
Janski et al., 1979, Phosphorylation of ATP citrate lyase in response to glucagon., J. Biol. Chem.
Chen et al., 2004, Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity., Biochem. Biophys. Res. Commun.
Masumoto et al., 1988, Effects of insulin, dexamethasone and glucagon on the production of apolipoprotein A-I in cultured rat hepatocytes., Atherosclerosis
Broglio et al., 2002, Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans., J. Clin. Endocrinol. Metab.
Brown et al., 1989, Glucagon, cyclic AMP and adrenaline stimulate the degradation of low-density lipoprotein by cultured rat hepatocytes., Biochem. J.
Minor et al., 1998, Enhancement of endogenous cyclic AMP signal: a new approach to allow for cold preservation of rat livers from non-heart-beating donors?, Transplantation
Hernández et al., 1996, Stimulation of microsomal cholesterol ester hydrolase by glucagon, cyclic AMP analogues, and vasopressin in isolated rat hepatocytes., Lipids
Boushey et al., 2001, Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor., Cancer Res.
Munroe et al., 1999, Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2., Proc. Natl. Acad. Sci. U.S.A.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Estall et al., 2005, The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation., J. Biol. Chem.

GLUCAGON CORT

Interaction Score: 10.33

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12364482

Sources:
NCI
GLUCAGON GLP2R

Interaction Score: 9.04

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
11212269 12529935 9990065 17139284 17016423 15817468

Sources:
DrugBank
GLUCAGON GCGR

Interaction Score: 6.46

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? True

Specific Action of the Ligand Full agonist

PMIDs:
22650618 22103243 8144028 12529935 17462598 17620721 17479245 17623014 11752352 17534934 8020989

Sources:
DTC DrugBank ChemblInteractions GuideToPharmacology
GLUCAGON ACLY

Interaction Score: 5.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
489538

Sources:
NCI
GLUCAGON LIPA

Interaction Score: 2.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8900456

Sources:
NCI
GLUCAGON GPT

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9808480

Sources:
NCI
GLUCAGON APOA1

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3130065

Sources:
NCI
GLUCAGON LDLR

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2552996

Sources:
NCI
GLUCAGON GLP1R

Interaction Score: 0.2

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Full agonist

PMIDs:
17498508 17475961 17534934 12529935

Sources:
DrugBank GuideToPharmacology
GLUCAGON BDNF

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17924870

Sources:
NCI
GLUCAGON PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15530428

Sources:
NCI

DrugBank: DB00040

Version: 5.1.7

Alternate Names:

GLUCAGON DrugBank Drug Name

16941-32-5 CAS Number

Baqsimi Drug Brand

Drug Info:

Drug Type biotech

Drug Groups approved

Drug Categories amino acids, peptides, and proteins

Publications:

Körner et al., 2007, GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting., J. Nucl. Med.

Baggio et al., 2007, Biology of incretins: GLP-1 and GIP., Gastroenterology

Brubaker et al., 2002, Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors., Recept. Channels

GuideToPharmacology: 135651778
- Version: 29-September-2020
Alternate Names:

GCG Gene Symbol (for Endogenous Peptides)

Gcg Gene Symbol (for Endogenous Peptides)

GLUCAGON GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Publications:

NCI: GLUCAGON

Version: 14-September-2017

Alternate Names:

C520 NCI drug code

Drug Info:

Publications:

Yamanaka et al., 2007, Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice., Diabetes Obes Metab

Janski et al., 1979, Phosphorylation of ATP citrate lyase in response to glucagon., J. Biol. Chem.

Masumoto et al., 1988, Effects of insulin, dexamethasone and glucagon on the production of apolipoprotein A-I in cultured rat hepatocytes., Atherosclerosis

DTC: GLUCAGON

Version: 02-September-2020

Alternate Names:

CHEMBL266481 ChEMBL Drug ID

Drug Info:

Publications:

Liu Q et al., 2012, Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor., J Med Chem

Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod

ChemblDrugs: chembl:CHEMBL266481
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL266481
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	True
Endogenous Drug?	True
Specific Action of the Ligand	Full agonist

GLUCAGON	DrugBank Drug Name
16941-32-5	CAS Number
Baqsimi	Drug Brand

GCG	Gene Symbol (for Endogenous Peptides)
Gcg	Gene Symbol (for Endogenous Peptides)
GLUCAGON	GuideToPharmacology Ligand Name

GLUCAGON Drug Record

GLUCAGON chembl:CHEMBL266481 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12364482

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 11212269 12529935 9990065 17139284 17016423 15817468

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? True Endogenous Drug? True Specific Action of the Ligand Full agonist

PMIDs: 22650618 22103243 8144028 12529935 17462598 17620721 17479245 17623014 11752352 17534934 8020989

Sources: DTC DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 489538

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8900456

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9808480

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3130065

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2552996

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? True Specific Action of the Ligand Full agonist

PMIDs: 17498508 17475961 17534934 12529935

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17924870

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15530428

Sources: NCI

DrugBank: DB00040

Alternate Names: GLUCAGON DrugBank Drug Name 16941-32-5 CAS Number Baqsimi Drug Brand

Drug Info: Drug Type biotech Drug Groups approved Drug Categories amino acids, peptides, and proteins

GuideToPharmacology: 135651778

Alternate Names: GCG Gene Symbol (for Endogenous Peptides) Gcg Gene Symbol (for Endogenous Peptides) GLUCAGON GuideToPharmacology Ligand Name

Drug Info: Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Publications:

NCI: GLUCAGON

Alternate Names: C520 NCI drug code

Drug Info:

DTC: GLUCAGON

Alternate Names: CHEMBL266481 ChEMBL Drug ID

Drug Info:

ChemblDrugs: chembl:CHEMBL266481

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL266481

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
12364482

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

PMIDs:
11212269 12529935 9990065 17139284 17016423 15817468

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? True

Specific Action of the Ligand Full agonist

PMIDs:
22650618 22103243 8144028 12529935 17462598 17620721 17479245 17623014 11752352 17534934 8020989

Sources:
DTC DrugBank ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
489538

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8900456

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9808480

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3130065

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2552996

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? True

Specific Action of the Ligand Full agonist

PMIDs:
17498508 17475961 17534934 12529935

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
17924870

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15530428

Sources:
NCI

Alternate Names:

GLUCAGON DrugBank Drug Name

16941-32-5 CAS Number

Baqsimi Drug Brand

Drug Info:

Drug Type biotech

Drug Groups approved

Drug Categories amino acids, peptides, and proteins

Alternate Names:

GCG Gene Symbol (for Endogenous Peptides)

Gcg Gene Symbol (for Endogenous Peptides)

GLUCAGON GuideToPharmacology Ligand Name

Drug Info:

Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

Alternate Names:

C520 NCI drug code

Alternate Names:

CHEMBL266481 ChEMBL Drug ID