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GLUCAGON Drug Record

  • Summary
  • Interactions
  • Claims
  • GLUCAGON chembl:CHEMBL266481 Approved

    Alternate Names:

    GLUCAGON
    GLUCAGEN HYPOKIT
    GLUCAGON RECOMBINANT
    GLUCAGON EMERGENCY KIT
    GCG(53-81)
    GLUCAGONUM
    GLUCAGONE
    HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
    drugbank:00040
    pubchem.compound:16186314
    chemidplus:9007-92-5
    chembl:CHEMBL266481

    Drug Info:

    Drug Type biotech
    Drug Groups approved
    Drug Categories amino acids, peptides, and proteins
    Drug Categories antihypoglycemic agent
    Drug Categories decreased gi motility
    Drug Categories decreased gi smooth muscle tone
    Drug Categories decreased glycolysis
    Drug Categories gastrointestinal agents
    Drug Categories gastrointestinal hormones
    Drug Categories gastrointestinal motility inhibitor
    Drug Categories glucagon, antagonists & inhibitors
    Drug Categories glycogenolytic agents
    Drug Categories glycogenolytic hormones
    Drug Categories hormones
    Drug Categories hormones, hormone substitutes, and hormone antagonists
    Drug Categories increased gluconeogenesis
    Drug Categories increased glycogenolysis
    Drug Categories pancreatic hormones
    Drug Categories peptide hormones
    Drug Categories peptides
    Drug Categories proglucagon
    Drug Categories protein precursors
    Drug Categories proteins
    Drug Categories systemic hormonal preparations, excl. sex hormones and insulins
    (2 More Sources)

    Publications:

    Baggio et al., 2007, Biology of incretins: GLP-1 and GIP., Gastroenterology
    Körner et al., 2007, GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting., J. Nucl. Med.
    Fischer et al., 2007, Development of bullwhip neurons in the embryonic chicken retina., J. Comp. Neurol.
    Brubaker et al., 2002, Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors., Recept. Channels
    Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod
    Liu Q et al., 2012, Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor., J Med Chem
    Lok et al., 1994, The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization., Gene
    Katayama et al., 2007, Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach., Biochem. Biophys. Res. Commun.
    Li et al., 2007, Design, synthesis and crystallization of a novel glucagon analog as a therapeutic agent., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
    Winzell et al., 2007, Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet., Diabetologia
    Li et al., 2007, Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise., Clin. Sci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Menzel et al., 1994, Localization of the glucagon receptor gene to human chromosome band 17q25., Genomics
    Yamanaka et al., 2007, Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice., Diabetes Obes Metab
    Janski et al., 1979, Phosphorylation of ATP citrate lyase in response to glucagon., J. Biol. Chem.
    Chen et al., 2004, Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity., Biochem. Biophys. Res. Commun.
    Masumoto et al., 1988, Effects of insulin, dexamethasone and glucagon on the production of apolipoprotein A-I in cultured rat hepatocytes., Atherosclerosis
    Broglio et al., 2002, Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans., J. Clin. Endocrinol. Metab.
    Brown et al., 1989, Glucagon, cyclic AMP and adrenaline stimulate the degradation of low-density lipoprotein by cultured rat hepatocytes., Biochem. J.
    Minor et al., 1998, Enhancement of endogenous cyclic AMP signal: a new approach to allow for cold preservation of rat livers from non-heart-beating donors?, Transplantation
    Hernández et al., 1996, Stimulation of microsomal cholesterol ester hydrolase by glucagon, cyclic AMP analogues, and vasopressin in isolated rat hepatocytes., Lipids
    Boushey et al., 2001, Glucagon-like peptide (GLP)-2 reduces chemotherapy-associated mortality and enhances cell survival in cells expressing a transfected GLP-2 receptor., Cancer Res.
    Munroe et al., 1999, Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2., Proc. Natl. Acad. Sci. U.S.A.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Estall et al., 2005, The glucagon-like peptide-2 receptor C terminus modulates beta-arrestin-2 association but is dispensable for ligand-induced desensitization, endocytosis, and G-protein-dependent effector activation., J. Biol. Chem.
  • GLUCAGON   CORT

    Interaction Score: 10.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12364482


    Sources:
    NCI

  • GLUCAGON   GLP2R

    Interaction Score: 9.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    11212269 12529935 9990065 17139284 17016423 15817468


    Sources:
    DrugBank

  • GLUCAGON   GCGR

    Interaction Score: 6.46

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? True
    Specific Action of the Ligand Full agonist

    PMIDs:
    22650618 22103243 8144028 12529935 17462598 17620721 17479245 17623014 11752352 17534934 8020989


    Sources:
    DTC DrugBank ChemblInteractions GuideToPharmacology

  • GLUCAGON   ACLY

    Interaction Score: 5.16

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    489538


    Sources:
    NCI

  • GLUCAGON   LIPA

    Interaction Score: 2.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8900456


    Sources:
    NCI

  • GLUCAGON   GPT

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9808480


    Sources:
    NCI

  • GLUCAGON   APOA1

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3130065


    Sources:
    NCI

  • GLUCAGON   LDLR

    Interaction Score: 0.49

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2552996


    Sources:
    NCI

  • GLUCAGON   GLP1R

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? True
    Specific Action of the Ligand Full agonist

    PMIDs:
    17498508 17475961 17534934 12529935


    Sources:
    DrugBank GuideToPharmacology

  • GLUCAGON   BDNF

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    17924870


    Sources:
    NCI

  • GLUCAGON   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15530428


    Sources:
    NCI

  • DrugBank: DB00040

    • Version: 5.1.7

    Alternate Names:
    GLUCAGON DrugBank Drug Name
    16941-32-5 CAS Number
    Baqsimi Drug Brand

    Drug Info:
    Drug Type biotech
    Drug Groups approved
    Drug Categories amino acids, peptides, and proteins

    Publications:
    Körner et al., 2007, GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting., J. Nucl. Med.
    Baggio et al., 2007, Biology of incretins: GLP-1 and GIP., Gastroenterology
    Brubaker et al., 2002, Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors., Recept. Channels

  • GuideToPharmacology: 135651778

    • Version: 29-September-2020

    Alternate Names:
    GCG Gene Symbol (for Endogenous Peptides)
    Gcg Gene Symbol (for Endogenous Peptides)
    GLUCAGON GuideToPharmacology Ligand Name

    Drug Info:
    Name of the Ligand Species (if a Peptide) Human|Mouse|Rat

    Publications:

  • NCI: GLUCAGON

    • Version: 14-September-2017

    Alternate Names:
    C520 NCI drug code

    Drug Info:

    Publications:
    Yamanaka et al., 2007, Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice., Diabetes Obes Metab
    Janski et al., 1979, Phosphorylation of ATP citrate lyase in response to glucagon., J. Biol. Chem.
    Masumoto et al., 1988, Effects of insulin, dexamethasone and glucagon on the production of apolipoprotein A-I in cultured rat hepatocytes., Atherosclerosis

  • DTC: GLUCAGON

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL266481 ChEMBL Drug ID

    Drug Info:

    Publications:
    Liu Q et al., 2012, Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor., J Med Chem
    Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod

  • ChemblDrugs: chembl:CHEMBL266481

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL266481

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21