DGIdb - GLUCAGON Drug Record

GLUCAGON chembl:CHEMBL266481 Approved

Alternate Names:

GLUCAGON
GLUCAGEN HYPOKIT
GLUCAGON RECOMBINANT
GLUCAGON EMERGENCY KIT
GCG(53-81)
GLUCAGONUM
GLUCAGONE
HSQGTFTSDYSKYLDSRRAQDFVQWLMNT
drugbank:00040
pubchem.compound:16186314
chemidplus:9007-92-5
chembl:CHEMBL266481

Drug Info:

(0 More Sources)

Publications:

Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod
Liu Q et al., 2012, Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor., J Med Chem
Lok et al., 1994, The human glucagon receptor encoding gene: structure, cDNA sequence and chromosomal localization., Gene
Brubaker et al., 2002, Structure-function of the glucagon receptor family of G protein-coupled receptors: the glucagon, GIP, GLP-1, and GLP-2 receptors., Recept. Channels
Katayama et al., 2007, Glucagon receptor expression and glucagon stimulation of ghrelin secretion in rat stomach., Biochem. Biophys. Res. Commun.
Li et al., 2007, Design, synthesis and crystallization of a novel glucagon analog as a therapeutic agent., Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.
Winzell et al., 2007, Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet., Diabetologia
Li et al., 2007, Targeting glucagon receptor signalling in treating metabolic syndrome and renal injury in Type 2 diabetes: theory versus promise., Clin. Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Fischer et al., 2007, Development of bullwhip neurons in the embryonic chicken retina., J. Comp. Neurol.
Menzel et al., 1994, Localization of the glucagon receptor gene to human chromosome band 17q25., Genomics
Yamanaka et al., 2007, Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice., Diabetes Obes Metab
Janski et al., 1979, Phosphorylation of ATP citrate lyase in response to glucagon., J. Biol. Chem.
Chen et al., 2004, Glucagon release is regulated by tyrosine phosphatase and PI3-kinase activity., Biochem. Biophys. Res. Commun.
Masumoto et al., 1988, Effects of insulin, dexamethasone and glucagon on the production of apolipoprotein A-I in cultured rat hepatocytes., Atherosclerosis
Broglio et al., 2002, Ghrelin secretion is inhibited by either somatostatin or cortistatin in humans., J. Clin. Endocrinol. Metab.
Brown et al., 1989, Glucagon, cyclic AMP and adrenaline stimulate the degradation of low-density lipoprotein by cultured rat hepatocytes., Biochem. J.
Minor et al., 1998, Enhancement of endogenous cyclic AMP signal: a new approach to allow for cold preservation of rat livers from non-heart-beating donors?, Transplantation
Hernández et al., 1996, Stimulation of microsomal cholesterol ester hydrolase by glucagon, cyclic AMP analogues, and vasopressin in isolated rat hepatocytes., Lipids

GLUCAGON CORT

Interaction Score: 13.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12364482

Sources:
NCI
GLUCAGON GCGR

Interaction Score: 8.12

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucagon receptor agonist

PMIDs:
22650618 22103243 8144028 12529935 17462598 17620721 17479245 17623014 11752352 17534934 8020989

Sources:
DTC ChemblInteractions
GLUCAGON GPT

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9808480

Sources:
NCI
GLUCAGON ACLY

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
489538

Sources:
NCI
GLUCAGON LIPA

Interaction Score: 2.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8900456

Sources:
NCI
GLUCAGON APOA1

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3130065

Sources:
NCI
GLUCAGON LDLR

Interaction Score: 0.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2552996

Sources:
NCI
GLUCAGON BDNF

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17924870

Sources:
NCI
GLUCAGON PIK3CG

Interaction Score: 0.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15530428

Sources:
NCI

NCI: GLUCAGON

Version: 14-September-2017

Alternate Names:

C520 NCI drug code

Drug Info:

Publications:

Yamanaka et al., 2007, Comparison of the antidiabetic effects of brain-derived neurotrophic factor and thiazolidinediones in obese diabetic mice., Diabetes Obes Metab

Janski et al., 1979, Phosphorylation of ATP citrate lyase in response to glucagon., J. Biol. Chem.

Masumoto et al., 1988, Effects of insulin, dexamethasone and glucagon on the production of apolipoprotein A-I in cultured rat hepatocytes., Atherosclerosis

DTC: GLUCAGON

Version: 02-September-2020

Alternate Names:

CHEMBL266481 ChEMBL Drug ID

Drug Info:

Publications:

Liu Q et al., 2012, Cyclobutane derivatives as novel nonpeptidic small molecule agonists of glucagon-like peptide-1 receptor., J Med Chem

Cui L et al., 2012, Rediocide A, an Insecticide, induces G-protein-coupled receptor desensitization via activation of conventional protein kinase C., J Nat Prod

ChemblDrugs: chembl:CHEMBL266481
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL266481
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Glucagon receptor agonist

GLUCAGON Drug Record

GLUCAGON chembl:CHEMBL266481 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12364482

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glucagon receptor agonist

PMIDs: 22650618 22103243 8144028 12529935 17462598 17620721 17479245 17623014 11752352 17534934 8020989

Sources: DTC ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9808480

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 489538

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8900456

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3130065

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2552996

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17924870

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15530428

Sources: NCI

NCI: GLUCAGON

Alternate Names: C520 NCI drug code

Drug Info:

DTC: GLUCAGON

Alternate Names: CHEMBL266481 ChEMBL Drug ID

Drug Info:

ChemblDrugs: chembl:CHEMBL266481

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL266481

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
12364482

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glucagon receptor agonist

PMIDs:
22650618 22103243 8144028 12529935 17462598 17620721 17479245 17623014 11752352 17534934 8020989

Sources:
DTC ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
9808480

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
489538

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8900456

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3130065

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2552996

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
17924870

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15530428

Sources:
NCI

Alternate Names:

C520 NCI drug code

Alternate Names:

CHEMBL266481 ChEMBL Drug ID