DGIdb - FUROSEMIDE Drug Record

FUROSEMIDE chembl:CHEMBL35 Approved

Alternate Names:

AQUAMED
FRUSEMIDE
FROOP
LASIX RET
RUSYDE
LASIX
FRUMIL
TENKOFRUSE
FRUSID
LB-502
NSC-269420
ALUZINE 40
DISAL
ALUZINE 500
FRUMAX
FRUSOL
HYDROLED
FRUSETIC
DRYPTAL
DIURESAL
FUROSEMIDE
ALUZINE 20
FUROSEMID
DIHYDROFLUMETHIAZIDE
METHFORYLTHIAZIDINE
FUROSEMIDU
2-FURFURYLAMINO-4-CHLORO-5-SULFAMOYLBENZOIC ACID
4-CHLORO-N-(2-FURYLMETHYL)-5-SULFAMOYLANTHRANILIC ACID
4-CHLORO-5-SULFAMOYL-N-FURFURYL-ANTHRANILIC ACID
LASIX (TN)
FUROSEMIDA
LASIX®
FUROSEMIDUM
4-CHLORO-N-FURFURYL-5-SULFAMOYLANTHRANILIC ACID
pubchem.compound:3440
rxcui:4603
chembl:CHEMBL35
drugbank:00695
chemidplus:54-31-9

Drug Info:

Year of Approval	1966
Drug Class	antihypertensive agents
Drug Class	diuretics
Drug Categories	sulfanilamides
FDA Approval	1966
Drug Indications	Diuretics
Drug Indications	Antihypertensive Agents
Drug Class	small molecule
Drug Categories	antihypertensive agents
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	drugs that are mainly renally excreted
Drug Categories	high-ceiling diuretics and potassium-sparing agents
Drug Categories	increased diuresis at loop of henle
Drug Categories	nephrotoxic agents
Drug Categories	non potassium sparing diuretics
Drug Categories	oat1/slc22a6 inhibitors
Drug Categories	oat3/slc22a8 inhibitors
Drug Categories	ototoxic agents
Drug Categories	photosensitizing agents
Drug Categories	thyroxine-binding globulin substrates
Drug Categories	ugt1a1 substrates

(5 More Sources)

Publications:

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.
Limmer F et al., 2015, Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration., FEBS J
Davies et al., 1975, Diuretics: mechanism of action and clinical application., Drugs
Giménez I, 2006, Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters., Curr Opin Nephrol Hypertens
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Brater, 2000, Pharmacology of diuretics., Am. J. Med. Sci.
Elwood et al., 1991, Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways., Am. Rev. Respir. Dis.
Molimard et al., 1995, Furosemide inhibits bradykinin-induced contraction of human bronchi: role of thromboxane A2 receptor antagonism., Eur. J. Pharmacol.
Ranjbar S et al., 2012, Spectroscopic characterization of furosemide binding to human carbonic anhydrase II., Int J Biol Macromol
Supuran, 2008, Diuretics: from classical carbonic anhydrase inhibitors to novel applications of the sulfonamides., Curr. Pharm. Des.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Chandan et al., 1988, Actions of gastrin-releasing peptide and related mammalian and amphibian peptides on ion transport in the porcine proximal jejunum., Regul. Pept.
de Denus S et al., 2017, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials., Pharmacogenomics J
Yang YY et al., 2011, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites., Clin Sci (Lond)
Benvenga et al., 1992, Thyroxine binding to the apolipoproteins of high density lipoproteins HDL2 and HDL3., Endocrinology
Yang et al., 2012, GPR35 is a target of the loop diuretic drugs bumetanide and furosemide., Pharmacology
Divorty N et al., 2018, The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice., Am J Hypertens
Divorty N et al., 2015, G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease., Front Pharmacol

FUROSEMIDE SLC12A1

Interaction Score: 3.25

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs:
17460608 26183401 1092541 16914965 11752352 10653443

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
FUROSEMIDE NPPA-AS1

Interaction Score: 2.71

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
FUROSEMIDE ADD1

Interaction Score: 2.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298 21692745

Sources:
PharmGKB
FUROSEMIDE GPR35

Interaction Score: 1.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
22236570 29860395 25805994

Sources:
DrugBank GuideToPharmacology
FUROSEMIDE GRP

Interaction Score: 1.16

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3238049

Sources:
NCI
FUROSEMIDE SLC12A2

Interaction Score: 0.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
FUROSEMIDE APOA1

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1446618

Sources:
NCI
FUROSEMIDE SLC12A3

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298 17460608

Sources:
PharmGKB
FUROSEMIDE GNB3

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
FUROSEMIDE TAC1

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2048822

Sources:
NCI
FUROSEMIDE TBXA2R

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7589163

Sources:
NCI
FUROSEMIDE ABCC4

Interaction Score: 0.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26927285

Sources:
PharmGKB
FUROSEMIDE CA2

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
22343084 18336309 10592235

Sources:
DrugBank
FUROSEMIDE ACE

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB

DrugBank: DB00695

Version: 5.1.7

Alternate Names:

FUROSEMIDE DrugBank Drug Name

54-31-9 CAS Number

Active-Medicated specimen collection kit Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Publications:

Yang et al., 2012, GPR35 is a target of the loop diuretic drugs bumetanide and furosemide., Pharmacology

Divorty N et al., 2018, The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice., Am J Hypertens

Divorty N et al., 2015, G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease., Front Pharmacol

TEND: FUROSEMIDE
- Version: 01-August-2011
Alternate Names:

FUROSEMIDE Primary Drug Name

Drug Info:

Drug Class diuretics

Drug Class antihypertensive agents

Year of Approval 1966

Publications:
TdgClinicalTrial: FUROSEMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class small molecule

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Publications:

NCI: FUROSEMIDE

Version: 14-September-2017

Alternate Names:

C515 NCI drug code

Drug Info:

Publications:

Chandan et al., 1988, Actions of gastrin-releasing peptide and related mammalian and amphibian peptides on ion transport in the porcine proximal jejunum., Regul. Pept.

Benvenga et al., 1992, Thyroxine binding to the apolipoproteins of high density lipoproteins HDL2 and HDL3., Endocrinology

Elwood et al., 1991, Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways., Am. Rev. Respir. Dis.

PharmGKB: furosemide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J

de Denus S et al., 2017, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials., Pharmacogenomics J

Yang YY et al., 2011, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites., Clin Sci (Lond)

GuideToPharmacology: 178101541
- Version: 29-September-2020
Alternate Names:

FUROSEMIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Furosemide
- Version: 2020.06.01
Alternate Names:

D0PQ3G TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL35
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL35
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Sodium-(potassium)-chloride cotransporter 2 inhibitor

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

FUROSEMIDE	DrugBank Drug Name
54-31-9	CAS Number
Active-Medicated specimen collection kit	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	vet_approved

FUROSEMIDE Drug Record

FUROSEMIDE chembl:CHEMBL35 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs: 17460608 26183401 1092541 16914965 11752352 10653443

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298 21692745

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False

PMIDs: 22236570 29860395 25805994

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3238049

Sources: NCI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1446618

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298 17460608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2048822

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7589163

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26927285

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 22343084 18336309 10592235

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

DrugBank: DB00695

Alternate Names: FUROSEMIDE DrugBank Drug Name 54-31-9 CAS Number Active-Medicated specimen collection kit Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups vet_approved

TEND: FUROSEMIDE

Alternate Names: FUROSEMIDE Primary Drug Name

Drug Info: Drug Class diuretics Drug Class antihypertensive agents Year of Approval 1966

Publications:

TdgClinicalTrial: FUROSEMIDE

Alternate Names:

Drug Info: Drug Class small molecule Drug Indications Antihypertensive Agents Drug Indications Diuretics

Publications:

NCI: FUROSEMIDE

Alternate Names: C515 NCI drug code

Drug Info:

PharmGKB: furosemide

Alternate Names:

Drug Info:

GuideToPharmacology: 178101541

Alternate Names: FUROSEMIDE GuideToPharmacology Ligand Name

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs:
17460608 26183401 1092541 16914965 11752352 10653443

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298 21692745

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
22236570 29860395 25805994

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
3238049

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
1446618

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20877298 17460608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
2048822

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
7589163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26927285

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
22343084 18336309 10592235

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Alternate Names:

FUROSEMIDE DrugBank Drug Name

54-31-9 CAS Number

Active-Medicated specimen collection kit Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups vet_approved

Alternate Names:

FUROSEMIDE Primary Drug Name

Drug Info:

Drug Class diuretics

Drug Class antihypertensive agents

Year of Approval 1966

Drug Info:

Drug Class small molecule

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Alternate Names:

C515 NCI drug code

Alternate Names:

FUROSEMIDE GuideToPharmacology Ligand Name

Alternate Names:

D0PQ3G TTD Drug ID