DGIdb - FUROSEMIDE Drug Record

FUROSEMIDE chembl:CHEMBL35 Approved

Alternate Names:

AQUAMED
FRUSEMIDE
FROOP
LASIX RET
RUSYDE
LASIX
FRUMIL
TENKOFRUSE
FRUSID
LB-502
NSC-269420
ALUZINE 40
DISAL
ALUZINE 500
FRUMAX
FRUSOL
HYDROLED
FRUSETIC
DRYPTAL
DIURESAL
FUROSEMIDE
ALUZINE 20
FUROSEMID
DIHYDROFLUMETHIAZIDE
METHFORYLTHIAZIDINE
FUROSEMIDU
2-FURFURYLAMINO-4-CHLORO-5-SULFAMOYLBENZOIC ACID
4-CHLORO-N-(2-FURYLMETHYL)-5-SULFAMOYLANTHRANILIC ACID
4-CHLORO-5-SULFAMOYL-N-FURFURYL-ANTHRANILIC ACID
LASIX (TN)
FUROSEMIDA
LASIX®
FUROSEMIDUM
4-CHLORO-N-FURFURYL-5-SULFAMOYLANTHRANILIC ACID
pubchem.compound:3440
rxcui:4603
chembl:CHEMBL35
drugbank:00695
chemidplus:54-31-9

Drug Info:

Year of Approval	1966
Drug Class	antihypertensive agents
Drug Class	diuretics
FDA Approval	1966
Drug Indications	Diuretics
Drug Indications	Antihypertensive Agents
Drug Class	small molecule

(4 More Sources)

Publications:

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J
Davies et al., 1975, Diuretics: mechanism of action and clinical application., Drugs
Brater, 2000, Pharmacology of diuretics., Am. J. Med. Sci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Vormfelde et al., 2007, Genetic variation in the renal sodium transporters NKCC2, NCC, and ENaC in relation to the effects of loop diuretic drugs., Clin. Pharmacol. Ther.
Limmer F et al., 2015, Regulation of the Na(+)-K(+)-2Cl(-) cotransporter by cGMP/cGMP-dependent protein kinase I after furosemide administration., FEBS J
Giménez I, 2006, Molecular mechanisms and regulation of furosemide-sensitive Na-K-Cl cotransporters., Curr Opin Nephrol Hypertens
Elwood et al., 1991, Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways., Am. Rev. Respir. Dis.
Molimard et al., 1995, Furosemide inhibits bradykinin-induced contraction of human bronchi: role of thromboxane A2 receptor antagonism., Eur. J. Pharmacol.
Chandan et al., 1988, Actions of gastrin-releasing peptide and related mammalian and amphibian peptides on ion transport in the porcine proximal jejunum., Regul. Pept.
de Denus S et al., 2017, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials., Pharmacogenomics J
Yang YY et al., 2011, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites., Clin Sci (Lond)
Benvenga et al., 1992, Thyroxine binding to the apolipoproteins of high density lipoproteins HDL2 and HDL3., Endocrinology
Divorty N et al., 2015, G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease., Front Pharmacol
Yang et al., 2012, GPR35 is a target of the loop diuretic drugs bumetanide and furosemide., Pharmacology
Divorty N et al., 2018, The Orphan Receptor GPR35 Contributes to Angiotensin II-Induced Hypertension and Cardiac Dysfunction in Mice., Am J Hypertens

FUROSEMIDE SLC12A1

Interaction Score: 3.86

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs:
1092541 10653443 11752352 17460608 26183401 16914965

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
FUROSEMIDE NPPA-AS1

Interaction Score: 3.27

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
FUROSEMIDE ADD1

Interaction Score: 2.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21692745 20877298

Sources:
PharmGKB
FUROSEMIDE SLC12A2

Interaction Score: 1.64

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
FUROSEMIDE GRP

Interaction Score: 1.4

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3238049

Sources:
NCI
FUROSEMIDE GPR35

Interaction Score: 1.31

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
25805994 22236570 29860395

Sources:
GuideToPharmacology
FUROSEMIDE APOA1

Interaction Score: 1.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1446618

Sources:
NCI
FUROSEMIDE SLC12A3

Interaction Score: 0.82

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298 17460608

Sources:
PharmGKB
FUROSEMIDE GNB3

Interaction Score: 0.75

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB
FUROSEMIDE TBXA2R

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7589163

Sources:
NCI
FUROSEMIDE TAC1

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2048822

Sources:
NCI
FUROSEMIDE ABCC4

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26927285

Sources:
PharmGKB
FUROSEMIDE ACE

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
20877298

Sources:
PharmGKB

TEND: FUROSEMIDE
- Version: 01-August-2011
Alternate Names:

FUROSEMIDE Primary Drug Name

Drug Info:

Drug Class diuretics

Drug Class antihypertensive agents

Year of Approval 1966

Publications:
TdgClinicalTrial: FUROSEMIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class small molecule

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Publications:

NCI: FUROSEMIDE

Version: 14-September-2017

Alternate Names:

C515 NCI drug code

Drug Info:

Publications:

Chandan et al., 1988, Actions of gastrin-releasing peptide and related mammalian and amphibian peptides on ion transport in the porcine proximal jejunum., Regul. Pept.

Benvenga et al., 1992, Thyroxine binding to the apolipoproteins of high density lipoproteins HDL2 and HDL3., Endocrinology

Elwood et al., 1991, Loop diuretics inhibit cholinergic and noncholinergic nerves in guinea pig airways., Am. Rev. Respir. Dis.

PharmGKB: furosemide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Vormfelde SV et al., 2012, The genetics of loop diuretic effects., Pharmacogenomics J

de Denus S et al., 2017, A pharmacogenetic investigation of intravenous furosemide in decompensated heart failure: a meta-analysis of three clinical trials., Pharmacogenomics J

Yang YY et al., 2011, Identification of diuretic non-responders with poor long-term clinical outcomes: a 1-year follow-up of 176 non-azotaemic cirrhotic patients with moderate ascites., Clin Sci (Lond)

GuideToPharmacology: 178101541
- Version: 29-September-2020
Alternate Names:

FUROSEMIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Furosemide
- Version: 2020.06.01
Alternate Names:

D0PQ3G TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL35
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL35
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	-
Mechanism of Interaction	Sodium-(potassium)-chloride cotransporter 2 inhibitor

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Direct Interaction?	False

FUROSEMIDE Drug Record

FUROSEMIDE chembl:CHEMBL35 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name - Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs: 1092541 10653443 11752352 17460608 26183401 16914965

Sources: TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21692745 20877298

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3238049

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False

PMIDs: 25805994 22236570 29860395

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1446618

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298 17460608

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7589163

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2048822

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26927285

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 20877298

Sources: PharmGKB

TEND: FUROSEMIDE

Alternate Names: FUROSEMIDE Primary Drug Name

Drug Info: Drug Class diuretics Drug Class antihypertensive agents Year of Approval 1966

Publications:

TdgClinicalTrial: FUROSEMIDE

Alternate Names:

Drug Info: Drug Class small molecule Drug Indications Antihypertensive Agents Drug Indications Diuretics

Publications:

NCI: FUROSEMIDE

Alternate Names: C515 NCI drug code

Drug Info:

PharmGKB: furosemide

Alternate Names:

Drug Info:

GuideToPharmacology: 178101541

Alternate Names: FUROSEMIDE GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Furosemide

Alternate Names: D0PQ3G TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name -

Mechanism of Interaction Sodium-(potassium)-chloride cotransporter 2 inhibitor

PMIDs:
1092541 10653443 11752352 17460608 26183401 16914965

Sources:
TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21692745 20877298

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
3238049

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

PMIDs:
25805994 22236570 29860395

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
1446618

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
20877298 17460608

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
7589163

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
2048822

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
26927285

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
20877298

Sources:
PharmGKB

Alternate Names:

FUROSEMIDE Primary Drug Name

Drug Info:

Drug Class diuretics

Drug Class antihypertensive agents

Year of Approval 1966

Drug Info:

Drug Class small molecule

Drug Indications Antihypertensive Agents

Drug Indications Diuretics

Alternate Names:

C515 NCI drug code

Alternate Names:

FUROSEMIDE GuideToPharmacology Ligand Name

Alternate Names:

D0PQ3G TTD Drug ID