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FOSTAMATINIB Drug Record

  • Summary
  • Interactions
  • Claims
  • FOSTAMATINIB chembl:CHEMBL2103830 ApprovedAntineoplastic

    Alternate Names:

    R-935788
    R-788 FREE ACID
    FOSTAMATINIB
    R-935788 FREE ACID
    R-788
    TAMATINIB FOSDIUM
    R7935788
    R 788
    drugbank:12010
    chemidplus:901119-35-5
    chembl:CHEMBL2103830
    pubchem.compound:11671467

    Drug Info:

    Drug Class Kinase Inhibitors
    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications antiinflammatory agent,DMARD
    (2 More Sources)

    Publications:

    Rolf MG et al., 2015, In vitro pharmacological profiling of R406 identifies molecular targets underlying the clinical effects of fostamatinib., Pharmacol Res Perspect
    Braselmann S et al., 2006, R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation., J Pharmacol Exp Ther
    Zhang et al., 2012, A novel retinoblastoma therapy from genomic and epigenetic analyses., Nature
  • FOSTAMATINIB   SYK

    Interaction Score: 6.62

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name Fostamatinib
    Novel drug target Novel Target
    Mechanism of Interaction Tyrosine-protein kinase SYK inhibitor

    PMIDs:
    26516587 16946104


    Sources:
    MyCancerGenome TdgClinicalTrial ChemblInteractions TTD

  • FOSTAMATINIB   RB1

    Interaction Score: 2.81

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type retinoblastoma
    Response Type sensitive
    Approval Status Preclinical

    PMIDs:
    22237022


    Sources:
    JAX-CKB

  • MyCancerGenome: FOSTAMATINIB

    • Version: 20-Jun-2017

    Alternate Names:
    FOSTAMATINIB Generic Name

    Drug Info:
    Drug Class Kinase Inhibitors

    Publications:

  • TdgClinicalTrial: FOSTAMATINIB

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antiinflammatory agent,DMARD
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • JAX-CKB: Fostamatinib

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Zhang et al., 2012, A novel retinoblastoma therapy from genomic and epigenetic analyses., Nature

  • TTD: Fostamatinib

    • Version: 2020.06.01

    Alternate Names:
    D0V8HJ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL2103830

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL2103830

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21