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FORETINIB Drug Record

  • Summary
  • Interactions
  • Claims
  • FORETINIB chembl:CHEMBL1230609 Antineoplastic

    Alternate Names:

    EXEL-2880
    XL880
    GSK-1363089G
    GSK1363089G
    XL-880
    GSK089
    GSK1363089
    FORETINIB
    GSK 1363089G
    XL 880
    chembl:CHEMBL1230609
    drugbank:12307
    chemidplus:849217-64-7
    pubchem.compound:42642645

    Drug Info:

    Pharmaceutical Developer GlaxoSmithKline
    Source Reported Drug Name(s) GSK1363089
    Drug Class MET/VEGFR Inhibitor
    Drug Class Kinase Inhibitors
    FDA Approval not approved
    Drug Class small molecule
    Drug Indications antineoplastic agent
    Drug Categories amides
    Drug Categories amines
    Drug Categories aniline compounds
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories receptors, vascular endothelial growth factor, antagonists & inhibitors
    Drug Categories tyrosine kinase inhibitors
    (9 More Sources)

    Publications:

    Choueiri et al., 2013, Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma., J. Clin. Oncol.
    Du et al., 2016, Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors., Nat. Med.
    Song et al., 2015, Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer., Clin. Cancer Res.
    Davare et al., 2015, Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors., Proc. Natl. Acad. Sci. U.S.A.
  • FORETINIB   PTCH1

    Interaction Score: 1.35

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family MET inhibitor
    Alteration PTCH1:.

    PMIDs:
    None found


    Sources:
    CGI

  • FORETINIB   ROS1

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25688157 26372962


    Sources:
    CIViC

  • FORETINIB   MET

    Interaction Score: 0.38

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Approval Status Preclinical
    combination therapy Foretinib + Rucaparib
    Evidence Type Actionable

    PMIDs:
    23213094 26779812


    Sources:
    CancerCommons JAX-CKB TdgClinicalTrial CIViC TTD TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • FORETINIB   HGF

    Interaction Score: 0.24

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • FORETINIB   KDR

    Interaction Score: 0.19

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • FORETINIB   TEK

    Interaction Score: 0.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase TIE-2 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FORETINIB   MST1R

    Interaction Score: 0.15

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Notes

    PMIDs:
    None found


    Sources:
    TALC

  • FORETINIB   FLT1

    Interaction Score: 0.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    MyCancerGenome GuideToPharmacology ChemblInteractions

  • FORETINIB   FLT4

    Interaction Score: 0.13

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    MyCancerGenome GuideToPharmacology ChemblInteractions

  • FORETINIB   PDGFRA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Platelet-derived growth factor receptor inhibitor

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FORETINIB   KIT

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Stem cell growth factor receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FORETINIB   PDGFRB

    Interaction Score: 0.05

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Platelet-derived growth factor receptor inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FORETINIB   FLT3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Tyrosine-protein kinase receptor FLT3 inhibitor
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FORETINIB   YES1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • CancerCommons: GSK1363089

    • Version: 25-July-2013

    Alternate Names:
    GSK1363089 PubChem Drug Name
    42642645 PubChem Drug ID
    Foretinib Drug Trade Name

    Drug Info:
    Drug Class MET/VEGFR Inhibitor
    Source Reported Drug Name(s) GSK1363089
    Pharmaceutical Developer GlaxoSmithKline

    Publications:

  • MyCancerGenome: FORETINIB

    • Version: 20-Jun-2017

    Alternate Names:
    EXEL-2880 Development Name
    GSK1363089 Development Name
    XL880 Development Name

    Drug Info:
    Drug Class Kinase Inhibitors

    Publications:

  • DrugBank: DB12307

    • Version: 5.1.7

    Alternate Names:
    FORETINIB DrugBank Drug Name
    849217-64-7 CAS Number
    CHEMBL1230609 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups investigational
    Drug Categories amides

    Publications:

  • TdgClinicalTrial: XL880

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class small molecule
    FDA Approval not approved

    Publications:

  • JAX-CKB: Foretinib

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Du et al., 2016, Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors., Nat. Med.

  • CIViC: FORETINIB

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Choueiri et al., 2013, Phase II and biomarker study of the dual MET/VEGFR2 inhibitor foretinib in patients with papillary renal cell carcinoma., J. Clin. Oncol.
    Song et al., 2015, Molecular Changes Associated with Acquired Resistance to Crizotinib in ROS1-Rearranged Non-Small Cell Lung Cancer., Clin. Cancer Res.
    Davare et al., 2015, Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors., Proc. Natl. Acad. Sci. U.S.A.

  • TTD: XL880

    • Version: 2020.06.01

    Alternate Names:
    D0D1GF TTD Drug ID

    Drug Info:

    Publications:

  • TALC: FORETINIB

    • Version: 12-May-2016

    Alternate Names:
    FORETINIB Primary Drug Name
    FORETINIB Drug Generic Name
    GSK1363089 Drug Synonym

    Drug Info:

    Publications:

  • DTC: FORETINIB

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1230609 ChEMBL Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 178102306

    • Version: 29-September-2020

    Alternate Names:
    FORETINIB GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1230609

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1230609

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • CGI: Foretinib

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21