DGIdb - FLURBIPROFEN Drug Record

FLURBIPROFEN chembl:CHEMBL563 Approved

Alternate Names:

STREFEN
U-27182
BTS-18322
ANSAID
FROBEN
BTS 18322
FLURBIPROFEN
TRANSACT
FLUBIPROFEN
CEBUTID
FROBEN SR
OCUFEN
FLURBIPROFENO
2-(2-FLUOROBIPHENYL-4-YL)PROPANOIC ACID
ANSAID®
FLURBIPROFENE
(+-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID
2-FLUORO-ALPHA-METHYL-(1,1'-BIPHENYL)-4-ACETIC ACID
FLURBIPROFENUM
3-FLUORO-4-PHENYLHYDRATROPIC ACID
FLP
S-FLURBIPROFEN
FROBEN®
rxcui:4502
drugbank:00712
chemidplus:5104-49-4
pubchem.compound:3394
chembl:CHEMBL563

Drug Info:

Drug Class	anti-inflammatory agents, non-steroidal
Year of Approval	1986
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiinflammatory agent,NSAID
Drug Categories	agents causing hyperkalemia
Drug Categories	agents that produce hypertension
Drug Categories	anti-inflammatory agents, non-steroidal (non-selective)
Drug Categories	antiinflammatory and antirheumatic products
Drug Categories	antiinflammatory and antirheumatic products, non-steroids
Drug Categories	antiinflammatory preparations, non-steroids for topical use
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs causing inadvertant photosensitivity
Drug Categories	drugs that are mainly renally excreted
Drug Categories	musculo-skeletal system
Drug Categories	nephrotoxic agents
Drug Categories	non cox-2 selective nsaids
Drug Categories	oat1/slc22a6 inhibitors
Drug Categories	other nonsteroidal anti-inflammatory agents
Drug Categories	photosensitizing agents
Drug Categories	throat preparations
Drug Categories	topical products for joint and muscular pain
Drug Categories	ugt1a1 inhibitors
Drug Categories	ugt1a1 substrates
Drug Categories	ugt1a3 substrates
Drug Categories	ugt1a9 substrates
Drug Categories	ugt2b7 substrates

(7 More Sources)

Publications:

Smith et al., 2000, Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2)., J. Biol. Chem.
Bayly et al., 1999, Structure-based design of COX-2 selectivity into flurbiprofen., Bioorg. Med. Chem. Lett.
Hinz et al., 2001, Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages., Pharm. Res.
Basselin et al., 2007, Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats., Neurochem. Res.
van Haeringen et al., 2000, Constitutive cyclooxygenase-1 and induced cyclooxygenase-2 in isolated human iris inhibited by S(+) flurbiprofen., J Ocul Pharmacol Ther
Nivsarkar et al., Cyclooxygenase inhibitors: a novel direction for Alzheimer's management., Pharmacol Rep
Hewett et al., 2000, Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture., J. Pharmacol. Exp. Ther.
Kurahashi et al., 2001, Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites., J. Cardiovasc. Pharmacol.
Klegeris et al., Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity., Neurobiol. Aging
Dröge et al., Alternative splicing of cyclooxygenase-1 mRNA in the human iris., Ophthalmic Res.
Rieke et al., 1999, The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors., J. Biol. Chem.
Wang H et al., 2011, Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen., Biochem Pharmacol
Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.
McDonald MG et al., 2020, Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People., J Pharmacol Exp Ther
Lee YJ et al., 2015, Effects of CYP2C91/3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects., Arch Pharm Res
Lee CR et al., 2003, Differences in flurbiprofen pharmacokinetics between CYP2C91/1, 1/2, and 1/3 genotypes., Eur J Clin Pharmacol

FLURBIPROFEN PTGS2

Interaction Score: 1.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name HCT 1026, NO-flurbiprofen

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
11006278 10091674 11405284 17562170 10977131 19066416 10773011

Sources:
DTC DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD
FLURBIPROFEN PTGS1

Interaction Score: 0.95

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources:
DrugBank ChemblInteractions TEND GuideToPharmacology
FLURBIPROFEN UGT2B7

Interaction Score: 0.9

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21856293

Sources:
PharmGKB
FLURBIPROFEN BDNF

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16531049

Sources:
NCI
FLURBIPROFEN CYP2C9

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
32423989 25712887 12698304

Sources:
PharmGKB FDA
FLURBIPROFEN TARDBP

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00712

Version: 5.1.7

Alternate Names:

5104-49-4 CAS Number

Acustop Cataplasma Drug Brand

Adofeed Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Kurahashi et al., 2001, Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites., J. Cardiovasc. Pharmacol.

Klegeris et al., Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity., Neurobiol. Aging

Nivsarkar et al., Cyclooxygenase inhibitors: a novel direction for Alzheimer's management., Pharmacol Rep

TEND: FLURBIPROFEN
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 1986

Drug Class anti-inflammatory agents, non-steroidal

Publications:
TdgClinicalTrial: FLURBIPROFEN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent,NSAID

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: FLURBIPROFEN

Version: 14-September-2017

Alternate Names:

C508 NCI drug code

Drug Info:

Publications:

Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.

PharmGKB: flurbiprofen

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Lee CR et al., 2003, Differences in flurbiprofen pharmacokinetics between CYP2C91/1, 1/2, and 1/3 genotypes., Eur J Clin Pharmacol

Lee YJ et al., 2015, Effects of CYP2C91/3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects., Arch Pharm Res

McDonald MG et al., 2020, Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People., J Pharmacol Exp Ther

DTC: FLURBIPROFEN
- Version: 02-September-2020
Alternate Names:

CHEMBL563 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Flurbiprofen
- Version: 2020.06.01
Alternate Names:

D0A1PX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL563
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 178101011
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:
FDA: Flurbiprofen
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL563
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Established target
Trial Name	HCT 1026, NO-flurbiprofen
Mechanism of Interaction	Cyclooxygenase inhibitor

Mechanism of Interaction	Cyclooxygenase inhibitor
Direct Interaction	yes
Specific Action of the Ligand	Inhibition

5104-49-4	CAS Number
Acustop Cataplasma	Drug Brand
Adofeed	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

FLURBIPROFEN Drug Record

FLURBIPROFEN chembl:CHEMBL563 Approved

Alternate Names:

Drug Info:

Publications:

FLURBIPROFEN PTGS2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name HCT 1026, NO-flurbiprofen Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs: 11006278 10091674 11405284 17562170 10977131 19066416 10773011

Sources: DTC DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

FLURBIPROFEN PTGS1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes Specific Action of the Ligand Inhibition

PMIDs: 11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources: DrugBank ChemblInteractions TEND GuideToPharmacology

FLURBIPROFEN UGT2B7

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21856293

Sources: PharmGKB

FLURBIPROFEN BDNF

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16531049

Sources: NCI

FLURBIPROFEN CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 32423989 25712887 12698304

Sources: PharmGKB FDA

FLURBIPROFEN TARDBP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00712

Alternate Names: 5104-49-4 CAS Number Acustop Cataplasma Drug Brand Adofeed Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: FLURBIPROFEN

Alternate Names:

Drug Info: Year of Approval 1986 Drug Class anti-inflammatory agents, non-steroidal

Publications:

TdgClinicalTrial: FLURBIPROFEN

Alternate Names:

Drug Info: Drug Indications antiinflammatory agent,NSAID Drug Class Small Molecule FDA Approval approved

Publications:

NCI: FLURBIPROFEN

Alternate Names: C508 NCI drug code

Drug Info:

Publications: Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.

PharmGKB: flurbiprofen

Alternate Names:

Drug Info:

DTC: FLURBIPROFEN

Alternate Names: CHEMBL563 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Flurbiprofen

Alternate Names: D0A1PX TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL563

Alternate Names:

Drug Info:

Publications:

GuideToPharmacology: 178101011

Alternate Names:

Drug Info:

Publications:

FDA: Flurbiprofen

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL563

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name HCT 1026, NO-flurbiprofen

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
11006278 10091674 11405284 17562170 10977131 19066416 10773011

Sources:
DTC DrugBank TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

Specific Action of the Ligand Inhibition

PMIDs:
11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources:
DrugBank ChemblInteractions TEND GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
21856293

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16531049

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
32423989 25712887 12698304

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

5104-49-4 CAS Number

Acustop Cataplasma Drug Brand

Adofeed Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Drug Info:

Year of Approval 1986

Drug Class anti-inflammatory agents, non-steroidal

Drug Info:

Drug Indications antiinflammatory agent,NSAID

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C508 NCI drug code

Publications:

Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.

Alternate Names:

CHEMBL563 ChEMBL Drug ID

Alternate Names:

D0A1PX TTD Drug ID