DGIdb - FLURBIPROFEN Drug Record

FLURBIPROFEN chembl:CHEMBL563 Approved

Alternate Names:

STREFEN
U-27182
BTS-18322
ANSAID
FROBEN
BTS 18322
FLURBIPROFEN
TRANSACT
FLUBIPROFEN
CEBUTID
FROBEN SR
OCUFEN
FLURBIPROFENO
2-(2-FLUOROBIPHENYL-4-YL)PROPANOIC ACID
ANSAID®
FLURBIPROFENE
(+-)-2-FLUORO-ALPHA-METHYL-4-BIPHENYLACETIC ACID
2-FLUORO-ALPHA-METHYL-(1,1'-BIPHENYL)-4-ACETIC ACID
FLURBIPROFENUM
3-FLUORO-4-PHENYLHYDRATROPIC ACID
FLP
S-FLURBIPROFEN
FROBEN®
rxcui:4502
drugbank:00712
chemidplus:5104-49-4
pubchem.compound:3394
chembl:CHEMBL563

Drug Info:

Drug Class	anti-inflammatory agents, non-steroidal
Year of Approval	1986
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antiinflammatory agent,NSAID

(5 More Sources)

Publications:

Smith et al., 2000, Arachidonic acid and nonsteroidal anti-inflammatory drugs induce conformational changes in the human prostaglandin endoperoxide H2 synthase-2 (cyclooxygenase-2)., J. Biol. Chem.
Bayly et al., 1999, Structure-based design of COX-2 selectivity into flurbiprofen., Bioorg. Med. Chem. Lett.
Hinz et al., 2001, Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages., Pharm. Res.
Basselin et al., 2007, Flurbiprofen, a cyclooxygenase inhibitor, reduces the brain arachidonic acid signal in response to the cholinergic muscarinic agonist, arecoline, in awake rats., Neurochem. Res.
van Haeringen et al., 2000, Constitutive cyclooxygenase-1 and induced cyclooxygenase-2 in isolated human iris inhibited by S(+) flurbiprofen., J Ocul Pharmacol Ther
Nivsarkar et al., Cyclooxygenase inhibitors: a novel direction for Alzheimer's management., Pharmacol Rep
Hewett et al., 2000, Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture., J. Pharmacol. Exp. Ther.
Kurahashi et al., 2001, Nicotine-induced contraction in the rat coronary artery: possible involvement of the endothelium, reactive oxygen species and COX-1 metabolites., J. Cardiovasc. Pharmacol.
Klegeris et al., Cyclooxygenase and 5-lipoxygenase inhibitors protect against mononuclear phagocyte neurotoxicity., Neurobiol. Aging
Dröge et al., Alternative splicing of cyclooxygenase-1 mRNA in the human iris., Ophthalmic Res.
Rieke et al., 1999, The role of arginine 120 of human prostaglandin endoperoxide H synthase-2 in the interaction with fatty acid substrates and inhibitors., J. Biol. Chem.
Wang H et al., 2011, Characterizing the effect of UDP-glucuronosyltransferase (UGT) 2B7 and UGT1A9 genetic polymorphisms on enantioselective glucuronidation of flurbiprofen., Biochem Pharmacol
Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.
McDonald MG et al., 2020, Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People., J Pharmacol Exp Ther
Lee YJ et al., 2015, Effects of CYP2C91/3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects., Arch Pharm Res
Lee CR et al., 2003, Differences in flurbiprofen pharmacokinetics between CYP2C91/1, 1/2, and 1/3 genotypes., Eur J Clin Pharmacol

FLURBIPROFEN PTGS1

Interaction Score: 1.52

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources:
ChemblInteractions TEND
FLURBIPROFEN PTGS2

Interaction Score: 1.49

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name HCT 1026, NO-flurbiprofen

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
11006278 10091674 11405284 17562170 10977131 19066416 10773011

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
FLURBIPROFEN UGT2B7

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21856293

Sources:
PharmGKB
FLURBIPROFEN BDNF

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16531049

Sources:
NCI
FLURBIPROFEN CYP2C9

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
32423989 25712887 12698304

Sources:
PharmGKB FDA
FLURBIPROFEN TARDBP

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: FLURBIPROFEN
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval 1986

Drug Class anti-inflammatory agents, non-steroidal

Publications:
TdgClinicalTrial: FLURBIPROFEN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antiinflammatory agent,NSAID

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: FLURBIPROFEN

Version: 14-September-2017

Alternate Names:

C508 NCI drug code

Drug Info:

Publications:

Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.

PharmGKB: flurbiprofen

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Lee CR et al., 2003, Differences in flurbiprofen pharmacokinetics between CYP2C91/1, 1/2, and 1/3 genotypes., Eur J Clin Pharmacol

McDonald MG et al., 2020, Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People., J Pharmacol Exp Ther

Lee YJ et al., 2015, Effects of CYP2C91/3 genotype on the pharmacokinetics of flurbiprofen in Korean subjects., Arch Pharm Res

DTC: FLURBIPROFEN
- Version: 02-September-2020
Alternate Names:

CHEMBL563 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Flurbiprofen
- Version: 2020.06.01
Alternate Names:

D0A1PX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL563
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Flurbiprofen
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL563
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Cyclooxygenase inhibitor
Direct Interaction	yes

Novel drug target	Established target
Trial Name	HCT 1026, NO-flurbiprofen
Mechanism of Interaction	Cyclooxygenase inhibitor

FLURBIPROFEN Drug Record

FLURBIPROFEN chembl:CHEMBL563 Approved

Alternate Names:

Drug Info:

Publications:

FLURBIPROFEN PTGS1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Cyclooxygenase inhibitor Direct Interaction yes

PMIDs: 11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources: ChemblInteractions TEND

FLURBIPROFEN PTGS2

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name HCT 1026, NO-flurbiprofen Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs: 11006278 10091674 11405284 17562170 10977131 19066416 10773011

Sources: DTC TdgClinicalTrial ChemblInteractions TEND TTD

FLURBIPROFEN UGT2B7

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21856293

Sources: PharmGKB

FLURBIPROFEN BDNF

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16531049

Sources: NCI

FLURBIPROFEN CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 32423989 25712887 12698304

Sources: PharmGKB FDA

FLURBIPROFEN TARDBP

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: FLURBIPROFEN

Alternate Names:

Drug Info: Year of Approval 1986 Drug Class anti-inflammatory agents, non-steroidal

Publications:

TdgClinicalTrial: FLURBIPROFEN

Alternate Names:

Drug Info: Drug Indications antiinflammatory agent,NSAID Drug Class Small Molecule FDA Approval approved

Publications:

NCI: FLURBIPROFEN

Alternate Names: C508 NCI drug code

Drug Info:

Publications: Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.

PharmGKB: flurbiprofen

Alternate Names:

Drug Info:

DTC: FLURBIPROFEN

Alternate Names: CHEMBL563 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Flurbiprofen

Alternate Names: D0A1PX TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL563

Alternate Names:

Drug Info:

Publications:

FDA: Flurbiprofen

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL563

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Cyclooxygenase inhibitor

Direct Interaction yes

PMIDs:
11811354 12392782 12711844 17562170 10358065 19066416 10773011

Sources:
ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name HCT 1026, NO-flurbiprofen

Mechanism of Interaction Cyclooxygenase inhibitor

PMIDs:
11006278 10091674 11405284 17562170 10977131 19066416 10773011

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
21856293

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
16531049

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
32423989 25712887 12698304

Sources:
PharmGKB FDA

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Drug Info:

Year of Approval 1986

Drug Class anti-inflammatory agents, non-steroidal

Drug Info:

Drug Indications antiinflammatory agent,NSAID

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C508 NCI drug code

Publications:

Ajmone-Cat et al., 2006, Prostaglandin E2 and BDNF levels in rat hippocampus are negatively correlated with status epilepticus severity: no impact on survival of seizure-generated neurons., Neurobiol. Dis.

Alternate Names:

CHEMBL563 ChEMBL Drug ID

Alternate Names:

D0A1PX TTD Drug ID