DGIdb - FLUPHENAZINE Drug Record

FLUPHENAZINE chembl:CHEMBL726 Approved

Alternate Names:

NSC-62323
PERMITIL
FLUPHENAZINE
PROLIXIN
FLUORPHENAZINE
FLUPHENAZINUM
4-(3-(2-TRIFLUOROMETHYL-10-PHENOTHIAZYL)-PROPYL)-1-PIPERAZINEETHANOL
4-(3-(2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZIN-10-YL)PROPYL)-1-PIPERAZINEETHANOL
FLUOROPHENAZINE
TRIFLUMETHAZINE
PROLIXIN®
4-(3-(-TRIFLUOROMETHYL-10-PHENOTHIAZYL)-PROPYL)-1-PIPERAZINEETHANOL
10-(3'-(4''-(BETA-HYDROXYETHYL)-1''-PIPERAZINYL)-PROPYL)-3-TRIFLUOROMETHYLPHENOTHIAZINE
10-(3-(2-HYDROXYETHYL)PIPERAZINOPROPYL)-2-(TRIFLUOROMETHYL)PHENOTHIAZINE
2-(TRIFLUOROMETHYL)-10-(3-(1-(BETA-HYDROXYETHYL)-4-PIPERAZINYL)PROPYL)PHENOTHIAZINE
FLUPHENAZIN
FLUFENAZINA
1-(2-HYDROXYETHYL)-4-(3-(TRIFLUOROMETHYL-10-PHENOTHIAZINYL)PROPYL)-PIPERAZINE
2-(4-(3-[2-(TRIFLUOROMETHYL)-10H-PHENOTHIAZIN-10-YL]PROPYL)-1-PIPERAZINYL)ETHANOL
FLUPHÉNAZINE
FLUORFENAZINE
chemidplus:69-23-8
drugbank:00623
pubchem.compound:3372
rxcui:4496
chembl:CHEMBL726

Drug Info:

FDA Approval	1959
Drug Class	small molecule
Drug Indications	Antipsychotic Agents
Year of Approval	1959
Drug Class	antipsychotic agents

(2 More Sources)

Publications:

Seeman, 2002, Atypical antipsychotics: mechanism of action., Can J Psychiatry
Van Kampen et al., 2000, Dopamine D(1A) receptor function in a rodent model of tardive dyskinesia., Neuroscience
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Cai et al., 1999, Inverse agonist properties of dopaminergic antagonists at the D(1A) dopamine receptor: uncoupling of the D(1A) dopamine receptor from G(s) protein., Mol. Pharmacol.
Tay JK et al., 2007, Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia., Prog Neuropsychopharmacol Biol Psychiatry
Høyberg et al., 1993, Risperidone versus perphenazine in the treatment of chronic schizophrenic patients with acute exacerbations., Acta Psychiatr Scand
Qin et al., 1994, Dopamine receptor blockade increases dopamine D2 receptor and glutamic acid decarboxylase mRNAs in mouse substantia nigra., Eur. J. Pharmacol.

FLUPHENAZINE DRD1

Interaction Score: 0.28

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11873706 11113312 11752352 10531405

Sources:
DTC TdgClinicalTrial TEND
FLUPHENAZINE DRD2

Interaction Score: 0.22

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11873706 7508675 11752352 7828655

Sources:
TdgClinicalTrial TEND
FLUPHENAZINE HTR1B

Interaction Score: 0.19

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
FLUPHENAZINE CBX1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUPHENAZINE CYP1A2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17611010

Sources:
DTC PharmGKB
FLUPHENAZINE USP1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUPHENAZINE ABCB1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FLUPHENAZINE CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC PharmGKB
FLUPHENAZINE TP53

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FLUPHENAZINE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: FLUPHENAZINE
- Version: 01-August-2011
Alternate Names:

FLUPHENAZINE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Year of Approval 1959

Publications:
TdgClinicalTrial: FLUPHENAZINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antipsychotic Agents

Drug Class small molecule

FDA Approval 1959

Publications:
PharmGKB: fluphenazine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Tay JK et al., 2007, Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia., Prog Neuropsychopharmacol Biol Psychiatry
DTC: FLUPHENAZINE
- Version: 02-September-2020
Alternate Names:

CHEMBL726 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Fluphenazine
- Version: 2020.06.01
Alternate Names:

D0P5SA TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL726
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

FLUPHENAZINE Drug Record

FLUPHENAZINE chembl:CHEMBL726 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11873706 11113312 11752352 10531405

Sources: DTC TdgClinicalTrial TEND

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11873706 7508675 11752352 7828655

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 17611010

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: FLUPHENAZINE

Alternate Names: FLUPHENAZINE Primary Drug Name

Drug Info: Drug Class antipsychotic agents Year of Approval 1959

Publications:

TdgClinicalTrial: FLUPHENAZINE

Alternate Names:

Drug Info: Drug Indications Antipsychotic Agents Drug Class small molecule FDA Approval 1959

Publications:

PharmGKB: fluphenazine

Alternate Names:

Drug Info:

Publications: Tay JK et al., 2007, Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia., Prog Neuropsychopharmacol Biol Psychiatry

DTC: FLUPHENAZINE

Alternate Names: CHEMBL726 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Fluphenazine

Alternate Names: D0P5SA TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL726

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11873706 11113312 11752352 10531405

Sources:
DTC TdgClinicalTrial TEND

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11873706 7508675 11752352 7828655

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
17611010

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

FLUPHENAZINE Primary Drug Name

Drug Info:

Drug Class antipsychotic agents

Year of Approval 1959

Drug Info:

Drug Indications Antipsychotic Agents

Drug Class small molecule

FDA Approval 1959

Publications:

Tay JK et al., 2007, Functional polymorphisms of the cytochrome P450 1A2 (CYP1A2) gene and prolonged QTc interval in schizophrenia., Prog Neuropsychopharmacol Biol Psychiatry

Alternate Names:

CHEMBL726 ChEMBL Drug ID

Alternate Names:

D0P5SA TTD Drug ID