DGIdb - FLUOXYMESTERONE Drug Record

FLUOXYMESTERONE chembl:CHEMBL1445 ApprovedAntineoplastic

Alternate Names:

FLUOXIMESTERONE
NSC-10704
ORA-TESTRYL
NSC-12165
FLUOXYMESTERONE CIII
FLUOXYMESTERONE
ANDROID-F
ANDROXY
HALOTESTIN
11BETA,17BETA-DIHYDROXY-9ALPHA-FLUORO-17ALPHA-METHYL-4-ANDROSTER-3-ONE
TESTOSTERONE, 9-FLUORO-11BETA-HYDROXY-17-METHYL-
9ALPHA-FLUORO-11BETA-HYDROXY-17-METHYLTESTOSTERONE
17ALPHA-METHYL-9ALPHA-FLUORO-11BETA-HYDROXYTESTERONE
HALOTESTIN®
9-FLUORO-11BETA,17BETA-DIHYDROXY-17-METHYLANDROST-4-EN-3-ONE
17Α-METHYL-9Α-FLUORO-11Β-HYDROXYTESTERONE
FLUOXIMESTERONA
FLUOXYMESTERONUM
chemidplus:76-43-7
rxcui:4494
pubchem.compound:6446
chembl:CHEMBL1445
drugbank:01185

Drug Info:

FDA Approval	1956
Drug Class	small molecule
Drug Indications	Antineoplastic Agents
Drug Indications	Anabolic Agents
Year of Approval	1956
Drug Class	antineoplastic agents
Drug Class	anabolic agents

(4 More Sources)

Publications:

Miner et al., 2007, An orally active selective androgen receptor modulator is efficacious on bone, muscle, and sex function with reduced impact on prostate., Endocrinology
Kasperk et al., 1989, Androgens directly stimulate proliferation of bone cells in vitro., Endocrinology
Kemppainen et al., 1999, Distinguishing androgen receptor agonists and antagonists: distinct mechanisms of activation by medroxyprogesterone acetate and dihydrotestosterone., Mol. Endocrinol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Fernández et al., 1994, Stanozolol and danazol, unlike natural androgens, interact with the low affinity glucocorticoid-binding sites from male rat liver microsomes., Endocrinology
Smallridge et al., 1984, Androgen receptor abnormalities in identical twins with oligospermia. Clinical and biochemical studies., Am. J. Med.
Mayer et al., 1975, Interaction of anabolic steroids with glucocorticoid receptor sites in rat muscle cytosol., Am. J. Physiol.
Morley et al., 1981, The relationship of androgen to the thyrotropin and prolactin responses to thyrotropin-releasing hormone in hypogonadal and normal men., J. Clin. Endocrinol. Metab.

FLUOXYMESTERONE PRL

Interaction Score: 1.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6161941

Sources:
NCI
FLUOXYMESTERONE NR3C1

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

PMIDs:
173192

Sources:
DTC
FLUOXYMESTERONE AR

Interaction Score: 0.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
17023534 2521824 10077001 11752352 8119180 6439037

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

TEND: FLUOXYMESTERONE
- Version: 01-August-2011
Alternate Names:

FLUOXYMESTERONE Primary Drug Name

Drug Info:

Drug Class anabolic agents

Drug Class antineoplastic agents

Year of Approval 1956

Publications:
TdgClinicalTrial: FLUOXYMESTERONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anabolic Agents

Drug Indications Antineoplastic Agents

Drug Class small molecule

Publications:
NCI: FLUOXYMESTERONE
- Version: 14-September-2017
Alternate Names:

C507 NCI drug code

Drug Info:

Publications:

Morley et al., 1981, The relationship of androgen to the thyrotropin and prolactin responses to thyrotropin-releasing hormone in hypogonadal and normal men., J. Clin. Endocrinol. Metab.
GuideToPharmacology: 135650271
- Version: 29-September-2020
Alternate Names:

FLUOXYMESTERONE GuideToPharmacology Ligand Name

Drug Info:

Publications:
DTC: FLUOXYMESTERONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1445 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Fluoxymesterone
- Version: 2020.06.01
Alternate Names:

D0L2LS TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1445
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1445
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Agonist
Endogenous Drug?	False
Direct Interaction?	True

FLUOXYMESTERONE Drug Record

FLUOXYMESTERONE chembl:CHEMBL1445 ApprovedAntineoplastic

Alternate Names:

Drug Info:

Publications:

FLUOXYMESTERONE PRL

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6161941

Sources: NCI

FLUOXYMESTERONE NR3C1

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info:

PMIDs: 173192

Sources: DTC

FLUOXYMESTERONE AR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 17023534 2521824 10077001 11752352 8119180 6439037

Sources: DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

TEND: FLUOXYMESTERONE

Alternate Names: FLUOXYMESTERONE Primary Drug Name

Drug Info: Drug Class anabolic agents Drug Class antineoplastic agents Year of Approval 1956

Publications:

TdgClinicalTrial: FLUOXYMESTERONE

Alternate Names:

Drug Info: Drug Indications Anabolic Agents Drug Indications Antineoplastic Agents Drug Class small molecule

Publications:

NCI: FLUOXYMESTERONE

Alternate Names: C507 NCI drug code

Drug Info:

Publications: Morley et al., 1981, The relationship of androgen to the thyrotropin and prolactin responses to thyrotropin-releasing hormone in hypogonadal and normal men., J. Clin. Endocrinol. Metab.

GuideToPharmacology: 135650271

Alternate Names: FLUOXYMESTERONE GuideToPharmacology Ligand Name

Drug Info:

Publications:

DTC: FLUOXYMESTERONE

Alternate Names: CHEMBL1445 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Fluoxymesterone

Alternate Names: D0L2LS TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1445

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1445

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
6161941

Sources:
NCI

Interaction Types & Directionality:

antagonist (inhibitory)

PMIDs:
173192

Sources:
DTC

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
17023534 2521824 10077001 11752352 8119180 6439037

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND GuideToPharmacology TTD

Alternate Names:

FLUOXYMESTERONE Primary Drug Name

Drug Info:

Drug Class anabolic agents

Drug Class antineoplastic agents

Year of Approval 1956

Drug Info:

Drug Indications Anabolic Agents

Drug Indications Antineoplastic Agents

Drug Class small molecule

Alternate Names:

C507 NCI drug code

Publications:

Morley et al., 1981, The relationship of androgen to the thyrotropin and prolactin responses to thyrotropin-releasing hormone in hypogonadal and normal men., J. Clin. Endocrinol. Metab.

Alternate Names:

FLUOXYMESTERONE GuideToPharmacology Ligand Name

Alternate Names:

CHEMBL1445 ChEMBL Drug ID

Alternate Names:

D0L2LS TTD Drug ID