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FLUDARABINE Drug Record

  • Summary
  • Interactions
  • Claims
  • FLUDARABINE chembl:CHEMBL1568 AntineoplasticImmunotherapy

    Alternate Names:

    FLUDARABINE
    2-FLUORO-ARA-A

    Drug Info:

    Drug Class antineoplastic agents
    Year of Approval 1991
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antineoplastic agent
    (5 More Sources)

    Publications:

    Butrym A et al., 2016, Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia., HLA
    Weston et al., 2010, The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo., Blood
    Doğan et al., 2004, Effect of fludarabine on leukocyte functions., Chemotherapy
    Lech-Maranda et al., 2009, Clofarabine as a novel nucleoside analogue approved to treat patients with haematological malignancies: mechanism of action and clinical activity., Mini Rev Med Chem
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Robak et al., 2009, Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseases., Molecules
    Bosanquet et al., 2002, Bax expression correlates with cellular drug sensitivity to doxorubicin, cyclophosphamide and chlorambucil but not fludarabine, cladribine or corticosteroids in B cell chronic lymphocytic leukemia., Leukemia
    Robak et al., 2006, Purine nucleoside analogs as immunosuppressive and antineoplastic agents: mechanism of action and clinical activity., Curr. Med. Chem.
    Barragán et al., 2002, Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells., Blood
    Iacobucci I et al., 2013, Profiling of drug-metabolizing enzymes/transporters in CD33+ acute myeloid leukemia patients treated with Gemtuzumab-Ozogamicin and Fludarabine, Cytarabine and Idarubicin., Pharmacogenomics J
    Jordheim et al., 2005, [Metabolism, mechanism of action and resistance to cytotoxic nucleoside analogues]., Bull Cancer
    Yao et al., 2010, [Correlation of deoxycytidine kinase gene expression with fludarabine resistance in patients with chronic lymphocytic leukemia]., Zhongguo Shi Yan Xue Ye Xue Za Zhi
    Zhang et al., 2006, The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation., Acta Crystallogr. D Biol. Crystallogr.
    Maggio et al., 2004, The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells., Cancer Res.
    Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos
    Younes et al., 1998, Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia., Br. J. Haematol.
    Yeoh AEJ et al., 2018, Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study., J Clin Oncol
  • FLUDARABINE   POLA1

    Interaction Score: 3.25

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name fludarabine phosphate,Fludara
    Novel drug target Established target

    PMIDs:
    19519505 17168705 17016423 17139284 19325518


    Sources:
    TdgClinicalTrial TEND

  • FLUDARABINE   SULT2B1

    Interaction Score: 2.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22584460


    Sources:
    PharmGKB

  • FLUDARABINE   RRM1

    Interaction Score: 1.39

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name fludarabine phosphate,Fludara
    Novel drug target Established target

    PMIDs:
    19519505 17016423 17139284 19325518


    Sources:
    TdgClinicalTrial TEND

  • FLUDARABINE   DCK

    Interaction Score: 1.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name fludarabine phosphate,Fludara
    Novel drug target Established target

    PMIDs:
    15820918 20137114 16421443


    Sources:
    TdgClinicalTrial

  • FLUDARABINE   IKZF1

    Interaction Score: 1.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30044693


    Sources:
    CIViC

  • FLUDARABINE   SLC22A12

    Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22584460


    Sources:
    PharmGKB

  • FLUDARABINE   CXCL12

    Interaction Score: 0.93

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    27173875


    Sources:
    PharmGKB

  • FLUDARABINE   CD40

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9450802


    Sources:
    NCI

  • FLUDARABINE   SLC29A1

    Interaction Score: 0.59

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    23388705


    Sources:
    DTC

  • FLUDARABINE   MPO

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15608444


    Sources:
    NCI

  • FLUDARABINE   XIAP

    Interaction Score: 0.33

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15059916


    Sources:
    NCI

  • FLUDARABINE   ADA

    Interaction Score: 0.3

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • FLUDARABINE   CYP2E1

    Interaction Score: 0.28

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22584460


    Sources:
    PharmGKB

  • FLUDARABINE   BAX

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12040435


    Sources:
    NCI

  • FLUDARABINE   SLCO1B1

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22584460


    Sources:
    PharmGKB

  • FLUDARABINE   ATM

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Evidence Type Actionable
    Approval Status Preclinical - Cell culture
    Response Type sensitive

    PMIDs:
    20739657


    Sources:
    JAX-CKB

  • FLUDARABINE   PIK3CG

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11929788


    Sources:
    NCI

  • FLUDARABINE   SMAD3

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FLUDARABINE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: FLUDARABINE

    • Version: 01-August-2011

    Alternate Names:
    FLUDARABINE Primary Drug Name

    Drug Info:
    Year of Approval 1991
    Drug Class antineoplastic agents

    Publications:

  • TdgClinicalTrial: FLUDARABINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: FLUDARABINE

    • Version: 14-September-2017

    Alternate Names:
    C1094 NCI drug code

    Drug Info:

    Publications:
    Maggio et al., 2004, The histone deacetylase inhibitor MS-275 interacts synergistically with fludarabine to induce apoptosis in human leukemia cells., Cancer Res.
    Younes et al., 1998, Elevated levels of biologically active soluble CD40 ligand in the serum of patients with chronic lymphocytic leukaemia., Br. J. Haematol.
    Barragán et al., 2002, Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells., Blood

  • DTC: FLUDARABINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1568 ChEMBL Drug ID

    Drug Info:

    Publications:
    Lepist EI et al., 2013, Transport of A1 adenosine receptor agonist tecadenoson by human and mouse nucleoside transporters: evidence for blood-brain barrier transport by murine equilibrative nucleoside transporter 1 mENT1., Drug Metab Dispos

  • JAX-CKB: Fludarabine

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Weston et al., 2010, The PARP inhibitor olaparib induces significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo., Blood

  • PharmGKB: fludarabine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Butrym A et al., 2016, Dual role of the CXCL12 polymorphism in patients with chronic lymphocytic leukemia., HLA
    Iacobucci I et al., 2013, Profiling of drug-metabolizing enzymes/transporters in CD33+ acute myeloid leukemia patients treated with Gemtuzumab-Ozogamicin and Fludarabine, Cytarabine and Idarubicin., Pharmacogenomics J

  • CIViC: FLUDARABINE

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Yeoh AEJ et al., 2018, Intensifying Treatment of Childhood B-Lymphoblastic Leukemia With IKZF1 Deletion Reduces Relapse and Improves Overall Survival: Results of Malaysia-Singapore ALL 2010 Study., J Clin Oncol

  • TTD: Fludarabine

    • Version: 2020.06.01

    Alternate Names:
    D0F2XQ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1568

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21