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FENTANYL Drug Record

  • Summary
  • Interactions
  • Claims
  • FENTANYL chembl:CHEMBL596 Approved

    Alternate Names:

    EFFENTORA
    FENTANYL-50
    DURAGESIC-12
    DURAGESIC-50
    FENTANYL-75
    FENTANYL-100
    BREAKYL
    N02AB03
    FENTANYL
    AD 923
    IONSYS
    DUROGESIC DTRANS
    VICTANYL
    FENTANYL-62
    MATRIFEN
    DURAGESIC-25
    R 4263
    FENTANYL-87
    IDS-NF-001
    OPIODUR
    YEMEX
    ORALET
    DUROGESIC
    FENTALIS RESERVOIR
    SUBSYS
    MYLAFENT
    LEPTANAL
    FENCINO
    MEZOLAR MATRIX
    INNOVAR
    DURAGESIC
    DURAGESIC-75
    FENTANYL-37
    AD-923
    FENTORA
    TILOFYL
    SUBLIMAZE
    PECFENT
    FENTANYL-12
    OSMANIL
    DURAGESIC-100
    FENTANYL CII
    RECIVIT
    ABSTRAL
    FENTANYL-25
    OSMACH
    ACTIQ
    DURAGESIC-37
    FENTANILO
    MCN-JR-4263-49
    FENTANIL
    N-PHENETHYL-4-(N-PROPIONYLANILINO)PIPERIDINE
    N-(1-PHENETHYL-4-PIPERIDINYL)-N-PHENYLPROPIONAMIDE
    N-(1-PHENETHYL-4-PIPERIDYL)PROPIONANILIDE
    N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-PROPIONAMIDE
    N-PHENYL-N-(1-(2-PHENYLETHYL)-4-PIPERIDINYL)PROPANAMIDE
    1-PHENETHYL-4-(N-PHENYLPROPIONAMIDO)PIPERIDINE
    1-PHENETHYL-4-N-PROPIONYLANILINOPIPERIDINE
    N-(1-PHENETHYLPIPERIDIN-4-YL)-N-PHENYLPROPIONAMIDE
    FENTANILA
    R-4263
    FENTANYLUM
    PHENTANYL
    chembl:CHEMBL596
    chemidplus:437-38-7
    rxcui:4337
    pubchem.compound:3345
    drugbank:00813

    Drug Info:

    Drug Indications adjuvant to anesthesia
    Drug Indications analgesic,opioid
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications analgesic
    Year of Approval approved before 1982
    Drug Class adjuvants, anesthesia
    Drug Class analgesics, opioid
    Drug Categories agents that produce hypertension
    Drug Categories agents that reduce seizure threshold
    Drug Categories antidepressive agents
    Drug Categories bradycardia-causing agents
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 cyp3a7 substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories drugs that are mainly renally excreted
    Drug Categories fentanyl and fentanyl analogues
    Drug Categories high-risk opioids
    Drug Categories neuraxial anesthetics
    Drug Categories opiate agonists
    Drug Categories opioid agonist
    Drug Categories opioid anesthetics
    Drug Categories opioids
    Drug Categories p-glycoprotein inhibitors
    Drug Categories phenylpiperidine opioids
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin agents
    (6 More Sources)

    Publications:

    Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand
    Muriel J et al., 2019, Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients., Basic Clin Pharmacol Toxicol
    You et al., 2005, The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes., Exp. Neurol.
    Scott et al., 2005, Spotlight on remifentanil for general anaesthesia., CNS Drugs
    Scott et al., 2005, Remifentanil: a review of its use during the induction and maintenance of general anaesthesia., Drugs
    Hajiha et al., 2009, Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo., J. Physiol. (Lond.)
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Dosen-Micovic et al., 2006, Steric interactions and the activity of fentanyl analogs at the mu-opioid receptor., Bioorg. Med. Chem.
    Dardonville et al., 2006, Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites., Bioorg. Med. Chem.
    Galvan A et al., 2011, Multiple Loci modulate opioid therapy response for cancer pain., Clin Cancer Res
    Nielsen et al., 1998, Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury., Anesthesiology
    Barratt DT et al., 2014, Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study., Pharmacogenet Genomics
    Saari et al., 2008, Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl., Eur. J. Clin. Pharmacol.
    Krumholz et al., 1993, The influence of fentanyl and alfentanil on functions of human polymorphonuclear leukocytes in vitro., Acta Anaesthesiol Scand
    Yeager et al., 2002, Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humans., Anesth. Analg.
    Rodrigues et al., 2005, Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats., Braz. J. Med. Biol. Res.
    Darwish et al., 2005, Pharmacokinetics and dose proportionality of fentanyl effervescent buccal tablets in healthy volunteers., Clin Pharmacokinet
    Sahin et al., 2005, The mechanisms of the direct vascular effects of fentanyl on isolated human saphenous veins in vitro., J. Cardiothorac. Vasc. Anesth.
    Darwish et al., 2006, Pharmacokinetic properties of fentanyl effervescent buccal tablets: a phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 microg in healthy adult volunteers., Clin Ther
    Poonawala et al., Opioids heal ischemic wounds in the rat., Wound Repair Regen
    Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
    Saiz-Rodríguez M et al., 2019, Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects., Basic Clin Pharmacol Toxicol
    Wu SB et al., 2015, Impact of CYP2D6 Polymorphisms on Postoperative Fentanyl Analgesia in Gastric Cancer Patients., Genet Test Mol Biomarkers
    Yang Z et al., 2020, Influences of UGT2B7 rs7439366 and rs12233719 Polymorphisms on Fentanyl Sensitivity in Chinese Gynecologic Patients., Med Sci Monit
    Pascoe et al., 2008, Effects of mu, kappa, and delta opioid receptor agonists on the function of hypothalamic-pituitary-adrenal axis in monkeys., Psychoneuroendocrinology
    Zhang J et al., 2018, Association between MDR<sub>1</sub>/CYP3A4/OPRM<sub>1</sub> gene polymorphisms and the post-caesarean fentanyl analgesic effect on Chinese women., Gene
    Takashina Y et al., 2012, Impact of CYP3A5 and ABCB1 gene polymorphisms on fentanyl pharmacokinetics and clinical responses in cancer patients undergoing conversion to a transdermal system., Drug Metab Pharmacokinet
    Dzambazovska-Trajkovska V et al., 2016, Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain., Pril (Makedon Akad Nauk Umet Odd Med Nauki)
    Park HJ et al., 2007, Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans., Clin Pharmacol Ther
    Wandel C et al., 2002, Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein., Anesthesiology
    Lötsch J et al., 2009, Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers., Pharmacogenet Genomics
    Kim KM et al., 2013, Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients., Int J Clin Pharmacol Ther
    Aoki Y et al., 2018, Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test., Neuropsychopharmacol Rep
    Menzebach et al., 2004, [Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependent mechanism]., Anasthesiol Intensivmed Notfallmed Schmerzther
    Tanaka N et al., 2014, Impact of CYP3A5*3 on plasma exposure and urinary excretion of fentanyl and norfentanyl in the early postsurgical period., Ther Drug Monit
    Ishida T et al., 2016, Relationship between the plasma fentanyl and serum 4β-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain., Drug Metab Pharmacokinet
    Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
    Nishizawa D et al., 2018, Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy., Pharmacogenomics
  • FENTANYL   TMEM8A

    Interaction Score: 2.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29207912


    Sources:
    PharmGKB

  • FENTANYL   ATF2

    Interaction Score: 1.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30106255


    Sources:
    PharmGKB

  • FENTANYL   RHBDF2

    Interaction Score: 1.46

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21622719


    Sources:
    PharmGKB

  • FENTANYL   ARRB2

    Interaction Score: 1.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30549211


    Sources:
    PharmGKB

  • FENTANYL   MYD88

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FENTANYL   ITGAM

    Interaction Score: 0.44

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15098168


    Sources:
    NCI

  • FENTANYL   OPRD1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name transmucosal fentanyl,Actiq
    Trial Name fentanyl transdermal system,Duragesic, Ionsys
    Trial Name fentanyl sublingual spray

    PMIDs:
    15665994 16372825 15868528 30549211 19403616 16861092 15828941


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank GuideToPharmacology

  • FENTANYL   KCNJ6

    Interaction Score: 0.27

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FENTANYL   CACNA1E

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FENTANYL   UGT2B7

    Interaction Score: 0.21

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    32401749


    Sources:
    PharmGKB

  • FENTANYL   P2RX7

    Interaction Score: 0.2

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FENTANYL   OPRM1

    Interaction Score: 0.18

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    15589524 16332149 16114980 19403616 11752352 16376082 16797997


    Sources:
    TEND TdgClinicalTrial DrugBank GuideToPharmacology ChemblInteractions

  • FENTANYL   XDH

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9637647


    Sources:
    NCI

  • FENTANYL   COMT

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    30281924 30549211


    Sources:
    PharmGKB

  • FENTANYL   MPO

    Interaction Score: 0.17

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8391745


    Sources:
    NCI

  • FENTANYL   FCGR3B

    Interaction Score: 0.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11772808


    Sources:
    NCI

  • FENTANYL   FCGR3A

    Interaction Score: 0.14

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11772808


    Sources:
    NCI

  • FENTANYL   IL6

    Interaction Score: 0.13

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9527747


    Sources:
    NCI

  • FENTANYL   CYP3A5

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22277678 30281924 24365989 27236640 18695978


    Sources:
    PharmGKB

  • FENTANYL   ABCB1

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29601950 22277678 27883323 17192767 11964599 19514130 23557865


    Sources:
    PharmGKB DrugBank

  • FENTANYL   CXCL8

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9527747


    Sources:
    NCI

  • FENTANYL   OPRK1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Partial agonist
    Endogenous Drug? False

    PMIDs:
    18325678


    Sources:
    DrugBank GuideToPharmacology

  • FENTANYL   ADRB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    26771271 30281924


    Sources:
    PharmGKB

  • FENTANYL   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    24469018 17987285


    Sources:
    NCI PharmGKB

  • FENTANYL   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25825958


    Sources:
    PharmGKB

  • FENTANYL   AR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00813

    • Version: 5.1.7

    Alternate Names:
    FENTANYL DrugBank Drug Name
    437-38-7 CAS Number
    Abstral Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups illicit

    Publications:
    Rodrigues et al., 2005, Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats., Braz. J. Med. Biol. Res.
    Darwish et al., 2005, Pharmacokinetics and dose proportionality of fentanyl effervescent buccal tablets in healthy volunteers., Clin Pharmacokinet
    Sahin et al., 2005, The mechanisms of the direct vascular effects of fentanyl on isolated human saphenous veins in vitro., J. Cardiothorac. Vasc. Anesth.

  • TEND: FENTANYL

    • Version: 01-August-2011

    Alternate Names:
    FENTANYL Primary Drug Name

    Drug Info:
    Drug Class analgesics, opioid
    Drug Class adjuvants, anesthesia
    Year of Approval approved before 1982

    Publications:

  • TdgClinicalTrial: FENTANYL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications analgesic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: FENTANYL

    • Version: 14-September-2017

    Alternate Names:
    C494 NCI drug code

    Drug Info:

    Publications:
    Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand
    Nielsen et al., 1998, Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury., Anesthesiology
    Yeager et al., 2002, Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humans., Anesth. Analg.

  • PharmGKB: fentanyl

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
    Saiz-Rodríguez M et al., 2019, Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects., Basic Clin Pharmacol Toxicol
    Muriel J et al., 2019, Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients., Basic Clin Pharmacol Toxicol

  • GuideToPharmacology: 135650258

    • Version: 29-September-2020

    Alternate Names:
    FENTANYL GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • DTC: FENTANYL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL596 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Fentanyl

    • Version: 2020.06.01

    Alternate Names:
    D0E1WI TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL596

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL596

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21