DGIdb - FENTANYL Drug Record

FENTANYL chembl:CHEMBL596 Approved

Alternate Names:

EFFENTORA
FENTANYL-50
DURAGESIC-12
DURAGESIC-50
FENTANYL-75
FENTANYL-100
BREAKYL
N02AB03
FENTANYL
AD 923
IONSYS
DUROGESIC DTRANS
VICTANYL
FENTANYL-62
MATRIFEN
DURAGESIC-25
R 4263
FENTANYL-87
IDS-NF-001
OPIODUR
YEMEX
ORALET
DUROGESIC
FENTALIS RESERVOIR
SUBSYS
MYLAFENT
LEPTANAL
FENCINO
MEZOLAR MATRIX
INNOVAR
DURAGESIC
DURAGESIC-75
FENTANYL-37
AD-923
FENTORA
TILOFYL
SUBLIMAZE
PECFENT
FENTANYL-12
OSMANIL
DURAGESIC-100
FENTANYL CII
RECIVIT
ABSTRAL
FENTANYL-25
OSMACH
ACTIQ
DURAGESIC-37
FENTANILO
MCN-JR-4263-49
FENTANIL
N-PHENETHYL-4-(N-PROPIONYLANILINO)PIPERIDINE
N-(1-PHENETHYL-4-PIPERIDINYL)-N-PHENYLPROPIONAMIDE
N-(1-PHENETHYL-4-PIPERIDYL)PROPIONANILIDE
N-(1-PHENETHYL-PIPERIDIN-4-YL)-N-PHENYL-PROPIONAMIDE
N-PHENYL-N-(1-(2-PHENYLETHYL)-4-PIPERIDINYL)PROPANAMIDE
1-PHENETHYL-4-(N-PHENYLPROPIONAMIDO)PIPERIDINE
1-PHENETHYL-4-N-PROPIONYLANILINOPIPERIDINE
N-(1-PHENETHYLPIPERIDIN-4-YL)-N-PHENYLPROPIONAMIDE
FENTANILA
R-4263
FENTANYLUM
PHENTANYL
chembl:CHEMBL596
chemidplus:437-38-7
rxcui:4337
pubchem.compound:3345
drugbank:00813

Drug Info:

Drug Indications	adjuvant to anesthesia
Drug Indications	analgesic,opioid
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	analgesic
Year of Approval	approved before 1982
Drug Class	adjuvants, anesthesia
Drug Class	analgesics, opioid

(4 More Sources)

Publications:

Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand
Muriel J et al., 2019, Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients., Basic Clin Pharmacol Toxicol
You et al., 2005, The novel analgesic and high-efficacy 5-HT1A receptor agonist F 13640 inhibits nociceptive responses, wind-up, and after-discharges in spinal neurons and withdrawal reflexes., Exp. Neurol.
Dosen-Micovic et al., 2006, Steric interactions and the activity of fentanyl analogs at the mu-opioid receptor., Bioorg. Med. Chem.
Scott et al., 2005, Spotlight on remifentanil for general anaesthesia., CNS Drugs
Scott et al., 2005, Remifentanil: a review of its use during the induction and maintenance of general anaesthesia., Drugs
Hajiha et al., 2009, Opioid receptor mechanisms at the hypoglossal motor pool and effects on tongue muscle activity in vivo., J. Physiol. (Lond.)
Dardonville et al., 2006, Synthesis and pharmacological studies of new hybrid derivatives of fentanyl active at the mu-opioid receptor and I2-imidazoline binding sites., Bioorg. Med. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Galvan A et al., 2011, Multiple Loci modulate opioid therapy response for cancer pain., Clin Cancer Res
Nielsen et al., 1998, Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury., Anesthesiology
Saari et al., 2008, Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl., Eur. J. Clin. Pharmacol.
Barratt DT et al., 2014, Genetic, pathological and physiological determinants of transdermal fentanyl pharmacokinetics in 620 cancer patients of the EPOS study., Pharmacogenet Genomics
Krumholz et al., 1993, The influence of fentanyl and alfentanil on functions of human polymorphonuclear leukocytes in vitro., Acta Anaesthesiol Scand
Yeager et al., 2002, Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humans., Anesth. Analg.
Sahin et al., 2005, The mechanisms of the direct vascular effects of fentanyl on isolated human saphenous veins in vitro., J. Cardiothorac. Vasc. Anesth.
Poonawala et al., Opioids heal ischemic wounds in the rat., Wound Repair Regen
Rodrigues et al., 2005, Participation of ATP-sensitive K+ channels in the peripheral antinociceptive effect of fentanyl in rats., Braz. J. Med. Biol. Res.
Darwish et al., 2006, Pharmacokinetic properties of fentanyl effervescent buccal tablets: a phase I, open-label, crossover study of single-dose 100, 200, 400, and 800 microg in healthy adult volunteers., Clin Ther
Darwish et al., 2005, Pharmacokinetics and dose proportionality of fentanyl effervescent buccal tablets in healthy volunteers., Clin Pharmacokinet
Saiz-Rodríguez M et al., 2019, Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects., Basic Clin Pharmacol Toxicol
Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg
Wu SB et al., 2015, Impact of CYP2D6 Polymorphisms on Postoperative Fentanyl Analgesia in Gastric Cancer Patients., Genet Test Mol Biomarkers
Yang Z et al., 2020, Influences of UGT2B7 rs7439366 and rs12233719 Polymorphisms on Fentanyl Sensitivity in Chinese Gynecologic Patients., Med Sci Monit
Zhang J et al., 2018, Association between MDR<sub>1</sub>/CYP3A4/OPRM<sub>1</sub> gene polymorphisms and the post-caesarean fentanyl analgesic effect on Chinese women., Gene
Dzambazovska-Trajkovska V et al., 2016, Association of Single-Nucleotide Polymorhism C3435T in the ABCB1 Gene with Opioid Sensitivity in Treatment of Postoperative Pain., Pril (Makedon Akad Nauk Umet Odd Med Nauki)
Kim KM et al., 2013, Effects of genetic polymorphisms of OPRM1, ABCB1, CYP3A4/5 on postoperative fentanyl consumption in Korean gynecologic patients., Int J Clin Pharmacol Ther
Takashina Y et al., 2012, Impact of CYP3A5 and ABCB1 gene polymorphisms on fentanyl pharmacokinetics and clinical responses in cancer patients undergoing conversion to a transdermal system., Drug Metab Pharmacokinet
Lötsch J et al., 2009, Cross-sectional analysis of the influence of currently known pharmacogenetic modulators on opioid therapy in outpatient pain centers., Pharmacogenet Genomics
Park HJ et al., 2007, Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans., Clin Pharmacol Ther
Wandel C et al., 2002, Interaction of morphine, fentanyl, sufentanil, alfentanil, and loperamide with the efflux drug transporter P-glycoprotein., Anesthesiology
Aoki Y et al., 2018, Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test., Neuropsychopharmacol Rep
Menzebach et al., 2004, [Morphine inhibits complement receptor expression, phagocytosis and oxidative burst by a nitric oxide dependent mechanism]., Anasthesiol Intensivmed Notfallmed Schmerzther
Ishida T et al., 2016, Relationship between the plasma fentanyl and serum 4β-hydroxycholesterol based on CYP3A5 genotype and gender in patients with cancer pain., Drug Metab Pharmacokinet
Tanaka N et al., 2014, Impact of CYP3A5*3 on plasma exposure and urinary excretion of fentanyl and norfentanyl in the early postsurgical period., Ther Drug Monit
Zanger UM et al., 2008, Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation., Anal Bioanal Chem
Nishizawa D et al., 2018, Genome-wide scan identifies candidate loci related to remifentanil requirements during laparoscopic-assisted colectomy., Pharmacogenomics

FENTANYL PGAP6

Interaction Score: 2.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29207912

Sources:
PharmGKB
FENTANYL ATF2

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30106255

Sources:
PharmGKB
FENTANYL RHBDF2

Interaction Score: 1.65

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21622719

Sources:
PharmGKB
FENTANYL ARRB2

Interaction Score: 1.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30549211

Sources:
PharmGKB
FENTANYL KCNJ6

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FENTANYL OPRD1

Interaction Score: 0.6

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name transmucosal fentanyl,Actiq

Trial Name fentanyl transdermal system,Duragesic, Ionsys

Trial Name fentanyl sublingual spray

PMIDs:
15868528 15828941 15665994 16861092 19403616 16372825 30549211

Sources:
TdgClinicalTrial TEND PharmGKB
FENTANYL MYD88

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FENTANYL ITGAM

Interaction Score: 0.49

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15098168

Sources:
NCI
FENTANYL P2RX7

Interaction Score: 0.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FENTANYL CACNA1E

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FENTANYL FCGR3B

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11772808

Sources:
NCI
FENTANYL MPO

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8391745

Sources:
NCI
FENTANYL OPRM1

Interaction Score: 0.24

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name AD 923

Novel drug target Established target

Trial Name AeroLEF

PMIDs:
15589524 16376082 16332149 16114980 19403616 16797997 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND
FENTANYL UGT2B7

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
32401749

Sources:
PharmGKB
FENTANYL XDH

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9637647

Sources:
NCI
FENTANYL COMT

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30549211 30281924

Sources:
PharmGKB
FENTANYL FCGR3A

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11772808

Sources:
NCI
FENTANYL IL6

Interaction Score: 0.2

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9527747

Sources:
NCI
FENTANYL CYP3A5

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30281924 27236640 24365989 22277678 18695978

Sources:
PharmGKB
FENTANYL CXCL8

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9527747

Sources:
NCI
FENTANYL ABCB1

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
29601950 27883323 23557865 22277678 19514130 17192767 11964599

Sources:
PharmGKB
FENTANYL ADRB2

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30281924 26771271

Sources:
PharmGKB
FENTANYL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
17987285 24469018

Sources:
NCI PharmGKB
FENTANYL CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25825958

Sources:
PharmGKB
FENTANYL AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: FENTANYL
- Version: 01-August-2011
Alternate Names:

FENTANYL Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Drug Class adjuvants, anesthesia

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: FENTANYL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: FENTANYL

Version: 14-September-2017

Alternate Names:

C494 NCI drug code

Drug Info:

Publications:

Brix-Christensen et al., 1998, Effects of anaesthesia based on high versus low doses of opioids on the cytokine and acute-phase protein responses in patients undergoing cardiac surgery., Acta Anaesthesiol Scand

Nielsen et al., 1998, Desflurane increases pulmonary alveolar-capillary membrane permeability after aortic occlusion-reperfusion in rabbits: evidence of oxidant-mediated lung injury., Anesthesiology

Yeager et al., 2002, Intravenous fentanyl increases natural killer cell cytotoxicity and circulating CD16(+) lymphocytes in humans., Anesth. Analg.

PharmGKB: fentanyl

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Nielsen M et al., 2016, The Gly16 Allele of the Gly16Arg Single-Nucleotide Polymorphism in the β₂-Adrenergic Receptor Gene Augments Perioperative Use of Vasopressors: A Retrospective Cohort Study., Anesth Analg

Saiz-Rodríguez M et al., 2019, Polymorphisms associated with fentanyl pharmacokinetics, pharmacodynamics and adverse effects., Basic Clin Pharmacol Toxicol

Muriel J et al., 2019, Pharmacogenetics and prediction of adverse events in prescription opioid use disorder patients., Basic Clin Pharmacol Toxicol

DTC: FENTANYL
- Version: 02-September-2020
Alternate Names:

CHEMBL596 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Fentanyl
- Version: 2020.06.01
Alternate Names:

D0E1WI TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL596
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL596
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	transmucosal fentanyl,Actiq
Trial Name	fentanyl transdermal system,Duragesic, Ionsys
Trial Name	fentanyl sublingual spray

Trial Name	AD 923
Novel drug target	Established target
Trial Name	AeroLEF

FENTANYL Drug Record

FENTANYL chembl:CHEMBL596 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 29207912

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30106255

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21622719

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30549211

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name transmucosal fentanyl,Actiq Trial Name fentanyl transdermal system,Duragesic, Ionsys Trial Name fentanyl sublingual spray

PMIDs: 15868528 15828941 15665994 16861092 19403616 16372825 30549211

Sources: TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15098168

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11772808

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8391745

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name AD 923 Novel drug target Established target Trial Name AeroLEF

PMIDs: 15589524 16376082 16332149 16114980 19403616 16797997 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 32401749

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9637647

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30549211 30281924

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11772808

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9527747

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30281924 27236640 24365989 22277678 18695978

Interaction Types & Directionality:

n/a

PMIDs:
29207912

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30106255

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21622719

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30549211

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name transmucosal fentanyl,Actiq

Trial Name fentanyl transdermal system,Duragesic, Ionsys

Trial Name fentanyl sublingual spray

PMIDs:
15868528 15828941 15665994 16861092 19403616 16372825 30549211

Sources:
TdgClinicalTrial TEND PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
15098168

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11772808

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
8391745

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name AD 923

Novel drug target Established target

Trial Name AeroLEF

PMIDs:
15589524 16376082 16332149 16114980 19403616 16797997 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

n/a

PMIDs:
32401749

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9637647

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
30549211 30281924

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
11772808

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
9527747

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
30281924 27236640 24365989 22277678 18695978

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9527747

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
29601950 27883323 23557865 22277678 19514130 17192767 11964599

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
30281924 26771271

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
17987285 24469018

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
25825958

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

FENTANYL Primary Drug Name

Drug Info:

Drug Class analgesics, opioid

Drug Class adjuvants, anesthesia

Year of Approval approved before 1982

Drug Info:

Drug Indications analgesic

Drug Class Small Molecule

FDA Approval approved