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FELODIPINE Drug Record

  • Summary
  • Interactions
  • Claims
  • FELODIPINE chembl:CHEMBL1480 Approved

    Alternate Names:

    FELODIPINE
    FELOTENS XL
    C08CA02
    H 154/82
    VASCALPHA
    CABREN
    PRESLOW
    FOLPIK XL
    PINEFELD XL
    NEOFEL XL
    PARMID XL
    FELOGEN XL
    KELOC SR
    CARDIOPLEN XL
    H-154/82
    PLENDIL
    FELODIPINA
    4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER
    (+-)-ETHYL METHYL 4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE
    RENEDIL®
    3-ETHYL 5-METHYL 4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE
    FELODIPINUM
    PLANDIL®
    rxcui:4316
    drugbank:01023
    chemidplus:72509-76-3
    pubchem.compound:3333
    chembl:CHEMBL1480

    Drug Info:

    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications antihypertensive agent
    Drug Class antihypertensive agents
    Year of Approval 1991
    (4 More Sources)

    Publications:

    Dietz et al., 2008, A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity., Hypertension
    Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
    Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.
    Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
    Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
    Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.
    Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.
  • FELODIPINE   CACNB2

    Interaction Score: 1.9

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name felodipine ,Plendil
    Novel drug target Established target
    Trial Name enalapril + felodipine,Lexxel

    PMIDs:
    17475903 10525060 11752352


    Sources:
    TdgClinicalTrial

  • FELODIPINE   CACNA2D1

    Interaction Score: 1.32

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name enalapril + felodipine,Lexxel
    Novel drug target Established target
    Trial Name felodipine ,Plendil

    PMIDs:
    17475903 10525060 11752352


    Sources:
    TdgClinicalTrial TEND

  • FELODIPINE   MYO9B

    Interaction Score: 0.86

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2833901


    Sources:
    NCI

  • FELODIPINE   CACNA1C

    Interaction Score: 0.77

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name enalapril + felodipine,Lexxel
    Novel drug target Established target
    Trial Name felodipine ,Plendil

    PMIDs:
    17475903 10525060 11752352


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FELODIPINE   LEP

    Interaction Score: 0.63

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16097363


    Sources:
    NCI

  • FELODIPINE   CACNA1D

    Interaction Score: 0.59

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Trial Name enalapril + felodipine,Lexxel
    Novel drug target Established target
    Trial Name felodipine ,Plendil

    PMIDs:
    19029287


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FELODIPINE   NR3C2

    Interaction Score: 0.53

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Mechanism of Interaction Mineralocorticoid receptor antagonist
    Direct Interaction yes

    PMIDs:
    18250364


    Sources:
    ChemblInteractions

  • FELODIPINE   CACNA1S

    Interaction Score: 0.46

    Interaction Types & Directionality:
    blocker (inhibitory)
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes
    Trial Name felodipine ,Plendil

    PMIDs:
    16675661


    Sources:
    TdgClinicalTrial ChemblInteractions

  • FELODIPINE   CACNA1F

    Interaction Score: 0.21

    Interaction Types & Directionality:
    blocker (inhibitory)

    Interaction Info:
    Mechanism of Interaction Voltage-gated L-type calcium channel blocker
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • FELODIPINE   ABCB1

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • FELODIPINE   MAPT

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • FELODIPINE   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    9187528


    Sources:
    PharmGKB

  • FELODIPINE   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: FELODIPINE

    • Version: 01-August-2011

    Alternate Names:
    FELODIPINE Primary Drug Name

    Drug Info:
    Year of Approval 1991
    Drug Class antihypertensive agents

    Publications:

  • TdgClinicalTrial: FELODIPINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antihypertensive agent
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: FELODIPINE

    • Version: 14-September-2017

    Alternate Names:
    C29046 NCI drug code

    Drug Info:

    Publications:
    Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.
    Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.

  • PharmGKB: felodipine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

  • TTD: Felodipine

    • Version: 2020.06.01

    Alternate Names:
    D0WN0U TTD Drug ID

    Drug Info:

    Publications:

  • DTC: FELODIPINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1480 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1480

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1480

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21