DGIdb - FELODIPINE Drug Record

FELODIPINE chembl:CHEMBL1480 Approved

Alternate Names:

FELODIPINE
FELOTENS XL
C08CA02
H 154/82
VASCALPHA
CABREN
PRESLOW
FOLPIK XL
PINEFELD XL
NEOFEL XL
PARMID XL
FELOGEN XL
KELOC SR
CARDIOPLEN XL
H-154/82
PLENDIL
FELODIPINA
4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER
(+-)-ETHYL METHYL 4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE
RENEDIL®
3-ETHYL 5-METHYL 4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE
FELODIPINUM
PLANDIL®
rxcui:4316
drugbank:01023
chemidplus:72509-76-3
pubchem.compound:3333
chembl:CHEMBL1480

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Class	antihypertensive agents
Year of Approval	1991

(4 More Sources)

Publications:

Dietz et al., 2008, A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity., Hypertension
Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.
Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.
Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.

FELODIPINE CACNB2

Interaction Score: 1.9

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name felodipine ,Plendil

Novel drug target Established target

Trial Name enalapril + felodipine,Lexxel

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial
FELODIPINE CACNA2D1

Interaction Score: 1.32

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial TEND
FELODIPINE MYO9B

Interaction Score: 0.86

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2833901

Sources:
NCI
FELODIPINE CACNA1C

Interaction Score: 0.77

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial ChemblInteractions
FELODIPINE LEP

Interaction Score: 0.63

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16097363

Sources:
NCI
FELODIPINE CACNA1D

Interaction Score: 0.59

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
19029287

Sources:
TdgClinicalTrial ChemblInteractions
FELODIPINE NR3C2

Interaction Score: 0.53

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
18250364

Sources:
ChemblInteractions
FELODIPINE CACNA1S

Interaction Score: 0.46

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name felodipine ,Plendil

PMIDs:
16675661

Sources:
TdgClinicalTrial ChemblInteractions
FELODIPINE CACNA1F

Interaction Score: 0.21

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
FELODIPINE ABCB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
FELODIPINE MAPT

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
FELODIPINE CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9187528

Sources:
PharmGKB
FELODIPINE GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: FELODIPINE
- Version: 01-August-2011
Alternate Names:

FELODIPINE Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: FELODIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: FELODIPINE

Version: 14-September-2017

Alternate Names:

C29046 NCI drug code

Drug Info:

Publications:

Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.

Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.

PharmGKB: felodipine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Felodipine
- Version: 2020.06.01
Alternate Names:

D0WN0U TTD Drug ID

Drug Info:

Publications:
DTC: FELODIPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1480 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1480
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1480
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	felodipine ,Plendil
Novel drug target	Established target
Trial Name	enalapril + felodipine,Lexxel

Mechanism of Interaction	Mineralocorticoid receptor antagonist
Direct Interaction	yes

Mechanism of Interaction	Voltage-gated L-type calcium channel blocker
Direct Interaction	yes
Trial Name	felodipine ,Plendil

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

blocker (inhibitory)
inhibitor (inhibitory)

FELODIPINE Drug Record

FELODIPINE chembl:CHEMBL1480 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name felodipine ,Plendil Novel drug target Established target Trial Name enalapril + felodipine,Lexxel

PMIDs: 17475903 10525060 11752352

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target Trial Name felodipine ,Plendil

PMIDs: 17475903 10525060 11752352

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2833901

Sources: NCI

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target Trial Name felodipine ,Plendil

PMIDs: 17475903 10525060 11752352

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16097363

Sources: NCI

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target Trial Name felodipine ,Plendil

PMIDs: 19029287

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

PMIDs: 18250364

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes Trial Name felodipine ,Plendil

PMIDs: 16675661

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9187528

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: FELODIPINE

Alternate Names: FELODIPINE Primary Drug Name

Drug Info: Year of Approval 1991 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: FELODIPINE

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: FELODIPINE

Alternate Names: C29046 NCI drug code

Drug Info:

PharmGKB: felodipine

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Felodipine

Alternate Names: D0WN0U TTD Drug ID

Drug Info:

Publications:

DTC: FELODIPINE

Alternate Names: CHEMBL1480 ChEMBL Drug ID

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name felodipine ,Plendil

Novel drug target Established target

Trial Name enalapril + felodipine,Lexxel

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
2833901

Sources:
NCI

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
17475903 10525060 11752352

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16097363

Sources:
NCI

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

PMIDs:
19029287

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

PMIDs:
18250364

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name felodipine ,Plendil

PMIDs:
16675661

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
9187528

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

FELODIPINE Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29046 NCI drug code

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

D0WN0U TTD Drug ID

Alternate Names:

CHEMBL1480 ChEMBL Drug ID