DGIdb - FELODIPINE Drug Record

FELODIPINE chembl:CHEMBL1480 Approved

Alternate Names:

FELODIPINE
FELOTENS XL
C08CA02
H 154/82
VASCALPHA
CABREN
PRESLOW
FOLPIK XL
PINEFELD XL
NEOFEL XL
PARMID XL
FELOGEN XL
KELOC SR
CARDIOPLEN XL
H-154/82
PLENDIL
FELODIPINA
4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL METHYL ESTER
(+-)-ETHYL METHYL 4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLATE
RENEDIL®
3-ETHYL 5-METHYL 4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYL-1,4-DIHYDRO-3,5-PYRIDINEDICARBOXYLATE
FELODIPINUM
PLANDIL®
rxcui:4316
drugbank:01023
chemidplus:72509-76-3
pubchem.compound:3333
chembl:CHEMBL1480

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antihypertensive agent
Drug Class	antihypertensive agents
Year of Approval	1991
Drug Categories	agents causing hyperkalemia
Drug Categories	antiarrhythmic agents
Drug Categories	antihypertensive agents indicated for hypertension
Drug Categories	beta blocking agents and calcium channel blockers
Drug Categories	bradycardia-causing agents
Drug Categories	bsep/abcb11 substrates
Drug Categories	calcium-regulating hormones and agents
Drug Categories	cytochrome p-450 cyp2c8 inhibitors (strong)
Drug Categories	cytochrome p-450 cyp2c9 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp2d6 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inhibitors
Drug Categories	cytochrome p-450 cyp3a4 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 cyp3a7 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	dihydropyridine derivatives
Drug Categories	p-glycoprotein inhibitors
Drug Categories	potential qtc-prolonging agents
Drug Categories	qtc prolonging agents
Drug Categories	selective calcium channel blockers with mainly vascular effects
Drug Categories	vasodilating agents

(6 More Sources)

Publications:

Dietz et al., 2008, A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity., Hypertension
Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.
Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.
Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
Sharma et al., 1997, Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists., J. Neurochem.
Lamers et al., 1985, Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase., Biochem. Pharmacol.
Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.
Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.
Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.
Cohen et al., 1992, Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists., J. Gen. Physiol.
Perez-Reyes et al., 2009, Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs., J. Pharmacol. Exp. Ther.
Lamers et al., 1987, The effects of felodipine and bepridil on calcium-stimulated calmodulin binding and calcium pumping ATPase of cardiac sarcolemma before and after removal of endogenous calmodulin., Mol. Cell. Biochem.
Johnson et al., 1987, The interaction of felodipine with calcium-binding proteins., J. Cardiovasc. Pharmacol.
Mills et al., 1985, Cooperativity among calmodulin's drug binding sites., Biochemistry

FELODIPINE CACNA1D

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

Publications:

Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.
FELODIPINE CACNA1S

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name felodipine ,Plendil

Publications:

Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.
FELODIPINE CACNA1F

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Publications:
FELODIPINE CFTR

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Potentiation

Endogenous Drug? False

Direct Interaction? False

Publications:
FELODIPINE NR3C2

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

Publications:

Dietz et al., 2008, A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity., Hypertension

FELODIPINE CACNB2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name felodipine ,Plendil

Novel drug target Established target

Trial Name enalapril + felodipine,Lexxel

Publications:

Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.

Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

FELODIPINE TNNC1

Interaction Types & Directionality:

other/unknown

Interaction Info:

Publications:

Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.

FELODIPINE CACNA1C

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

Publications:

Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.

Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

FELODIPINE CACNA2D1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

Publications:

Zahradníková et al., 2007, Competitive and cooperative effects of Bay K8644 on the L-type calcium channel current inhibition by calcium channel antagonists., J. Pharmacol. Exp. Ther.

Furukawa et al., 1999, Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes., J. Pharmacol. Exp. Ther.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

FELODIPINE PDE1B

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Sharma et al., 1997, Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists., J. Neurochem.

Lamers et al., 1985, Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase., Biochem. Pharmacol.

FELODIPINE TNNC2

Interaction Types & Directionality:

other/unknown

Interaction Info:

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.

FELODIPINE CACNA2D2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Cohen et al., 1992, Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists., J. Gen. Physiol.

Perez-Reyes et al., 2009, Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs., J. Pharmacol. Exp. Ther.

FELODIPINE CALM1

Interaction Types & Directionality:

other/unknown

Interaction Info:

Publications:

Lamers et al., 1987, The effects of felodipine and bepridil on calcium-stimulated calmodulin binding and calcium pumping ATPase of cardiac sarcolemma before and after removal of endogenous calmodulin., Mol. Cell. Biochem.

Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.

Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.

FELODIPINE PDE1A

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Sharma et al., 1997, Mechanisms of inhibition of calmodulin-stimulated cyclic nucleotide phosphodiesterase by dihydropyridine calcium antagonists., J. Neurochem.

Lamers et al., 1985, Slow calcium channel blockers and calmodulin. Effect of felodipine, nifedipine, prenylamine and bepridil on cardiac sarcolemmal calcium pumping ATPase., Biochem. Pharmacol.

FELODIPINE CACNA1H

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Publications:

Cohen et al., 1992, Block of T-type Ca channels in guinea pig atrial cells by antiarrhythmic agents and Ca channel antagonists., J. Gen. Physiol.

Perez-Reyes et al., 2009, Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs., J. Pharmacol. Exp. Ther.

FELODIPINE CYP3A4

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
FELODIPINE MYO9B

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.
FELODIPINE LEP

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.
FELODIPINE MAPT

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
FELODIPINE ABCB1

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:
FELODIPINE GMNN

Interaction Types & Directionality:

n/a

Interaction Info:

Publications:

DrugBank: DB01023

Version: 5.1.7

Alternate Names:

FELODIPINE DrugBank Drug Name

72509-76-3 CAS Number

Altace Plus Felodipine 2.5mg + 2.5mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.

Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

TEND: FELODIPINE
- Version: 01-August-2011
Alternate Names:

FELODIPINE Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: FELODIPINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: FELODIPINE

Version: 14-September-2017

Alternate Names:

C29046 NCI drug code

Drug Info:

Publications:

Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.

Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.

PharmGKB: felodipine
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev
TTD: Felodipine
- Version: 2020.06.01
Alternate Names:

D0WN0U TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178101007
- Version: 29-September-2020
Alternate Names:

FELODIPINE GuideToPharmacology Ligand Name

Drug Info:

Publications:
DTC: FELODIPINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1480 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1480
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1480
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	enalapril + felodipine,Lexxel
Novel drug target	Established target
Trial Name	felodipine ,Plendil

Mechanism of Interaction	Voltage-gated L-type calcium channel blocker
Direct Interaction	yes
Trial Name	felodipine ,Plendil

Specific Action of the Ligand	Potentiation
Endogenous Drug?	False
Direct Interaction?	False

Mechanism of Interaction	Mineralocorticoid receptor antagonist
Direct Interaction	yes

FELODIPINE	DrugBank Drug Name
72509-76-3	CAS Number
Altace Plus Felodipine 2.5mg + 2.5mg	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

FELODIPINE Drug Record

FELODIPINE chembl:CHEMBL1480 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target Trial Name felodipine ,Plendil

Publications: Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes Trial Name felodipine ,Plendil

Publications: Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Voltage-gated L-type calcium channel blocker Direct Interaction yes

Publications:

Interaction Types & Directionality: activator (activating)

Interaction Info: Specific Action of the Ligand Potentiation Endogenous Drug? False Direct Interaction? False

Publications:

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Mechanism of Interaction Mineralocorticoid receptor antagonist Direct Interaction yes

Publications: Dietz et al., 2008, A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity., Hypertension

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name felodipine ,Plendil Novel drug target Established target Trial Name enalapril + felodipine,Lexxel

Interaction Types & Directionality: other/unknown

Interaction Info:

Publications: Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.

Interaction Types & Directionality: inhibitor (inhibitory) blocker (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target Trial Name felodipine ,Plendil

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name enalapril + felodipine,Lexxel Novel drug target Established target Trial Name felodipine ,Plendil

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: other/unknown

Interaction Info:

Publications: Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res. Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: other/unknown

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.

Interaction Types & Directionality: n/a

Interaction Info:

Publications: Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

Publications:

DrugBank: DB01023

Alternate Names: FELODIPINE DrugBank Drug Name 72509-76-3 CAS Number Altace Plus Felodipine 2.5mg + 2.5mg Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: FELODIPINE

Alternate Names: FELODIPINE Primary Drug Name

Drug Info: Year of Approval 1991 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: FELODIPINE

Alternate Names:

Drug Info: Drug Indications antihypertensive agent Drug Class Small Molecule FDA Approval approved

Publications:

NCI: FELODIPINE

Alternate Names: C29046 NCI drug code

Drug Info:

PharmGKB: felodipine

Alternate Names:

Drug Info:

Publications: Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

TTD: Felodipine

Alternate Names: D0WN0U TTD Drug ID

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

Publications:

Sinnegger-Brauns et al., 2009, Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms., Mol. Pharmacol.

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Trial Name felodipine ,Plendil

Publications:

Peterson et al., 2006, Allosteric interactions required for high-affinity binding of dihydropyridine antagonists to Ca(V)1.1 Channels are modulated by calcium in the pore., Mol. Pharmacol.

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Voltage-gated L-type calcium channel blocker

Direct Interaction yes

Interaction Types & Directionality:

activator (activating)

Interaction Info:

Specific Action of the Ligand Potentiation

Endogenous Drug? False

Direct Interaction? False

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Mechanism of Interaction Mineralocorticoid receptor antagonist

Direct Interaction yes

Publications:

Dietz et al., 2008, A number of marketed dihydropyridine calcium channel blockers have mineralocorticoid receptor antagonist activity., Hypertension

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name felodipine ,Plendil

Novel drug target Established target

Trial Name enalapril + felodipine,Lexxel

Interaction Types & Directionality:

other/unknown

Publications:

Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.

Interaction Types & Directionality:

inhibitor (inhibitory)

blocker (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name enalapril + felodipine,Lexxel

Novel drug target Established target

Trial Name felodipine ,Plendil

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

other/unknown

Publications:

Berman et al., 2000, The Protein Data Bank., Nucleic Acids Res.

Boström et al., 1988, Binding of a dihydropyridine felodipine-analogue to calmodulin and related calcium-binding proteins., Biochem. Pharmacol.

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

other/unknown

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Types & Directionality:

n/a

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Interaction Types & Directionality:

n/a

Publications:

Walsh et al., 1988, Effects of felodipine (a dihydropyridine calcium channel blocker) and analogues on calmodulin-dependent enzymes., Biochem. Pharmacol.

Interaction Types & Directionality:

n/a

Publications:

Fogari et al., 2005, Comparison of the effects of valsartan and felodipine on plasma leptin and insulin sensitivity in hypertensive obese patients., Hypertens. Res.

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Interaction Types & Directionality:

n/a

Alternate Names:

FELODIPINE DrugBank Drug Name

72509-76-3 CAS Number

Altace Plus Felodipine 2.5mg + 2.5mg Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

FELODIPINE Primary Drug Name

Drug Info:

Year of Approval 1991

Drug Class antihypertensive agents

Drug Info:

Drug Indications antihypertensive agent

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29046 NCI drug code

Publications:

Rendic S et al., 1997, Human cytochrome P450 enzymes: a status report summarizing their reactions, substrates, inducers, and inhibitors., Drug Metab Rev

Alternate Names:

D0WN0U TTD Drug ID

Alternate Names:

FELODIPINE GuideToPharmacology Ligand Name

Alternate Names:

CHEMBL1480 ChEMBL Drug ID