• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

FAMOTIDINE Drug Record

  • Summary
  • Interactions
  • Claims
  • FAMOTIDINE chembl:CHEMBL902 Approved

    Alternate Names:

    PEPCID
    L 643341
    PEPCID AC
    PEPCID RPD
    MK-208
    PEPCID PRESERVATIVE FREE
    FAMOTIDINE PRESERVATIVE FREE
    FLUXID
    FAMOTIDINE
    YM-11170
    3-(((2-((AMINOIMINOMETHYL)AMINO)-4-THIAZOLYL)METHYL)THIO)-N-(AMINOSULFONYL)PROPANIMIDAMIDE
    FAMOTIN
    VAGOSTAL
    FAMOGARD
    MIDEFAM
    FAMODIN
    FAMOTEP
    FAMOWAL
    FAMODIL
    FAMODINE
    QUAMATEL
    FAMODAR
    RUBACINA
    FAMOCID
    HACIP
    MUCLOX
    LECEDIL
    3-(((2-((DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)-N(SUP 2)-SULFAMOYLPROPIONAMIDINE
    FAMOTIDINA
    GASTRODOMINA
    PEPDUL
    PURIFAM
    ULCEPRAX
    INGASTRI
    FAMOPSIN
    PEPFAMIN
    ULFAMID
    AMFAMOX
    HUBERDINA
    NEOCIDINE
    FAMOTIDINUM
    GASTRO
    FAMOTAL
    ULCATIF
    ULCOFAM
    PANALBA
    INVIGAN
    MOSUL
    NEVOFAM
    NOVO-FAMOTIDINE
    CEPAL
    APO-FAMOTIDINE
    MOTIAX
    PEPCIDIN
    BROLIN
    ULGARINE
    BESTIDINE
    PEPTAN
    FAMOSAN
    GASTRION
    TAMIN
    ULFINOL
    PEPCIDIN PEPCIDINE
    FAMOS
    GASTROPEN
    TOPCID
    FAMOVANE
    GASTRIDAN
    ROGASTI
    ULFAM
    QUAMTEL
    CONFOBOS
    PEPDINE
    RENAPEPSA
    CUANTIN
    GASTER®
    NULCERAN
    GASTRIDIN
    BLOCACID
    GASTROSIDIN
    GASTROFAM
    NOTIDIN
    ANTODINE
    3-{[(2-CARBAMIMIDAMIDO-1,3-THIAZOL-4-YL)METHYL]SULFANYL}-N-SULFAMOYLPROPANIMIDAMIDE
    N-SULFAMOYL-3-((2-GUANIDINOTHIAZOL-4-YL)METHYLTHIO)PROPIONAMIDE
    PEPCID®
    FAMONIT
    PEPTIDIN
    TIPODEX
    (1-AMINO-3-(((2-((DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)PROPYLIDENE)SULFAMIDE
    MENSOMA
    APOGASTINE
    RESTADIN
    LOGOS
    ULFAGEL
    NULCERIN
    CRONOL
    MYLANTA AR
    drugbank:00927
    chemidplus:76824-35-6
    chembl:CHEMBL902
    pubchem.compound:5702160
    rxcui:4278

    Drug Info:

    Drug Indications for treatment of gastric ulcer and gastroesophageal reflux
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications acid reducer
    Year of Approval 1986
    Drug Class gi anti-ulcer agents, antihistamines
    (3 More Sources)

    Publications:

    Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
    Fukuda et al., 2007, Cimetidine induces apoptosis of human salivary gland tumor cells., Oncol. Rep.
    Amagase et al., 2003, On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion., J. Pharmacol. Sci.
    Inan et al., 2009, Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats., Clinics (Sao Paulo)
    Miyata et al., 1991, Studies on the mechanism for the gastric mucosal protection by famotidine in rats., Jpn. J. Pharmacol.
    Ojiako et al., 2008, Famotidine versus pantoprazole for preventing bleeding in the upper gastrointestinal tract of critically ill patients receiving mechanical ventilation., Am. J. Crit. Care
    Leurs et al., 1991, Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine., Br. J. Pharmacol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Takahashi et al., 2006, Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes., Mol. Pharmacol.
    Kesiova et al., Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues., Pharmacol Rep
    Weydert et al., 2003, Systematic review of treatments for recurrent abdominal pain., Pediatrics
    Lesclous et al., 2006, Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats., Exp. Physiol.
    Chremos AN, 1987, Clinical pharmacology of famotidine: a summary., J Clin Gastroenterol
    Esaki et al., 2002, Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans., Eur J Gastroenterol Hepatol
  • FAMOTIDINE   HRH2

    Interaction Score: 16.49

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Histamine H2 receptor antagonist
    Trial Name HZT-501, ibuprofen + famotidine,Duexa

    PMIDs:
    17273750 12832840 19578661 2067140 18310651 1646056 11752352 16723495 16702624 12509588 16513821 2887616


    Sources:
    TdgClinicalTrial ChemblInteractions TEND TTD

  • FAMOTIDINE   FGF2

    Interaction Score: 1.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11943947


    Sources:
    NCI

  • FAMOTIDINE   TAC1

    Interaction Score: 1.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12495560


    Sources:
    NCI

  • FAMOTIDINE   KDM4A

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: FAMOTIDINE

    • Version: 01-August-2011

    Alternate Names:
    FAMOTIDINE Primary Drug Name

    Drug Info:
    Drug Class gi anti-ulcer agents, antihistamines
    Year of Approval 1986

    Publications:

  • TdgClinicalTrial: FAMOTIDINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications acid reducer
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: FAMOTIDINE

    • Version: 14-September-2017

    Alternate Names:
    C29045 NCI drug code

    Drug Info:

    Publications:
    Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
    Esaki et al., 2002, Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans., Eur J Gastroenterol Hepatol

  • DTC: FAMOTIDINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL902 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Famotidine

    • Version: 2020.06.01

    Alternate Names:
    D0K0OZ TTD Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL902

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL902

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21