DGIdb - FAMOTIDINE Drug Record

FAMOTIDINE chembl:CHEMBL902 Approved

Alternate Names:

PEPCID
L 643341
PEPCID AC
PEPCID RPD
MK-208
PEPCID PRESERVATIVE FREE
FAMOTIDINE PRESERVATIVE FREE
FLUXID
FAMOTIDINE
YM-11170
3-(((2-((AMINOIMINOMETHYL)AMINO)-4-THIAZOLYL)METHYL)THIO)-N-(AMINOSULFONYL)PROPANIMIDAMIDE
FAMOTIN
VAGOSTAL
FAMOGARD
MIDEFAM
FAMODIN
FAMOTEP
FAMOWAL
FAMODIL
FAMODINE
QUAMATEL
FAMODAR
RUBACINA
FAMOCID
HACIP
MUCLOX
LECEDIL
3-(((2-((DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)-N(SUP 2)-SULFAMOYLPROPIONAMIDINE
FAMOTIDINA
GASTRODOMINA
PEPDUL
PURIFAM
ULCEPRAX
INGASTRI
FAMOPSIN
PEPFAMIN
ULFAMID
AMFAMOX
HUBERDINA
NEOCIDINE
FAMOTIDINUM
GASTRO
FAMOTAL
ULCATIF
ULCOFAM
PANALBA
INVIGAN
MOSUL
NEVOFAM
NOVO-FAMOTIDINE
CEPAL
APO-FAMOTIDINE
MOTIAX
PEPCIDIN
BROLIN
ULGARINE
BESTIDINE
PEPTAN
FAMOSAN
GASTRION
TAMIN
ULFINOL
PEPCIDIN PEPCIDINE
FAMOS
GASTROPEN
TOPCID
FAMOVANE
GASTRIDAN
ROGASTI
ULFAM
QUAMTEL
CONFOBOS
PEPDINE
RENAPEPSA
CUANTIN
GASTER®
NULCERAN
GASTRIDIN
BLOCACID
GASTROSIDIN
GASTROFAM
NOTIDIN
ANTODINE
3-{[(2-CARBAMIMIDAMIDO-1,3-THIAZOL-4-YL)METHYL]SULFANYL}-N-SULFAMOYLPROPANIMIDAMIDE
N-SULFAMOYL-3-((2-GUANIDINOTHIAZOL-4-YL)METHYLTHIO)PROPIONAMIDE
PEPCID®
FAMONIT
PEPTIDIN
TIPODEX
(1-AMINO-3-(((2-((DIAMINOMETHYLENE)AMINO)-4-THIAZOLYL)METHYL)THIO)PROPYLIDENE)SULFAMIDE
MENSOMA
APOGASTINE
RESTADIN
LOGOS
ULFAGEL
NULCERIN
CRONOL
MYLANTA AR
drugbank:00927
chemidplus:76824-35-6
chembl:CHEMBL902
pubchem.compound:5702160
rxcui:4278

Drug Info:

Drug Indications	for treatment of gastric ulcer and gastroesophageal reflux
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	acid reducer
Year of Approval	1986
Drug Class	gi anti-ulcer agents, antihistamines

(3 More Sources)

Publications:

Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.
Fukuda et al., 2007, Cimetidine induces apoptosis of human salivary gland tumor cells., Oncol. Rep.
Amagase et al., 2003, On the mechanisms underlying histamine induction of gastric mucosal lesions in rats with partial gastric vascular occlusion., J. Pharmacol. Sci.
Inan et al., 2009, Effects of the histamine H2 receptor antagonist famotidine on the healing of colonic anastomosis in rats., Clinics (Sao Paulo)
Miyata et al., 1991, Studies on the mechanism for the gastric mucosal protection by famotidine in rats., Jpn. J. Pharmacol.
Ojiako et al., 2008, Famotidine versus pantoprazole for preventing bleeding in the upper gastrointestinal tract of critically ill patients receiving mechanical ventilation., Am. J. Crit. Care
Leurs et al., 1991, Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Takahashi et al., 2006, Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes., Mol. Pharmacol.
Kesiova et al., Effects of diphenhydramine and famotidine on lipid peroxidation and activities of antioxidant enzymes in different rat tissues., Pharmacol Rep
Weydert et al., 2003, Systematic review of treatments for recurrent abdominal pain., Pediatrics
Lesclous et al., 2006, Histamine mediates osteoclastic resorption only during the acute phase of bone loss in ovariectomized rats., Exp. Physiol.
Chremos AN, 1987, Clinical pharmacology of famotidine: a summary., J Clin Gastroenterol
Esaki et al., 2002, Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans., Eur J Gastroenterol Hepatol

FAMOTIDINE HRH2

Interaction Score: 16.49

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histamine H2 receptor antagonist

Trial Name HZT-501, ibuprofen + famotidine,Duexa

PMIDs:
17273750 12832840 19578661 2067140 18310651 1646056 11752352 16723495 16702624 12509588 16513821 2887616

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
FAMOTIDINE FGF2

Interaction Score: 1.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
11943947

Sources:
NCI
FAMOTIDINE TAC1

Interaction Score: 1.41

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12495560

Sources:
NCI
FAMOTIDINE KDM4A

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: FAMOTIDINE
- Version: 01-August-2011
Alternate Names:

FAMOTIDINE Primary Drug Name

Drug Info:

Drug Class gi anti-ulcer agents, antihistamines

Year of Approval 1986

Publications:
TdgClinicalTrial: FAMOTIDINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications acid reducer

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: FAMOTIDINE

Version: 14-September-2017

Alternate Names:

C29045 NCI drug code

Drug Info:

Publications:

Itoh et al., 2002, Effects of histamine H(2)-receptor antagonists on human plasma levels of calcitonin gene-related peptide, substance P and vasoactive intestinal peptide., J. Pharm. Pharmacol.

Esaki et al., 2002, Effects of omeprazole and famotidine on fibroblast growth factor-2 during artificial gastric ulcer healing in humans., Eur J Gastroenterol Hepatol

DTC: FAMOTIDINE
- Version: 02-September-2020
Alternate Names:

CHEMBL902 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Famotidine
- Version: 2020.06.01
Alternate Names:

D0K0OZ TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL902
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL902
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Histamine H2 receptor antagonist
Trial Name	HZT-501, ibuprofen + famotidine,Duexa

FAMOTIDINE Drug Record

FAMOTIDINE chembl:CHEMBL902 Approved

Alternate Names:

Drug Info:

Publications:

FAMOTIDINE HRH2

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Histamine H2 receptor antagonist Trial Name HZT-501, ibuprofen + famotidine,Duexa

PMIDs: 17273750 12832840 19578661 2067140 18310651 1646056 11752352 16723495 16702624 12509588 16513821 2887616

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

FAMOTIDINE FGF2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 11943947

Sources: NCI

FAMOTIDINE TAC1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12495560

Sources: NCI

FAMOTIDINE KDM4A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: FAMOTIDINE

Alternate Names: FAMOTIDINE Primary Drug Name

Drug Info: Drug Class gi anti-ulcer agents, antihistamines Year of Approval 1986

Publications:

TdgClinicalTrial: FAMOTIDINE

Alternate Names:

Drug Info: Drug Indications acid reducer Drug Class Small Molecule FDA Approval approved

Publications:

NCI: FAMOTIDINE

Alternate Names: C29045 NCI drug code

Drug Info:

DTC: FAMOTIDINE

Alternate Names: CHEMBL902 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Famotidine

Alternate Names: D0K0OZ TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL902

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL902

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Histamine H2 receptor antagonist

Trial Name HZT-501, ibuprofen + famotidine,Duexa

PMIDs:
17273750 12832840 19578661 2067140 18310651 1646056 11752352 16723495 16702624 12509588 16513821 2887616

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
11943947

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12495560

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

FAMOTIDINE Primary Drug Name

Drug Info:

Drug Class gi anti-ulcer agents, antihistamines

Year of Approval 1986

Drug Info:

Drug Indications acid reducer

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

C29045 NCI drug code

Alternate Names:

CHEMBL902 ChEMBL Drug ID

Alternate Names:

D0K0OZ TTD Drug ID