DGIdb - ETONOGESTREL Drug Record

ETONOGESTREL chembl:CHEMBL1531 Approved

Alternate Names:

ETONOGESTREL
ORG-3236
NEXPLANON
IMPLANON
ETONOGESTRELUM
NEXPLANON®
3-OXODESOGESTREL
3-KETODESOGESTREL
3-KETO-DESOGESTREL
IMPLANON®
ÉTONOGESTREL
chemidplus:54048-10-1
chembl:CHEMBL1531
pubchem.compound:6917715
rxcui:14584
drugbank:00294

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	contraceptive
Drug Class	contraceptives
Year of Approval	2001

(3 More Sources)

Publications:

Lazorwitz A et al., 2019, Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users., Obstet Gynecol
Charnock-Jones et al., 2000, The effect of progestins on vascular endothelial growth factor, oestrogen receptor and progesterone receptor immunoreactivity and endothelial cell density in human endometrium., Hum. Reprod.
Sitruk-Ware, 2004, Pharmacological profile of progestins., Maturitas
Macpherson et al., 1999, The effect of etonogestrel on VEGF, oestrogen and progesterone receptor immunoreactivity and endothelial cell number in human endometrium., Hum. Reprod.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov

ETONOGESTREL CYP3A7

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
30870275

Sources:
PharmGKB
ETONOGESTREL PGR

Interaction Score: 2.42

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name etonogestrel implant,Implanon

Novel drug target Established target

Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs:
11041225 15063480 10601100 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ETONOGESTREL ESR1

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name etonogestrel implant,Implanon

Novel drug target Established target

Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
ETONOGESTREL AR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: ETONOGESTREL
- Version: 01-August-2011
Alternate Names:

ETONOGESTREL Primary Drug Name

Drug Info:

Year of Approval 2001

Drug Class contraceptives

Publications:
TdgClinicalTrial: ETONOGESTREL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications contraceptive

Drug Class Small Molecule

FDA Approval approved

Publications:
PharmGKB: etonogestrel
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Lazorwitz A et al., 2019, Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users., Obstet Gynecol
DTC: ETONOGESTREL
- Version: 02-September-2020
Alternate Names:

CHEMBL1531 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Etonogestrel
- Version: 2020.06.01
Alternate Names:

D02KIU TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1531
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1531
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Trial Name	etonogestrel implant,Implanon
Novel drug target	Established target
Trial Name	etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

ETONOGESTREL Drug Record

ETONOGESTREL chembl:CHEMBL1531 Approved

Alternate Names:

Drug Info:

Publications:

ETONOGESTREL CYP3A7

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 30870275

Sources: PharmGKB

ETONOGESTREL PGR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name etonogestrel implant,Implanon Novel drug target Established target Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs: 11041225 15063480 10601100 11752352

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

ETONOGESTREL ESR1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name etonogestrel implant,Implanon Novel drug target Established target Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

ETONOGESTREL AR

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: ETONOGESTREL

Alternate Names: ETONOGESTREL Primary Drug Name

Drug Info: Year of Approval 2001 Drug Class contraceptives

Publications:

TdgClinicalTrial: ETONOGESTREL

Alternate Names:

Drug Info: Drug Indications contraceptive Drug Class Small Molecule FDA Approval approved

Publications:

PharmGKB: etonogestrel

Alternate Names:

Drug Info:

Publications: Lazorwitz A et al., 2019, Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users., Obstet Gynecol

DTC: ETONOGESTREL

Alternate Names: CHEMBL1531 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Etonogestrel

Alternate Names: D02KIU TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1531

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1531

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
30870275

Sources:
PharmGKB

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name etonogestrel implant,Implanon

Novel drug target Established target

Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs:
11041225 15063480 10601100 11752352

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name etonogestrel implant,Implanon

Novel drug target Established target

Trial Name etonogestrel/ethinyl estradiol vaginal ring,Nuvaring

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

ETONOGESTREL Primary Drug Name

Drug Info:

Year of Approval 2001

Drug Class contraceptives

Drug Info:

Drug Indications contraceptive

Drug Class Small Molecule

FDA Approval approved

Publications:

Lazorwitz A et al., 2019, Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users., Obstet Gynecol

Alternate Names:

CHEMBL1531 ChEMBL Drug ID

Alternate Names:

D02KIU TTD Drug ID