DGIdb - ETHOTOIN Drug Record

ETHOTOIN chembl:CHEMBL1095 Approved

Alternate Names:

ETHOTOIN
PEGANONE
ETHOTOÏNE
3-ETHYL-5-PHENYL-IMIDAZOLIDINE-2,4-DIONE
3-ETHYL-5-PHENYLIMIDAZOLIDIN-2,4-DIONE
ETHOTOINUM
3-ETHYL-5-PHENYLHYDANTOIN
1-ETHYL-2,5-DIOXO-4-PHENYLIMIDAZOLIDINE
ETOTOINA
PEGANONE®
3-ETHYL-5-PHENYL-2,4-IMIDAZOLIDINEDIONE
(+-)-3-ETHYL-5-PHENYLHYDANTOIN
chembl:CHEMBL1095
pubchem.compound:3292
drugbank:00754
rxcui:4136
chemidplus:86-35-1

Drug Info:

Drug Class	anticonvulsants
Year of Approval	1957
FDA Approval	1957
Drug Class	small molecule
Drug Indications	Anticonvulsants

(1 More Sources)

Publications:

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Lenkowski et al., 2004, Block of human NaV1.5 sodium channels by novel alpha-hydroxyphenylamide analogues of phenytoin., Eur J Pharm Sci

ETHOTOIN SCN5A

Interaction Score: 0.58

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
11752352 17016423 17139284 15066664

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
ETHOTOIN SCN7A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN8A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN3A

Interaction Score: 0.11

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN11A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN1A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN2A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN4A

Interaction Score: 0.1

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN9A

Interaction Score: 0.09

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ETHOTOIN SCN10A

Interaction Score: 0.08

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

TEND: ETHOTOIN
- Version: 01-August-2011
Alternate Names:

ETHOTOIN Primary Drug Name

Drug Info:

Year of Approval 1957

Drug Class anticonvulsants

Publications:
TdgClinicalTrial: ETHOTOIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticonvulsants

Drug Class small molecule

FDA Approval 1957

Publications:
TTD: Ethotoin
- Version: 2020.06.01
Alternate Names:

D05EPM TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1095
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1095
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target
Mechanism of Interaction	Sodium channel alpha subunit blocker

Mechanism of Interaction	Sodium channel alpha subunit blocker
Direct Interaction	yes

blocker (inhibitory)
inhibitor (inhibitory)

ETHOTOIN Drug Record

ETHOTOIN chembl:CHEMBL1095 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: blocker (inhibitory) inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: 11752352 17016423 17139284 15066664

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Mechanism of Interaction Sodium channel alpha subunit blocker Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: blocker (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs: None found

Sources: ChemblInteractions

TEND: ETHOTOIN

Alternate Names: ETHOTOIN Primary Drug Name

Drug Info: Year of Approval 1957 Drug Class anticonvulsants

Publications:

TdgClinicalTrial: ETHOTOIN

Alternate Names:

Drug Info: Drug Indications Anticonvulsants Drug Class small molecule FDA Approval 1957

Publications:

TTD: Ethotoin

Alternate Names: D05EPM TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1095

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1095

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

blocker (inhibitory)

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
11752352 17016423 17139284 15066664

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Mechanism of Interaction Sodium channel alpha subunit blocker

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

blocker (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Sodium channel alpha subunit blocker

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

ETHOTOIN Primary Drug Name

Drug Info:

Year of Approval 1957

Drug Class anticonvulsants

Drug Info:

Drug Indications Anticonvulsants

Drug Class small molecule

FDA Approval 1957

Alternate Names:

D05EPM TTD Drug ID