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ESTRONE Drug Record

  • Summary
  • Interactions
  • Claims
  • ESTRONE chembl:CHEMBL1405 Approved

    Alternate Names:

    WAY 164397
    THEELIN
    NSC-9699
    ESTROGENIC SUBSTANCE
    ESTRONE
    OESTRONE
    1,3,5(10)-ESTRATRIEN-3-OL-17-ONE
    FOLLICULIN
    ESTRONA
    KESTRONE®
    D1,3,5(10)-ESTRATRIEN-3-OL-17-ONE
    3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE
    3-HYDROXY-17-KETO-ESTRA-1,3,5-TRIENE
    FOLLICULAR HORMONE
    (1S,10R,11S,15S)-5-HYDROXY-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIEN-14-ONE
    3-HYDROXYESTRA-1,3,5(10)-TRIENE-17-ONE
    3-HYDROXYOESTRA-1,3,5(10)-TRIEN-17-ONE
    ESTRONE:E1
    (+)-ESTRONE
    ESTRONUM
    E1
    AQUEST®
    (8R,9S,13S,14S)-3-HYDROXY-13-METHYL-7,8,9,11,12,14,15,16-OCTAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-ONE
    3-HYDROXY-1,3,5(10)-ESTRATRIEN-17-ONE
    chembl:CHEMBL1405
    pubchem.compound:5870
    rxcui:4103
    chemidplus:53-16-7
    drugbank:00655

    Drug Info:

    Drug Class hormone replacement agents
    Year of Approval not approved by the fda
    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Hormone Replacement Agents
    (3 More Sources)

    Publications:

    Kojima H et al., 2003, Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities., Environ Health Perspect
    Margeat et al., 2003, Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta., J. Mol. Biol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
    Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
    Falany et al., Steroid 3- and 17-OH UDP-glucuronosyltransferase activities in rat and rabbit liver microsomes., Drug Metab. Dispos.
    Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids
    Weng et al., 2002, C-mycprotein expression upregulated by 2-(3-estrone-N-ethyl piperazine-methyl) tetracycline in bone., Yao Xue Xue Bao
    Li et al., 2000, [Effect of estrogen on the expression of c-myc protein of bone in mice]., Wei Sheng Yan Jiu
    Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.
    Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi
  • ESTRONE   AKR1C1

    Interaction Score: 3.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3859707


    Sources:
    NCI

  • ESTRONE   STS

    Interaction Score: 2.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6581863 2796962


    Sources:
    NCI

  • ESTRONE   UGT1A5

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6138227


    Sources:
    NCI

  • ESTRONE   MYC

    Interaction Score: 0.58

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12567859 12520970


    Sources:
    NCI

  • ESTRONE   ESR1

    Interaction Score: 0.32

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes
    Trial Name -

    PMIDs:
    12547192 11752352 2011412


    Sources:
    DTC TdgClinicalTrial ChemblInteractions TEND TTD

  • ESTRONE   PIK3CG

    Interaction Score: 0.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16860831


    Sources:
    NCI

  • ESTRONE   TARDBP

    Interaction Score: 0.07

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ESTRONE   AR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12676605


    Sources:
    DTC

  • TdgClinicalTrial: ESTRONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hormone Replacement Agents
    Drug Class small molecule
    FDA Approval not approved by the FDA

    Publications:

  • TEND: ESTRONE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval not approved by the fda
    Drug Class hormone replacement agents

    Publications:

  • NCI: ESTRONE

    • Version: 14-September-2017

    Alternate Names:
    C484 NCI drug code

    Drug Info:

    Publications:
    Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids
    Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
    Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi

  • TTD: Estrone

    • Version: 2020.06.01

    Alternate Names:
    D00ZFP TTD Drug ID

    Drug Info:

    Publications:

  • DTC: ESTRONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1405 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1405

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1405

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21