DGIdb - ESTRONE Drug Record

ESTRONE chembl:CHEMBL1405 Approved

Alternate Names:

WAY 164397
THEELIN
NSC-9699
ESTROGENIC SUBSTANCE
ESTRONE
OESTRONE
1,3,5(10)-ESTRATRIEN-3-OL-17-ONE
FOLLICULIN
ESTRONA
KESTRONE®
D1,3,5(10)-ESTRATRIEN-3-OL-17-ONE
3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE
3-HYDROXY-17-KETO-ESTRA-1,3,5-TRIENE
FOLLICULAR HORMONE
(1S,10R,11S,15S)-5-HYDROXY-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIEN-14-ONE
3-HYDROXYESTRA-1,3,5(10)-TRIENE-17-ONE
3-HYDROXYOESTRA-1,3,5(10)-TRIEN-17-ONE
ESTRONE：E1
(+)-ESTRONE
ESTRONUM
E1
AQUEST®
(8R,9S,13S,14S)-3-HYDROXY-13-METHYL-7,8,9,11,12,14,15,16-OCTAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-ONE
3-HYDROXY-1,3,5(10)-ESTRATRIEN-17-ONE
chembl:CHEMBL1405
pubchem.compound:5870
rxcui:4103
chemidplus:53-16-7
drugbank:00655

Drug Info:

Drug Class	hormone replacement agents
Year of Approval	not approved by the fda
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Hormone Replacement Agents

(3 More Sources)

Publications:

Kojima H et al., 2003, Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities., Environ Health Perspect
Margeat et al., 2003, Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta., J. Mol. Biol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
Falany et al., Steroid 3- and 17-OH UDP-glucuronosyltransferase activities in rat and rabbit liver microsomes., Drug Metab. Dispos.
Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids
Weng et al., 2002, C-mycprotein expression upregulated by 2-(3-estrone-N-ethyl piperazine-methyl) tetracycline in bone., Yao Xue Xue Bao
Li et al., 2000, [Effect of estrogen on the expression of c-myc protein of bone in mice]., Wei Sheng Yan Jiu
Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.
Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi

ESTRONE AKR1C1

Interaction Score: 3.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3859707

Sources:
NCI
ESTRONE STS

Interaction Score: 2.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6581863 2796962

Sources:
NCI
ESTRONE UGT1A5

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6138227

Sources:
NCI
ESTRONE MYC

Interaction Score: 0.58

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12567859 12520970

Sources:
NCI
ESTRONE ESR1

Interaction Score: 0.32

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Estrogen receptor alpha agonist

Direct Interaction yes

Trial Name -

PMIDs:
12547192 11752352 2011412

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
ESTRONE PIK3CG

Interaction Score: 0.18

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16860831

Sources:
NCI
ESTRONE TARDBP

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTRONE AR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12676605

Sources:
DTC

TdgClinicalTrial: ESTRONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:
TEND: ESTRONE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval not approved by the fda

Drug Class hormone replacement agents

Publications:

NCI: ESTRONE

Version: 14-September-2017

Alternate Names:

C484 NCI drug code

Drug Info:

Publications:

Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids

Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.

Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi

TTD: Estrone
- Version: 2020.06.01
Alternate Names:

D00ZFP TTD Drug ID

Drug Info:

Publications:
DTC: ESTRONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1405 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1405
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1405
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Estrogen receptor alpha agonist
Direct Interaction	yes
Trial Name	-

ESTRONE Drug Record

ESTRONE chembl:CHEMBL1405 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3859707

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6581863 2796962

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6138227

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12567859 12520970

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Estrogen receptor alpha agonist Direct Interaction yes Trial Name -

PMIDs: 12547192 11752352 2011412

Sources: DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16860831

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12676605

Sources: DTC

TdgClinicalTrial: ESTRONE

Alternate Names:

Drug Info: Drug Indications Hormone Replacement Agents Drug Class small molecule FDA Approval not approved by the FDA

Publications:

TEND: ESTRONE

Alternate Names:

Drug Info: Year of Approval not approved by the fda Drug Class hormone replacement agents

Publications:

NCI: ESTRONE

Alternate Names: C484 NCI drug code

Drug Info:

TTD: Estrone

Alternate Names: D00ZFP TTD Drug ID

Drug Info:

Publications:

DTC: ESTRONE

Alternate Names: CHEMBL1405 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1405

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1405

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
3859707

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6581863 2796962

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6138227

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12567859 12520970

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Estrogen receptor alpha agonist

Direct Interaction yes

Trial Name -

PMIDs:
12547192 11752352 2011412

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
16860831

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12676605

Sources:
DTC

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Drug Info:

Year of Approval not approved by the fda

Drug Class hormone replacement agents

Alternate Names:

C484 NCI drug code

Alternate Names:

D00ZFP TTD Drug ID

Alternate Names:

CHEMBL1405 ChEMBL Drug ID