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ESTRONE Drug Record

  • Summary
  • Interactions
  • Claims
  • ESTRONE chembl:CHEMBL1405 Approved

    Alternate Names:

    WAY 164397
    THEELIN
    NSC-9699
    ESTROGENIC SUBSTANCE
    ESTRONE
    OESTRONE
    1,3,5(10)-ESTRATRIEN-3-OL-17-ONE
    FOLLICULIN
    ESTRONA
    KESTRONE®
    D1,3,5(10)-ESTRATRIEN-3-OL-17-ONE
    3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE
    3-HYDROXY-17-KETO-ESTRA-1,3,5-TRIENE
    FOLLICULAR HORMONE
    (1S,10R,11S,15S)-5-HYDROXY-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIEN-14-ONE
    3-HYDROXYESTRA-1,3,5(10)-TRIENE-17-ONE
    3-HYDROXYOESTRA-1,3,5(10)-TRIEN-17-ONE
    ESTRONE:E1
    (+)-ESTRONE
    ESTRONUM
    E1
    AQUEST®
    (8R,9S,13S,14S)-3-HYDROXY-13-METHYL-7,8,9,11,12,14,15,16-OCTAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-ONE
    3-HYDROXY-1,3,5(10)-ESTRATRIEN-17-ONE
    chembl:CHEMBL1405
    pubchem.compound:5870
    rxcui:4103
    chemidplus:53-16-7
    drugbank:00655

    Drug Info:

    Drug Class hormone replacement agents
    Year of Approval not approved by the fda
    FDA Approval not approved by the FDA
    Drug Class small molecule
    Drug Indications Hormone Replacement Agents
    Drug Categories estrogens
    Drug Categories cytochrome p-450 cyp2e1 substrates
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 cyp3a5 substrates
    Drug Categories cytochrome p-450 substrates
    Drug Categories fused-ring compounds
    Drug Categories natural and semisynthetic estrogens, plain
    Drug Categories oat3/slc22a8 substrates
    Drug Categories oatp1b1/slco1b1 inhibitors
    Drug Categories p-glycoprotein inducers
    Drug Categories p-glycoprotein substrates
    Drug Categories thyroxine-binding globulin inducers
    (5 More Sources)

    Publications:

    Kojima H et al., 2003, Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities., Environ Health Perspect
    Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
    Margeat et al., 2003, Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta., J. Mol. Biol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
    Falany et al., Steroid 3- and 17-OH UDP-glucuronosyltransferase activities in rat and rabbit liver microsomes., Drug Metab. Dispos.
    Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids
    Li et al., 2000, [Effect of estrogen on the expression of c-myc protein of bone in mice]., Wei Sheng Yan Jiu
    Weng et al., 2002, C-mycprotein expression upregulated by 2-(3-estrone-N-ethyl piperazine-methyl) tetracycline in bone., Yao Xue Xue Bao
    Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi
    Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.
    Gutendorf B et al., 2001, Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens., Toxicology
    Dang Z, 2010, Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications., Toxicol Lett
    Numazawa M et al., 2005, Structure-activity relationships of 2-, 4-, or 6-substituted estrogens as aromatase inhibitors., J Steroid Biochem Mol Biol
    Hong H et al., 2015, Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein., Toxicol Sci
  • ESTRONE   STS

    Interaction Score: 1.72

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    2796962 6581863


    Sources:
    NCI

  • ESTRONE   UGT1A5

    Interaction Score: 1.15

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    6138227


    Sources:
    NCI

  • ESTRONE   AKR1C1

    Interaction Score: 0.94

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    3859707


    Sources:
    NCI

  • ESTRONE   MYC

    Interaction Score: 0.37

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12520970 12567859


    Sources:
    NCI

  • ESTRONE   SHBG

    Interaction Score: 0.34

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25349334


    Sources:
    DrugBank

  • ESTRONE   CYP19A1

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16039845


    Sources:
    DrugBank

  • ESTRONE   ESR2

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Agonist
    Endogenous Drug? True

    PMIDs:
    11518614 19913605


    Sources:
    DrugBank GuideToPharmacology

  • ESTRONE   ESR1

    Interaction Score: 0.21

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction? True
    Endogenous Drug? True
    Specific Action of the Ligand Agonist

    PMIDs:
    2011412 12547192 11752352


    Sources:
    TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

  • ESTRONE   PIK3CG

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16860831


    Sources:
    NCI

  • ESTRONE   TARDBP

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • ESTRONE   AR

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12676605


    Sources:
    DTC DrugBank

  • DrugBank: DB00655

    • Version: 5.1.7

    Alternate Names:
    53-16-7 CAS Number
    Estragyn Vaginal Cream Drug Brand
    Oestrilin Cones Vaginaux Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Categories 17-ketosteroids

    Publications:
    Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
    Margeat et al., 2003, Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta., J. Mol. Biol.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

  • TdgClinicalTrial: ESTRONE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hormone Replacement Agents
    Drug Class small molecule
    FDA Approval not approved by the FDA

    Publications:

  • TEND: ESTRONE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval not approved by the fda
    Drug Class hormone replacement agents

    Publications:

  • NCI: ESTRONE

    • Version: 14-September-2017

    Alternate Names:
    C484 NCI drug code

    Drug Info:

    Publications:
    Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids
    Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
    Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi

  • TTD: Estrone

    • Version: 2020.06.01

    Alternate Names:
    D00ZFP TTD Drug ID

    Drug Info:

    Publications:

  • DTC: ESTRONE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1405 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1405

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • GuideToPharmacology: 135651484

    • Version: 29-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1405

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21