DGIdb - ESTRONE Drug Record

ESTRONE chembl:CHEMBL1405 Approved

Alternate Names:

WAY 164397
THEELIN
NSC-9699
ESTROGENIC SUBSTANCE
ESTRONE
OESTRONE
1,3,5(10)-ESTRATRIEN-3-OL-17-ONE
FOLLICULIN
ESTRONA
KESTRONE®
D1,3,5(10)-ESTRATRIEN-3-OL-17-ONE
3-HYDROXYESTRA-1,3,5(10)-TRIEN-17-ONE
3-HYDROXY-17-KETO-ESTRA-1,3,5-TRIENE
FOLLICULAR HORMONE
(1S,10R,11S,15S)-5-HYDROXY-15-METHYLTETRACYCLO[8.7.0.0^{2,7}.0^{11,15}]HEPTADECA-2,4,6-TRIEN-14-ONE
3-HYDROXYESTRA-1,3,5(10)-TRIENE-17-ONE
3-HYDROXYOESTRA-1,3,5(10)-TRIEN-17-ONE
ESTRONE：E1
(+)-ESTRONE
ESTRONUM
E1
AQUEST®
(8R,9S,13S,14S)-3-HYDROXY-13-METHYL-7,8,9,11,12,14,15,16-OCTAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-ONE
3-HYDROXY-1,3,5(10)-ESTRATRIEN-17-ONE
chembl:CHEMBL1405
pubchem.compound:5870
rxcui:4103
chemidplus:53-16-7
drugbank:00655

Drug Info:

Drug Class	hormone replacement agents
Year of Approval	not approved by the fda
FDA Approval	not approved by the FDA
Drug Class	small molecule
Drug Indications	Hormone Replacement Agents
Drug Categories	estrogens
Drug Categories	cytochrome p-450 cyp2e1 substrates
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 substrates
Drug Categories	fused-ring compounds
Drug Categories	natural and semisynthetic estrogens, plain
Drug Categories	oat3/slc22a8 substrates
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	p-glycoprotein inducers
Drug Categories	p-glycoprotein substrates
Drug Categories	thyroxine-binding globulin inducers

(5 More Sources)

Publications:

Kojima H et al., 2003, Effects of a diphenyl ether-type herbicide, chlornitrofen, and its amino derivative on androgen and estrogen receptor activities., Environ Health Perspect
Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.
Margeat et al., 2003, Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta., J. Mol. Biol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.
Falany et al., Steroid 3- and 17-OH UDP-glucuronosyltransferase activities in rat and rabbit liver microsomes., Drug Metab. Dispos.
Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids
Li et al., 2000, [Effect of estrogen on the expression of c-myc protein of bone in mice]., Wei Sheng Yan Jiu
Weng et al., 2002, C-mycprotein expression upregulated by 2-(3-estrone-N-ethyl piperazine-methyl) tetracycline in bone., Yao Xue Xue Bao
Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi
Prost et al., 1984, Estrone and dehydroepiandrosterone sulfatase activities and plasma estrone sulfate levels in human breast carcinoma., Cancer Res.
Gutendorf B et al., 2001, Comparison of an array of in vitro assays for the assessment of the estrogenic potential of natural and synthetic estrogens, phytoestrogens and xenoestrogens., Toxicology
Dang Z, 2010, Comparison of relative binding affinities to fish and mammalian estrogen receptors: the regulatory implications., Toxicol Lett
Numazawa M et al., 2005, Structure-activity relationships of 2-, 4-, or 6-substituted estrogens as aromatase inhibitors., J Steroid Biochem Mol Biol
Hong H et al., 2015, Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein., Toxicol Sci

ESTRONE STS

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2796962 6581863

Sources:
NCI
ESTRONE UGT1A5

Interaction Score: 1.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
6138227

Sources:
NCI
ESTRONE AKR1C1

Interaction Score: 0.94

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
3859707

Sources:
NCI
ESTRONE MYC

Interaction Score: 0.37

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12520970 12567859

Sources:
NCI
ESTRONE SHBG

Interaction Score: 0.34

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25349334

Sources:
DrugBank
ESTRONE CYP19A1

Interaction Score: 0.26

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16039845

Sources:
DrugBank
ESTRONE ESR2

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? True

PMIDs:
11518614 19913605

Sources:
DrugBank GuideToPharmacology
ESTRONE ESR1

Interaction Score: 0.21

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? True

Specific Action of the Ligand Agonist

PMIDs:
2011412 12547192 11752352

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions
ESTRONE PIK3CG

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16860831

Sources:
NCI
ESTRONE TARDBP

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESTRONE AR

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12676605

Sources:
DTC DrugBank

DrugBank: DB00655

Version: 5.1.7

Alternate Names:

53-16-7 CAS Number

Estragyn Vaginal Cream Drug Brand

Oestrilin Cones Vaginaux Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories 17-ketosteroids

Publications:

Sasson, 1991, Equilibrium binding analysis of estrogen agonists and antagonists: relation to the activation of the estrogen receptor., Pathol. Biol.

Margeat et al., 2003, Ligands differentially modulate the protein interactions of the human estrogen receptors alpha and beta., J. Mol. Biol.

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

TdgClinicalTrial: ESTRONE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Publications:
TEND: ESTRONE
- Version: 01-August-2011
Alternate Names:

Drug Info:

Year of Approval not approved by the fda

Drug Class hormone replacement agents

Publications:

NCI: ESTRONE

Version: 14-September-2017

Alternate Names:

C484 NCI drug code

Drug Info:

Publications:

Massheimer et al., 2006, Signal transduction pathways involved in non-genomic action of estrone on vascular tissue., Steroids

Rabe et al., 1985, Regulation of human placental progesterone synthesis in vitro by naturally occurring steroids., J. Steroid Biochem.

Utsumi, 1989, [Local production of estrogen via aromatase and estrone sulfatase in breast cancer tissue]., Nihon Geka Gakkai Zasshi

TTD: Estrone
- Version: 2020.06.01
Alternate Names:

D00ZFP TTD Drug ID

Drug Info:

Publications:
DTC: ESTRONE
- Version: 02-September-2020
Alternate Names:

CHEMBL1405 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1405
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
GuideToPharmacology: 135651484
- Version: 29-September-2020
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1405
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	True
Endogenous Drug?	True
Specific Action of the Ligand	Agonist

53-16-7	CAS Number
Estragyn Vaginal Cream	Drug Brand
Oestrilin Cones Vaginaux	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	17-ketosteroids

ESTRONE Drug Record

ESTRONE chembl:CHEMBL1405 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2796962 6581863

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 6138227

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 3859707

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12520970 12567859

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25349334

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16039845

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Agonist Endogenous Drug? True

PMIDs: 11518614 19913605

Sources: DrugBank GuideToPharmacology

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? True Endogenous Drug? True Specific Action of the Ligand Agonist

PMIDs: 2011412 12547192 11752352

Sources: TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16860831

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12676605

Sources: DTC DrugBank

DrugBank: DB00655

Alternate Names: 53-16-7 CAS Number Estragyn Vaginal Cream Drug Brand Oestrilin Cones Vaginaux Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories 17-ketosteroids

TdgClinicalTrial: ESTRONE

Alternate Names:

Drug Info: Drug Indications Hormone Replacement Agents Drug Class small molecule FDA Approval not approved by the FDA

Publications:

TEND: ESTRONE

Alternate Names:

Drug Info: Year of Approval not approved by the fda Drug Class hormone replacement agents

Publications:

NCI: ESTRONE

Alternate Names: C484 NCI drug code

Drug Info:

TTD: Estrone

Alternate Names: D00ZFP TTD Drug ID

Drug Info:

Publications:

DTC: ESTRONE

Alternate Names: CHEMBL1405 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1405

Alternate Names:

Drug Info:

Publications:

GuideToPharmacology: 135651484

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1405

Interaction Types & Directionality:

n/a

PMIDs:
2796962 6581863

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
6138227

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
3859707

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12520970 12567859

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
25349334

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16039845

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Agonist

Endogenous Drug? True

PMIDs:
11518614 19913605

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? True

Specific Action of the Ligand Agonist

PMIDs:
2011412 12547192 11752352

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
16860831

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
12676605

Sources:
DTC DrugBank

Alternate Names:

53-16-7 CAS Number

Estragyn Vaginal Cream Drug Brand

Oestrilin Cones Vaginaux Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories 17-ketosteroids

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval not approved by the FDA

Drug Info:

Year of Approval not approved by the fda

Drug Class hormone replacement agents

Alternate Names:

C484 NCI drug code

Alternate Names:

D00ZFP TTD Drug ID

Alternate Names:

CHEMBL1405 ChEMBL Drug ID