DGIdb - ESKETAMINE Drug Record

ESKETAMINE chembl:CHEMBL395091 Approved

Alternate Names:

ESKETAMINE
SPRAVATO
(S)-KETAMINE
(-)-KETAMINE
(S)-(-)-KETAMINE
(S)-2-(O-CHLOROPHENYL)-2-(METHYLAMINO)CYCLOHEXANONE
KETANEST
pubchem.compound:182137
chembl:CHEMBL395091
drugbank:11823
chemidplus:33643-46-8

Drug Info:

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational
Drug Categories	agents producing tachycardia
Drug Categories	anesthetics
Drug Categories	anesthetics, general
Drug Categories	antidepressive agents
Drug Categories	central nervous system agents
Drug Categories	central nervous system depressants
Drug Categories	cyclohexanes
Drug Categories	cycloparaffins
Drug Categories	cytochrome p-450 cyp2b6 inducers
Drug Categories	cytochrome p-450 cyp2b6 inducers (weak)
Drug Categories	cytochrome p-450 cyp2b6 substrates
Drug Categories	cytochrome p-450 cyp2c19 substrates
Drug Categories	cytochrome p-450 cyp2c9 substrates
Drug Categories	cytochrome p-450 cyp3a inducers
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a4 inducers
Drug Categories	cytochrome p-450 cyp3a4 inducers (weak)
Drug Categories	cytochrome p-450 cyp3a4 substrates
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	nervous system
Drug Categories	psychotropic drugs

(0 More Sources)

Publications:

Molero P et al., 2018, Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review., CNS Drugs
Morrison RL et al., 2018, Effect of intranasal esketamine on cognitive functioning in healthy participants: a randomized, double-blind, placebo-controlled study., Psychopharmacology (Berl)
van de Loo AJAE et al., 2017, The effects of intranasal esketamine (84 mg) and oral mirtazapine (30 mg) on on-road driving performance: a double-blind, placebo-controlled study., Psychopharmacology (Berl)
Autry AE et al., 2012, Brain-derived neurotrophic factor and neuropsychiatric disorders., Pharmacol Rev
Haile CN et al., 2014, Plasma brain derived neurotrophic factor (BDNF) and response to ketamine in treatment-resistant depression., Int J Neuropsychopharmacol
Zanos P et al., 2018, Convergent Mechanisms Underlying Rapid Antidepressant Action., CNS Drugs

ESKETAMINE EEF2

Interaction Score: 2.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
29516301 29736744

Sources:
DrugBank
ESKETAMINE NTRK2

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
28755104 22407616 29736744

Sources:
DrugBank
ESKETAMINE BDNF

Interaction Score: 0.34

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
24103211 29736744 22407616

Sources:
DrugBank
ESKETAMINE GRIN2B

Interaction Score: 0.32

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29736744

Sources:
DrugBank ChemblInteractions
ESKETAMINE GRIN1

Interaction Score: 0.25

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29392371

Sources:
DrugBank ChemblInteractions
ESKETAMINE GRIN3B

Interaction Score: 0.21

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN2D

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN2C

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN2A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ESKETAMINE GRIN3A

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

DrugBank: DB11823

Version: 5.1.7

Alternate Names:

ESKETAMINE DrugBank Drug Name

33643-46-8 CAS Number

Keta-S Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Molero P et al., 2018, Antidepressant Efficacy and Tolerability of Ketamine and Esketamine: A Critical Review., CNS Drugs

Autry AE et al., 2012, Brain-derived neurotrophic factor and neuropsychiatric disorders., Pharmacol Rev

van de Loo AJAE et al., 2017, The effects of intranasal esketamine (84 mg) and oral mirtazapine (30 mg) on on-road driving performance: a double-blind, placebo-controlled study., Psychopharmacology (Berl)

TTD: Esketamine
- Version: 2020.06.01
Alternate Names:

D0TP5H TTD Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL395091
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL395091
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Glutamate [NMDA] receptor negative allosteric modulator

ESKETAMINE	DrugBank Drug Name
33643-46-8	CAS Number
Keta-S	Drug Brand

ESKETAMINE Drug Record

ESKETAMINE chembl:CHEMBL395091 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 29516301 29736744

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 28755104 22407616 29736744

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 24103211 29736744 22407616

Sources: DrugBank

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs: 29736744

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: antagonist (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs: 29392371

Sources: DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

DrugBank: DB11823

Alternate Names: ESKETAMINE DrugBank Drug Name 33643-46-8 CAS Number Keta-S Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TTD: Esketamine

Alternate Names: D0TP5H TTD Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL395091

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL395091

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
29516301 29736744

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
28755104 22407616 29736744

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

PMIDs:
24103211 29736744 22407616

Sources:
DrugBank

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29736744

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

antagonist (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

PMIDs:
29392371

Sources:
DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Glutamate [NMDA] receptor negative allosteric modulator

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Alternate Names:

ESKETAMINE DrugBank Drug Name

33643-46-8 CAS Number

Keta-S Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

D0TP5H TTD Drug ID