DGIdb - ESCITALOPRAM Drug Record

ESCITALOPRAM chembl:CHEMBL1508 Approved

Alternate Names:

CIPRALEX
LU-26-054
ESCITALOPRAM
(+)-CITALOPRAM
S(+)-CITALOPRAM
CIPRALEX®
S-(+)-CITALOPRAM
ESCITALOPRAMUM
LEXAPRO
ENTACT
LEXAPRO®
LU-26-054-0
(S)-CITALOPRAM
drugbank:01175
chemidplus:128196-01-0
chembl:CHEMBL1508
rxcui:321988
pubchem.compound:146570

Drug Info:

FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	antidepressant
Drug Class	antidepressive agents
Year of Approval	2002

(3 More Sources)

Publications:

Brasch-Andersen C et al., 2011, A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C)., Eur J Clin Pharmacol
Sanchez C et al., 2014, A comparative review of escitalopram, paroxetine, and sertraline: Are they all alike?, Int Clin Psychopharmacol
Kuo HW et al., 2013, CYP1A2 genetic polymorphisms are associated with early antidepressant escitalopram metabolism and adverse reactions., Pharmacogenomics
Perroud N et al., 2009, Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project., Neuropsychopharmacology
Powell TR et al., 2013, Tumor necrosis factor and its targets in the inflammatory cytokine pathway are identified as putative transcriptomic biomarkers for escitalopram response., Eur Neuropsychopharmacol
Ji Y et al., 2011, Glycine and a glycine dehydrogenase (GLDC) SNP as citalopram/escitalopram response biomarkers in depression: pharmacometabolomics-informed pharmacogenomics., Clin Pharmacol Ther
Uher R et al., 2009, Genetic predictors of response to antidepressants in the GENDEP project., Pharmacogenomics J
Niitsu T et al., 2013, Pharmacogenetics in major depression: a comprehensive meta-analysis., Prog Neuropsychopharmacol Biol Psychiatry
Arias B et al., 2013, TPH1, MAOA, serotonin receptor 2A and 2C genes in citalopram response: possible effect in melancholic and psychotic depression., Neuropsychobiology
Illi A et al., 2009, 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression., Neuroreport
Fabre et al., [Mechanisms of action of antidepressants: new data from Escitalopram]., Encephale
Bareggi et al., 2007, The use of escitalopram beyond major depression: pharmacological aspects, efficacy and tolerability in anxiety disorders., Expert Opin Drug Metab Toxicol
Zhong et al., 2009, An allosteric binding site at the human serotonin transporter mediates the inhibition of escitalopram by R-citalopram: kinetic binding studies with the ALI/VFL-SI/TT mutant., Neurosci. Lett.
Owens et al., 2001, Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine., Biol. Psychiatry
Waugh et al., 2003, Escitalopram : a review of its use in the management of major depressive and anxiety disorders., CNS Drugs
Sánchez et al., 2003, Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities., Psychopharmacology (Berl.)
Burke, 2002, Escitalopram., Expert Opin Investig Drugs
Owens et al., [Second generation SSRIS: human monoamine transporter binding profile of escitalopram and R-fluoxetine]., Encephale
Gupta M et al., 2016, TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics., Mol Psychiatry
Tammiste A et al., 2013, Whole-exome sequencing identifies a polymorphism in the BMP5 gene associated with SSRI treatment response in major depression., J Psychopharmacol

ESCITALOPRAM BMP5

Interaction Score: 6.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23926243

Sources:
PharmGKB
ESCITALOPRAM TSPAN5

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26903268

Sources:
PharmGKB
ESCITALOPRAM ERICH3

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
26903268

Sources:
PharmGKB
ESCITALOPRAM GLDC

Interaction Score: 3.43

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
21107318

Sources:
PharmGKB
ESCITALOPRAM RFK

Interaction Score: 1.72

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ESCITALOPRAM TPH1

Interaction Score: 1.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB
ESCITALOPRAM IL11

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23142150

Sources:
PharmGKB
ESCITALOPRAM SLC6A4

Interaction Score: 0.73

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Cipralex, escitalopram,Lexapro

Novel drug target Established target

PMIDs:
12876551 17916059 19616061 11543737 12665392 12719960 12387707 12232544 24424469

Sources:
TdgClinicalTrial TEND
ESCITALOPRAM GRK5

Interaction Score: 0.31

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ESCITALOPRAM FKBP5

Interaction Score: 0.29

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ESCITALOPRAM HTR2C

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
21614492 24424469

Sources:
PharmGKB
ESCITALOPRAM BDNF

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19641488

Sources:
PharmGKB
ESCITALOPRAM HTR1B

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
ESCITALOPRAM HTR2A

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19365399 24424469

Sources:
PharmGKB
ESCITALOPRAM CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC FDA
ESCITALOPRAM CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23859573

Sources:
PharmGKB
ESCITALOPRAM CYP2C9

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
ESCITALOPRAM CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
FDA

TEND: ESCITALOPRAM
- Version: 01-August-2011
Alternate Names:

ESCITALOPRAM Primary Drug Name

Drug Info:

Year of Approval 2002

Drug Class antidepressive agents

Publications:
TdgClinicalTrial: ESCITALOPRAM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Publications:

PharmGKB: escitalopram

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Brasch-Andersen C et al., 2011, A candidate gene study of serotonergic pathway genes and pain relief during treatment with escitalopram in patients with neuropathic pain shows significant association to serotonin receptor2C (HTR2C)., Eur J Clin Pharmacol

Gupta M et al., 2016, TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: pharmacometabolomics-informed pharmacogenomics., Mol Psychiatry

Perroud N et al., 2009, Genetic predictors of increase in suicidal ideation during antidepressant treatment in the GENDEP project., Neuropsychopharmacology

TTD: Escitalopram
- Version: 2020.06.01
Alternate Names:

D08RBC TTD Drug ID

Drug Info:

Publications:
DTC: ESCITALOPRAM
- Version: 02-September-2020
Alternate Names:

CHEMBL1508 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1508
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
FDA: Escitalopram
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	Cipralex, escitalopram,Lexapro
Novel drug target	Established target

ESCITALOPRAM Drug Record

ESCITALOPRAM chembl:CHEMBL1508 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23926243

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26903268

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 26903268

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 21107318

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23733030 23221997 19590397

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23142150

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name Cipralex, escitalopram,Lexapro Novel drug target Established target

PMIDs: 12876551 17916059 19616061 11543737 12665392 12719960 12387707 12232544 24424469

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 21614492 24424469

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19641488

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19365399 24424469

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC FDA

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23859573

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: FDA

TEND: ESCITALOPRAM

Alternate Names: ESCITALOPRAM Primary Drug Name

Drug Info: Year of Approval 2002 Drug Class antidepressive agents

Interaction Types & Directionality:

n/a

PMIDs:
23926243

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26903268

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
26903268

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
21107318

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23733030 23221997 19590397

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
23142150

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name Cipralex, escitalopram,Lexapro

Novel drug target Established target

PMIDs:
12876551 17916059 19616061 11543737 12665392 12719960 12387707 12232544 24424469

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
21614492 24424469

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
19641488

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19365399 24424469

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC FDA

Interaction Types & Directionality:

n/a

PMIDs:
23859573

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
FDA

Alternate Names:

ESCITALOPRAM Primary Drug Name

Drug Info:

Year of Approval 2002

Drug Class antidepressive agents

Drug Info:

Drug Indications antidepressant

Drug Class Small Molecule

FDA Approval approved

Alternate Names:

D08RBC TTD Drug ID

Alternate Names:

CHEMBL1508 ChEMBL Drug ID