DGIdb - EPOPROSTENOL Drug Record

EPOPROSTENOL chembl:CHEMBL1139 Approved

Alternate Names:

PROSTAGLANDIN I2
PROSTAGLANDIN X
U-53217
PGX
PROSTACYCLIN
FLOLAN
PG-I2
EPOPROSTENOL
ACT-385781A
PGI2

Drug Info:

FDA Approval	1995
Drug Class	small molecule
Drug Indications	Platelet Aggregation Inhibitors
Drug Indications	Antihypertensive Agents
Drug Class	platelet aggregation inhibitors
Drug Class	antihypertensive agents
Year of Approval	1995
Drug Categories	prostacyclin analogues
Drug Categories	anticoagulants
Drug Categories	antiplatelet agents
Drug Categories	drugs that are mainly renally excreted
Drug Categories	prostacycline vasodilator
Drug Categories	vasodilating agents
Drug Categories	vasodilation

(2 More Sources)

Publications:

Ibrahim et al., 2010, Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease., Arterioscler. Thromb. Vasc. Biol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kasza et al., 2009, Novel signaling pathways promote a paracrine wave of prostacyclin-induced vascular smooth muscle differentiation., J. Mol. Cell. Cardiol.
Yang et al., 2002, Signaling through Gi family members in platelets. Redundancy and specificity in the regulation of adenylyl cyclase and other effectors., J. Biol. Chem.
Kobsar et al., 2010, Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system., Platelets
Cattaneo et al., 2007, Inhibition of the platelet P2Y12 receptor for adenosine diphosphate potentiates the antiplatelet effect of prostacyclin., J. Thromb. Haemost.
Nakayama, 2010, Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease., Int Angiol
Ruan et al., 2008, Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin., Biochemistry

EPOPROSTENOL PTGIS

Interaction Score: 17.04

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

PMIDs:
20357747 18081314

Sources:
DrugBank
EPOPROSTENOL PTGIR

Interaction Score: 5.68

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? True

Specific Action of the Ligand Agonist

PMIDs:
20522800 11752352 19302827 12297509

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
EPOPROSTENOL P2RY12

Interaction Score: 2.39

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
20085435 12297509 17155953

Sources:
DrugBank
EPOPROSTENOL PTGER4

Interaction Score: 0.57

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology
EPOPROSTENOL PTGER1

Interaction Score: 0.54

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? True

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology

DrugBank: DB01240

Version: 5.1.7

Alternate Names:

EPOPROSTENOL DrugBank Drug Name

35121-78-9 CAS Number

Caripul Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories anticoagulants

Publications:

Nakayama, 2010, Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease., Int Angiol

Ruan et al., 2008, Characterization of the substrate mimic bound to engineered prostacyclin synthase in solution using high-resolution NMR spectroscopy and mutagenesis: implication of the molecular mechanism in biosynthesis of prostacyclin., Biochemistry

Kobsar et al., 2010, Prostacyclin receptor stimulation facilitates detection of human platelet P2Y(12) receptor inhibition by the PFA-100 system., Platelets

TEND: EPOPROSTENOL
- Version: 01-August-2011
Alternate Names:

EPOPROSTENOL Primary Drug Name

Drug Info:

Year of Approval 1995

Drug Class antihypertensive agents

Drug Class platelet aggregation inhibitors

Publications:
TdgClinicalTrial: EPOPROSTENOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Platelet Aggregation Inhibitors

Drug Class small molecule

Publications:
GuideToPharmacology: 135651541
- Version: 29-September-2020
Alternate Names:

PGI2 GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Epoprostenol
- Version: 2020.06.01
Alternate Names:

D0V0IX TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1139
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Direct Interaction?	False
Endogenous Drug?	True
Specific Action of the Ligand	Agonist

Specific Action of the Ligand	Full agonist
Endogenous Drug?	True

EPOPROSTENOL	DrugBank Drug Name
35121-78-9	CAS Number
Caripul	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	anticoagulants

EPOPROSTENOL Drug Record

EPOPROSTENOL chembl:CHEMBL1139 Approved

Alternate Names:

Drug Info:

Publications:

EPOPROSTENOL PTGIS

Interaction Types & Directionality: inducer (activating)

Interaction Info:

PMIDs: 20357747 18081314

Sources: DrugBank

EPOPROSTENOL PTGIR

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? False Endogenous Drug? True Specific Action of the Ligand Agonist

PMIDs: 20522800 11752352 19302827 12297509

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

EPOPROSTENOL P2RY12

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 20085435 12297509 17155953

Sources: DrugBank

EPOPROSTENOL PTGER4

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? True

PMIDs: None found

Sources: GuideToPharmacology

EPOPROSTENOL PTGER1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Direct Interaction? True Endogenous Drug? True Specific Action of the Ligand Full agonist

PMIDs: None found

Sources: GuideToPharmacology

DrugBank: DB01240

Alternate Names: EPOPROSTENOL DrugBank Drug Name 35121-78-9 CAS Number Caripul Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories anticoagulants

TEND: EPOPROSTENOL

Alternate Names: EPOPROSTENOL Primary Drug Name

Drug Info: Year of Approval 1995 Drug Class antihypertensive agents Drug Class platelet aggregation inhibitors

Publications:

TdgClinicalTrial: EPOPROSTENOL

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Platelet Aggregation Inhibitors Drug Class small molecule

Publications:

GuideToPharmacology: 135651541

Alternate Names: PGI2 GuideToPharmacology Ligand Name

Drug Info:

Publications:

TTD: Epoprostenol

Alternate Names: D0V0IX TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1139

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inducer (activating)

PMIDs:
20357747 18081314

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? False

Endogenous Drug? True

Specific Action of the Ligand Agonist

PMIDs:
20522800 11752352 19302827 12297509

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

PMIDs:
20085435 12297509 17155953

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? True

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Direct Interaction? True

Endogenous Drug? True

Specific Action of the Ligand Full agonist

PMIDs:
None found

Sources:
GuideToPharmacology

Alternate Names:

EPOPROSTENOL DrugBank Drug Name

35121-78-9 CAS Number

Caripul Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories anticoagulants

Alternate Names:

EPOPROSTENOL Primary Drug Name

Drug Info:

Year of Approval 1995

Drug Class antihypertensive agents

Drug Class platelet aggregation inhibitors

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Platelet Aggregation Inhibitors

Drug Class small molecule

Alternate Names:

PGI2 GuideToPharmacology Ligand Name

Alternate Names:

D0V0IX TTD Drug ID