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EPINEPHRINE Drug Record

  • Summary
  • Interactions
  • Claims
  • EPINEPHRINE chembl:CHEMBL679 Approved

    Alternate Names:

    ASTHMAHALER
    EPPY
    JEXT
    RIDDOFAN
    BRONKAID MIST
    MEDIHALER-EPI
    SUS-PHRINE SULFITE FREE
    ANA-GUARD
    ADREN CO
    EMERADE
    ADRENALINE
    ADRENACLICK
    SYMJEPI
    TWINJECT 0.15
    GPPE INH SOLN
    AUVI-Q
    ANA-KIT
    EPIPEN JR.
    RYBARVIN
    EPI E Z PEN JR
    SUS-PHRINE
    EPINEPHRINE HCL
    EPIPEN
    EPIPEN E Z PEN
    ANAPHYLACTIC SHOCK DRUG KIT
    NSC-62786
    EPIPEN JR
    ADRENALIN
    EPINEPHRINE
    ASMA-VYDRIN
    SIMPLENE
    BROVON
    RIDDOBRON
    SOLN MADE TO RYBARVIN FOR
    SUS-PHRINE SULFITE-FREE
    TWINJECT 0.3
    TWINJECT
    PRIMATENE MIST
    ANAPEN
    LEVO-METHYLAMINOETHANOLCATECHOL
    PRIMATENE
    (R)-(-)-ADNEPHRINE
    LEVOEPINEPHRINE
    (R)-EPINEPHRINE
    (-)-ADRENALINE
    (-)-EPINEPHRINE
    (R)-(-)-EPIRENAMINE
    L-EPINEPHRINE
    (R)-(-)-EPINEPHRINE
    (-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]BENZYL ALCOHOL(-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL
    4-[(1R)-1-HYDROXY-2-METHYLAMINOETHYL]BENZENE-1,2-DIOL
    (R)-(-)-ADRENALINE
    L-ADRENALINE
    (-)-3,4-DIHYDROXY-ALPHA-[(METHYLAMINO)METHYL]-BENZYL ALCOHOL
    4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]PYROCATECHOL
    (-)-3,4-DIHYDROXY-ALPHA-[2-(METHYLAMINO)ETHYL]BENZYL ALCOHOL
    (R)-4-[1-HYDROXY-2-(METHYLAMINO)ETHYL]-1,2-BENZENEDIOL
    (−)-ADRENALINE
    L-DETHYLAMINOETHANOLCATECHOL
    (R)-ADRENALINE
    (-)-3,4-DIHYDROXY-A-[2-(METHYLAMINO)ETHYL]BENZYL ALCOHOL
    L-1-(3,4-DIHYDROXYPHENYL)-2-METHYLAMINOETHANOL
    R-(-)-EPINEPHRINE
    4-[(1R)-1-HYDROXY-2-METHYLAMINO-ETHYL]BENZENE-1,2-DIOL
    4-[(1R)-1-HYDROXY-2-(METHYLAMINO)ETHYL]-1,2-BENZENEDIOL
    (-)-(R)-EPINEPHRINE
    L-EPIRENAMINE
    (R)-(−)-ADRENALINE
    chembl:CHEMBL679
    rxcui:3992
    pubchem.compound:5816
    chemidplus:51-43-4
    drugbank:00668

    Drug Info:

    Drug Categories bronchodilator agents
    Drug Categories local hemostatics
    FDA Approval approved
    Drug Class Small Molecule
    Drug Indications anestethic
    Drug Class vasoconstrictor agents
    Drug Class bronchodilator agents
    Year of Approval approved before 1982
    Drug Categories adrenergic alpha-1 receptor agonists
    Drug Categories adrenergic alpha-2 receptor agonists
    Drug Categories adrenergic and dopaminergic agents
    Drug Categories adrenergic beta-1 receptor agonists
    Drug Categories adrenergic beta-2 receptor agonists
    Drug Categories adrenergic beta-3 receptor agonists
    Drug Categories adrenergics, inhalants
    Drug Categories agents producing tachycardia
    Drug Categories agents that produce hypertension
    Drug Categories alpha-and beta-adrenergic agonists
    Drug Categories antiglaucoma preparations and miotics
    Drug Categories benzene derivatives
    Drug Categories cardiac stimulants excl. cardiac glycosides
    Drug Categories cardiac therapy
    Drug Categories catechols
    Drug Categories comt substrates
    Drug Categories cytochrome p-450 cyp2c9 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 cyp3a4 inhibitors
    Drug Categories cytochrome p-450 cyp3a4 inhibitors (strength unknown)
    Drug Categories cytochrome p-450 enzyme inhibitors
    Drug Categories dental agents
    Drug Categories drugs for obstructive airway diseases
    Drug Categories epinephrine and similars
    Drug Categories nasal preparations
    Drug Categories oct1 substrates
    Drug Categories oct2 inhibitors
    Drug Categories ophthalmologicals
    Drug Categories phenols
    Drug Categories stomatological preparations
    Drug Categories sympathomimetic (adrenergic) agents
    Drug Categories sympathomimetics in glaucoma therapy
    Drug Categories sympathomimetics, plain
    (6 More Sources)

    Publications:

    Cotecchia, 2010, The α1-adrenergic receptors: diversity of signaling networks and regulation., J. Recept. Signal Transduct. Res.
    Du et al., 2010, Modeling the interactions between alpha(1)-adrenergic receptors and their antagonists., Curr Comput Aided Drug Des
    Shieh et al., 2009, Epinephrine, phenylephrine, and methoxamine induce infiltrative anesthesia via alpha1-adrenoceptors in rats., Acta Pharmacol. Sin.
    Jensen et al., 2010, Functional alpha-1B adrenergic receptors on human epicardial coronary artery endothelial cells., Naunyn Schmiedebergs Arch. Pharmacol.
    Hayasaka et al., 1978, Effects of epinephrine, indomethacin, acetylsalicyclic acid, dexamethasone, and cyclic AMP on the in vitro activity of lysosomal hyaluronidase from the rabbit iris., Invest. Ophthalmol. Vis. Sci.
    Tomiyama et al., 2007, Expressions and mechanical functions of alpha1-adrenoceptor subtypes in hamster ureter., Eur. J. Pharmacol.
    Sanbe et al., 2007, Alpha1-adrenoceptors are required for normal male sexual function., Br. J. Pharmacol.
    Bylund, 1992, Subtypes of alpha 1- and alpha 2-adrenergic receptors., FASEB J.
    Ariëns EJ et al., 1983, Physiological and pharmacological aspects of adrenergic receptor classification., Biochem Pharmacol
    Rudling et al., 2000, A comparison of agonist-specific coupling of cloned human alpha(2)-adrenoceptor subtypes., Br. J. Pharmacol.
    Gilsbach et al., 2008, Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline., Handb Exp Pharmacol
    Gobbi et al., 1990, The modulation of [3H]noradrenaline and [3H]serotonin release from rat brain synaptosomes is not mediated by the alpha 2B-adrenoceptor subtype., Naunyn Schmiedebergs Arch. Pharmacol.
    Nash, 1990, Alpha-adrenergic blockers: mechanism of action, blood pressure control, and effects of lipoprotein metabolism., Clin Cardiol
    Vizi et al., 2001, Evidence for presynaptic cannabinoid CB(1) receptor-mediated inhibition of noradrenaline release in the guinea pig lung., Eur. J. Pharmacol.
    Takeuchi et al., 2001, Adrenergic stimulation of osteoclastogenesis mediated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cells., Biochem. Pharmacol.
    Patil et al., 2008, Analysis of efficacy of chiral adrenergic agonists., Chirality
    Young et al., 2002, Effects of rearing temperature on sympathoadrenal activity in young adult rats., Am. J. Physiol. Regul. Integr. Comp. Physiol.
    Leineweber et al., 2007, In patients chronically treated with metoprolol, the demand of inotropic catecholamine support after coronary artery bypass grafting is determined by the Arg389Gly-beta 1-adrenoceptor polymorphism., Naunyn Schmiedebergs Arch. Pharmacol.
    Ozakca et al., 2007, Role of beta-3-adrenoceptor in catecholamine-induced relaxations in gastric fundus from control and diabetic rats., Pharmacology
    Strosberg AD, 1993, Structure, function, and regulation of adrenergic receptors., Protein Sci
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Khasar SG et al., 1999, Epinephrine produces a beta-adrenergic receptor-mediated mechanical hyperalgesia and in vitro sensitization of rat nociceptors., J Neurophysiol
    Nyrönen et al., 2001, Molecular mechanism for agonist-promoted alpha(2A)-adrenoceptor activation by norepinephrine and epinephrine., Mol. Pharmacol.
    MacLennan et al., 2000, Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using extracellular acidification rate changes., Br. J. Pharmacol.
    Giovannoni et al., 2009, Alpha2-agonists as analgesic agents., Med Res Rev
    Hieble et al., 1998, Molecular basis for the stereoselective interactions of catecholamines with alpha-adrenoceptors., Proc. West. Pharmacol. Soc.
    Lucin et al., 2007, Impaired antibody synthesis after spinal cord injury is level dependent and is due to sympathetic nervous system dysregulation., Exp. Neurol.
    Prenner et al., 2007, Reduction of high-affinity beta2-adrenergic receptor binding by hyperforin and hyperoside on rat C6 glioblastoma cells measured by fluorescence correlation spectroscopy., Biochemistry
    Reiner S et al., 2010, Differential signaling of the endogenous agonists at the beta2-adrenergic receptor., J Biol Chem
    van der Poll et al., 1996, Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia., J. Clin. Invest.
    Liao J et al., 1995, Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver., Am J Physiol
    Lova et al., 2003, A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B., J. Biol. Chem.
    Saeed et al., 2004, Signaling mechanisms mediated by G-protein coupled receptors in human platelets., Acta Pharmacol. Sin.
    Mundinger et al., 2006, Direct stimulation of ghrelin secretion by sympathetic nerves., Endocrinology
    Ertbjerg et al., 2000, Epinephrine upregulates calpain activity in cultured C2C12 muscle cells., Biochimie
  • EPINEPHRINE   HYAL2

    Interaction Score: 1.83

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    212383


    Sources:
    NCI

  • EPINEPHRINE   TNFRSF11B

    Interaction Score: 0.73

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    11239501


    Sources:
    NCI

  • EPINEPHRINE   CAST

    Interaction Score: 0.61

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10863002


    Sources:
    NCI

  • EPINEPHRINE   TPM3

    Interaction Score: 0.41

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    18172836


    Sources:
    NCI

  • EPINEPHRINE   GHRL

    Interaction Score: 0.31

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16527847


    Sources:
    NCI

  • EPINEPHRINE   ADRA2B

    Interaction Score: 0.2

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite
    Novel drug target Established target
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    6134529 11053214 18064417 1979424 1980236 11728431


    Sources:
    PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • EPINEPHRINE   ADRA1D

    Interaction Score: 0.18

    Interaction Types & Directionality:
    antagonist (inhibitory)

    Interaction Info:
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite
    Novel drug target Established target

    PMIDs:
    20954794 20412040 19730427 20857090


    Sources:
    PharmGKB TdgClinicalTrial DrugBank

  • EPINEPHRINE   ADRB1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Novel drug target Established target
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    17541557 17622774 8401205 11752352 10085337


    Sources:
    TEND PharmGKB TdgClinicalTrial TTD DrugBank ChemblInteractions

  • EPINEPHRINE   ADRA2A

    Interaction Score: 0.15

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite
    Novel drug target Established target
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    11306720 6134529 18064417 1980236 10742288 18680204 9836297


    Sources:
    PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • EPINEPHRINE   ADRA1B

    Interaction Score: 0.13

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    20954794 20412040 19730427 20857090


    Sources:
    PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • EPINEPHRINE   ADRB2

    Interaction Score: 0.11

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite
    Novel drug target Established target
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    17622774 17597612 17417877 20837485 11752352


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • EPINEPHRINE   ADRA1A

    Interaction Score: 0.09

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes
    Trial Name transdermal lidocaine/epinephrine patch,Lidosite

    PMIDs:
    20412040 17658513 17603545 20857090


    Sources:
    TEND PharmGKB TdgClinicalTrial DrugBank ChemblInteractions

  • EPINEPHRINE   SLC2A4

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12376414


    Sources:
    NCI

  • EPINEPHRINE   MAPK10

    Interaction Score: 0.08

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15210061


    Sources:
    NCI

  • EPINEPHRINE   TNF

    Interaction Score: 0.06

    Interaction Types & Directionality:
    agonist (activating)
    antagonist (inhibitory)

    Interaction Info:

    PMIDs:
    8609227 7733399


    Sources:
    DrugBank

  • EPINEPHRINE   PIK3CB

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12407113


    Sources:
    NCI

  • EPINEPHRINE   ADRA2C

    Interaction Score: 0.05

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Direct Interaction yes
    Mechanism of Interaction Adrenergic receptor agonist

    PMIDs:
    1346768


    Sources:
    PharmGKB ChemblInteractions

  • EPINEPHRINE   ADRB3

    Interaction Score: 0.04

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Adrenergic receptor agonist
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • EPINEPHRINE   G6PD

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Combination therapy Articaine,Epinephrine

    PMIDs:
    None found


    Sources:
    FDA

  • EPINEPHRINE   MTOR

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   HIF1A

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   RECQL

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   APEX1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   DRD1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   FEN1

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   POLK

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   KDM4E

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   HSD17B10

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   MAPT

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   VDR

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • EPINEPHRINE   NFE2L2

    Interaction Score: 0.0

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00668

    • Version: 5.1.7

    Alternate Names:
    51-43-4 CAS Number
    2% Lidocaine and Epinephrine 1:100,000 Injection USP Drug Brand
    4% Astracaine Dental With Epinephrine 1:200,000 (0.005mg/ml) Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups vet_approved

    Publications:
    van der Poll et al., 1996, Epinephrine inhibits tumor necrosis factor-alpha and potentiates interleukin 10 production during human endotoxemia., J. Clin. Invest.
    Liao J et al., 1995, Role of epinephrine in TNF and IL-6 production from isolated perfused rat liver., Am J Physiol
    Cotecchia, 2010, The α1-adrenergic receptors: diversity of signaling networks and regulation., J. Recept. Signal Transduct. Res.

  • TEND: EPINEPHRINE

    • Version: 01-August-2011

    Alternate Names:

    Drug Info:
    Year of Approval approved before 1982
    Drug Class bronchodilator agents
    Drug Class vasoconstrictor agents

    Publications:

  • TdgClinicalTrial: EPINEPHRINE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications anestethic
    Drug Class Small Molecule
    FDA Approval approved

    Publications:

  • NCI: EPINEPHRINE

    • Version: 14-September-2017

    Alternate Names:
    C473 NCI drug code

    Drug Info:

    Publications:
    Hayasaka et al., 1978, Effects of epinephrine, indomethacin, acetylsalicyclic acid, dexamethasone, and cyclic AMP on the in vitro activity of lysosomal hyaluronidase from the rabbit iris., Invest. Ophthalmol. Vis. Sci.
    Ertbjerg et al., 2000, Epinephrine upregulates calpain activity in cultured C2C12 muscle cells., Biochimie
    Takeuchi et al., 2001, Adrenergic stimulation of osteoclastogenesis mediated by expression of osteoclast differentiation factor in MC3T3-E1 osteoblast-like cells., Biochem. Pharmacol.

  • TTD: Epinephrine

    • Version: 2020.06.01

    Alternate Names:
    D04PHC TTD Drug ID

    Drug Info:

    Publications:

  • DTC: EPINEPHRINE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL679 ChEMBL Drug ID

    Drug Info:

    Publications:

  • FDA: Epinephrine

    • Version: 04-September-2020

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL679

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL679

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: epinephrine

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21