DGIdb - ENZASTAURIN Drug Record

ENZASTAURIN chembl:CHEMBL300138 Antineoplastic

Alternate Names:

LY-317615
LY317615
ENZASTAURIN
chembl:CHEMBL300138
pubchem.compound:176167
chemidplus:170364-57-5

Drug Info:

Drug Class	Kinase Inhibitors
FDA Approval	not approved
Drug Indications	antineoplastic agent
Drug Class	Small molecule
Drug Type	small molecule
Drug Groups	investigational
Drug Categories	heterocyclic compounds, fused-ring

(7 More Sources)

Publications:

Shimokawa et al., 2012, Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules., Br. J. Cancer
Wu et al., 2012, The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma., PLoS ONE

ENZASTAURIN BCOR

Interaction Score: 1.78

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family PKCb inhibitor

Alteration BCOR:.

PMIDs:
None found

Sources:
CGI
ENZASTAURIN PRKCB

Interaction Score: 1.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C beta inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions
ENZASTAURIN GNAQ

Interaction Score: 0.55

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type uveal melanoma

Response Type sensitive

Approval Status Preclinical - Cell culture

PMIDs:
22253748

Sources:
JAX-CKB
ENZASTAURIN CDK15

Interaction Score: 0.51

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ENZASTAURIN PRKCG

Interaction Score: 0.28

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
MyCancerGenome GuideToPharmacology
ENZASTAURIN PRKCA

Interaction Score: 0.24

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
MyCancerGenome GuideToPharmacology
ENZASTAURIN PRKCE

Interaction Score: 0.22

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
ENZASTAURIN JAK1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22333600

Sources:
CIViC
ENZASTAURIN CHEK2

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ENZASTAURIN PIK3R1

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ENZASTAURIN PRKCD

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
ENZASTAURIN AKT1

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD DrugBank
ENZASTAURIN CHEK1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ENZASTAURIN AURKA

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ENZASTAURIN AURKB

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DrugBank
ENZASTAURIN PIK3CG

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD

MyCancerGenome: ENZASTAURIN
- Version: 20-Jun-2017
Alternate Names:

LY317615 Development Name

ENZASTAURIN Generic Name

Drug Info:

Drug Class Kinase Inhibitors

Publications:
DrugBank: DB06486
- Version: 5.1.7
Alternate Names:

ENZASTAURIN DrugBank Drug Name

170364-57-5 CAS Number

CHEMBL300138 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories heterocyclic compounds, fused-ring

Publications:
TdgClinicalTrial: ENZASTAURIN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small molecule

Drug Indications antineoplastic agent

FDA Approval not approved

Publications:
JAX-CKB: Enzastaurin
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Wu et al., 2012, The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma., PLoS ONE
CIViC: ENZASTAURIN
- Version: 14-September-2020
Alternate Names:

Drug Info:

Publications:

Shimokawa et al., 2012, Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules., Br. J. Cancer
TALC: ENZASTAURIN
- Version: 12-May-2016
Alternate Names:

ENZASTAURIN Primary Drug Name

ENZASTAURIN Drug Generic Name

LY-317615 Drug Synonym

Drug Info:

Publications:
TTD: Enzastaurin
- Version: 2020.06.01
Alternate Names:

D0I6VU TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 178102320
- Version: 29-September-2020
Alternate Names:

ENZASTAURIN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblInteractions: CHEMBL300138
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL300138
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
CGI: Enzastaurin
- Version: 27-September-2017
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Protein kinase C beta inhibitor
Direct Interaction	yes
Notes

Indication/Tumor Type	uveal melanoma
Response Type	sensitive
Approval Status	Preclinical - Cell culture

Direct Interaction?	False
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

ENZASTAURIN	DrugBank Drug Name
170364-57-5	CAS Number
CHEMBL300138	ChEMBL ID

ENZASTAURIN	Primary Drug Name
ENZASTAURIN	Drug Generic Name
LY-317615	Drug Synonym

Drug family	PKCb inhibitor
Alteration	BCOR:.

ENZASTAURIN Drug Record

ENZASTAURIN chembl:CHEMBL300138 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info: Drug family PKCb inhibitor Alteration BCOR:.

PMIDs: None found

Sources: CGI

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Protein kinase C beta inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type uveal melanoma Response Type sensitive Approval Status Preclinical - Cell culture

PMIDs: 22253748

Sources: JAX-CKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? False Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: MyCancerGenome GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: MyCancerGenome GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: None found

Sources: MyCancerGenome

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 22333600

Sources: CIViC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? False

PMIDs: None found

Sources: GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

MyCancerGenome: ENZASTAURIN

Alternate Names: LY317615 Development Name ENZASTAURIN Generic Name

Drug Info: Drug Class Kinase Inhibitors

Publications:

DrugBank: DB06486

Alternate Names: ENZASTAURIN DrugBank Drug Name 170364-57-5 CAS Number CHEMBL300138 ChEMBL ID

Drug Info: Drug Type small molecule Drug Groups investigational Drug Categories heterocyclic compounds, fused-ring

Publications:

TdgClinicalTrial: ENZASTAURIN

Alternate Names:

Drug Info: Drug Class Small molecule Drug Indications antineoplastic agent FDA Approval not approved

Interaction Types & Directionality:

n/a

Interaction Info:

Drug family PKCb inhibitor

Alteration BCOR:.

PMIDs:
None found

Sources:
CGI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Protein kinase C beta inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type uveal melanoma

Response Type sensitive

Approval Status Preclinical - Cell culture

PMIDs:
22253748

Sources:
JAX-CKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? False

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
MyCancerGenome GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
MyCancerGenome GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
None found

Sources:
MyCancerGenome

Interaction Types & Directionality:

n/a

PMIDs:
22333600

Sources:
CIViC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Alternate Names:

LY317615 Development Name

ENZASTAURIN Generic Name

Drug Info:

Drug Class Kinase Inhibitors

Alternate Names:

ENZASTAURIN DrugBank Drug Name

170364-57-5 CAS Number

CHEMBL300138 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories heterocyclic compounds, fused-ring

Drug Info:

Drug Class Small molecule

Drug Indications antineoplastic agent

FDA Approval not approved

Publications:

Wu et al., 2012, The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma., PLoS ONE

Publications:

Shimokawa et al., 2012, Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules., Br. J. Cancer

Alternate Names:

ENZASTAURIN Primary Drug Name

ENZASTAURIN Drug Generic Name

LY-317615 Drug Synonym

Alternate Names:

D0I6VU TTD Drug ID

Alternate Names:

ENZASTAURIN GuideToPharmacology Ligand Name