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ENZASTAURIN Drug Record

  • Summary
  • Interactions
  • Claims
  • ENZASTAURIN chembl:CHEMBL300138 Antineoplastic

    Alternate Names:

    LY-317615
    LY317615
    ENZASTAURIN
    chembl:CHEMBL300138
    pubchem.compound:176167
    chemidplus:170364-57-5

    Drug Info:

    Drug Class Kinase Inhibitors
    FDA Approval not approved
    Drug Indications antineoplastic agent
    Drug Class Small molecule
    Drug Type small molecule
    Drug Groups investigational
    Drug Categories heterocyclic compounds, fused-ring
    (7 More Sources)

    Publications:

    Shimokawa et al., 2012, Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules., Br. J. Cancer
    Wu et al., 2012, The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma., PLoS ONE
  • ENZASTAURIN   BCOR

    Interaction Score: 1.78

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Drug family PKCb inhibitor
    Alteration BCOR:.

    PMIDs:
    None found


    Sources:
    CGI

  • ENZASTAURIN   PRKCB

    Interaction Score: 1.18

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Mechanism of Interaction Protein kinase C beta inhibitor
    Direct Interaction yes
    Notes

    PMIDs:
    None found


    Sources:
    TdgClinicalTrial TTD DrugBank TALC MyCancerGenome GuideToPharmacology ChemblInteractions

  • ENZASTAURIN   GNAQ

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Indication/Tumor Type uveal melanoma
    Response Type sensitive
    Approval Status Preclinical - Cell culture

    PMIDs:
    22253748


    Sources:
    JAX-CKB

  • ENZASTAURIN   CDK15

    Interaction Score: 0.51

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ENZASTAURIN   PRKCG

    Interaction Score: 0.28

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Direct Interaction? False
    Endogenous Drug? False
    Specific Action of the Ligand Inhibition

    PMIDs:
    None found


    Sources:
    MyCancerGenome GuideToPharmacology

  • ENZASTAURIN   PRKCA

    Interaction Score: 0.24

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    MyCancerGenome GuideToPharmacology

  • ENZASTAURIN   PRKCE

    Interaction Score: 0.22

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    None found


    Sources:
    MyCancerGenome

  • ENZASTAURIN   JAK1

    Interaction Score: 0.22

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    22333600


    Sources:
    CIViC

  • ENZASTAURIN   CHEK2

    Interaction Score: 0.12

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ENZASTAURIN   PIK3R1

    Interaction Score: 0.1

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ENZASTAURIN   PRKCD

    Interaction Score: 0.1

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:
    Specific Action of the Ligand Inhibition
    Endogenous Drug? False
    Direct Interaction? False

    PMIDs:
    None found


    Sources:
    GuideToPharmacology

  • ENZASTAURIN   AKT1

    Interaction Score: 0.09

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD DrugBank

  • ENZASTAURIN   CHEK1

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ENZASTAURIN   AURKA

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ENZASTAURIN   AURKB

    Interaction Score: 0.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DrugBank

  • ENZASTAURIN   PIK3CG

    Interaction Score: 0.03

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • MyCancerGenome: ENZASTAURIN

    • Version: 20-Jun-2017

    Alternate Names:
    LY317615 Development Name
    ENZASTAURIN Generic Name

    Drug Info:
    Drug Class Kinase Inhibitors

    Publications:

  • DrugBank: DB06486

    • Version: 5.1.7

    Alternate Names:
    ENZASTAURIN DrugBank Drug Name
    170364-57-5 CAS Number
    CHEMBL300138 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups investigational
    Drug Categories heterocyclic compounds, fused-ring

    Publications:

  • TdgClinicalTrial: ENZASTAURIN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    FDA Approval not approved

    Publications:

  • JAX-CKB: Enzastaurin

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:
    Wu et al., 2012, The protein kinase C inhibitor enzastaurin exhibits antitumor activity against uveal melanoma., PLoS ONE

  • CIViC: ENZASTAURIN

    • Version: 14-September-2020

    Alternate Names:

    Drug Info:

    Publications:
    Shimokawa et al., 2012, Enzastaurin has anti-tumour effects in lung cancers with overexpressed JAK pathway molecules., Br. J. Cancer

  • TALC: ENZASTAURIN

    • Version: 12-May-2016

    Alternate Names:
    ENZASTAURIN Primary Drug Name
    ENZASTAURIN Drug Generic Name
    LY-317615 Drug Synonym

    Drug Info:

    Publications:

  • TTD: Enzastaurin

    • Version: 2020.06.01

    Alternate Names:
    D0I6VU TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 178102320

    • Version: 29-September-2020

    Alternate Names:
    ENZASTAURIN GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL300138

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL300138

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • CGI: Enzastaurin

    • Version: 27-September-2017

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13