DGIdb - ENMD-2076 Drug Record

ENMD-2076 chembl:CHEMBL482968 Antineoplastic

Alternate Names:

ENMD 2076
ENMD-2076

Drug Info:

FDA Approval	not approved
Drug Class	Small molecule
Drug Indications	antineoplastic agent
Drug Class	Kinase Inhibitors

(5 More Sources)

Publications:

Yee et al., 2016, A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia., Invest New Drugs

ENMD-2076 AURKA

Interaction Score: 0.37

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name ENMD-2076

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology TTD
ENMD-2076 NPM1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute myeloid leukemia

Response Type sensitive

Approval Status Phase I

PMIDs:
27406088

Sources:
JAX-CKB
ENMD-2076 PTK2

Interaction Score: 0.2

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
ENMD-2076 FGFR3

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor 3 inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions
ENMD-2076 FLT3

Interaction Score: 0.17

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ENMD-2076

Indication/Tumor Type acute myeloid leukemia

PMIDs:
27406088

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology
ENMD-2076 FGFR2

Interaction Score: 0.1

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial
ENMD-2076 KDR

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor 2 inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology
ENMD-2076 FGFR4

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial
ENMD-2076 CSF1R

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ENMD-2076 SRC

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
ENMD-2076 PDGFRA

Interaction Score: 0.08

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology
ENMD-2076 BLK

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial
ENMD-2076 KIT

Interaction Score: 0.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Stem cell growth factor receptor inhibitor

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions
ENMD-2076 FYN

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ENMD-2076 FLT4

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ENMD-2076

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial
ENMD-2076 FGFR1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial
ENMD-2076 NTRK1

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial
ENMD-2076 LCK

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ENMD-2076 AURKB

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
ENMD-2076 RET

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ENMD-2076 ABL1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial
ENMD-2076 JAK2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Novel Target

PMIDs:
None found

Sources:
TdgClinicalTrial
ENMD-2076 FLT1

Interaction Score: 0.03

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
None found

Sources:
MyCancerGenome
ENMD-2076 YES1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

MyCancerGenome: ENMD-2076
- Version: 20-Jun-2017
Alternate Names:

ENMD-2076 Development Name

Drug Info:

Drug Class Kinase Inhibitors

Publications:
TdgClinicalTrial: ENMD-2076
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval not approved

Publications:

JAX-CKB: ENMD-2076

Version: 27-September-2017

Alternate Names:

Drug Info:

Publications:

Yee et al., 2016, A phase I trial of the aurora kinase inhibitor, ENMD-2076, in patients with relapsed or refractory acute myeloid leukemia or chronic myelomonocytic leukemia., Invest New Drugs

TALC: ENMD-2076
- Version: 12-May-2016
Alternate Names:

ENMD-2076 Drug Synonym

ENMD-2076 Primary Drug Name

Drug Info:

Publications:
GuideToPharmacology: 249565576
- Version: 29-September-2020
Alternate Names:

ENMD-2076 GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: ENMD-2076
- Version: 2020.06.01
Alternate Names:

D0S7HM TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL482968
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ClearityFoundationClinicalTrial: ENMD-2076
- Version: 15-June-2013
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL482968
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Novel drug target	Novel Target
Trial Name	ENMD-2076
Mechanism of Interaction	Serine/threonine-protein kinase Aurora-A inhibitor

Indication/Tumor Type	acute myeloid leukemia
Response Type	sensitive
Approval Status	Phase I

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

Mechanism of Interaction	Fibroblast growth factor receptor 3 inhibitor
Direct Interaction	yes
Notes

Novel drug target	Established target
Trial Name	ENMD-2076
Indication/Tumor Type	acute myeloid leukemia

Direct Interaction	yes
Mechanism of Interaction	Macrophage colony stimulating factor receptor inhibitor
Trial Name	ENMD-2076

Direct Interaction	yes
Mechanism of Interaction	Stem cell growth factor receptor inhibitor
Novel drug target	Established target

Mechanism of Interaction	Serine/threonine-protein kinase Aurora-B inhibitor
Direct Interaction	yes

ENMD-2076 Drug Record

ENMD-2076 chembl:CHEMBL482968 Antineoplastic

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Novel Target Trial Name ENMD-2076 Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality: n/a

Interaction Info: Indication/Tumor Type acute myeloid leukemia Response Type sensitive Approval Status Phase I

PMIDs: 27406088

Sources: JAX-CKB

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Fibroblast growth factor receptor 3 inhibitor Direct Interaction yes Notes

PMIDs: None found

Sources: TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ENMD-2076 Indication/Tumor Type acute myeloid leukemia

PMIDs: 27406088

Sources: TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ENMD-2076 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial ClearityFoundationClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Notes Direct Interaction yes Mechanism of Interaction Vascular endothelial growth factor receptor 2 inhibitor

PMIDs: None found

Sources: TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: ClearityFoundationClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor Trial Name ENMD-2076

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Direct Interaction? True

PMIDs: None found

Sources: TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Novel Target Trial Name ENMD-2076

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Stem cell growth factor receptor inhibitor Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ENMD-2076 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Novel drug target Established target Trial Name ENMD-2076

PMIDs: None found

Sources: MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ENMD-2076 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial ClearityFoundationClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name ENMD-2076

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info: Trial Name ENMD-2076 Novel drug target Established target

PMIDs: None found

Sources: TdgClinicalTrial

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor Direct Interaction yes

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Novel Target

Trial Name ENMD-2076

Mechanism of Interaction Serine/threonine-protein kinase Aurora-A inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ClearityFoundationClinicalTrial ChemblInteractions GuideToPharmacology TTD

Interaction Types & Directionality:

n/a

Interaction Info:

Indication/Tumor Type acute myeloid leukemia

Response Type sensitive

Approval Status Phase I

PMIDs:
27406088

Sources:
JAX-CKB

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Fibroblast growth factor receptor 3 inhibitor

Direct Interaction yes

Notes

PMIDs:
None found

Sources:
TALC MyCancerGenome ClearityFoundationClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ENMD-2076

Indication/Tumor Type acute myeloid leukemia

PMIDs:
27406088

Sources:
TALC TdgClinicalTrial JAX-CKB ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Notes

Direct Interaction yes

Mechanism of Interaction Vascular endothelial growth factor receptor 2 inhibitor

PMIDs:
None found

Sources:
TALC MyCancerGenome TdgClinicalTrial ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
ClearityFoundationClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Macrophage colony stimulating factor receptor inhibitor

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? True

PMIDs:
None found

Sources:
TdgClinicalTrial GuideToPharmacology

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Novel Target

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Stem cell growth factor receptor inhibitor

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Novel drug target Established target

Trial Name ENMD-2076

PMIDs:
None found

Sources:
MyCancerGenome TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial ClearityFoundationClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name ENMD-2076

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Serine/threonine-protein kinase Aurora-B inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name ENMD-2076

Novel drug target Established target

PMIDs:
None found

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a