DGIdb - ENILURACIL Drug Record

ENILURACIL chembl:CHEMBL355200 Antineoplastic

Alternate Names:

776-C-85
ENILURACIL
776C85

Drug Info:

FDA Approval	not approved
Drug Class	Small molecule
Drug Indications	antineoplastic agent

(1 More Sources)

Publications:

Porter, 1994, Reaction of 5-ethynyluracil with rat liver xanthine oxidase., J. Biol. Chem.
Czito et al., 2006, A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract., Cancer Invest.
Cao et al., 2000, alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil., Biochem. Pharmacol.
Porter et al., 1994, 5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase., Biochem. Pharmacol.

ENILURACIL AOX1

Interaction Score: 4.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8161345

Sources:
DrugBank
ENILURACIL DPYD

Interaction Score: 3.79

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name eniluracil

Novel drug target Novel Target

PMIDs:
16466986

Sources:
TdgClinicalTrial TTD DrugBank
ENILURACIL XDH

Interaction Score: 1.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
7961725

Sources:
DrugBank
ENILURACIL TYMS

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10692560

Sources:
NCI

DrugBank: DB03516

Version: 5.1.7

Alternate Names:

ENILURACIL DrugBank Drug Name

59989-18-3 CAS Number

CHEMBL355200 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories enzyme inhibitors

Publications:

Czito et al., 2006, A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract., Cancer Invest.

Porter, 1994, Reaction of 5-ethynyluracil with rat liver xanthine oxidase., J. Biol. Chem.

Porter et al., 1994, 5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase., Biochem. Pharmacol.

TdgClinicalTrial: ENILURACIL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval not approved

Publications:
NCI: ENILURACIL
- Version: 14-September-2017
Alternate Names:

C1773 NCI drug code

Drug Info:

Publications:

Cao et al., 2000, alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil., Biochem. Pharmacol.
TTD: Eniluracil
- Version: 2020.06.01
Alternate Names:

D09QOR TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL355200
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

ENILURACIL	DrugBank Drug Name
59989-18-3	CAS Number
CHEMBL355200	ChEMBL ID

Drug Type	small molecule
Drug Groups	investigational
Drug Categories	enzyme inhibitors

Trial Name	eniluracil
Novel drug target	Novel Target

ENILURACIL Drug Record

ENILURACIL chembl:CHEMBL355200 Antineoplastic

Alternate Names:

Drug Info:

Publications:

ENILURACIL AOX1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8161345

Sources: DrugBank

ENILURACIL DPYD

Interaction Types & Directionality: n/a

Interaction Info: Trial Name eniluracil Novel drug target Novel Target

PMIDs: 16466986

Sources: TdgClinicalTrial TTD DrugBank

ENILURACIL XDH

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 7961725

Sources: DrugBank

ENILURACIL TYMS

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10692560

Sources: NCI

DrugBank: DB03516

Alternate Names: ENILURACIL DrugBank Drug Name 59989-18-3 CAS Number CHEMBL355200 ChEMBL ID

Drug Info: Drug Type small molecule Drug Groups investigational Drug Categories enzyme inhibitors

TdgClinicalTrial: ENILURACIL

Alternate Names:

Drug Info: Drug Indications antineoplastic agent Drug Class Small molecule FDA Approval not approved

Publications:

NCI: ENILURACIL

Alternate Names: C1773 NCI drug code

Drug Info:

Publications: Cao et al., 2000, alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil., Biochem. Pharmacol.

TTD: Eniluracil

Alternate Names: D09QOR TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL355200

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
8161345

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Trial Name eniluracil

Novel drug target Novel Target

PMIDs:
16466986

Sources:
TdgClinicalTrial TTD DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
7961725

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
10692560

Sources:
NCI

Alternate Names:

ENILURACIL DrugBank Drug Name

59989-18-3 CAS Number

CHEMBL355200 ChEMBL ID

Drug Info:

Drug Type small molecule

Drug Groups investigational

Drug Categories enzyme inhibitors

Drug Info:

Drug Indications antineoplastic agent

Drug Class Small molecule

FDA Approval not approved

Alternate Names:

C1773 NCI drug code

Publications:

Cao et al., 2000, alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil., Biochem. Pharmacol.

Alternate Names:

D09QOR TTD Drug ID