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ENILURACIL Drug Record

  • Summary
  • Interactions
  • Claims
  • ENILURACIL chembl:CHEMBL355200 Antineoplastic

    Alternate Names:

    776-C-85
    ENILURACIL
    776C85

    Drug Info:

    FDA Approval not approved
    Drug Class Small molecule
    Drug Indications antineoplastic agent
    (1 More Sources)

    Publications:

    Porter, 1994, Reaction of 5-ethynyluracil with rat liver xanthine oxidase., J. Biol. Chem.
    Czito et al., 2006, A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract., Cancer Invest.
    Cao et al., 2000, alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil., Biochem. Pharmacol.
    Porter et al., 1994, 5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase., Biochem. Pharmacol.
  • ENILURACIL   AOX1

    Interaction Score: 4.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8161345


    Sources:
    DrugBank

  • ENILURACIL   DPYD

    Interaction Score: 3.79

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Trial Name eniluracil
    Novel drug target Novel Target

    PMIDs:
    16466986


    Sources:
    TdgClinicalTrial TTD DrugBank

  • ENILURACIL   XDH

    Interaction Score: 1.14

    Interaction Types & Directionality:
    inhibitor (inhibitory)

    Interaction Info:

    PMIDs:
    7961725


    Sources:
    DrugBank

  • ENILURACIL   TYMS

    Interaction Score: 0.62

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    10692560


    Sources:
    NCI

  • DrugBank: DB03516

    • Version: 5.1.7

    Alternate Names:
    ENILURACIL DrugBank Drug Name
    59989-18-3 CAS Number
    CHEMBL355200 ChEMBL ID

    Drug Info:
    Drug Type small molecule
    Drug Groups investigational
    Drug Categories enzyme inhibitors

    Publications:
    Czito et al., 2006, A phase I study of eniluracil/5-FU in combination with radiation therapy for potentially resectable and/or unresectable cancer of the pancreas and distal biliary tract., Cancer Invest.
    Porter, 1994, Reaction of 5-ethynyluracil with rat liver xanthine oxidase., J. Biol. Chem.
    Porter et al., 1994, 5-ethynyl-2(1H)-pyrimidinone: aldehyde oxidase-activation to 5-ethynyluracil, a mechanism-based inactivator of dihydropyrimidine dehydrogenase., Biochem. Pharmacol.

  • TdgClinicalTrial: ENILURACIL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications antineoplastic agent
    Drug Class Small molecule
    FDA Approval not approved

    Publications:

  • NCI: ENILURACIL

    • Version: 14-September-2017

    Alternate Names:
    C1773 NCI drug code

    Drug Info:

    Publications:
    Cao et al., 2000, alpha-fluoro-beta-alanine: effects on the antitumor activity and toxicity of 5-fluorouracil., Biochem. Pharmacol.

  • TTD: Eniluracil

    • Version: 2020.06.01

    Alternate Names:
    D09QOR TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL355200

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

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A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13