DGIdb - ELETRIPTAN Drug Record

ELETRIPTAN chembl:CHEMBL1510 Approved

Alternate Names:

UK-116044-04
UK-116044-04 [AS HYDROBROMIDE)
RELPAX
UK-116044
ELETRIPTAN
UK-116,044-04 FREE BASE
UK-116044-04 FREE BASE
UK 116044
ELETRIPTANUM
RELPAX®
chembl:CHEMBL1510
drugbank:00216
chemidplus:143322-58-1
rxcui:231049
pubchem.compound:77993

Drug Info:

FDA Approval	approved
Drug Indications	antimigraine agent
Drug Class	Small Molecule
Drug Class	anti-migraine agents
Year of Approval	2002
Drug Categories	triptans
Drug Categories	agents that produce hypertension
Drug Categories	antidepressive agents
Drug Categories	central nervous system depressants
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 enzyme inducers
Drug Categories	cytochrome p-450 substrates
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	p-glycoprotein substrates
Drug Categories	selective serotonin 5-ht1 receptor agonists
Drug Categories	selective serotonin agonists
Drug Categories	serotonergic drugs shown to increase risk of serotonin syndrome
Drug Categories	serotonin 1b receptor agonists
Drug Categories	serotonin 1d receptor agonists
Drug Categories	serotonin-1b and serotonin-1d receptor agonist

(3 More Sources)

Publications:

Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
Lambert et al., 2002, Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate., Brain Res.
van den Broek et al., 2000, Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels., Eur. J. Pharmacol.
Knyihár-Csillik et al., 2000, Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model., Eur. J. Neurosci.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Bhalla et al., 2002, Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor., Eur. J. Pharmacol.
Jähnichen et al., 2004, Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery., Naunyn Schmiedebergs Arch. Pharmacol.
Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
Strijbos et al., 2002, Eletriptan Pfizer., Curr Opin Investig Drugs
Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs

ELETRIPTAN HTR1F

Interaction Score: 1.58

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11834243 15185063 10193663

Sources:
DrugBank GuideToPharmacology
ELETRIPTAN HTR1D

Interaction Score: 1.55

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Relpax

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
11513839 15821444 12498013 11752352 11152011 10193663

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology
ELETRIPTAN HTR1B

Interaction Score: 1.23

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11513839 12384251 11050304 11069595 11752352 10193663

Sources:
TEND TTD DrugBank GuideToPharmacology
ELETRIPTAN HTR1E

Interaction Score: 0.81

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
17139284 17016423

Sources:
GuideToPharmacology
ELETRIPTAN HTR1A

Interaction Score: 0.19

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
11513839

Sources:
DrugBank GuideToPharmacology
ELETRIPTAN CYP2D6

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

DrugBank: DB00216

Version: 5.1.7

Alternate Names:

ELETRIPTAN DrugBank Drug Name

143322-58-1 CAS Number

Apo-eletriptan Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.

Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.

Strijbos et al., 2002, Eletriptan Pfizer., Curr Opin Investig Drugs

TEND: ELETRIPTAN
- Version: 01-August-2011
Alternate Names:

ELETRIPTAN Primary Drug Name

Drug Info:

Year of Approval 2002

Drug Class anti-migraine agents

Publications:
TdgClinicalTrial: ELETRIPTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small Molecule

Drug Indications antimigraine agent

FDA Approval approved

Publications:
TTD: Eletriptan
- Version: 2020.06.01
Alternate Names:

D02DMQ TTD Drug ID

Drug Info:

Publications:
GuideToPharmacology: 135650227
- Version: 29-September-2020
Alternate Names:

ELETRIPTAN GuideToPharmacology Ligand Name

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1510
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: eletriptan
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Full agonist
Endogenous Drug?	False
Direct Interaction?	True

Trial Name	Relpax
Novel drug target	Established target
Specific Action of the Ligand	Full agonist

ELETRIPTAN	DrugBank Drug Name
143322-58-1	CAS Number
Apo-eletriptan	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

ELETRIPTAN Drug Record

ELETRIPTAN chembl:CHEMBL1510 Approved

Alternate Names:

Drug Info:

Publications:

ELETRIPTAN HTR1F

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 11834243 15185063 10193663

Sources: DrugBank GuideToPharmacology

ELETRIPTAN HTR1D

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Relpax Novel drug target Established target Specific Action of the Ligand Full agonist

PMIDs: 11513839 15821444 12498013 11752352 11152011 10193663

Sources: TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

ELETRIPTAN HTR1B

Interaction Types & Directionality: agonist (activating)

Interaction Info: Specific Action of the Ligand Full agonist Endogenous Drug? False Direct Interaction? True

PMIDs: 11513839 12384251 11050304 11069595 11752352 10193663

Sources: TEND TTD DrugBank GuideToPharmacology

ELETRIPTAN HTR1E

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Full agonist

PMIDs: 17139284 17016423

Sources: GuideToPharmacology

ELETRIPTAN HTR1A

Interaction Types & Directionality: agonist (activating)

Interaction Info: Endogenous Drug? False Specific Action of the Ligand Full agonist

PMIDs: 11513839

Sources: DrugBank GuideToPharmacology

ELETRIPTAN CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

DrugBank: DB00216

Alternate Names: ELETRIPTAN DrugBank Drug Name 143322-58-1 CAS Number Apo-eletriptan Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: ELETRIPTAN

Alternate Names: ELETRIPTAN Primary Drug Name

Drug Info: Year of Approval 2002 Drug Class anti-migraine agents

Publications:

TdgClinicalTrial: ELETRIPTAN

Alternate Names:

Drug Info: Drug Class Small Molecule Drug Indications antimigraine agent FDA Approval approved

Publications:

TTD: Eletriptan

Alternate Names: D02DMQ TTD Drug ID

Drug Info:

Publications:

GuideToPharmacology: 135650227

Alternate Names: ELETRIPTAN GuideToPharmacology Ligand Name

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1510

Alternate Names:

Drug Info:

Publications:

PharmGKB: eletriptan

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11834243 15185063 10193663

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Relpax

Novel drug target Established target

Specific Action of the Ligand Full agonist

PMIDs:
11513839 15821444 12498013 11752352 11152011 10193663

Sources:
TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Specific Action of the Ligand Full agonist

Endogenous Drug? False

Direct Interaction? True

PMIDs:
11513839 12384251 11050304 11069595 11752352 10193663

Sources:
TEND TTD DrugBank GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
17139284 17016423

Sources:
GuideToPharmacology

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Endogenous Drug? False

Specific Action of the Ligand Full agonist

PMIDs:
11513839

Sources:
DrugBank GuideToPharmacology

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

ELETRIPTAN DrugBank Drug Name

143322-58-1 CAS Number

Apo-eletriptan Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

ELETRIPTAN Primary Drug Name

Drug Info:

Year of Approval 2002

Drug Class anti-migraine agents

Drug Info:

Drug Class Small Molecule

Drug Indications antimigraine agent

FDA Approval approved

Alternate Names:

D02DMQ TTD Drug ID

Alternate Names:

ELETRIPTAN GuideToPharmacology Ligand Name