DGIdb - ELETRIPTAN Drug Record

ELETRIPTAN chembl:CHEMBL1510 Approved

Alternate Names:

UK-116044-04
UK-116044-04 [AS HYDROBROMIDE)
RELPAX
UK-116044
ELETRIPTAN
UK-116,044-04 FREE BASE
UK-116044-04 FREE BASE
UK 116044
ELETRIPTANUM
RELPAX®
chembl:CHEMBL1510
drugbank:00216
chemidplus:143322-58-1
rxcui:231049
pubchem.compound:77993

Drug Info:

FDA Approval	approved
Drug Indications	antimigraine agent
Drug Class	Small Molecule
Drug Class	anti-migraine agents
Year of Approval	2002

(1 More Sources)

Publications:

Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
van den Broek et al., 2000, Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels., Eur. J. Pharmacol.
Lambert et al., 2002, Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate., Brain Res.
Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Knyihár-Csillik et al., 2000, Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model., Eur. J. Neurosci.
Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs
Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
Strijbos et al., 2002, Eletriptan Pfizer., Curr Opin Investig Drugs

ELETRIPTAN HTR1D

Interaction Score: 8.06

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Relpax

Novel drug target Established target

PMIDs:
11152011 15821444 10193663 11513839 11752352 12498013

Sources:
TdgClinicalTrial TEND TTD
ELETRIPTAN HTR1B

Interaction Score: 5.0

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

PMIDs:
10193663 11050304 12384251 11513839 11752352 11069595

Sources:
TEND TTD
ELETRIPTAN CYP2D6

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB

TEND: ELETRIPTAN
- Version: 01-August-2011
Alternate Names:

ELETRIPTAN Primary Drug Name

Drug Info:

Year of Approval 2002

Drug Class anti-migraine agents

Publications:
TdgClinicalTrial: ELETRIPTAN
- Version: January-2014
Alternate Names:

Drug Info:

Drug Class Small Molecule

Drug Indications antimigraine agent

FDA Approval approved

Publications:
TTD: Eletriptan
- Version: 2020.06.01
Alternate Names:

D02DMQ TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1510
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: eletriptan
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	Relpax
Novel drug target	Established target

ELETRIPTAN Drug Record

ELETRIPTAN chembl:CHEMBL1510 Approved

Alternate Names:

Drug Info:

Publications:

ELETRIPTAN HTR1D

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Relpax Novel drug target Established target

PMIDs: 11152011 15821444 10193663 11513839 11752352 12498013

Sources: TdgClinicalTrial TEND TTD

ELETRIPTAN HTR1B

Interaction Types & Directionality: agonist (activating)

Interaction Info:

PMIDs: 10193663 11050304 12384251 11513839 11752352 11069595

Sources: TEND TTD

ELETRIPTAN CYP2D6

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

TEND: ELETRIPTAN

Alternate Names: ELETRIPTAN Primary Drug Name

Drug Info: Year of Approval 2002 Drug Class anti-migraine agents

Publications:

TdgClinicalTrial: ELETRIPTAN

Alternate Names:

Drug Info: Drug Class Small Molecule Drug Indications antimigraine agent FDA Approval approved

Publications:

TTD: Eletriptan

Alternate Names: D02DMQ TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1510

Alternate Names:

Drug Info:

Publications:

PharmGKB: eletriptan

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Relpax

Novel drug target Established target

PMIDs:
11152011 15821444 10193663 11513839 11752352 12498013

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

agonist (activating)

PMIDs:
10193663 11050304 12384251 11513839 11752352 11069595

Sources:
TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Alternate Names:

ELETRIPTAN Primary Drug Name

Drug Info:

Year of Approval 2002

Drug Class anti-migraine agents

Drug Info:

Drug Class Small Molecule

Drug Indications antimigraine agent

FDA Approval approved

Alternate Names:

D02DMQ TTD Drug ID