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ELETRIPTAN Drug Record

  • Summary
  • Interactions
  • Claims
  • ELETRIPTAN chembl:CHEMBL1510 Approved

    Alternate Names:

    UK-116044-04
    UK-116044-04 [AS HYDROBROMIDE)
    RELPAX
    UK-116044
    ELETRIPTAN
    UK-116,044-04 FREE BASE
    UK-116044-04 FREE BASE
    UK 116044
    ELETRIPTANUM
    RELPAX®
    chembl:CHEMBL1510
    drugbank:00216
    chemidplus:143322-58-1
    rxcui:231049
    pubchem.compound:77993

    Drug Info:

    FDA Approval approved
    Drug Indications antimigraine agent
    Drug Class Small Molecule
    Drug Class anti-migraine agents
    Year of Approval 2002
    Drug Categories triptans
    Drug Categories agents that produce hypertension
    Drug Categories antidepressive agents
    Drug Categories central nervous system depressants
    Drug Categories cytochrome p-450 cyp3a substrates
    Drug Categories cytochrome p-450 enzyme inducers
    Drug Categories cytochrome p-450 substrates
    Drug Categories heterocyclic compounds, fused-ring
    Drug Categories p-glycoprotein substrates
    Drug Categories selective serotonin 5-ht1 receptor agonists
    Drug Categories selective serotonin agonists
    Drug Categories serotonergic drugs shown to increase risk of serotonin syndrome
    Drug Categories serotonin 1b receptor agonists
    Drug Categories serotonin 1d receptor agonists
    Drug Categories serotonin-1b and serotonin-1d receptor agonist
    (3 More Sources)

    Publications:

    Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
    Lambert et al., 2002, Suppression by eletriptan of the activation of trigeminovascular sensory neurons by glyceryl trinitrate., Brain Res.
    van den Broek et al., 2000, Pharmacological analysis of contractile effects of eletriptan and sumatriptan on human isolated blood vessels., Eur. J. Pharmacol.
    Knyihár-Csillik et al., 2000, Effects of eletriptan on the peptidergic innervation of the cerebral dura mater and trigeminal ganglion, and on the expression of c-fos and c-jun in the trigeminal complex of the rat in an experimental migraine model., Eur. J. Neurosci.
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Napier et al., 1999, Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors., Eur. J. Pharmacol.
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Bhalla et al., 2002, Molecular cloning and expression of the porcine trigeminal ganglion cDNA encoding a 5-ht(1F) receptor., Eur. J. Pharmacol.
    Jähnichen et al., 2004, Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery., Naunyn Schmiedebergs Arch. Pharmacol.
    Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
    Strijbos et al., 2002, Eletriptan Pfizer., Curr Opin Investig Drugs
    Tfelt-Hansen et al., 2000, Triptans in migraine: a comparative review of pharmacology, pharmacokinetics and efficacy., Drugs
  • ELETRIPTAN   HTR1F

    Interaction Score: 1.58

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11834243 15185063 10193663


    Sources:
    DrugBank GuideToPharmacology

  • ELETRIPTAN   HTR1D

    Interaction Score: 1.55

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Trial Name Relpax
    Novel drug target Established target
    Specific Action of the Ligand Full agonist

    PMIDs:
    11513839 15821444 12498013 11752352 11152011 10193663


    Sources:
    TEND TdgClinicalTrial TTD DrugBank GuideToPharmacology

  • ELETRIPTAN   HTR1B

    Interaction Score: 1.23

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Specific Action of the Ligand Full agonist
    Endogenous Drug? False
    Direct Interaction? True

    PMIDs:
    11513839 12384251 11050304 11069595 11752352 10193663


    Sources:
    TEND TTD DrugBank GuideToPharmacology

  • ELETRIPTAN   HTR1E

    Interaction Score: 0.81

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    17139284 17016423


    Sources:
    GuideToPharmacology

  • ELETRIPTAN   HTR1A

    Interaction Score: 0.19

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Endogenous Drug? False
    Specific Action of the Ligand Full agonist

    PMIDs:
    11513839


    Sources:
    DrugBank GuideToPharmacology

  • ELETRIPTAN   CYP2D6

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DrugBank: DB00216

    • Version: 5.1.7

    Alternate Names:
    ELETRIPTAN DrugBank Drug Name
    143322-58-1 CAS Number
    Apo-eletriptan Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Johnson et al., 2001, Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain., Eur. J. Pharmacol.
    Wackenfors et al., 2005, Triptans induce vasoconstriction of human arteries and veins from the thoracic wall., J. Cardiovasc. Pharmacol.
    Strijbos et al., 2002, Eletriptan Pfizer., Curr Opin Investig Drugs

  • TEND: ELETRIPTAN

    • Version: 01-August-2011

    Alternate Names:
    ELETRIPTAN Primary Drug Name

    Drug Info:
    Year of Approval 2002
    Drug Class anti-migraine agents

    Publications:

  • TdgClinicalTrial: ELETRIPTAN

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Class Small Molecule
    Drug Indications antimigraine agent
    FDA Approval approved

    Publications:

  • TTD: Eletriptan

    • Version: 2020.06.01

    Alternate Names:
    D02DMQ TTD Drug ID

    Drug Info:

    Publications:

  • GuideToPharmacology: 135650227

    • Version: 29-September-2020

    Alternate Names:
    ELETRIPTAN GuideToPharmacology Ligand Name

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1510

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • PharmGKB: eletriptan

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21