DGIdb - DRONABINOL Drug Record

DRONABINOL chembl:CHEMBL465 Approved

Alternate Names:

ABBOTT-40566
SP-104
NSC-134454
DELTA-9-THC
DRONABINOL
MARINOL
J882F
SYNDROS
QCD-84924
DELTA-9-TETRAHYDROCANNABINOL
QCD 84924
ABBOTT 40566
SP 104
Δ9-THC
1-TRANS-DELTA-9-TETRAHYDROCANNABINOL
DELTA9-THC
3-PENTYL-6,6,9-TRIMETHYL-6A,7,8,10A-TETRAHYDRO-6H-DIBENZO(B,D)PYRAN-1-OL
(-)-DELTA9-TRANS-TETRAHYDROCANNABINOL
DELTA(1)-TETRAHYDROCANNABINOL
DRONABINOLUM
DRONABINOLEN
6,6,9-TRIMETHYL-3-PENTYL-6A,7,8,10A-TETRAHYDRO-6H-BENZO[C]CHROMEN-1-OL
MARINOL®
THC
6H-DIBENZO(B,D)PYRAN-1-OL, 6A,7,8,10A-TETRAHYDRO-6,6,9-TRIMETHYL-3-PENTYL-, (6AR,10AR)-
DELTA(9)-THC
DELTA9-TETRAHYDROCANNABINOL
Δ9-TETRAHYDROCANNABINOL
drugbank:00470
rxcui:10402
chemidplus:1972-08-3
pubchem.compound:16078
chembl:CHEMBL465

Drug Info:

FDA Approval	approved
Drug Class	plant extract
Drug Indications	analgesic,neuropathic pain,for treatment of restlegs legs syndrome
Drug Indications	appetite stimulant
Drug Class	Small molecule
Drug Indications	analgesic

(4 More Sources)

Publications:

Suárez et al., 2000, Neuronal and astroglial response to pre- and perinatal exposure to delta-9-tetra- hydrocannabinol in the rat substantia nigra., Dev. Neurosci.
Burstein et al., 1994, Phospholipase participation in cannabinoid-induced release of free arachidonic acid., Biochem. Pharmacol.
Davis et al., 2007, The emerging role of cannabinoid neuromodulators in symptom management., Support Care Cancer
Pertwee, 2009, Emerging strategies for exploiting cannabinoid receptor agonists as medicines., Br. J. Pharmacol.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Pryce et al., 2003, Mifepristone or inhibition of 11beta-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Delta(9)-tetrahydrocannabinol in mice., Neurosci. Lett.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Tsai et al., 2000, Association study of a cannabinoid receptor gene (CNR1) polymorphism and schizophrenia., Psychiatr. Genet.
Gorriti et al., 2005, Acute delta9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion., Pharmacol. Biochem. Behav.
Schuel, 2006, Tuning the oviduct to the anandamide tone., J. Clin. Invest.
Zhu et al., 2006, Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana., J. Pharmacol. Exp. Ther.
Butovsky et al., 2005, In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol., J. Neurochem.

DRONABINOL PLA2G2A

Interaction Score: 2.21

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7945419

Sources:
NCI
DRONABINOL CNR1

Interaction Score: 2.17

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Sativex

Novel drug target Established target

Mechanism of Interaction Cannabinoid CB1 receptor agonist

PMIDs:
11752352 12686391 17016423 17139284 11204352 15894066

Sources:
TdgClinicalTrial ChemblInteractions NCI
DRONABINOL CNR2

Interaction Score: 1.29

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name CAT-310,Relivar

Novel drug target Established target

Trial Name Sativex

PMIDs:
17139494 19226257

Sources:
TdgClinicalTrial
DRONABINOL FAAH

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16886056

Sources:
NCI
DRONABINOL GFAP

Interaction Score: 0.62

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10965147

Sources:
NCI
DRONABINOL BDNF

Interaction Score: 0.24

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15857384

Sources:
NCI
DRONABINOL ABCB1

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16439618

Sources:
NCI
DRONABINOL CYP2C9

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB FDA

TdgClinicalTrial: DRONABINOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic

Drug Class Small molecule

FDA Approval approved

Publications:
TdgClinicalTrial: TETRAHYDROCANNABINOL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications analgesic,neuropathic pain,for treatment of restlegs legs syndrome

Drug Class plant extract

FDA Approval approved

Publications:

NCI: TETRAHYDROCANNABINOL

Version: 14-September-2017

Alternate Names:

C867 NCI drug code

Drug Info:

Publications:

Butovsky et al., 2005, In vivo up-regulation of brain-derived neurotrophic factor in specific brain areas by chronic exposure to Delta-tetrahydrocannabinol., J. Neurochem.

Gorriti et al., 2005, Acute delta9-tetrahydrocannabinol exposure facilitates quinpirole-induced hyperlocomotion., Pharmacol. Biochem. Behav.

Schuel, 2006, Tuning the oviduct to the anandamide tone., J. Clin. Invest.

NCI: THC

Version: 14-September-2017

Alternate Names:

C867 NCI drug code

Drug Info:

Publications:

Suárez et al., 2000, Neuronal and astroglial response to pre- and perinatal exposure to delta-9-tetra- hydrocannabinol in the rat substantia nigra., Dev. Neurosci.

Burstein et al., 1994, Phospholipase participation in cannabinoid-induced release of free arachidonic acid., Biochem. Pharmacol.

Zhu et al., 2006, Characterization of P-glycoprotein inhibition by major cannabinoids from marijuana., J. Pharmacol. Exp. Ther.

ChemblDrugs: chembl:CHEMBL465
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL465
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: dronabinol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:
FDA: Dronabinol
- Version: 04-September-2020
Alternate Names:

Drug Info:

Publications:

Trial Name	Sativex
Novel drug target	Established target
Mechanism of Interaction	Cannabinoid CB1 receptor agonist

Trial Name	CAT-310,Relivar
Novel drug target	Established target
Trial Name	Sativex

DRONABINOL Drug Record

DRONABINOL chembl:CHEMBL465 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7945419

Sources: NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name Sativex Novel drug target Established target Mechanism of Interaction Cannabinoid CB1 receptor agonist

PMIDs: 11752352 12686391 17016423 17139284 11204352 15894066

Sources: TdgClinicalTrial ChemblInteractions NCI

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name CAT-310,Relivar Novel drug target Established target Trial Name Sativex

PMIDs: 17139494 19226257

Sources: TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16886056

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 10965147

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15857384

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16439618

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB FDA

TdgClinicalTrial: DRONABINOL

Alternate Names:

Drug Info: Drug Indications analgesic Drug Class Small molecule FDA Approval approved

Publications:

TdgClinicalTrial: TETRAHYDROCANNABINOL

Alternate Names:

Drug Info: Drug Indications analgesic,neuropathic pain,for treatment of restlegs legs syndrome Drug Class plant extract FDA Approval approved

Publications:

NCI: TETRAHYDROCANNABINOL

Alternate Names: C867 NCI drug code

Drug Info:

NCI: THC

Alternate Names: C867 NCI drug code

Drug Info:

ChemblDrugs: chembl:CHEMBL465

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL465

Alternate Names:

Drug Info:

Publications:

PharmGKB: dronabinol

Alternate Names:

Drug Info:

Publications:

FDA: Dronabinol

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
7945419

Sources:
NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name Sativex

Novel drug target Established target

Mechanism of Interaction Cannabinoid CB1 receptor agonist

PMIDs:
11752352 12686391 17016423 17139284 11204352 15894066

Sources:
TdgClinicalTrial ChemblInteractions NCI

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name CAT-310,Relivar

Novel drug target Established target

Trial Name Sativex

PMIDs:
17139494 19226257

Sources:
TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
16886056

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
10965147

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15857384

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16439618

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB FDA

Drug Info:

Drug Indications analgesic

Drug Class Small molecule

FDA Approval approved

Drug Info:

Drug Indications analgesic,neuropathic pain,for treatment of restlegs legs syndrome

Drug Class plant extract

FDA Approval approved

Alternate Names:

C867 NCI drug code

Alternate Names:

C867 NCI drug code