DGIdb - DOBUTAMINE Drug Record

DOBUTAMINE chembl:CHEMBL926 Approved

Alternate Names:

DOBUTREX
DOBUTAMINE
COMPOUND-81929
COMPOUND 81929

Drug Info:

Drug Class	cardiotonic agents
Year of Approval	1978
FDA Approval	1978
Drug Class	small molecule
Drug Indications	Cardiotonic Agents

(2 More Sources)

Publications:

Rydén M et al., 2001, The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis., Int J Obes Relat Metab Disord
Bruck et al., 2005, The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity., J. Am. Coll. Cardiol.
La Rosée et al., 2004, The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines., Pharmacogenetics
Junker et al., 2002, Stimulation of beta-adrenoceptors activates astrocytes and provides neuroprotection., Eur. J. Pharmacol.
Raddatz et al., 2006, Dobutamine improves liver function after hemorrhagic shock through induction of heme oxygenase-1., Am. J. Respir. Crit. Care Med.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Mao YM et al., 2009, Effect of 393T>C polymorphism of GNAS1 gene on dobutamine response in Chinese healthy subjects., J Clin Pharmacol

DOBUTAMINE ADRB1

Interaction Score: 2.48

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11753577 16325050 15564877 12098582 16627864 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD
DOBUTAMINE GNAS

Interaction Score: 1.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19542315

Sources:
PharmGKB
DOBUTAMINE DRD1

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DOBUTAMINE
- Version: 01-August-2011
Alternate Names:

DOBUTAMINE Primary Drug Name

Drug Info:

Year of Approval 1978

Drug Class cardiotonic agents

Publications:
TdgClinicalTrial: DOBUTAMINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Cardiotonic Agents

Drug Class small molecule

FDA Approval 1978

Publications:

PharmGKB: dobutamine

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Mao YM et al., 2009, Effect of 393T>C polymorphism of GNAS1 gene on dobutamine response in Chinese healthy subjects., J Clin Pharmacol

La Rosée et al., 2004, The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines., Pharmacogenetics

Bruck et al., 2005, The Arg389Gly beta1-adrenoceptor polymorphism and catecholamine effects on plasma-renin activity., J. Am. Coll. Cardiol.

DTC: DOBUTAMINE
- Version: 02-September-2020
Alternate Names:

CHEMBL926 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Dobutamine
- Version: 2020.06.01
Alternate Names:

D0J7RK TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL926
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

DOBUTAMINE Drug Record

DOBUTAMINE chembl:CHEMBL926 Approved

Alternate Names:

Drug Info:

Publications:

DOBUTAMINE ADRB1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 11753577 16325050 15564877 12098582 16627864 11752352

Sources: TdgClinicalTrial TEND PharmGKB TTD

DOBUTAMINE GNAS

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19542315

Sources: PharmGKB

DOBUTAMINE DRD1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DOBUTAMINE

Alternate Names: DOBUTAMINE Primary Drug Name

Drug Info: Year of Approval 1978 Drug Class cardiotonic agents

Publications:

TdgClinicalTrial: DOBUTAMINE

Alternate Names:

Drug Info: Drug Indications Cardiotonic Agents Drug Class small molecule FDA Approval 1978

Publications:

PharmGKB: dobutamine

Alternate Names:

Drug Info:

DTC: DOBUTAMINE

Alternate Names: CHEMBL926 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Dobutamine

Alternate Names: D0J7RK TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL926

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
11753577 16325050 15564877 12098582 16627864 11752352

Sources:
TdgClinicalTrial TEND PharmGKB TTD

Interaction Types & Directionality:

n/a

PMIDs:
19542315

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DOBUTAMINE Primary Drug Name

Drug Info:

Year of Approval 1978

Drug Class cardiotonic agents

Drug Info:

Drug Indications Cardiotonic Agents

Drug Class small molecule

FDA Approval 1978

Alternate Names:

CHEMBL926 ChEMBL Drug ID

Alternate Names:

D0J7RK TTD Drug ID