DGIdb - DISULFIRAM Drug Record

DISULFIRAM chembl:CHEMBL964 Approved

Alternate Names:

ESPERAL
NSC-25953
DISULFIRAM
ANTABUSE
ORA-102
ORA102
TETRAETHYLTHIOPEROXYDICARBONIC DIAMIDE
TETRAETHYLTHIURAM DISULPHIDE
TETRAETHYLTHIURAM DISULFIDE
N,N,N',N'-TETRAETHYLTHIURAM DISULFIDE
ANTABUSE®
BIS(DIETHYLTHIOCARBAMOYL) DISULFIDE
ANTABUSE (TN)
1,1'-DITHIOBIS(N,N-DIETHYLTHIOFORMAMIDE)
rxcui:3554
chembl:CHEMBL964
pubchem.compound:3117
drugbank:00822
chemidplus:97-77-8

Drug Info:

Drug Categories	thiocarbamates
Drug Categories	sulfur containing products
Drug Categories	sulfides
Drug Categories	ions
Drug Categories	gases
Drug Categories	alcohol deterrents
FDA Approval	1951
Drug Class	small molecule
Drug Indications	Alcohol Deterrents
Drug Class	alcohol deterrents
Year of Approval	1951
Drug Categories	acetyl aldehyde dehydrogenase inhibitors
Drug Categories	agents that reduce seizure threshold
Drug Categories	aldehyde dehydrogenase inhibitor
Drug Categories	bsep/abcb11 substrates
Drug Categories	cytochrome p-450 cyp2e1 inhibitors (strength unknown)
Drug Categories	cytochrome p-450 cyp3a substrates
Drug Categories	cytochrome p-450 cyp3a5 substrates
Drug Categories	cytochrome p-450 enzyme inhibitors
Drug Categories	cytochrome p-450 substrates
Drug Categories	drugs used in addictive disorders
Drug Categories	drugs used in alcohol dependence
Drug Categories	nervous system
Drug Categories	potential qtc-prolonging agents
Drug Categories	qtc prolonging agents

(5 More Sources)

Publications:

Helander et al., 1996, Carbohydrate-deficient transferrin and gamma-glutamyl transferase levels during disulfiram therapy., Alcohol. Clin. Exp. Res.
Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol
Johnsen et al., 1990, [Disulfiram implants. Lack of pharmacological and clinical effects]., Tidsskr. Nor. Laegeforen.
Mackenzie et al., 2005, Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans., Arterioscler. Thromb. Vasc. Biol.
Ho et al., 2007, Refractive hypotension in a patient with disulfiram-ethanol reaction., Am. J. Med. Sci.
Luthman et al., 1991, Combined lead acetate and disulfiram treatment-induced alterations of glial fibrillary acidic protein (GFA) immunoreactive astrocytes in brain smears., Toxicology
Gaval-Cruz et al., 2009, mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse., Mol. Interv.
Katz et al., 1992, Disulfiram and diethyldithiocarbamate are competitive inhibitors at the peripheral benzodiazepine receptor., J. Pharmacol. Exp. Ther.
Spellicy CJ et al., 2013, ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse., Pharmacogenet Genomics
Spellicy CJ et al., 2013, The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency., Front Psychiatry

DISULFIRAM ALDH2

Interaction Score: 0.97

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Aldehyde dehydrogenase inhibitor

Trial Name -

PMIDs:
16051882 17220694

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions
DISULFIRAM ALDH3A2

Interaction Score: 0.73

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DISULFIRAM DBH

Interaction Score: 0.55

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
19720750

Sources:
PharmGKB DrugBank
DISULFIRAM ALDH3A1

Interaction Score: 0.42

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
2185582

Sources:
NCI
DISULFIRAM ANKK1

Interaction Score: 0.22

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23635803

Sources:
PharmGKB
DISULFIRAM GGT1

Interaction Score: 0.15

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8904971

Sources:
NCI
DISULFIRAM GFAP

Interaction Score: 0.12

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1992564

Sources:
NCI
DISULFIRAM MTHFR

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23335901

Sources:
PharmGKB
DISULFIRAM TSPO

Interaction Score: 0.09

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1320691

Sources:
NCI
DISULFIRAM CBFB

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM RUNX1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM AGTR1

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM THPO

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM SLC6A3

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DISULFIRAM NFKB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM RGS4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM DRD2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
23635803

Sources:
PharmGKB
DISULFIRAM MPHOSPH8

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM MTOR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM PPARD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM ADRB2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM HSP90AA1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM PLK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM CBX1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM CYP2C19

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DISULFIRAM HPGD

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM ABCB1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DISULFIRAM CYP1A2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
22931300

Sources:
DTC
DISULFIRAM ATAD5

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM ALDH1A1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM CYP2C9

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM KDM4A

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM VDR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM GMNN

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM NFE2L2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM AR

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DISULFIRAM CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00822

Version: 5.1.7

Alternate Names:

DISULFIRAM DrugBank Drug Name

97-77-8 CAS Number

Antabus Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories acetyl aldehyde dehydrogenase inhibitors

Publications:

Mackenzie et al., 2005, Aldehyde dehydrogenase 2 plays a role in the bioactivation of nitroglycerin in humans., Arterioscler. Thromb. Vasc. Biol.

Ho et al., 2007, Refractive hypotension in a patient with disulfiram-ethanol reaction., Am. J. Med. Sci.

Gaval-Cruz et al., 2009, mechanisms of disulfiram-induced cocaine abstinence: antabuse and cocaine relapse., Mol. Interv.

TEND: DISULFIRAM
- Version: 01-August-2011
Alternate Names:

DISULFIRAM Primary Drug Name

Drug Info:

Year of Approval 1951

Drug Class alcohol deterrents

Publications:
TdgClinicalTrial: DISULFIRAM
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Alcohol Deterrents

Drug Class small molecule

FDA Approval 1951

Publications:
DTC: DISULFIRAM
- Version: 02-September-2020
Alternate Names:

CHEMBL964 ChEMBL Drug ID

Drug Info:

Publications:

Sakatis MZ et al., 2012, Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds., Chem Res Toxicol

NCI: DISULFIRAM

Version: 14-September-2017

Alternate Names:

C447 NCI drug code

Drug Info:

Publications:

Johnsen et al., 1990, [Disulfiram implants. Lack of pharmacological and clinical effects]., Tidsskr. Nor. Laegeforen.

Luthman et al., 1991, Combined lead acetate and disulfiram treatment-induced alterations of glial fibrillary acidic protein (GFA) immunoreactive astrocytes in brain smears., Toxicology

Helander et al., 1996, Carbohydrate-deficient transferrin and gamma-glutamyl transferase levels during disulfiram therapy., Alcohol. Clin. Exp. Res.

PharmGKB: disulfiram

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Spellicy CJ et al., 2013, The MTHFR C677T Variant is Associated with Responsiveness to Disulfiram Treatment for Cocaine Dependency., Front Psychiatry

Spellicy CJ et al., 2013, ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse., Pharmacogenet Genomics

TTD: Disulfiram
- Version: 2020.06.01
Alternate Names:

D0X5SD TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL964
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL964
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Direct Interaction	yes
Mechanism of Interaction	Aldehyde dehydrogenase inhibitor
Trial Name	-

DISULFIRAM	DrugBank Drug Name
97-77-8	CAS Number
Antabus	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	acetyl aldehyde dehydrogenase inhibitors

DISULFIRAM Drug Record

DISULFIRAM chembl:CHEMBL964 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction Aldehyde dehydrogenase inhibitor Trial Name -

PMIDs: 16051882 17220694

Sources: TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 19720750

Sources: PharmGKB DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 2185582

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23635803

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8904971

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1992564

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23335901

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1320691

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 23635803

Sources: PharmGKB

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction Aldehyde dehydrogenase inhibitor

Trial Name -

PMIDs:
16051882 17220694

Sources:
TEND TdgClinicalTrial DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
19720750

Sources:
PharmGKB DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
2185582

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23635803

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
8904971

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
1992564

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
23335901

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
1320691

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
23635803

Sources:
PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
22931300

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a