DGIdb - DIPYRIDAMOLE Drug Record

DIPYRIDAMOLE chembl:CHEMBL932 Approved

Alternate Names:

PERSANTIN
PERSANTIN RET
CEREBROVASE 100
PYRIDANTIN
B01AC07
RA-8
IV PERSANTINE
CEREBROVASE 25
MODAPLATE
PERSANTINE
DIPYRIDAMOLE
ATTIA
VASYROL
NSC-515776
OFCRAM PR
PERSANTINE®
DIPYRIDAMINE
DIPYUDAMINE
DIPYRIDAMOLUM
DIPIRIDAMOL
DYPYRIDAMOL
CURANTYL
CLERIDIUM 150
pubchem.compound:3108
rxcui:3521
chembl:CHEMBL932
chemidplus:58-32-2
drugbank:00975

Drug Info:

Drug Class	vasodilator agents
Year of Approval	1961
Drug Class	platelet aggregation inhibitors
Drug Indications	antithrombotic
FDA Approval	approved
Drug Class	Small Molecule
Drug Indications	anticoagulant
Drug Categories	anticoagulants
Drug Categories	antiplatelet agents
Drug Categories	bsep/abcb11 substrates
Drug Categories	decreased platelet aggregation
Drug Categories	miscellaneous vasodilatating agents
Drug Categories	oatp1b1/slco1b1 inhibitors
Drug Categories	oatp1b3 inhibitors
Drug Categories	p-glycoprotein inhibitors
Drug Categories	p-glycoprotein substrates
Drug Categories	phosphodiesterase 5 inhibitors
Drug Categories	vasodilating agents

(6 More Sources)

Publications:

Fujishige et al., 1999, Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)., J. Biol. Chem.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Kruuse et al., 2006, Dipyridamole may induce migraine in patients with migraine without aura., Cephalalgia
Jackson et al., 2007, Characterization of renal ecto-phosphodiesterase., J. Pharmacol. Exp. Ther.
Kulkarni et al., 2004, Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects., Methods Find Exp Clin Pharmacol
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Santini et al., 2005, Hemodynamic effects of inhaled nitric oxide and phosphodiesterase inhibitor (dipyridamole) on secondary pulmonary hypertension following heart valve surgery in adults., Int. J. Cardiol.
Simiti et al., Increased plasma levels of interleukin-8 in patients with unstable angina pectoris., Rom J Intern Med
Hosoi et al., 1998, Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP., Int. J. Oncol.
Hellwig et al., 1991, Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine., Mol. Pharmacol.
Hervé et al., 1996, Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein., Pharmacogenetics
Mulero MC et al., 2009, Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity., J Biol Chem

DIPYRIDAMOLE RCAN1

Interaction Score: 2.1

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
19189965

Sources:
DrugBank
DIPYRIDAMOLE PDE8B

Interaction Score: 0.7

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
DIPYRIDAMOLE PDE10A

Interaction Score: 0.57

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs:
10373451 17016423 17139284

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND
DIPYRIDAMOLE PDE6D

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE6A

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE7B

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
DIPYRIDAMOLE PDE8A

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
DIPYRIDAMOLE PDE6B

Interaction Score: 0.53

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE5A

Interaction Score: 0.39

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

Novel drug target Established target

Trial Name CRx-150, amoxapine plus dipyridamole

PMIDs:
16886928 17308037 15672122 11752352 16080974

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND TTD
DIPYRIDAMOLE ORM1

Interaction Score: 0.35

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8946472

Sources:
DrugBank
DIPYRIDAMOLE PDE1C

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE6C

Interaction Score: 0.35

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE9A

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE6H

Interaction Score: 0.26

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE6G

Interaction Score: 0.21

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE ADA

Interaction Score: 0.19

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-150, amoxapine plus dipyridamole

Novel drug target Established target

Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs:
11752352

Sources:
DrugBank TdgClinicalTrial TEND
DIPYRIDAMOLE PDE1B

Interaction Score: 0.18

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE7A

Interaction Score: 0.15

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE4A

Interaction Score: 0.14

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs:
11752352

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND
DIPYRIDAMOLE SLC29A1

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology
DIPYRIDAMOLE PDE1A

Interaction Score: 0.12

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE PDE2A

Interaction Score: 0.11

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE SLC29A4

Interaction Score: 0.1

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Direct Interaction? False

PMIDs:
None found

Sources:
GuideToPharmacology
DIPYRIDAMOLE PDE3B

Interaction Score: 0.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE TSG101

Interaction Score: 0.08

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE PDE4C

Interaction Score: 0.06

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE SLC2A4

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1716731

Sources:
NCI
DIPYRIDAMOLE PDE3A

Interaction Score: 0.04

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE ABCC1

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9664131

Sources:
NCI
DIPYRIDAMOLE CXCL8

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
10660968

Sources:
NCI
DIPYRIDAMOLE RAPGEF3

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE HSP90AB1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE PDE4D

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE RAPGEF4

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE PDE4B

Interaction Score: 0.02

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIPYRIDAMOLE ATM

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE ALOX15B

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE TSHR

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE BRCA1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE THRB

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE KAT2A

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE HSP90AA1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE PLK1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE DRD1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE USP1

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE ABCB1

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
PharmGKB
DIPYRIDAMOLE ATAD5

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE HSD17B10

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE CYP2C9

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE CYP2C19

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE GMNN

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE CYP2D6

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIPYRIDAMOLE CYP3A4

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00975

Version: 5.1.7

Alternate Names:

DIPYRIDAMOLE DrugBank Drug Name

58-32-2 CAS Number

Aggrenox Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories anticoagulants

Publications:

Hervé et al., 1996, Binding of disopyramide, methadone, dipyridamole, chlorpromazine, lignocaine and progesterone to the two main genetic variants of human alpha 1-acid glycoprotein: evidence for drug-binding differences between the variants and for the presence of two separate drug-binding sites on alpha 1-acid glycoprotein., Pharmacogenetics

Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.

Mulero MC et al., 2009, Inhibiting the calcineurin-NFAT (nuclear factor of activated T cells) signaling pathway with a regulator of calcineurin-derived peptide without affecting general calcineurin phosphatase activity., J Biol Chem

TEND: DIPYRIDAMOLE
- Version: 01-August-2011
Alternate Names:

DIPYRIDAMOLE Primary Drug Name

Drug Info:

Drug Class platelet aggregation inhibitors

Year of Approval 1961

Drug Class vasodilator agents

Publications:
TdgClinicalTrial: DIPYRIDAMOLE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications anticoagulant

Drug Class Small Molecule

FDA Approval approved

Publications:

NCI: DIPYRIDAMOLE

Version: 14-September-2017

Alternate Names:

C445 NCI drug code

Drug Info:

Publications:

Hosoi et al., 1998, Effect of MDR antagonists on the cidal activity of vincristine for cells expressing MDR-1 is superior to those expressing MRP., Int. J. Oncol.

Simiti et al., Increased plasma levels of interleukin-8 in patients with unstable angina pectoris., Rom J Intern Med

Hellwig et al., 1991, Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine., Mol. Pharmacol.

GuideToPharmacology: 178101509
- Version: 29-September-2020
Alternate Names:

DIPYRIDAMOLE GuideToPharmacology Ligand Name

Drug Info:

Publications:
TTD: Dipyridamole
- Version: 2020.06.01
Alternate Names:

D0F9GE TTD Drug ID

Drug Info:

Publications:
DTC: DIPYRIDAMOLE
- Version: 02-September-2020
Alternate Names:

CHEMBL932 ChEMBL Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL932
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL932
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
PharmGKB: dipyridamole
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Specific Action of the Ligand	Inhibition
Endogenous Drug?	False
Mechanism of Interaction	3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction	yes
Mechanism of Interaction	3',5'-cyclic phosphodiesterase inhibitor
Trial Name	CRx-102, prednisolone plus dipyridamole,Synavive

Trial Name	CRx-102, prednisolone plus dipyridamole,Synavive
Novel drug target	Established target
Trial Name	CRx-150, amoxapine plus dipyridamole

Direct Interaction?	True
Endogenous Drug?	False
Specific Action of the Ligand	Inhibition

DIPYRIDAMOLE	DrugBank Drug Name
58-32-2	CAS Number
Aggrenox	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	anticoagulants

DIPYRIDAMOLE Drug Record

DIPYRIDAMOLE chembl:CHEMBL932 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 19189965

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs: 10373451 17016423 17139284

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Specific Action of the Ligand Inhibition

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Specific Action of the Ligand Inhibition Endogenous Drug? False Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions GuideToPharmacology

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CRx-102, prednisolone plus dipyridamole,Synavive Novel drug target Established target Trial Name CRx-150, amoxapine plus dipyridamole

PMIDs: 16886928 17308037 15672122 11752352 16080974

Sources: DrugBank TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8946472

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name CRx-150, amoxapine plus dipyridamole Novel drug target Established target Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs: 11752352

Sources: DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Direct Interaction yes Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor Direct Interaction yes Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs: 11752352

Interaction Types & Directionality:

n/a

PMIDs:
19189965

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs:
10373451 17016423 17139284

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Specific Action of the Ligand Inhibition

Endogenous Drug? False

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

Novel drug target Established target

Trial Name CRx-150, amoxapine plus dipyridamole

PMIDs:
16886928 17308037 15672122 11752352 16080974

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
8946472

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name CRx-150, amoxapine plus dipyridamole

Novel drug target Established target

Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs:
11752352

Sources:
DrugBank TdgClinicalTrial TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction yes

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes

Trial Name CRx-102, prednisolone plus dipyridamole,Synavive

PMIDs:
11752352

Sources:
DrugBank TdgClinicalTrial ChemblInteractions TEND

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Direct Interaction? True

Endogenous Drug? False

Specific Action of the Ligand Inhibition

PMIDs:
None found

Sources:
ChemblInteractions GuideToPharmacology

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction 3',5'-cyclic phosphodiesterase inhibitor

Direct Interaction yes