DGIdb - DIENESTROL Drug Record

DIENESTROL chembl:CHEMBL1018 Approved

Alternate Names:

DIENESTROL
HORMOFEMIN
ESTRAGUARD
DV
DIÈNESTROL
DIENESTROLUM
ALPHA-DIENESTROL DIACETATE
CYCLADIENE
DEHYDROSTILBESTROL
ESTRAGUARD®
chembl:CHEMBL1018
rxcui:3368
chemidplus:84-17-3
chemidplus:13029-44-2
pubchem.compound:667476
drugbank:00890

Drug Info:

Drug Class	hormone replacement agents
Year of Approval	approved before 1982
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hormone Replacement Agents
Drug Groups	investigational
Drug Categories	synthetic estrogens, plain

(3 More Sources)

Publications:

Bovee et al., 2004, Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types., J. Steroid Biochem. Mol. Biol.
Grove et al., 1987, Estrogen stimulation of phosphatidylinositol metabolism in mouse uterine tissue., Endocrinology
Kuiper et al., 1997, Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta., Endocrinology
Chae et al., 1998, Estrogen-dependent gene regulation by an oxidative metabolite of diethylstilbestrol, diethylstilbestrol-4',4"-quinone., Steroids
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Juriansz et al., 1988, Interactions of putative estrogens with the intracellular receptor complex in mouse Leydig cells: relationship to preneoplastic hyperplasia., Cancer Res.
Maru et al., 2009, Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity., Bone
Hong H et al., 2015, Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein., Toxicol Sci

DIENESTROL SHBG

Interaction Score: 0.47

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
25349334

Sources:
DrugBank
DIENESTROL ESR1

Interaction Score: 0.37

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Estrogen receptor alpha agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
15276617 3622377 9048584 9558716 11752352 3334987 18976723

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank ChemblInteractions
DIENESTROL ALOX15B

Interaction Score: 0.11

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL ALOX15

Interaction Score: 0.05

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL ADRB2

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL GMNN

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB00890

Version: 5.1.7

Alternate Names:

DIENESTROL DrugBank Drug Name

13029-44-2 CAS Number

Estraguard Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Publications:

Bovee et al., 2004, Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types., J. Steroid Biochem. Mol. Biol.

Grove et al., 1987, Estrogen stimulation of phosphatidylinositol metabolism in mouse uterine tissue., Endocrinology

Kuiper et al., 1997, Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta., Endocrinology

TEND: DIENESTROL
- Version: 01-August-2011
Alternate Names:

DIENESTROL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class hormone replacement agents

Publications:
TdgClinicalTrial: DIENESTROL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
TTD: Dienestrol
- Version: 2020.06.01
Alternate Names:

D09ZQN TTD Drug ID

Drug Info:

Publications:
DTC: DIENESTROL
- Version: 02-September-2020
Alternate Names:

CHEMBL1018 ChEMBL Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1018
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1018
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Estrogen receptor alpha agonist
Direct Interaction	yes
Novel drug target	Established target

DIENESTROL	DrugBank Drug Name
13029-44-2	CAS Number
Estraguard	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Groups	investigational

DIENESTROL Drug Record

DIENESTROL chembl:CHEMBL1018 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 25349334

Sources: DrugBank

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Estrogen receptor alpha agonist Direct Interaction yes Novel drug target Established target

PMIDs: 15276617 3622377 9048584 9558716 11752352 3334987 18976723

Sources: TEND DTC TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB00890

Alternate Names: DIENESTROL DrugBank Drug Name 13029-44-2 CAS Number Estraguard Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Groups investigational

TEND: DIENESTROL

Alternate Names: DIENESTROL Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class hormone replacement agents

Publications:

TdgClinicalTrial: DIENESTROL

Alternate Names:

Drug Info: Drug Indications Hormone Replacement Agents Drug Class small molecule FDA Approval Approved before 1982

Publications:

TTD: Dienestrol

Alternate Names: D09ZQN TTD Drug ID

Drug Info:

Publications:

DTC: DIENESTROL

Alternate Names: CHEMBL1018 ChEMBL Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1018

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1018

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
25349334

Sources:
DrugBank

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Estrogen receptor alpha agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
15276617 3622377 9048584 9558716 11752352 3334987 18976723

Sources:
TEND DTC TdgClinicalTrial TTD DrugBank ChemblInteractions

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DIENESTROL DrugBank Drug Name

13029-44-2 CAS Number

Estraguard Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Groups investigational

Alternate Names:

DIENESTROL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class hormone replacement agents

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

D09ZQN TTD Drug ID

Alternate Names:

CHEMBL1018 ChEMBL Drug ID