DGIdb - DIENESTROL Drug Record

DIENESTROL chembl:CHEMBL1018 Approved

Alternate Names:

DIENESTROL
HORMOFEMIN
ESTRAGUARD
DV
DIÈNESTROL
DIENESTROLUM
ALPHA-DIENESTROL DIACETATE
CYCLADIENE
DEHYDROSTILBESTROL
ESTRAGUARD®
chembl:CHEMBL1018
rxcui:3368
chemidplus:84-17-3
chemidplus:13029-44-2
pubchem.compound:667476
drugbank:00890

Drug Info:

Drug Class	hormone replacement agents
Year of Approval	approved before 1982
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Hormone Replacement Agents

(2 More Sources)

Publications:

Grove et al., 1987, Estrogen stimulation of phosphatidylinositol metabolism in mouse uterine tissue., Endocrinology
Juriansz et al., 1988, Interactions of putative estrogens with the intracellular receptor complex in mouse Leydig cells: relationship to preneoplastic hyperplasia., Cancer Res.
Chae et al., 1998, Estrogen-dependent gene regulation by an oxidative metabolite of diethylstilbestrol, diethylstilbestrol-4',4"-quinone., Steroids
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Kuiper et al., 1997, Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta., Endocrinology
Bovee et al., 2004, Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types., J. Steroid Biochem. Mol. Biol.
Maru et al., 2009, Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity., Bone

DIENESTROL ESR1

Interaction Score: 0.55

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Estrogen receptor alpha agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
3622377 3334987 9558716 11752352 9048584 15276617 18976723

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD
DIENESTROL ALOX15B

Interaction Score: 0.14

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL ADRB2

Interaction Score: 0.07

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL ALOX15

Interaction Score: 0.06

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL GMNN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL NFE2L2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIENESTROL CYP3A4

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DIENESTROL
- Version: 01-August-2011
Alternate Names:

DIENESTROL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class hormone replacement agents

Publications:
TdgClinicalTrial: DIENESTROL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
TTD: Dienestrol
- Version: 2020.06.01
Alternate Names:

D09ZQN TTD Drug ID

Drug Info:

Publications:
DTC: DIENESTROL
- Version: 02-September-2020
Alternate Names:

CHEMBL1018 ChEMBL Drug ID

Drug Info:

Publications:
ChemblInteractions: CHEMBL1018
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1018
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Estrogen receptor alpha agonist
Direct Interaction	yes
Novel drug target	Established target

DIENESTROL Drug Record

DIENESTROL chembl:CHEMBL1018 Approved

Alternate Names:

Drug Info:

Publications:

DIENESTROL ESR1

Interaction Types & Directionality: agonist (activating)

Interaction Info: Mechanism of Interaction Estrogen receptor alpha agonist Direct Interaction yes Novel drug target Established target

PMIDs: 3622377 3334987 9558716 11752352 9048584 15276617 18976723

Sources: DTC TdgClinicalTrial ChemblInteractions TEND TTD

DIENESTROL ALOX15B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DIENESTROL ADRB2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DIENESTROL ALOX15

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DIENESTROL GMNN

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DIENESTROL NFE2L2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DIENESTROL CYP3A4

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DIENESTROL

Alternate Names: DIENESTROL Primary Drug Name

Drug Info: Year of Approval approved before 1982 Drug Class hormone replacement agents

Publications:

TdgClinicalTrial: DIENESTROL

Alternate Names:

Drug Info: Drug Indications Hormone Replacement Agents Drug Class small molecule FDA Approval Approved before 1982

Publications:

TTD: Dienestrol

Alternate Names: D09ZQN TTD Drug ID

Drug Info:

Publications:

DTC: DIENESTROL

Alternate Names: CHEMBL1018 ChEMBL Drug ID

Drug Info:

Publications:

ChemblInteractions: CHEMBL1018

Alternate Names:

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1018

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

agonist (activating)

Interaction Info:

Mechanism of Interaction Estrogen receptor alpha agonist

Direct Interaction yes

Novel drug target Established target

PMIDs:
3622377 3334987 9558716 11752352 9048584 15276617 18976723

Sources:
DTC TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DIENESTROL Primary Drug Name

Drug Info:

Year of Approval approved before 1982

Drug Class hormone replacement agents

Drug Info:

Drug Indications Hormone Replacement Agents

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

D09ZQN TTD Drug ID

Alternate Names:

CHEMBL1018 ChEMBL Drug ID