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DIENESTROL Drug Record

  • Summary
  • Interactions
  • Claims
  • DIENESTROL chembl:CHEMBL1018 Approved

    Alternate Names:

    DIENESTROL
    HORMOFEMIN
    ESTRAGUARD
    DV
    DIÈNESTROL
    DIENESTROLUM
    ALPHA-DIENESTROL DIACETATE
    CYCLADIENE
    DEHYDROSTILBESTROL
    ESTRAGUARD®
    chembl:CHEMBL1018
    rxcui:3368
    chemidplus:84-17-3
    chemidplus:13029-44-2
    pubchem.compound:667476
    drugbank:00890

    Drug Info:

    Drug Class hormone replacement agents
    Year of Approval approved before 1982
    FDA Approval Approved before 1982
    Drug Class small molecule
    Drug Indications Hormone Replacement Agents
    Drug Groups investigational
    Drug Categories synthetic estrogens, plain
    (3 More Sources)

    Publications:

    Bovee et al., 2004, Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types., J. Steroid Biochem. Mol. Biol.
    Grove et al., 1987, Estrogen stimulation of phosphatidylinositol metabolism in mouse uterine tissue., Endocrinology
    Kuiper et al., 1997, Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta., Endocrinology
    Chae et al., 1998, Estrogen-dependent gene regulation by an oxidative metabolite of diethylstilbestrol, diethylstilbestrol-4',4"-quinone., Steroids
    Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
    Juriansz et al., 1988, Interactions of putative estrogens with the intracellular receptor complex in mouse Leydig cells: relationship to preneoplastic hyperplasia., Cancer Res.
    Maru et al., 2009, Potential use of an estrogen-glucocorticoid receptor chimera as a drug screen for tissue selective estrogenic activity., Bone
    Hong H et al., 2015, Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and α-fetoprotein., Toxicol Sci
  • DIENESTROL   SHBG

    Interaction Score: 0.47

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    25349334


    Sources:
    DrugBank

  • DIENESTROL   ESR1

    Interaction Score: 0.37

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:
    Mechanism of Interaction Estrogen receptor alpha agonist
    Direct Interaction yes
    Novel drug target Established target

    PMIDs:
    15276617 3622377 9048584 9558716 11752352 3334987 18976723


    Sources:
    TEND DTC TdgClinicalTrial TTD DrugBank ChemblInteractions

  • DIENESTROL   ALOX15B

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIENESTROL   ALOX15

    Interaction Score: 0.05

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIENESTROL   ADRB2

    Interaction Score: 0.04

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIENESTROL   GMNN

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIENESTROL   NFE2L2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIENESTROL   CYP3A4

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DrugBank: DB00890

    • Version: 5.1.7

    Alternate Names:
    DIENESTROL DrugBank Drug Name
    13029-44-2 CAS Number
    Estraguard Drug Brand

    Drug Info:
    Drug Type small molecule
    Drug Groups approved
    Drug Groups investigational

    Publications:
    Bovee et al., 2004, Rapid yeast estrogen bioassays stably expressing human estrogen receptors alpha and beta, and green fluorescent protein: a comparison of different compounds with both receptor types., J. Steroid Biochem. Mol. Biol.
    Grove et al., 1987, Estrogen stimulation of phosphatidylinositol metabolism in mouse uterine tissue., Endocrinology
    Kuiper et al., 1997, Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta., Endocrinology

  • TEND: DIENESTROL

    • Version: 01-August-2011

    Alternate Names:
    DIENESTROL Primary Drug Name

    Drug Info:
    Year of Approval approved before 1982
    Drug Class hormone replacement agents

    Publications:

  • TdgClinicalTrial: DIENESTROL

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Hormone Replacement Agents
    Drug Class small molecule
    FDA Approval Approved before 1982

    Publications:

  • TTD: Dienestrol

    • Version: 2020.06.01

    Alternate Names:
    D09ZQN TTD Drug ID

    Drug Info:

    Publications:

  • DTC: DIENESTROL

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL1018 ChEMBL Drug ID

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL1018

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL1018

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2021-04-13