DGIdb - DICUMAROL Drug Record

DICUMAROL chembl:CHEMBL1466 Approved

Alternate Names:

DICOUMAROL
BISHYDROXYCOUMARIN
DICUMAROL
BIS-HYDROXYCOUMARIN
DI-(4-HYDROXY-3-COUMARINYL)METHANE
3,3'-METHYLENEBIS(4-HYDROXY-2H-1-BENZOPYRAN-2-ONE)
3,3'-METHYLENEBIS(4-HYDROXYCOUMARIN)
3,3'-METHYLEN-BIS(4-HYDROXY-CUMARIN)
3,3'-METHYLENEBIS(4-HYDROXY-1,2-BENZOPYRONE)
BIS-3,3'-(4-HYDROXYCOUMARINYL)METHANE
3,3'-METHYLENE-BIS(4-HYDROXYCOUMARINE)
DICOUMAROLUM
BIS(4-HYDROXYCOUMARIN-3-YL)METHANE
MELITOXIN®
chemidplus:66-76-2
drugbank:00266
chembl:CHEMBL1466
pubchem.compound:54676038
rxcui:1598

Drug Info:

Year of Approval	approved before 1982
Drug Class	anticoagulants
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Anticoagulants

(5 More Sources)

Publications:

Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Wallin et al., 1986, Vitamin K antagonism of coumarin intoxication in the rat., Thromb. Haemost.
Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.
Asher et al., 2003, P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1., Proc. Natl. Acad. Sci. U.S.A.
Preusch et al., 1990, Vitamin K1 2,3-epoxide and quinone reduction: mechanism and inhibition., Free Radic. Res. Commun.
Chen et al., 1999, Molecular characterization of binding of substrates and inhibitors to DT-diaphorase: combined approach involving site-directed mutagenesis, inhibitor-binding analysis, and computer modeling., Mol. Pharmacol.
Arriagada et al., 2000, Studies of aminochrome toxicity in a mouse derived neuronal cell line: is this toxicity mediated via glutamate transmission?, Amino Acids
Floreani et al., 2000, Protective action of cardiac DT-diaphorase against menadione toxicity in guinea pig isolated atria., Biochem. Pharmacol.
Joseph et al., 2000, A unique cytosolic activity related but distinct from NQO1 catalyses metabolic activation of mitomycin C., Br. J. Cancer
Jaiswal, 2000, Characterization and partial purification of microsomal NAD(P)H:quinone oxidoreductases., Arch. Biochem. Biophys.
Kotlo et al., 2003, Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells., Oncogene
Qiu et al., 1997, The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells., Arch. Biochem. Biophys.

DICUMAROL VKORC1

Interaction Score: 7.07

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
17016423 17139284 11752352 2424118

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD
DICUMAROL NQO1

Interaction Score: 3.79

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
14634213 2113031 10419545 10949919 10874136 10755406 10683249

Sources:
NCI PharmGKB
DICUMAROL CDKN1A

Interaction Score: 0.98

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
9343371

Sources:
NCI
DICUMAROL GSTM1

Interaction Score: 0.84

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15044619

Sources:
NCI
DICUMAROL NFE2L2

Interaction Score: 0.03

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12584558

Sources:
DTC NCI
DICUMAROL ALDH1A1

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DICUMAROL CYP2C9

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DICUMAROL
- Version: 01-August-2011
Alternate Names:

DICUMAROL Primary Drug Name

Drug Info:

Drug Class anticoagulants

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: DICUMAROL
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anticoagulants

Drug Class small molecule

FDA Approval Approved before 1982

Publications:

NCI: DICUMAROL

Version: 14-September-2017

Alternate Names:

C310 NCI drug code

Drug Info:

Publications:

Qiu et al., 1997, The role of NAD(P)H:quinone oxidoreductase in quinone-mediated p21 induction in human colon carcinoma cells., Arch. Biochem. Biophys.

Depeille et al., 2004, Glutathione S-transferase M1 and multidrug resistance protein 1 act in synergy to protect melanoma cells from vincristine effects., Mol. Pharmacol.

Kotlo et al., 2003, Nrf2 is an inhibitor of the Fas pathway as identified by Achilles' Heel Method, a new function-based approach to gene identification in human cells., Oncogene

NCI: DICOUMAROL
- Version: 14-September-2017
Alternate Names:

C310 NCI drug code

Drug Info:

Publications:

Asher et al., 2003, P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1., Proc. Natl. Acad. Sci. U.S.A.
TTD: Dicumarol
- Version: 2020.06.01
Alternate Names:

D02TJS TTD Drug ID

Drug Info:

Publications:
DTC: DICUMAROL
- Version: 02-September-2020
Alternate Names:

CHEMBL1466 ChEMBL Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1466
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL1466
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:
PharmGKB: dicumarol
- Version: 18-August-2020
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor
Direct Interaction	yes
Trial Name	-

DICUMAROL Drug Record

DICUMAROL chembl:CHEMBL1466 Approved

Alternate Names:

Drug Info:

Publications:

DICUMAROL VKORC1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Mechanism of Interaction Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor Direct Interaction yes Trial Name -

PMIDs: 17016423 17139284 11752352 2424118

Sources: TdgClinicalTrial ChemblInteractions TEND TTD

DICUMAROL NQO1

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 14634213 2113031 10419545 10949919 10874136 10755406 10683249

Sources: NCI PharmGKB

DICUMAROL CDKN1A

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 9343371

Sources: NCI

DICUMAROL GSTM1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15044619

Sources: NCI

DICUMAROL NFE2L2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12584558

Sources: DTC NCI

DICUMAROL ALDH1A1

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DICUMAROL CYP2C9

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DICUMAROL

Alternate Names: DICUMAROL Primary Drug Name

Drug Info: Drug Class anticoagulants Year of Approval approved before 1982

Publications:

TdgClinicalTrial: DICUMAROL

Alternate Names:

Drug Info: Drug Indications Anticoagulants Drug Class small molecule FDA Approval Approved before 1982

Publications:

NCI: DICUMAROL

Alternate Names: C310 NCI drug code

Drug Info:

NCI: DICOUMAROL

Alternate Names: C310 NCI drug code

Drug Info:

Publications: Asher et al., 2003, P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1., Proc. Natl. Acad. Sci. U.S.A.

TTD: Dicumarol

Alternate Names: D02TJS TTD Drug ID

Drug Info:

Publications:

DTC: DICUMAROL

Alternate Names: CHEMBL1466 ChEMBL Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1466

Alternate Names:

Drug Info:

Publications:

ChemblInteractions: CHEMBL1466

Alternate Names:

Drug Info:

Publications:

PharmGKB: dicumarol

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Mechanism of Interaction Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor

Direct Interaction yes

Trial Name -

PMIDs:
17016423 17139284 11752352 2424118

Sources:
TdgClinicalTrial ChemblInteractions TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
14634213 2113031 10419545 10949919 10874136 10755406 10683249

Sources:
NCI PharmGKB

Interaction Types & Directionality:

n/a

PMIDs:
9343371

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15044619

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12584558

Sources:
DTC NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DICUMAROL Primary Drug Name

Drug Info:

Drug Class anticoagulants

Year of Approval approved before 1982

Drug Info:

Drug Indications Anticoagulants

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

C310 NCI drug code

Alternate Names:

C310 NCI drug code

Publications:

Asher et al., 2003, P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1., Proc. Natl. Acad. Sci. U.S.A.

Alternate Names:

D02TJS TTD Drug ID

Alternate Names:

CHEMBL1466 ChEMBL Drug ID