DGIdb - DIBUCAINE Drug Record

DIBUCAINE chembl:CHEMBL1086 Approved

Alternate Names:

DIBUCAINE
CINCHOCAINE
NUPERCAINAL
ALPHA-BUTYLOXYCINCHONINIC ACID DIETHYLETHYLENEDIAMIDE
DIBUCAINE BASE
2-BUTOXY-QUINOLINE-4-CARBOXYLIC ACID (2-DIETHYLAMINO-ETHYL)-AMIDE
CINCAIN ®
NUPERCAINE ®
2-BUTOXY-N-[2-(DIETHYLAMINO)ETHYL]-4-QUINOLINECARBOXAMIDE
2-BUTOXY-N-(2-(DIETHYLAMINO)ETHYL)CINCHONINAMIDE
CINCHOCAINUM
2-BUTOXY-N-(ALPHA-DIETHYLAMINOETHYL)CINCHONINAMIDE
2-BUTOXY-N-(BETA-DIETHYLAMINOETHYL)CINCHONINAMIDE
N-(2-(DIETHYLAMINO)ETHYL)-2-BUTOXYCINCHONINAMIDE
2-BUTOXYQUINOLINE-4-CARBOXYLIC ACID DIETHYLAMINOETHYLAMIDE
ALPHA-BUTYLOXYCINCHONIC ACID-GAMMA-DIETHYLETHYLENEDIAMINE
CINCOCAINIO
CINCAINE CHLORIDE
2-N-BUTOXY-N-(2-DIETHYLAMINOETHYL)CINCHONINAMIDE
chembl:CHEMBL1086
chemidplus:85-79-0
pubchem.compound:3025
drugbank:00527
rxcui:3339

Drug Info:

Year of Approval	approved before 1982
Drug Class	anesthetics, local
FDA Approval	Approved before 1982
Drug Class	small molecule
Drug Indications	Anesthetics, Local

(2 More Sources)

Publications:

Louro et al., 1998, Carboxyl groups at the membrane interface as molecular targets for local anesthetics., Biophys. Chem.
Oka et al., 2002, Halothane attenuates the cerebroprotective action of several Na+ and Ca2+ channel blockers via reversal of their ion channel blockade., Eur. J. Pharmacol.
Ryan et al., 1996, Structural effects of neutral and anionic lipids on the nicotinic acetylcholine receptor. An infrared difference spectroscopy study., J. Biol. Chem.
Chen et al., 2002, TTD: Therapeutic Target Database., Nucleic Acids Res.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Oda et al., 1995, TMB-8 and dibucaine induce tyrosine phosphorylation and dephosphorylation of a common set of proteins in platelets., Am. J. Physiol.

DIBUCAINE MYO9B

Interaction Score: 1.87

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
7631738

Sources:
NCI
DIBUCAINE SCN5A

Interaction Score: 1.09

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9742684 12354567 8798723 11752352 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD
DIBUCAINE SCN10A

Interaction Score: 0.81

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9742684 17016423 17139284 8798723

Sources:
TdgClinicalTrial TEND
DIBUCAINE KDM4E

Interaction Score: 0.04

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIBUCAINE GMNN

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIBUCAINE CYP1A2

Interaction Score: 0.02

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DIBUCAINE
- Version: 01-August-2011
Alternate Names:

DIBUCAINE Primary Drug Name

Drug Info:

Drug Class anesthetics, local

Year of Approval approved before 1982

Publications:
TdgClinicalTrial: DIBUCAINE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Anesthetics, Local

Drug Class small molecule

FDA Approval Approved before 1982

Publications:
NCI: DIBUCAINE
- Version: 14-September-2017
Alternate Names:

C28984 NCI drug code

Drug Info:

Publications:

Oda et al., 1995, TMB-8 and dibucaine induce tyrosine phosphorylation and dephosphorylation of a common set of proteins in platelets., Am. J. Physiol.
DTC: DIBUCAINE
- Version: 02-September-2020
Alternate Names:

CHEMBL1086 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Dibucaine
- Version: 2020.06.01
Alternate Names:

D0P5GE TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL1086
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:

Trial Name	-
Novel drug target	Established target

Trial Name	-
Novel drug target	Established target

DIBUCAINE Drug Record

DIBUCAINE chembl:CHEMBL1086 Approved

Alternate Names:

Drug Info:

Publications:

DIBUCAINE MYO9B

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 7631738

Sources: NCI

DIBUCAINE SCN5A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9742684 12354567 8798723 11752352 17016423 17139284

Sources: TdgClinicalTrial TEND TTD

DIBUCAINE SCN10A

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info: Trial Name - Novel drug target Established target

PMIDs: 9742684 17016423 17139284 8798723

Sources: TdgClinicalTrial TEND

DIBUCAINE KDM4E

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DIBUCAINE GMNN

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DIBUCAINE CYP1A2

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DIBUCAINE

Alternate Names: DIBUCAINE Primary Drug Name

Drug Info: Drug Class anesthetics, local Year of Approval approved before 1982

Publications:

TdgClinicalTrial: DIBUCAINE

Alternate Names:

Drug Info: Drug Indications Anesthetics, Local Drug Class small molecule FDA Approval Approved before 1982

Publications:

NCI: DIBUCAINE

Alternate Names: C28984 NCI drug code

Drug Info:

Publications: Oda et al., 1995, TMB-8 and dibucaine induce tyrosine phosphorylation and dephosphorylation of a common set of proteins in platelets., Am. J. Physiol.

DTC: DIBUCAINE

Alternate Names: CHEMBL1086 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Dibucaine

Alternate Names: D0P5GE TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL1086

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
7631738

Sources:
NCI

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9742684 12354567 8798723 11752352 17016423 17139284

Sources:
TdgClinicalTrial TEND TTD

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

Trial Name -

Novel drug target Established target

PMIDs:
9742684 17016423 17139284 8798723

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DIBUCAINE Primary Drug Name

Drug Info:

Drug Class anesthetics, local

Year of Approval approved before 1982

Drug Info:

Drug Indications Anesthetics, Local

Drug Class small molecule

FDA Approval Approved before 1982

Alternate Names:

C28984 NCI drug code

Publications:

Oda et al., 1995, TMB-8 and dibucaine induce tyrosine phosphorylation and dephosphorylation of a common set of proteins in platelets., Am. J. Physiol.

Alternate Names:

CHEMBL1086 ChEMBL Drug ID

Alternate Names:

D0P5GE TTD Drug ID