DGIdb - DIAZOXIDE Drug Record

DIAZOXIDE chembl:CHEMBL181 Approved

Alternate Names:

SRG-95213
HYPERSTAT
DIAZOXIDE
EUDIMINE
EUDEMINE
MUTABASE
SCH-6783
NSC-64198
PROGLYCEM
NSC-76130
PROGLYCEM®
DIAZOSSIDO
DIAZOXIDUM
DIAZOXIDO
chemidplus:364-98-7
pubchem.compound:3019
chembl:CHEMBL181
rxcui:3327
drugbank:01119

Drug Info:

FDA Approval	1973
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Antihypertensive Agents
Drug Class	antihypertensive agents
Year of Approval	1973
Drug Class	vasodilator agents

(4 More Sources)

Publications:

Oyekan et al., 1994, Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors., J. Pharmacol. Exp. Ther.
Darendeliler F et al., 2002, ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures., J Pediatr Endocrinol Metab
Pearson ER et al., 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., N Engl J Med
Ohkubo K et al., 2005, Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy., Clin Endocrinol (Oxf)
de Lonlay et al., 2002, Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases., Eur. J. Pediatr.
Russ et al., 2003, Binding and effect of K ATP channel openers in the absence of Mg2+., Br. J. Pharmacol.
Shindo et al., 2000, MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel., J. Pharmacol. Exp. Ther.
Sakura et al., 1999, Altered functional properties of KATP channel conferred by a novel splice variant of SUR1., J. Physiol. (Lond.)
D'hahan et al., 1999, Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP., Proc. Natl. Acad. Sci. U.S.A.
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Pulinilkunnil et al., 2003, Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining., Cardiovasc. Res.
Nayeem et al., Ischemic and pharmacological induction of delayed cellular protection in iNOS gene-disrupted mice myocytes., Pol J Pharmacol
Tsukamoto et al., 2005, A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart., Biochem. Biophys. Res. Commun.
Pedrazzoli et al., 1976, [Influence of diazoxide on the response of the rat exocrine pancreas cholecystokinin-pancreozymin]., Chir Patol Sper
Ma et al., 2005, Evidence that insulin secretion influences SNAP-25 through proteasomal activation., Biochem. Biophys. Res. Commun.

DIAZOXIDE CCK

Interaction Score: 4.76

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1032363

Sources:
NCI
DIAZOXIDE SNAP25

Interaction Score: 2.38

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15752769

Sources:
NCI
DIAZOXIDE KCNJ11

Interaction Score: 1.7

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener

Direct Interaction yes

PMIDs:
12199344 16885550 15807877 11808879 12770942 10604939 10581306 10518593

Sources:
ChemblInteractions PharmGKB
DIAZOXIDE KCNJ8

Interaction Score: 1.19

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 8 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIAZOXIDE SLC12A3

Interaction Score: 1.06

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND
DIAZOXIDE CYP7B1

Interaction Score: 0.95

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8301566

Sources:
NCI
DIAZOXIDE NT5E

Interaction Score: 0.68

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16271703

Sources:
NCI
DIAZOXIDE LPL

Interaction Score: 0.53

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14499880

Sources:
NCI
DIAZOXIDE NOS2

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12856829

Sources:
NCI
DIAZOXIDE CALCA

Interaction Score: 0.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIAZOXIDE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIAZOXIDE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIAZOXIDE EHMT2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

TEND: DIAZOXIDE
- Version: 01-August-2011
Alternate Names:

DIAZOXIDE Primary Drug Name

Drug Info:

Drug Class vasodilator agents

Year of Approval 1973

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: DIAZOXIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:

NCI: DIAZOXIDE

Version: 14-September-2017

Alternate Names:

C428 NCI drug code

Drug Info:

Publications:

Oyekan et al., 1994, Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors., J. Pharmacol. Exp. Ther.

Pulinilkunnil et al., 2003, Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining., Cardiovasc. Res.

Pedrazzoli et al., 1976, [Influence of diazoxide on the response of the rat exocrine pancreas cholecystokinin-pancreozymin]., Chir Patol Sper

PharmGKB: diazoxide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Pearson ER et al., 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., N Engl J Med

Darendeliler F et al., 2002, ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures., J Pediatr Endocrinol Metab

Ohkubo K et al., 2005, Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy., Clin Endocrinol (Oxf)

DTC: DIAZOXIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL181 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Diazoxide
- Version: 2020.06.01
Alternate Names:

D07WEP TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL181
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL181
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Potassium channel, inwardly rectifying, subfamily J, member 11 opener
Direct Interaction	yes

Novel drug target	Established target
Trial Name	-

DIAZOXIDE Drug Record

DIAZOXIDE chembl:CHEMBL181 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1032363

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15752769

Sources: NCI

Interaction Types & Directionality: inducer (activating)

Interaction Info: Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener Direct Interaction yes

PMIDs: 12199344 16885550 15807877 11808879 12770942 10604939 10581306 10518593

Sources: ChemblInteractions PharmGKB

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 8 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17016423 17139284

Sources: TdgClinicalTrial TEND

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8301566

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16271703

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14499880

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12856829

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

TEND: DIAZOXIDE

Alternate Names: DIAZOXIDE Primary Drug Name

Drug Info: Drug Class vasodilator agents Year of Approval 1973 Drug Class antihypertensive agents

Publications:

TdgClinicalTrial: DIAZOXIDE

Alternate Names:

Drug Info: Drug Indications Antihypertensive Agents Drug Indications Vasodilator Agents Drug Class small molecule

Publications:

NCI: DIAZOXIDE

Alternate Names: C428 NCI drug code

Drug Info:

PharmGKB: diazoxide

Alternate Names:

Drug Info:

DTC: DIAZOXIDE

Alternate Names: CHEMBL181 ChEMBL Drug ID

Drug Info:

Publications:

TTD: Diazoxide

Alternate Names: D07WEP TTD Drug ID

Drug Info:

Publications:

ChemblDrugs: chembl:CHEMBL181

Interaction Types & Directionality:

n/a

PMIDs:
1032363

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15752769

Sources:
NCI

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener

Direct Interaction yes

PMIDs:
12199344 16885550 15807877 11808879 12770942 10604939 10581306 10518593

Sources:
ChemblInteractions PharmGKB

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 8 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17016423 17139284

Sources:
TdgClinicalTrial TEND

Interaction Types & Directionality:

n/a

PMIDs:
8301566

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
16271703

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14499880

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
12856829

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DIAZOXIDE Primary Drug Name

Drug Info:

Drug Class vasodilator agents

Year of Approval 1973

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Alternate Names:

C428 NCI drug code

Alternate Names:

CHEMBL181 ChEMBL Drug ID

Alternate Names:

D07WEP TTD Drug ID