DGIdb - DIAZOXIDE Drug Record

DIAZOXIDE chembl:CHEMBL181 Approved

Alternate Names:

SRG-95213
HYPERSTAT
DIAZOXIDE
EUDIMINE
EUDEMINE
MUTABASE
SCH-6783
NSC-64198
PROGLYCEM
NSC-76130
PROGLYCEM®
DIAZOSSIDO
DIAZOXIDUM
DIAZOXIDO
chemidplus:364-98-7
pubchem.compound:3019
chembl:CHEMBL181
rxcui:3327
drugbank:01119

Drug Info:

Drug Categories	thiazide derivatives
FDA Approval	1973
Drug Class	small molecule
Drug Indications	Vasodilator Agents
Drug Indications	Antihypertensive Agents
Drug Class	antihypertensive agents
Year of Approval	1973
Drug Class	vasodilator agents
Drug Categories	direct vasodilators
Drug Categories	diuretics
Drug Categories	drugs for treatment of hypoglycemia
Drug Categories	genito urinary system and sex hormones
Drug Categories	gynecological antiinfectives and antiseptics
Drug Categories	heterocyclic compounds, fused-ring
Drug Categories	hypotensive agents
Drug Categories	vasodilating agents

(5 More Sources)

Publications:

Oyekan et al., 1994, Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors., J. Pharmacol. Exp. Ther.
Pearson ER et al., 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., N Engl J Med
Sakura et al., 1999, Altered functional properties of KATP channel conferred by a novel splice variant of SUR1., J. Physiol. (Lond.)
de Lonlay et al., 2002, Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases., Eur. J. Pediatr.
Russ et al., 2003, Binding and effect of K ATP channel openers in the absence of Mg2+., Br. J. Pharmacol.
Shindo et al., 2000, MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel., J. Pharmacol. Exp. Ther.
D'hahan et al., 1999, Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP., Proc. Natl. Acad. Sci. U.S.A.
Darendeliler F et al., 2002, ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures., J Pediatr Endocrinol Metab
Ohkubo K et al., 2005, Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy., Clin Endocrinol (Oxf)
Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
Pulinilkunnil et al., 2003, Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining., Cardiovasc. Res.
Nayeem et al., Ischemic and pharmacological induction of delayed cellular protection in iNOS gene-disrupted mice myocytes., Pol J Pharmacol
Tsukamoto et al., 2005, A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart., Biochem. Biophys. Res. Commun.
Sekine et al., 1996, Postreceptor signalling of growth hormone and prolactin and their effects in the differentiated insulin-secreting cell line, INS-1., Endocrinology
Muñoz et al., 2003, Ischemic preconditioning in the hippocampus of a knockout mouse lacking SUR1-based K(ATP) channels., Stroke
Pedrazzoli et al., 1976, [Influence of diazoxide on the response of the rat exocrine pancreas cholecystokinin-pancreozymin]., Chir Patol Sper
Erdemli et al., 1993, Diazoxide suppresses slowly-inactivating outward and inward currents in CA1 hippocampal neurones., Neuroreport
Domoki et al., 2004, Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs., Brain Res.
Crépel et al., 1993, The K+ channel opener diazoxide enhances glutamatergic currents and reduces GABAergic currents in hippocampal neurons., J. Neurophysiol.
Scuvée-Moreau et al., 1997, Effect of potassium channel openers on the firing rate of hippocampal pyramidal cells and A10 dopaminergic neurons in vitro., Arch. Physiol. Biochem.
Erdemli et al., 1995, Actions of diazoxide on CA1 neurons in hippocampal slices from rats., Can. J. Physiol. Pharmacol.
Zhang et al., 2006, Possible role of potassium channel, big K in etiology of schizophrenia., Med. Hypotheses
Klöckner et al., 1989, Pharmacological modulation of calcium and potassium channels in isolated vascular smooth muscle cells., Arzneimittelforschung
O'Malley et al., 2003, Insulin inhibits rat hippocampal neurones via activation of ATP-sensitive K+ and large conductance Ca2+-activated K+ channels., Neuropharmacology
Lawrence et al., 2002, Effect of metabolic inhibition on glimepiride block of native and cloned cardiac sarcolemmal K(ATP) channels., Br. J. Pharmacol.
Comelli et al., 2007, Downmodulation of mitochondrial F0F1 ATP synthase by diazoxide in cardiac myoblasts: a dual effect of the drug., Am. J. Physiol. Heart Circ. Physiol.
Guo et al., 2005, Activation of Mitochondrial ATP-Sensitive Potassium Channel Contributes to Protective Effect in Prolonged Myocardial Preservation., Conf Proc IEEE Eng Med Biol Soc
Ma et al., 2005, Evidence that insulin secretion influences SNAP-25 through proteasomal activation., Biochem. Biophys. Res. Commun.

DIAZOXIDE CCK

Interaction Score: 2.23

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
1032363

Sources:
NCI
DIAZOXIDE SNAP25

Interaction Score: 1.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
15752769

Sources:
NCI
DIAZOXIDE KCNJ11

Interaction Score: 1.15

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener

Direct Interaction yes

PMIDs:
16885550 10581306 11808879 12770942 10604939 10518593 12199344 15807877

Sources:
PharmGKB DrugBank ChemblInteractions
DIAZOXIDE KCNMA1

Interaction Score: 0.74

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
16446048 2541731 12726817

Sources:
DrugBank
DIAZOXIDE SLC12A3

Interaction Score: 0.74

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17139284 17016423

Sources:
TEND TdgClinicalTrial
DIAZOXIDE CYP7B1

Interaction Score: 0.67

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
8301566

Sources:
NCI
DIAZOXIDE ATP1A1

Interaction Score: 0.53

Interaction Types & Directionality:

other/unknown

Interaction Info:

PMIDs:
12086984 17287451 17281115

Sources:
DrugBank
DIAZOXIDE CA1

Interaction Score: 0.51

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8298083 15306243 7681475 9439778 7585327

Sources:
DrugBank
DIAZOXIDE NT5E

Interaction Score: 0.45

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
16271703

Sources:
NCI
DIAZOXIDE LPL

Interaction Score: 0.32

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
14499880

Sources:
NCI
DIAZOXIDE KCNJ8

Interaction Score: 0.28

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 8 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions
DIAZOXIDE CA2

Interaction Score: 0.13

Interaction Types & Directionality:

inhibitor (inhibitory)

Interaction Info:

PMIDs:
8612523 12511769

Sources:
DrugBank
DIAZOXIDE CALCA

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
TTD
DIAZOXIDE NOS2

Interaction Score: 0.13

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
12856829

Sources:
NCI
DIAZOXIDE CYP1A2

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIAZOXIDE CYP2D6

Interaction Score: 0.01

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC
DIAZOXIDE EHMT2

Interaction Score: 0.0

Interaction Types & Directionality:

n/a

Interaction Info:

PMIDs:
None found

Sources:
DTC

DrugBank: DB01119

Version: 5.1.7

Alternate Names:

DIAZOXIDE DrugBank Drug Name

364-98-7 CAS Number

Diazoxide Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories amides

Publications:

Erdemli et al., 1993, Diazoxide suppresses slowly-inactivating outward and inward currents in CA1 hippocampal neurones., Neuroreport

Domoki et al., 2004, Diazoxide prevents mitochondrial swelling and Ca2+ accumulation in CA1 pyramidal cells after cerebral ischemia in newborn pigs., Brain Res.

Crépel et al., 1993, The K+ channel opener diazoxide enhances glutamatergic currents and reduces GABAergic currents in hippocampal neurons., J. Neurophysiol.

TEND: DIAZOXIDE
- Version: 01-August-2011
Alternate Names:

DIAZOXIDE Primary Drug Name

Drug Info:

Drug Class vasodilator agents

Year of Approval 1973

Drug Class antihypertensive agents

Publications:
TdgClinicalTrial: DIAZOXIDE
- Version: January-2014
Alternate Names:

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Publications:

NCI: DIAZOXIDE

Version: 14-September-2017

Alternate Names:

C428 NCI drug code

Drug Info:

Publications:

Oyekan et al., 1994, Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors., J. Pharmacol. Exp. Ther.

Pulinilkunnil et al., 2003, Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining., Cardiovasc. Res.

Pedrazzoli et al., 1976, [Influence of diazoxide on the response of the rat exocrine pancreas cholecystokinin-pancreozymin]., Chir Patol Sper

PharmGKB: diazoxide

Version: 18-August-2020

Alternate Names:

Drug Info:

Publications:

Pearson ER et al., 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., N Engl J Med

Darendeliler F et al., 2002, ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures., J Pediatr Endocrinol Metab

Ohkubo K et al., 2005, Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy., Clin Endocrinol (Oxf)

DTC: DIAZOXIDE
- Version: 02-September-2020
Alternate Names:

CHEMBL181 ChEMBL Drug ID

Drug Info:

Publications:
TTD: Diazoxide
- Version: 2020.06.01
Alternate Names:

D07WEP TTD Drug ID

Drug Info:

Publications:
ChemblDrugs: chembl:CHEMBL181
- Version: ChEMBL_27
Alternate Names:

Drug Info:

Publications:
ChemblInteractions: CHEMBL181
- Version: chembl_23
Alternate Names:

Drug Info:

Publications:

Mechanism of Interaction	Potassium channel, inwardly rectifying, subfamily J, member 11 opener
Direct Interaction	yes

DIAZOXIDE	DrugBank Drug Name
364-98-7	CAS Number
Diazoxide	Drug Brand

Drug Type	small molecule
Drug Groups	approved
Drug Categories	amides

Novel drug target	Established target
Trial Name	-

DIAZOXIDE Drug Record

DIAZOXIDE chembl:CHEMBL181 Approved

Alternate Names:

Drug Info:

Publications:

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 1032363

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 15752769

Sources: NCI

Interaction Types & Directionality: inducer (activating)

Interaction Info: Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener Direct Interaction yes

PMIDs: 16885550 10581306 11808879 12770942 10604939 10518593 12199344 15807877

Sources: PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: 16446048 2541731 12726817

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info: Novel drug target Established target Trial Name -

PMIDs: 17139284 17016423

Sources: TEND TdgClinicalTrial

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 8301566

Sources: NCI

Interaction Types & Directionality: other/unknown

Interaction Info:

PMIDs: 12086984 17287451 17281115

Sources: DrugBank

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 8298083 15306243 7681475 9439778 7585327

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 16271703

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 14499880

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info: Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 8 opener Direct Interaction yes

PMIDs: None found

Sources: ChemblInteractions

Interaction Types & Directionality: inhibitor (inhibitory)

Interaction Info:

PMIDs: 8612523 12511769

Sources: DrugBank

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: TTD

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: 12856829

Sources: NCI

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

Interaction Types & Directionality: n/a

Interaction Info:

PMIDs: None found

Sources: DTC

DrugBank: DB01119

Alternate Names: DIAZOXIDE DrugBank Drug Name 364-98-7 CAS Number Diazoxide Drug Brand

Drug Info: Drug Type small molecule Drug Groups approved Drug Categories amides

TEND: DIAZOXIDE

Alternate Names: DIAZOXIDE Primary Drug Name

Drug Info: Drug Class vasodilator agents Year of Approval 1973 Drug Class antihypertensive agents

Publications:

Interaction Types & Directionality:

n/a

PMIDs:
1032363

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
15752769

Sources:
NCI

Interaction Types & Directionality:

inducer (activating)

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener

Direct Interaction yes

PMIDs:
16885550 10581306 11808879 12770942 10604939 10518593 12199344 15807877

Sources:
PharmGKB DrugBank ChemblInteractions

Interaction Types & Directionality:

other/unknown

PMIDs:
16446048 2541731 12726817

Sources:
DrugBank

Interaction Types & Directionality:

n/a

Interaction Info:

Novel drug target Established target

Trial Name -

PMIDs:
17139284 17016423

Sources:
TEND TdgClinicalTrial

Interaction Types & Directionality:

n/a

PMIDs:
8301566

Sources:
NCI

Interaction Types & Directionality:

other/unknown

PMIDs:
12086984 17287451 17281115

Sources:
DrugBank

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
8298083 15306243 7681475 9439778 7585327

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
16271703

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
14499880

Sources:
NCI

Interaction Types & Directionality:

n/a

Interaction Info:

Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 8 opener

Direct Interaction yes

PMIDs:
None found

Sources:
ChemblInteractions

Interaction Types & Directionality:

inhibitor (inhibitory)

PMIDs:
8612523 12511769

Sources:
DrugBank

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
TTD

Interaction Types & Directionality:

n/a

PMIDs:
12856829

Sources:
NCI

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Interaction Types & Directionality:

n/a

PMIDs:
None found

Sources:
DTC

Alternate Names:

DIAZOXIDE DrugBank Drug Name

364-98-7 CAS Number

Diazoxide Drug Brand

Drug Info:

Drug Type small molecule

Drug Groups approved

Drug Categories amides

Alternate Names:

DIAZOXIDE Primary Drug Name

Drug Info:

Drug Class vasodilator agents

Year of Approval 1973

Drug Class antihypertensive agents

Drug Info:

Drug Indications Antihypertensive Agents

Drug Indications Vasodilator Agents

Drug Class small molecule

Alternate Names:

C428 NCI drug code

Alternate Names:

CHEMBL181 ChEMBL Drug ID

Alternate Names:

D07WEP TTD Drug ID