• Search
      • Search Interactions Search Categories
    • Browse
      • Browse Categories Browse Sources
    • Information
      • About Publications Interaction Types & Directionalities Interaction Score & Query Score API Documentation FAQ Known Data Clients News Contact
    • Downloads
      • Data Source Code

DIAZOXIDE Drug Record

  • Summary
  • Interactions
  • Claims
  • DIAZOXIDE chembl:CHEMBL181 Approved

    Alternate Names:

    SRG-95213
    HYPERSTAT
    DIAZOXIDE
    EUDIMINE
    EUDEMINE
    MUTABASE
    SCH-6783
    NSC-64198
    PROGLYCEM
    NSC-76130
    PROGLYCEM®
    DIAZOSSIDO
    DIAZOXIDUM
    DIAZOXIDO
    chemidplus:364-98-7
    pubchem.compound:3019
    chembl:CHEMBL181
    rxcui:3327
    drugbank:01119

    Drug Info:

    FDA Approval 1973
    Drug Class small molecule
    Drug Indications Vasodilator Agents
    Drug Indications Antihypertensive Agents
    Drug Class antihypertensive agents
    Year of Approval 1973
    Drug Class vasodilator agents
    (4 More Sources)

    Publications:

    Oyekan et al., 1994, Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors., J. Pharmacol. Exp. Ther.
    Darendeliler F et al., 2002, ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures., J Pediatr Endocrinol Metab
    Pearson ER et al., 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., N Engl J Med
    Ohkubo K et al., 2005, Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy., Clin Endocrinol (Oxf)
    de Lonlay et al., 2002, Heterogeneity of persistent hyperinsulinaemic hypoglycaemia. A series of 175 cases., Eur. J. Pediatr.
    Russ et al., 2003, Binding and effect of K ATP channel openers in the absence of Mg2+., Br. J. Pharmacol.
    Shindo et al., 2000, MCC-134, a novel vascular relaxing agent, is an inverse agonist for the pancreatic-type ATP-sensitive K(+) channel., J. Pharmacol. Exp. Ther.
    Sakura et al., 1999, Altered functional properties of KATP channel conferred by a novel splice variant of SUR1., J. Physiol. (Lond.)
    D'hahan et al., 1999, Pharmacological plasticity of cardiac ATP-sensitive potassium channels toward diazoxide revealed by ADP., Proc. Natl. Acad. Sci. U.S.A.
    Imming et al., 2006, Drugs, their targets and the nature and number of drug targets., Nat Rev Drug Discov
    Overington et al., 2006, How many drug targets are there?, Nat Rev Drug Discov
    Pulinilkunnil et al., 2003, Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining., Cardiovasc. Res.
    Nayeem et al., Ischemic and pharmacological induction of delayed cellular protection in iNOS gene-disrupted mice myocytes., Pol J Pharmacol
    Tsukamoto et al., 2005, A role of opening of mitochondrial ATP-sensitive potassium channels in the infarct size-limiting effect of ischemic preconditioning via activation of protein kinase C in the canine heart., Biochem. Biophys. Res. Commun.
    Pedrazzoli et al., 1976, [Influence of diazoxide on the response of the rat exocrine pancreas cholecystokinin-pancreozymin]., Chir Patol Sper
    Ma et al., 2005, Evidence that insulin secretion influences SNAP-25 through proteasomal activation., Biochem. Biophys. Res. Commun.
  • DIAZOXIDE   CCK

    Interaction Score: 4.76

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    1032363


    Sources:
    NCI

  • DIAZOXIDE   SNAP25

    Interaction Score: 2.38

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    15752769


    Sources:
    NCI

  • DIAZOXIDE   KCNJ11

    Interaction Score: 1.7

    Interaction Types & Directionality:
    inducer (activating)

    Interaction Info:
    Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 11 opener
    Direct Interaction yes

    PMIDs:
    12199344 16885550 15807877 11808879 12770942 10604939 10581306 10518593


    Sources:
    ChemblInteractions PharmGKB

  • DIAZOXIDE   KCNJ8

    Interaction Score: 1.19

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Mechanism of Interaction Potassium channel, inwardly rectifying, subfamily J, member 8 opener
    Direct Interaction yes

    PMIDs:
    None found


    Sources:
    ChemblInteractions

  • DIAZOXIDE   SLC12A3

    Interaction Score: 1.06

    Interaction Types & Directionality:
    n/a

    Interaction Info:
    Novel drug target Established target
    Trial Name -

    PMIDs:
    17016423 17139284


    Sources:
    TdgClinicalTrial TEND

  • DIAZOXIDE   CYP7B1

    Interaction Score: 0.95

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    8301566


    Sources:
    NCI

  • DIAZOXIDE   NT5E

    Interaction Score: 0.68

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    16271703


    Sources:
    NCI

  • DIAZOXIDE   LPL

    Interaction Score: 0.53

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    14499880


    Sources:
    NCI

  • DIAZOXIDE   NOS2

    Interaction Score: 0.45

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    12856829


    Sources:
    NCI

  • DIAZOXIDE   CALCA

    Interaction Score: 0.23

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    TTD

  • DIAZOXIDE   CYP1A2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIAZOXIDE   CYP2D6

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • DIAZOXIDE   EHMT2

    Interaction Score: 0.01

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    DTC

  • TEND: DIAZOXIDE

    • Version: 01-August-2011

    Alternate Names:
    DIAZOXIDE Primary Drug Name

    Drug Info:
    Drug Class vasodilator agents
    Year of Approval 1973
    Drug Class antihypertensive agents

    Publications:

  • TdgClinicalTrial: DIAZOXIDE

    • Version: January-2014

    Alternate Names:

    Drug Info:
    Drug Indications Antihypertensive Agents
    Drug Indications Vasodilator Agents
    Drug Class small molecule

    Publications:

  • NCI: DIAZOXIDE

    • Version: 14-September-2017

    Alternate Names:
    C428 NCI drug code

    Drug Info:

    Publications:
    Oyekan et al., 1994, Relaxant responses of rabbit aorta: influence of cytochrome P450 inhibitors., J. Pharmacol. Exp. Ther.
    Pulinilkunnil et al., 2003, Circulating triglyceride lipolysis facilitates lipoprotein lipase translocation from cardiomyocyte to myocardial endothelial lining., Cardiovasc. Res.
    Pedrazzoli et al., 1976, [Influence of diazoxide on the response of the rat exocrine pancreas cholecystokinin-pancreozymin]., Chir Patol Sper

  • PharmGKB: diazoxide

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Pearson ER et al., 2006, Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations., N Engl J Med
    Darendeliler F et al., 2002, ABCC8 (SUR1) and KCNJ11 (KIR6.2) mutations in persistent hyperinsulinemic hypoglycemia of infancy and evaluation of different therapeutic measures., J Pediatr Endocrinol Metab
    Ohkubo K et al., 2005, Genotypes of the pancreatic beta-cell K-ATP channel and clinical phenotypes of Japanese patients with persistent hyperinsulinaemic hypoglycaemia of infancy., Clin Endocrinol (Oxf)

  • DTC: DIAZOXIDE

    • Version: 02-September-2020

    Alternate Names:
    CHEMBL181 ChEMBL Drug ID

    Drug Info:

    Publications:

  • TTD: Diazoxide

    • Version: 2020.06.01

    Alternate Names:
    D07WEP TTD Drug ID

    Drug Info:

    Publications:

  • ChemblDrugs: chembl:CHEMBL181

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

  • ChemblInteractions: CHEMBL181

    • Version: chembl_23

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

The dgidb.org website does not provide any medical or healthcare products, services or advice, and is not for medical emergencies or urgent situations. IF YOU THINK YOU MAY HAVE A MEDICAL EMERGENCY, CALL YOUR DOCTOR OR 911 IMMEDIATELY. Information contained on this website is not a substitute for a doctor's medical judgment or advice. We recommend that you discuss your specific, individual health concerns with your doctor or health care professional.

DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21