ALUPRAM 5 |
ALUPRAM 2 |
DIALAR FTE |
DIASTAT |
RELANIUM |
VALIUM |
SOLIS |
LA-III |
E-PAM |
DIAZEPAM INTENSOL |
RO-5-2807 |
RO-52807 |
STESOLID |
SERENACK |
TRANIMUL |
DIZAC |
Q-PAM |
PAXEL |
VALRELEASE |
DIASTAT ACUDIAL |
APOZEPAM |
VIVOL |
ATENSINE |
WY-3467 |
NSC-77518 |
DIAZEPAM CIV |
TENSIUM |
DIAZEPAM |
ALUPRAM 10 |
SCRIPTOPAM |
NSC-169897 |
DIALAR |
VALCLAIR |
METHYL DIAZEPINONE |
VALIUM® |
DIASTAT® |
7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE |
rxcui:3322 |
chembl:CHEMBL12 |
drugbank:00829 |
chemidplus:439-14-5 |
pubchem.compound:3016 |
Drug Categories | adjuvants, anesthesia |
Drug Class | hypnotics and sedatives |
Year of Approval | 1963 |
Drug Class | Small Molecule |
Drug Indications | anticonvulsant |
FDA Approval | approved |
Drug Groups | investigational |
Drug Categories | benzodiazepine hypnotics and sedatives |
Drug Categories | benzodiazepines and benzodiazepine derivatives |
Drug Categories | cytochrome p-450 cyp2c18 substrates |
Drug Categories | cytochrome p-450 cyp2c19 inhibitors (strength unknown) |
Drug Categories | cytochrome p-450 cyp2e1 inhibitors (strength unknown) |
Drug Categories | cytochrome p-450 cyp3a substrates |
Drug Categories | cytochrome p-450 cyp3a4 inhibitors |
Drug Categories | cytochrome p-450 cyp3a4 inhibitors (strength unknown) |
Drug Categories | cytochrome p-450 cyp3a5 substrates |
Drug Categories | cytochrome p-450 cyp3a7 substrates |
Drug Categories | cytochrome p-450 enzyme inhibitors |
Drug Categories | cytochrome p-450 substrates |
Drug Categories | drugs that are mainly renally excreted |
Drug Categories | heterocyclic compounds, fused-ring |
Drug Categories | muscle relaxants |
Drug Categories | muscle relaxants, centrally acting agents |
Drug Categories | p-glycoprotein substrates |
potentiator |
Trial Name | diazepam rectal gel |
Novel drug target | Established target |
Trial Name | NRL-01 |
potentiator |
Trial Name | diazepam rectal gel |
Novel drug target | Established target |
Trial Name | NRL-01 |
potentiator |
Trial Name | diazepam rectal gel |
Novel drug target | Established target |
Trial Name | NRL-01 |
potentiator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | diazepam rectal gel |
potentiator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | diazepam rectal gel |
potentiator |
positive modulator (activating) |
Trial Name | diazepam rectal gel |
Novel drug target | Established target |
Trial Name | NRL-01 |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | diazepam rectal gel |
potentiator |
positive modulator (activating) |
allosteric modulator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | diazepam rectal gel |
positive modulator (activating) |
potentiator |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | NRL-01 |
allosteric modulator |
potentiator |
positive modulator (activating) |
Specific Binding Site for Interaction | benzodiazepine site |
Details of the Assay for Interaction | Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α3β1γ2. |
Specific Action of the Ligand | Positive |
allosteric modulator |
potentiator |
positive modulator (activating) |
ligand |
Direct Interaction? | True |
Endogenous Drug? | False |
Specific Action of the Ligand | Positive |
potentiator |
positive modulator (activating) |
Direct Interaction | yes |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Trial Name | diazepam rectal gel |
potentiator |
positive modulator (activating) |
Trial Name | diazepam rectal gel |
Novel drug target | Established target |
Trial Name | NRL-01 |
positive modulator (activating) |
potentiator |
Trial Name | diazepam rectal gel |
Novel drug target | Established target |
Trial Name | NRL-01 |
potentiator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
Trial Name | diazepam rectal gel |
potentiator |
positive modulator (activating) |
Trial Name | NRL-01 |
Novel drug target | Established target |
Trial Name | diazepam rectal gel |
potentiator |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
positive modulator (activating) |
Mechanism of Interaction | GABA-A receptor; anion channel positive allosteric modulator |
Direct Interaction | yes |
DIAZEPAM | DrugBank Drug Name |
439-14-5 | CAS Number |
Bio-diazepam | Drug Brand |
Drug Type | small molecule |
Drug Groups | approved |
Drug Groups | illicit |
DIAZEPAM | Primary Drug Name |
Year of Approval | 1963 |
Drug Class | hypnotics and sedatives |
FDA Approval | approved |
Drug Indications | anticonvulsant |
Drug Class | Small Molecule |
C28982 | NCI drug code |
CHEMBL12 | ChEMBL Drug ID |
D07JVL | TTD Drug ID |
DIAZEPAM | GuideToPharmacology Ligand Name |