DIAZEPAM Drug Record
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DIAZEPAM chembl:CHEMBL12 Approved
Alternate Names:
ALUPRAM 5 ALUPRAM 2 DIALAR FTE DIASTAT RELANIUM VALIUM SOLIS LA-III E-PAM DIAZEPAM INTENSOL RO-5-2807 RO-52807 STESOLID SERENACK TRANIMUL DIZAC Q-PAM PAXEL VALRELEASE DIASTAT ACUDIAL APOZEPAM VIVOL ATENSINE WY-3467 NSC-77518 DIAZEPAM CIV TENSIUM DIAZEPAM ALUPRAM 10 SCRIPTOPAM NSC-169897 DIALAR VALCLAIR METHYL DIAZEPINONE VALIUM® DIASTAT® 7-CHLORO-1,3-DIHYDRO-1-METHYL-5-PHENYL-2H-1,4-BENZODIAZEPIN-2-ONE rxcui:3322 chembl:CHEMBL12 drugbank:00829 chemidplus:439-14-5 pubchem.compound:3016 Drug Info:
Drug Categories adjuvants, anesthesia Drug Class hypnotics and sedatives Year of Approval 1963 Drug Class Small Molecule Drug Indications anticonvulsant FDA Approval approved Drug Groups investigational Drug Categories benzodiazepine hypnotics and sedatives Drug Categories benzodiazepines and benzodiazepine derivatives Drug Categories cytochrome p-450 cyp2c18 substrates Drug Categories cytochrome p-450 cyp2c19 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp2e1 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp3a substrates Drug Categories cytochrome p-450 cyp3a4 inhibitors Drug Categories cytochrome p-450 cyp3a4 inhibitors (strength unknown) Drug Categories cytochrome p-450 cyp3a5 substrates Drug Categories cytochrome p-450 cyp3a7 substrates Drug Categories cytochrome p-450 enzyme inhibitors Drug Categories cytochrome p-450 substrates Drug Categories drugs that are mainly renally excreted Drug Categories heterocyclic compounds, fused-ring Drug Categories muscle relaxants Drug Categories muscle relaxants, centrally acting agents Drug Categories p-glycoprotein substrates Publications:
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Interaction Types & Directionality:
potentiator Interaction Info:
Trial Name diazepam rectal gel Novel drug target Established target Trial Name NRL-01 -
Interaction Types & Directionality:
potentiator Interaction Info:
Trial Name diazepam rectal gel Novel drug target Established target Trial Name NRL-01 -
Interaction Types & Directionality:
potentiator Interaction Info:
Trial Name diazepam rectal gel Novel drug target Established target Trial Name NRL-01 -
Interaction Types & Directionality:
potentiator positive modulator (activating) Interaction Info:
Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes Trial Name diazepam rectal gel -
Interaction Types & Directionality:
potentiator positive modulator (activating) Interaction Info:
Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes Trial Name diazepam rectal gel -
Interaction Types & Directionality:
potentiator positive modulator (activating) Interaction Info:
Trial Name diazepam rectal gel Novel drug target Established target Trial Name NRL-01 -
Interaction Types & Directionality:
positive modulator (activating) potentiator Interaction Info:
Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Trial Name diazepam rectal gel -
Interaction Types & Directionality:
potentiator positive modulator (activating) allosteric modulator Interaction Info:
Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Trial Name diazepam rectal gel
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Interaction Types & Directionality:
positive modulator (activating) potentiator Interaction Info:
Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Trial Name NRL-01 -
Interaction Types & Directionality:
allosteric modulator potentiator positive modulator (activating) Interaction Info:
Specific Binding Site for Interaction benzodiazepine site Details of the Assay for Interaction Assay using recombinant GABA<sub>A</sub> channels with subunit composition; α3β1γ2. Specific Action of the Ligand Positive
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Interaction Types & Directionality:
allosteric modulator potentiator positive modulator (activating) ligand Interaction Info:
Direct Interaction? True Endogenous Drug? False Specific Action of the Ligand Positive -
Interaction Types & Directionality:
potentiator positive modulator (activating) Interaction Info:
Direct Interaction yes Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Trial Name diazepam rectal gel -
Interaction Types & Directionality:
potentiator positive modulator (activating) Interaction Info:
Trial Name diazepam rectal gel Novel drug target Established target Trial Name NRL-01 -
Interaction Types & Directionality:
positive modulator (activating) potentiator Interaction Info:
Trial Name diazepam rectal gel Novel drug target Established target Trial Name NRL-01 -
Interaction Types & Directionality:
potentiator positive modulator (activating) Interaction Info:
Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes Trial Name diazepam rectal gel -
Interaction Types & Directionality:
potentiator positive modulator (activating) Interaction Info:
Trial Name NRL-01 Novel drug target Established target Trial Name diazepam rectal gel -
Interaction Types & Directionality:
potentiator positive modulator (activating) Interaction Info:
Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes -
Interaction Types & Directionality:
positive modulator (activating) Interaction Info:
Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes -
Interaction Types & Directionality:
positive modulator (activating) Interaction Info:
Mechanism of Interaction GABA-A receptor; anion channel positive allosteric modulator Direct Interaction yes
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Alternate Names:
DIAZEPAM DrugBank Drug Name 439-14-5 CAS Number Bio-diazepam Drug Brand Drug Info:
Drug Type small molecule Drug Groups approved Drug Groups illicit -
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DIAZEPAM Primary Drug Name Drug Info:
Year of Approval 1963 Drug Class hypnotics and sedatives Publications:
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- Version: January-2014
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Drug Info:
FDA Approval approved Drug Indications anticonvulsant Drug Class Small Molecule Publications:
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C28982 NCI drug code Drug Info:
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CHEMBL12 ChEMBL Drug ID Drug Info:
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D07JVL TTD Drug ID Drug Info:
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- Version: 29-September-2020
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DIAZEPAM GuideToPharmacology Ligand Name Drug Info:
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- Version: ChEMBL_27
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- Version: chembl_23
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