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DIACETYLMORPHINE Drug Record

  • Summary
  • Interactions
  • Claims
  • DIACETYLMORPHINE chembl:CHEMBL459324 Approved

    Alternate Names:

    DIACETYLMORPHINE
    J6.494G
    IDS-NH-001
    IDS-NH-001(SECT.3)
    HEROIN
    (5Α,6Α)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINAN-3,6-DIOL DIACETATE (ESTER)
    DIAMORPHINE
    3,6-DIACETYLMORPHINE
    ACETOMORPHINE
    7,8-DIHYDRO-4,5-ALPHA-EPOXY-17-METHYLMORPHINAN-3,6-ALPHA-DIOL DIACETATE
    (5ALPHA,6ALPHA)-7,8-DIDEHYDRO-4,5-EPOXY-17-METHYLMORPHINAN-3,6-DIOL DIACETATE (ESTER)
    O,O'-DIACETYLMORPHINE
    drugbank:01452
    chemidplus:561-27-3
    rxcui:3304
    chembl:CHEMBL459324
    pubchem.compound:5462328

    Drug Info:

    Drug Categories drugs used in opioid dependence
    (0 More Sources)

    Publications:

    Gao X et al., 2017, Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese., OMICS
    Iamjan SA et al., 2015, BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence., Pharmacogenomics
    Haerian BS, 2013, BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis., Pharmacogenomics
    Boroumand F et al., 2018, Association of the SOD2 (rs2758339 and rs5746136) polymorphisms with the risk of heroin dependency and the SOD2 expression levels., Gene
    Tolami HF et al., 2020, Haplotype-Based Association and In Silico Studies of OPRM1 Gene Variants with Susceptibility to Opioid Dependence Among Addicted Iranians Undergoing Methadone Treatment., J Mol Neurosci
    Haerian BS et al., 2013, OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis., Pharmacogenomics
    Deb I et al., 2010, Single-nucleotide polymorphism (A118G) in exon 1 of OPRM1 gene causes alteration in downstream signaling by mu-opioid receptor and may contribute to the genetic risk for addiction., J Neurochem
    Tan EC et al., 2003, Mu opioid receptor gene polymorphisms and heroin dependence in Asian populations., Neuroreport
    Shi et al., 2002, Sequence variations in the mu-opioid receptor gene (OPRM1) associated with human addiction to heroin., Hum. Mutat.
    Franke P et al., 2001, Nonreplication of association between mu-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependence., Am J Med Genet
    Szeto CY et al., 2001, Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts., Neuroreport
    Antonilli et al., 2005, Effect of repeated administrations of heroin, naltrexone, methadone, and alcohol on morphine glucuronidation in the rat., Psychopharmacology (Berl.)
    Yao et al., 2005, Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behavior., Proc. Natl. Acad. Sci. U.S.A.
    Greenwald et al., 2003, Effects of buprenorphine maintenance dose on mu-opioid receptor availability, plasma concentrations, and antagonist blockade in heroin-dependent volunteers., Neuropsychopharmacology
    Choi et al., 2006, The opioid ligand binding of human mu-opioid receptor is modulated by novel splice variants of the receptor., Biochem. Biophys. Res. Commun.
    Becker et al., 2004, MOR1 receptor mRNA expression in human brains of drug-related fatalities-a real-time PCR quantification., Forensic Sci. Int.
    Wang TY et al., 2012, The aldehyde dehydrogenase 2 gene is associated with heroin dependence., Drug Alcohol Depend
    Qian Y et al., 2020, The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin., Chem Biol Interact
    Klein et al., 2008, Acute and chronic heroin dependence in mice: contribution of opioid and excitatory amino acid receptors., Eur. J. Pharmacol.
    Wee et al., 2010, The role of the dynorphin-kappa opioid system in the reinforcing effects of drugs of abuse., Psychopharmacology (Berl.)
    Gerra G et al., 2007, Human kappa opioid receptor gene (OPRK1) polymorphism is associated with opiate addiction., Am J Med Genet B Neuropsychiatr Genet
    Sun Y et al., 2019, Identification of novel risk loci with shared effects on alcoholism, heroin, and methamphetamine dependence., Mol Psychiatry
  • DIACETYLMORPHINE   ANKS1B

    Interaction Score: 2.18

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31462767


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   SOD2

    Interaction Score: 1.25

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    29459008


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   ALDH2

    Interaction Score: 0.97

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    21723677


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   GAL

    Interaction Score: 0.87

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   CSNK1E

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   GRM3

    Interaction Score: 0.55

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   OPRM1

    Interaction Score: 0.42

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    31853823 28692418 23651028 19891732 12657887 11933204 11424981 11338173 15986196 15937104 12902992 16580639 15013161


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   CES1

    Interaction Score: 0.36

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    31837295


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   HTR3B

    Interaction Score: 0.29

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   BDNF

    Interaction Score: 0.26

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    28692418 26401760 24279859


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   OPRK1

    Interaction Score: 0.16

    Interaction Types & Directionality:
    agonist (activating)

    Interaction Info:

    PMIDs:
    18343363 20352414 17373729


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   COMT

    Interaction Score: 0.11

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • DIACETYLMORPHINE   DRD2

    Interaction Score: 0.02

    Interaction Types & Directionality:
    n/a

    Interaction Info:

    PMIDs:
    None found


    Sources:
    PharmGKB

  • PharmGKB: heroin

    • Version: 18-August-2020

    Alternate Names:

    Drug Info:

    Publications:
    Haerian BS, 2013, BDNF rs6265 polymorphism and drug addiction: a systematic review and meta-analysis., Pharmacogenomics
    Iamjan SA et al., 2015, BDNF (Val66Met) genetic polymorphism is associated with vulnerability for methamphetamine dependence., Pharmacogenomics
    Gao X et al., 2017, Contribution of Genetic Polymorphisms and Haplotypes in DRD2, BDNF, and Opioid Receptors to Heroin Dependence and Endophenotypes Among the Han Chinese., OMICS

  • ChemblDrugs: chembl:CHEMBL459324

    • Version: ChEMBL_27

    Alternate Names:

    Drug Info:

    Publications:

Disclaimer: This resource is intended for purely research purposes. It should not be used for emergencies or medical or professional advice.

A finding of a drug-gene interaction or potentially druggable category does not necessarily indicate effectiveness (or lack thereof) of any drug or treatment regimen. A finding of no interaction or no potentially druggable category does not necessarily indicate lack of effectiveness of any drug or treatment regimen. Drug-gene interactions or potentially druggable categories are not presented in ranked order of potential or predicted efficacy.

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DGIdb (v4.2.0 - sha1 afd9f30b) • Last updated 2020-10-21